HighVista Strategies
Latest statistics and disclosures from HighVista Strategies's latest quarterly 13F-HR filing:
- Top 5 stock holdings are DBC, ABVX, PRAX, COGT, SYRE, and represent 18.41% of HighVista Strategies's stock portfolio.
- Added to shares of these 10 stocks: ABVX, ORKA, TYRA, MLTX, DFTX, NRIX, IVA, ERAS, XENE, VERA.
- Started 35 new stock positions in MIRM, MU, PDD, KOD, BLTE, IVA, RLX, ASMB, MLTX, VERA.
- Reduced shares in these 10 stocks: COGT (-$5.4M), CDTX (-$5.1M), RVMD, ACLX, VRDN, APGE, PTGX, AGIO, APLS, CYTK.
- Sold out of its positions in ACHC, AFRM, AGIO, APLS, APP, ACLX, ALV, Avidity Biosciences Ord, CNX, CDTX. BVN, CMPX, DBVT, GTLB, OFIX, RBLX, SNDK, SCHW, SEPN, FOUR, TMO, UNF, VST, ALC.
- HighVista Strategies was a net seller of stock by $-30M.
- HighVista Strategies has $362M in assets under management (AUM), dropping by -6.73%.
- Central Index Key (CIK): 0001335325
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Portfolio Holdings for HighVista Strategies
HighVista Strategies holds 156 positions in its portfolio as reported in the March 2026 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Invesco Db Commdy Indx Trck Unit (DBC) | 8.5 | $31M | 1.1M | 28.95 |
|
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| Abivax Sa Sponsored Ads (ABVX) | 3.5 | $13M | +56% | 113k | 111.35 |
|
| Praxis Precision Medicines I Com New (PRAX) | 2.3 | $8.5M | 26k | 322.19 |
|
|
| Cogent Biosciences (COGT) | 2.1 | $7.6M | -41% | 197k | 38.49 |
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| Spyre Therapeutics Com New (SYRE) | 2.0 | $7.4M | -22% | 146k | 50.44 |
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| Vaxcyte (PCVX) | 2.0 | $7.2M | +9% | 125k | 58.11 |
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| Revolution Medicines (RVMD) | 1.9 | $6.7M | -42% | 69k | 97.25 |
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| Terns Pharmaceuticals (TERN) | 1.7 | $6.0M | -34% | 114k | 52.72 |
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| Structure Therapeutics Sponsored Ads (GPCR) | 1.6 | $6.0M | -35% | 124k | 48.20 |
|
| Nuvalent Inc-a (NUVL) | 1.6 | $5.8M | -22% | 57k | 102.45 |
|
| Immunovant (IMVT) | 1.5 | $5.6M | 225k | 24.84 |
|
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| Soleno Therapeutics (SLNO) | 1.5 | $5.5M | +22% | 165k | 33.48 |
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| Tyra Biosciences (TYRA) | 1.4 | $5.0M | +274% | 131k | 38.30 |
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| Amylyx Pharmaceuticals (AMLX) | 1.4 | $4.9M | +47% | 352k | 13.90 |
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| Amazon (AMZN) | 1.3 | $4.7M | +28% | 22k | 208.27 |
|
| Lb Pharmaceuticals Com Shs (LBRX) | 1.2 | $4.3M | +23% | 174k | 24.66 |
|
| Relay Therapeutics (RLAY) | 1.2 | $4.2M | -22% | 422k | 9.95 |
|
| Insmed Com Par $.01 (INSM) | 1.1 | $4.0M | -38% | 24k | 163.52 |
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| NVIDIA Corporation (NVDA) | 1.1 | $3.9M | +57% | 22k | 174.40 |
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| Oruka Therapeutics (ORKA) | 1.1 | $3.9M | NEW | 79k | 49.05 |
|
| Cytokinetics Com New (CYTK) | 1.1 | $3.9M | -48% | 59k | 65.91 |
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| Liquidia Corporation Com New (LQDA) | 1.0 | $3.8M | -36% | 100k | 37.74 |
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| Ocular Therapeutix (OCUL) | 1.0 | $3.7M | +28% | 442k | 8.47 |
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| Tarsus Pharmaceuticals (TARS) | 1.0 | $3.7M | -2% | 53k | 70.15 |
|
| Bridgebio Pharma (BBIO) | 1.0 | $3.7M | -38% | 50k | 74.26 |
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| Moonlake Immunotherapeutics Class A Ord (MLTX) | 1.0 | $3.6M | NEW | 194k | 18.64 |
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| Argenx Se Sponsored Adr (ARGX) | 1.0 | $3.6M | +37% | 4.9k | 730.25 |
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| Protagonist Therapeutics (PTGX) | 1.0 | $3.6M | -53% | 34k | 105.40 |
