HighVista Strategies
Latest statistics and disclosures from HighVista Strategies's latest quarterly 13F-HR filing:
- Top 5 stock holdings are DBC, GPCR, COGT, VRDN, ABVX, and represent 18.12% of HighVista Strategies's stock portfolio.
- Added to shares of these 10 stocks: TERN (+$7.1M), MAZE (+$7.1M), SLNO (+$5.4M), PHVS, STOK, CMPS, LBRX, PALI, TDG, AMLX.
- Started 33 new stock positions in TRVI, APP, GTLB, MAZE, PHVS, CMPS, PALI, DBVT, TMO, UTHR.
- Reduced shares in these 10 stocks: PRAX (-$20M), ABVX (-$15M), MRUS (-$13M), CDTX (-$11M), SNDK (-$10M), DBC (-$8.5M), AKRO (-$5.2M), OLMA, COGT, RVMD.
- Sold out of its positions in ADMA, AMD, AKRO, BABA, AURA, AVTR, BAC, CZR, COF, CSCO.
- HighVista Strategies was a net seller of stock by $-132M.
- HighVista Strategies has $388M in assets under management (AUM), dropping by -4.82%.
- Central Index Key (CIK): 0001335325
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Portfolio Holdings for HighVista Strategies
HighVista Strategies holds 145 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Invesco Db Commdy Indx Trck Unit (DBC) | 6.1 | $24M | -26% | 1.1M | 22.36 |
|
| Structure Therapeutics Sponsored Ads (GPCR) | 3.5 | $13M | -18% | 193k | 69.55 |
|
| Cogent Biosciences (COGT) | 3.1 | $12M | -27% | 337k | 35.52 |
|
| Miragen Therapeutics (VRDN) | 3.0 | $12M | -20% | 373k | 31.12 |
|
| Abivax Sa Sponsored Ads (ABVX) | 2.5 | $9.7M | -60% | 72k | 134.85 |
|
| Revolution Medicines (RVMD) | 2.5 | $9.6M | -31% | 120k | 79.65 |
|
| Praxis Precision Medicines I Com New (PRAX) | 2.0 | $7.6M | -72% | 26k | 294.74 |
|
| Nuvalent Inc-a (NUVL) | 1.9 | $7.4M | -21% | 73k | 100.59 |
|
| Cytokinetics Com New (CYTK) | 1.9 | $7.3M | -13% | 115k | 63.54 |
|
| Terns Pharmaceuticals (TERN) | 1.8 | $7.1M | NEW | 176k | 40.40 |
|
| Maze Therapeatics (MAZE) | 1.8 | $7.1M | NEW | 170k | 41.43 |
|
| Insmed Com Par $.01 (INSM) | 1.8 | $6.9M | -21% | 39k | 174.04 |
|
| Apogee Therapeutics (APGE) | 1.7 | $6.7M | -16% | 89k | 75.48 |
|
| Protagonist Therapeutics (PTGX) | 1.7 | $6.4M | -39% | 74k | 87.34 |
|
| Soleno Therapeutics (SLNO) | 1.6 | $6.3M | +622% | 135k | 46.30 |
|
| Spyre Therapeutics Com New (SYRE) | 1.6 | $6.2M | -12% | 188k | 32.76 |
|
| Bridgebio Pharma (BBIO) | 1.6 | $6.1M | -2% | 80k | 76.49 |
|
| Olema Pharmaceuticals (OLMA) | 1.6 | $6.0M | -44% | 242k | 25.00 |
|
| Immunovant (IMVT) | 1.5 | $5.6M | -12% | 222k | 25.42 |
|
| Liquidia Corporation Com New (LQDA) | 1.4 | $5.4M | -11% | 156k | 34.49 |
|
| Vaxcyte (PCVX) | 1.4 | $5.3M | +31% | 114k | 46.14 |
|
| Cidara Therapeutics Com New (CDTX) | 1.3 | $5.1M | -67% | 23k | 220.89 |
|
| Arcellx Common Stock (ACLX) | 1.3 | $4.9M | -22% | 75k | 65.20 |
|
| Relay Therapeutics (RLAY) | 1.2 | $4.6M | +126% | 545k | 8.46 |
|
| Rhythm Pharmaceuticals (RYTM) | 1.2 | $4.6M | +14% | 43k | 107.04 |
|
| Mineralys Therapeutics (MLYS) | 1.2 | $4.5M | -40% | 125k | 36.29 |
|
| Pharvaris N V (PHVS) | 1.2 | $4.5M | NEW | 162k | 27.75 |
|
| Tarsus Pharmaceuticals (TARS) | 1.1 | $4.4M | +115% | 54k | 81.88 |
|
| Edgewise Therapeutics (EWTX) | 1.1 | $4.2M | -17% | 171k | 24.82 |
|
| Ocular Therapeutix (OCUL) | 1.1 | $4.2M | +222% | 344k | 12.14 |
|
