5AM Venture Management

Latest statistics and disclosures from 5AM Venture Management's latest quarterly 13F-HR filing:

  • Top 5 stock holdings are TRDA, CAMP, TYRA, VRDN, PHVS, and represent 47.09% of 5AM Venture Management's stock portfolio.
  • Added to shares of these 7 stocks: MPLT (+$17M), ZNTL, TARA, BHVN, TYRA, TECX, SRZN.
  • Started 1 new stock position in MPLT.
  • Reduced shares in these 7 stocks: DNTH (-$14M), PRAX (-$9.0M), ALEC, CNTA, ADVM, TRDA, MRSN.
  • Sold out of its positions in ADVM, ALEC, DNTH, MRSN, PRAX.
  • 5AM Venture Management was a net seller of stock by $-312k.
  • 5AM Venture Management has $318M in assets under management (AUM), dropping by 16.50%.
  • Central Index Key (CIK): 0001799883

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Portfolio Holdings for 5AM Venture Management

5AM Venture Management holds 21 positions in its portfolio as reported in the December 2025 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Entrada Therapeutics (TRDA) 13.1 $42M -4% 4.1M 10.28
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Camp4 Therapeutics Corp (CAMP) 11.3 $36M 5.9M 6.13
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Tyra Biosciences (TYRA) 8.5 $27M +9% 1.0M 26.29
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Miragen Therapeutics (VRDN) 7.2 $23M 737k 31.12
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Pharvaris N V (PHVS) 7.0 $22M 798k 27.75
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Erasca (ERAS) 6.3 $20M 5.4M 3.72
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Eyepoint Com New (EYPT) 6.0 $19M 1.1M 18.27
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Maplight Therapeutics (MPLT) 5.2 $17M NEW 950k 17.57
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Centessa Pharmaceuticals Sponsored Ads (CNTA) 4.6 $15M -14% 581k 25.01
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Celldex Therapeutics Com New (CLDX) 4.2 $14M 497k 27.16
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Tectonic Therapeutic (TECX) 4.0 $13M +18% 607k 20.86
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Enliven Therapeutics (ELVN) 3.7 $12M 773k 15.40
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Artiva Biotherapeutics (ARTV) 3.2 $10M 2.4M 4.29
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Surrozen Com New (SRZN) 2.8 $8.8M +25% 388k 22.60
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Biohaven (BHVN) 2.6 $8.3M +54% 739k 11.29
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Protara Therapeutics Com Stk (TARA) 2.3 $7.3M +71% 1.4M 5.33
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Gh Research Ordinary Shares (GHRS) 2.3 $7.3M 573k 12.70
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Skye Bioscience Com New (SKYE) 2.3 $7.3M 9.7M 0.75
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Zentalis Pharmaceuticals (ZNTL) 1.7 $5.3M +705% 3.9M 1.35
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Silence Therapeutics Ads (SLN) 0.9 $2.9M 476k 6.08
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Rallybio Corp (RLYB) 0.8 $2.5M 3.6M 0.69
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Past Filings by 5AM Venture Management

SEC 13F filings are viewable for 5AM Venture Management going back to 2019

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