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| Palisade Bio (PALI) | 1.0 | $3.5M | +55% | 2.0M | 1.75 |
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| Definium Therapeutics Com Shs (DFTX) | 1.0 | $3.5M | NEW | 186k | 18.90 |
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| Nurix Therapeutics (NRIX) | 1.0 | $3.5M | NEW | 227k | 15.50 |
|
| Axsome Therapeutics (AXSM) | 1.0 | $3.5M | +83% | 20k | 169.02 |
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| Inventiva Sa Ads (IVA) | 0.9 | $3.4M | NEW | 616k | 5.55 |
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| Dyne Therapeutics (DYN) | 0.9 | $3.3M | +206% | 183k | 18.13 |
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| Apogee Therapeutics (APGE) | 0.8 | $3.0M | -59% | 36k | 84.17 |
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| Gh Research Ordinary Shares (GHRS) | 0.8 | $3.0M | -11% | 213k | 14.06 |
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| Dianthus Therapeutics (DNTH) | 0.8 | $3.0M | -26% | 36k | 83.92 |
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| Maze Therapeatics (MAZE) | 0.8 | $3.0M | -41% | 100k | 29.85 |
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| Erasca (ERAS) | 0.8 | $2.9M | NEW | 181k | 16.18 |
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| Edgewise Therapeutics (EWTX) | 0.8 | $2.9M | -46% | 92k | 31.50 |
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| Enliven Therapeutics (ELVN) | 0.8 | $2.9M | -11% | 73k | 39.20 |
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| Xenon Pharmaceuticals (XENE) | 0.8 | $2.9M | NEW | 49k | 58.15 |
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| Celldex Therapeutics Com New (CLDX) | 0.8 | $2.8M | +72% | 89k | 31.72 |
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| Vera Therapeutics Cl A (VERA) | 0.8 | $2.8M | NEW | 69k | 40.23 |
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| Pharvaris N V (PHVS) | 0.8 | $2.8M | -39% | 98k | 28.25 |
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| Miragen Therapeutics (VRDN) | 0.7 | $2.6M | -63% | 134k | 19.56 |
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| Alkermes SHS (ALKS) | 0.7 | $2.6M | +177% | 73k | 35.36 |
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| Alumis (ALMS) | 0.7 | $2.5M | NEW | 113k | 22.03 |
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| Microsoft Corporation (MSFT) | 0.7 | $2.4M | 6.5k | 370.17 |
|
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| Eyepoint Com New (EYPT) | 0.7 | $2.4M | NEW | 183k | 12.89 |
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| Lumentum Hldgs (LITE) | 0.6 | $2.2M | -27% | 3.1k | 702.76 |
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| Tango Therapeutics (TNGX) | 0.6 | $2.2M | NEW | 104k | 20.92 |
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| Visa Com Cl A (V) | 0.6 | $2.2M | +13% | 7.1k | 302.24 |
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| Guardant Health (GH) | 0.6 | $2.2M | -36% | 23k | 92.37 |
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| Hewlett Packard Enterprise (HPE) | 0.6 | $2.1M | +18% | 90k | 23.81 |
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| Assembly Biosciences Com New (ASMB) | 0.6 | $2.1M | NEW | 75k | 27.75 |
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| Ciena Corp Com New (CIEN) | 0.6 | $2.1M | 5.3k | 388.23 |
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| Jazz Pharmaceuticals Shs Usd (JAZZ) | 0.6 | $2.0M | NEW | 11k | 189.05 |
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| Stoke Therapeutics (STOK) | 0.6 | $2.0M | -45% | 63k | 32.56 |
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| Compass Pathways Sponsored Ads (CMPS) | 0.6 | $2.0M | -26% | 364k | 5.53 |
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| Flowserve Corporation (FLS) | 0.5 | $1.8M | 25k | 73.51 |
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| Immunocore Hldgs Ads (IMCR) | 0.5 | $1.8M | +77% | 59k | 30.15 |
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| Olema Pharmaceuticals (OLMA) | 0.5 | $1.8M | -51% | 118k | 14.91 |
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| Ncr Atleos Corporation Com Shs (NATL) | 0.5 | $1.7M | NEW | 40k | 43.58 |
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| Xpo Logistics Inc equity (XPO) | 0.5 | $1.7M | -29% | 8.9k | 194.55 |
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| ON Semiconductor (ON) | 0.5 | $1.7M | NEW | 28k | 61.92 |
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| Broadcom (AVGO) | 0.5 | $1.7M | 5.6k | 309.51 |
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| Kodiak Sciences (KOD) | 0.5 | $1.7M | NEW | 44k | 38.12 |
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| Constellation Energy (CEG) | 0.4 | $1.6M | +19% | 5.8k | 279.25 |
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| Clean Harbors (CLH) | 0.4 | $1.6M | -11% | 5.5k | 286.73 |
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| Alphabet Cap Stk Cl C (GOOG) | 0.4 | $1.6M | -12% | 5.5k | 286.86 |
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| salesforce (CRM) | 0.4 | $1.6M | -3% | 8.3k | 186.67 |
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| Core Scientific (CORZ) | 0.4 | $1.5M | +62% | 103k | 14.96 |
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| Entergy Corporation (ETR) | 0.4 | $1.5M | +30% | 14k | 112.36 |
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| Celcuity (CELC) | 0.4 | $1.5M | -20% | 13k | 114.14 |
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| Xoma Royalty Corporation Com New (XOMA) | 0.4 | $1.5M | -58% | 47k | 31.37 |
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| Avantor (AVTR) | 0.4 | $1.5M | NEW | 187k | 7.84 |
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| Mastercard Incorporated Cl A (MA) | 0.4 | $1.5M | +5% | 2.9k | 499.66 |
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| Rhythm Pharmaceuticals (RYTM) | 0.4 | $1.5M | -60% | 17k | 86.97 |
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| KBR (KBR) | 0.4 | $1.5M | +31% | 39k | 36.86 |
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| RBC Bearings Incorporated (RBC) | 0.4 | $1.4M | 2.7k | 543.12 |
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| Mirum Pharmaceuticals (MIRM) | 0.4 | $1.4M | NEW | 16k | 92.38 |
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| Unity Software (U) | 0.4 | $1.4M | +118% | 63k | 21.94 |
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| Savara (SVRA) | 0.4 | $1.4M | NEW | 251k | 5.46 |
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| Madrigal Pharmaceuticals (MDGL) | 0.4 | $1.4M | -8% | 2.6k | 523.47 |
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| Cytomx Therapeutics (CTMX) | 0.4 | $1.4M | +48% | 288k | 4.70 |
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| Cg Oncology (CGON) | 0.4 | $1.3M | -32% | 20k | 67.68 |
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| TransDigm Group Incorporated (TDG) | 0.4 | $1.3M | -47% | 1.1k | 1158.96 |
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| Ascendis Pharma A/s Sponsored Adr (ASND) | 0.4 | $1.3M | +57% | 5.8k | 228.73 |
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| Knight-swift Transn Hldgs In Cl A (KNX) | 0.4 | $1.3M | NEW | 23k | 57.58 |
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| Rocket Cos Com Cl A (RKT) | 0.4 | $1.3M | -5% | 92k | 14.25 |
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| Intuit (INTU) | 0.4 | $1.3M | +65% | 3.0k | 432.38 |
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| Micron Technology (MU) | 0.4 | $1.3M | NEW | 3.8k | 337.84 |
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| Belite Bio Sponsored Ads (BLTE) | 0.4 | $1.3M | NEW | 8.0k | 159.44 |
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| Mineralys Therapeutics (MLYS) | 0.3 | $1.3M | -62% | 47k | 27.09 |
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| James Hardie Inds Ord Shs (JHX) | 0.3 | $1.2M | NEW | 66k | 18.94 |
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| Amphenol Corp Cl A (APH) | 0.3 | $1.2M | +38% | 9.8k | 126.35 |
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| Booking Holdings (BKNG) | 0.3 | $1.2M | +16% | 283.00 | 4210.32 |
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| Kilroy Realty Corporation (KRC) | 0.3 | $1.2M | NEW | 42k | 28.21 |
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| MasTec (MTZ) | 0.3 | $1.2M | -27% | 3.6k | 321.74 |
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| EQT Corporation (EQT) | 0.3 | $1.2M | -32% | 18k | 63.64 |
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| Seagate Technology Hldngs Pl Ord Shs (STX) | 0.3 | $1.1M | NEW | 2.9k | 391.76 |
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| Petroleo Brasileiro S A Sp Adr Non Vtg (PBR.A) | 0.3 | $1.1M | +7% | 59k | 18.75 |
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| Western Digital (WDC) | 0.3 | $1.1M | NEW | 4.1k | 270.49 |
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| Ferguson Enterprises Common Stock New (FERG) | 0.3 | $1.1M | -32% | 4.7k | 233.26 |
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| Api Group Corp Com Stk (APG) | 0.3 | $1.1M | -13% | 27k | 40.52 |
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| Travere Therapeutics (TVTX) | 0.3 | $1.1M | NEW | 36k | 29.71 |
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| Workday Cl A (WDAY) | 0.3 | $1.1M | +27% | 8.3k | 129.92 |
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| Ptc (PTC) | 0.3 | $1.1M | +17% | 7.5k | 142.49 |
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| Ge Vernova (GEV) | 0.3 | $1.1M | -31% | 1.2k | 872.90 |
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| Nektar Therapeutics Com New (NKTR) | 0.3 | $1.0M | +23% | 15k | 71.95 |
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| Argan (AGX) | 0.3 | $1.0M | 1.9k | 544.65 |
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| Nextera Energy (NEE) | 0.3 | $1.0M | -42% | 11k | 92.88 |
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| Doordash Cl A (DASH) | 0.3 | $1.0M | NEW | 6.7k | 150.15 |
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| Xcel Energy (XEL) | 0.3 | $998k | +55% | 13k | 79.44 |
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| Meta Platforms Cl A (META) | 0.3 | $997k | -32% | 1.7k | 572.13 |
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| Talen Energy Corp (TLN) | 0.3 | $995k | -10% | 3.1k | 319.23 |
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| Amrize SHS (AMRZ) | 0.3 | $956k | -49% | 17k | 56.02 |
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| Reddit Cl A (RDDT) | 0.3 | $929k | +30% | 6.9k | 134.65 |
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| United Therapeutics Corporation (UTHR) | 0.2 | $898k | -35% | 1.5k | 592.98 |
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| 3M Company (MMM) | 0.2 | $893k | +55% | 6.2k | 145.23 |
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| Union Pacific Corporation (UNP) | 0.2 | $888k | -54% | 3.7k | 242.62 |
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| Avalo Therapeutics Com New (AVTX) | 0.2 | $875k | -38% | 59k | 14.93 |
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| Coupang Cl A (CPNG) | 0.2 | $869k | +85% | 46k | 18.88 |
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| Cleveland-cliffs (CLF) | 0.2 | $866k | -13% | 103k | 8.45 |
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| Zymeworks Del (ZYME) | 0.2 | $854k | NEW | 34k | 25.04 |
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| Everpure Cl A (PSTG) | 0.2 | $827k | -19% | 14k | 59.04 |
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| Banco Bradesco S A Sp Adr Pfd New (BBD) | 0.2 | $760k | +9% | 208k | 3.65 |
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| Corporacion Amer Arpts S A (CAAP) | 0.2 | $752k | -19% | 30k | 25.29 |
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| MercadoLibre (MELI) | 0.2 | $752k | -6% | 435.00 | 1729.02 |
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| Palvella Therapeutics Inc Ne (PVLA) | 0.2 | $736k | NEW | 5.9k | 124.65 |
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| Icici Bank Adr (IBN) | 0.2 | $722k | +6% | 28k | 25.90 |
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| Nu Hldgs Ord Shs Cl A (NU) | 0.2 | $712k | -20% | 50k | 14.37 |
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| Pdd Holdings Sponsored Ads (PDD) | 0.2 | $705k | NEW | 6.9k | 102.18 |
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| Bridgebio Oncology Therapeut Com New (BBOT) | 0.2 | $700k | -65% | 78k | 8.95 |
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| New Oriental Ed & Technology Spon Adr (EDU) | 0.2 | $698k | -3% | 12k | 56.63 |
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| Janux Therapeutics (JANX) | 0.2 | $686k | +19% | 49k | 13.90 |
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| Rlx Technology Sponsored Ads (RLX) | 0.2 | $686k | NEW | 312k | 2.20 |
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| Hdfc Bank Sponsored Ads (HDB) | 0.2 | $650k | +18% | 26k | 24.88 |
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| Newamsterdam Pharma Company Ordinary Shares (NAMS) | 0.2 | $642k | -43% | 20k | 32.01 |
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| Full Truck Alliance Sponsored Ads (YMM) | 0.2 | $641k | -11% | 77k | 8.30 |
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| Xencor (XNCR) | 0.2 | $640k | NEW | 53k | 12.06 |
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| Trevi Therapeutics (TRVI) | 0.2 | $639k | -49% | 54k | 11.93 |
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| Pennymac Financial Services (PFSI) | 0.2 | $639k | -6% | 7.3k | 87.40 |
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| Rxo Common Stock (RXO) | 0.2 | $629k | -52% | 43k | 14.62 |
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| Sea Sponsord Ads (SE) | 0.2 | $617k | 7.5k | 82.81 |
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| Nokia Corp Sponsored Adr (NOK) | 0.2 | $569k | +18% | 71k | 8.04 |
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| Qxo Com New (QXO) | 0.1 | $511k | -55% | 26k | 19.42 |
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| Urogen Pharma (URGN) | 0.1 | $477k | -5% | 27k | 17.98 |
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| Krystal Biotech (KRYS) | 0.1 | $471k | NEW | 1.8k | 258.32 |
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| Jd.com Spon Ads Cl A (JD) | 0.1 | $398k | -22% | 14k | 29.57 |
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| Mbx Biosciences (MBX) | 0.1 | $342k | NEW | 12k | 29.85 |
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| Kymera Therapeutics (KYMR) | 0.1 | $315k | -44% | 3.8k | 83.29 |
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| Kanzhun Sponsored Ads (BZ) | 0.1 | $285k | +3% | 21k | 13.39 |
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| Trip Com Group Ads (TCOM) | 0.1 | $273k | -48% | 5.5k | 49.79 |
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| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.1 | $237k | -86% | 6.0k | 39.72 |
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Past Filings by HighVista Strategies
SEC 13F filings are viewable for HighVista Strategies going back to 2010
- HighVista Strategies 2026 Q1 filed May 15, 2026
- HighVista Strategies 2025 Q4 filed Feb. 17, 2026
- HighVista Strategies 2025 Q3 filed Nov. 14, 2025
- HighVista Strategies 2025 Q2 filed Aug. 14, 2025
- HighVista Strategies 2025 Q1 filed May 15, 2025
- HighVista Strategies 2024 Q4 filed Feb. 14, 2025
- HighVista Strategies 2024 Q3 filed Nov. 14, 2024
- HighVista Strategies 2024 Q2 filed Aug. 14, 2024
- HighVista Strategies 2024 Q1 filed May 15, 2024
- HighVista Strategies 2023 Q3 filed Nov. 14, 2023
- HighVista Strategies 2023 Q2 filed Aug. 14, 2023
- HighVista Strategies 2023 Q1 filed May 15, 2023
- HighVista Strategies 2022 Q4 filed Feb. 14, 2023
- HighVista Strategies 2022 Q3 filed Nov. 14, 2022
- HighVista Strategies 2022 Q2 filed Aug. 15, 2022
- HighVista Strategies 2022 Q1 filed May 16, 2022