| Agios Pharmaceuticals (AGIO) | 1.0 | $4.0M | -24% | 148k | 27.22 |
|
| Amazon (AMZN) | 1.0 | $4.0M | -34% | 17k | 230.82 |
|
| Apellis Pharmaceuticals (APLS) | 1.0 | $3.8M | +3% | 151k | 25.12 |
|
| Guardant Health (GH) | 1.0 | $3.8M | -43% | 37k | 102.14 |
|
| Stoke Therapeutics (STOK) | 0.9 | $3.7M | NEW | 116k | 31.74 |
|
| Compass Pathways Sponsored Ads (CMPS) | 0.9 | $3.4M | NEW | 499k | 6.90 |
|
| Microsoft Corporation (MSFT) | 0.8 | $3.2M | -30% | 6.5k | 483.62 |
|
| Lb Pharmaceuticals Com Shs (LBRX) | 0.8 | $3.1M | NEW | 140k | 22.26 |
|
| Palisade Bio (PALI) | 0.8 | $3.1M | NEW | 1.3M | 2.35 |
|
| Gh Research Ordinary Shares (GHRS) | 0.8 | $3.1M | 241k | 12.70 |
|
|
| Argenx Se Sponsored Adr (ARGX) | 0.8 | $3.0M | -11% | 3.6k | 840.95 |
|
| Xoma Royalty Corporation Com New (XOMA) | 0.8 | $3.0M | +6% | 113k | 26.59 |
|
| TransDigm Group Incorporated (TDG) | 0.7 | $2.9M | NEW | 2.2k | 1329.85 |
|
| Avidity Biosciences Ord | 0.7 | $2.9M | -38% | 40k | 72.13 |
|
| Amylyx Pharmaceuticals (AMLX) | 0.7 | $2.9M | NEW | 239k | 12.08 |
|
| Bridgebio Oncology Therapeut Com New (BBOT) | 0.7 | $2.9M | NEW | 229k | 12.52 |
|
| NVIDIA Corporation (NVDA) | 0.7 | $2.7M | +6% | 14k | 186.50 |
|
| salesforce (CRM) | 0.6 | $2.3M | -33% | 8.6k | 264.91 |
|
| Visa Com Cl A (V) | 0.6 | $2.2M | -19% | 6.3k | 350.71 |
|
| Septerna (SEPN) | 0.6 | $2.2M | NEW | 79k | 27.88 |
|
| Axsome Therapeutics (AXSM) | 0.5 | $2.0M | +19% | 11k | 182.64 |
|
| Dianthus Therapeutics (DNTH) | 0.5 | $2.0M | -10% | 49k | 41.21 |
|
| Alphabet Cap Stk Cl C (GOOG) | 0.5 | $2.0M | -35% | 6.3k | 313.80 |
|
| Broadcom (AVGO) | 0.5 | $2.0M | -44% | 5.6k | 346.10 |
|
| Rocket Cos Com Cl A (RKT) | 0.5 | $1.9M | NEW | 97k | 19.36 |
|
| Union Pacific Corporation (UNP) | 0.5 | $1.9M | NEW | 8.1k | 231.32 |
|
| Hewlett Packard Enterprise (HPE) | 0.5 | $1.8M | -22% | 76k | 24.02 |
|
| Amrize SHS (AMRZ) | 0.5 | $1.8M | NEW | 34k | 54.08 |
|
| Avalo Therapeutics Com New (AVTX) | 0.4 | $1.7M | +244% | 96k | 18.16 |
|
| Flowserve Corporation (FLS) | 0.4 | $1.7M | -35% | 25k | 69.38 |
|
| Xpo Logistics Inc equity (XPO) | 0.4 | $1.7M | -39% | 13k | 135.91 |
|
| Constellation Energy (CEG) | 0.4 | $1.7M | -36% | 4.8k | 353.27 |
|
| Meta Platforms Cl A (META) | 0.4 | $1.7M | -43% | 2.6k | 660.09 |
|
| Applovin Corp Com Cl A (APP) | 0.4 | $1.7M | NEW | 2.5k | 673.82 |
|
| Madrigal Pharmaceuticals (MDGL) | 0.4 | $1.7M | -19% | 2.8k | 582.34 |
|
| Celcuity (CELC) | 0.4 | $1.6M | +20% | 17k | 99.74 |
|
| Lumentum Hldgs (LITE) | 0.4 | $1.6M | -66% | 4.3k | 368.59 |
|
| Mastercard Incorporated Cl A (MA) | 0.4 | $1.6M | -33% | 2.8k | 570.88 |
|
| Cleveland-cliffs (CLF) | 0.4 | $1.6M | NEW | 119k | 13.28 |
|
| Ferguson Enterprises Common Stock New (FERG) | 0.4 | $1.6M | -27% | 7.0k | 222.63 |
|
| Nextera Energy (NEE) | 0.4 | $1.5M | +22% | 19k | 80.28 |
|
| UniFirst Corporation (UNF) | 0.4 | $1.5M | NEW | 7.7k | 192.90 |
|
| Clean Harbors (CLH) | 0.4 | $1.5M | -31% | 6.2k | 234.48 |
|
| EQT Corporation (EQT) | 0.4 | $1.5M | NEW | 27k | 53.60 |
|
| Celldex Therapeutics Com New (CLDX) | 0.4 | $1.4M | -61% | 52k | 27.16 |
|
| Workday Cl A (WDAY) | 0.4 | $1.4M | -20% | 6.5k | 214.78 |
|
| Trevi Therapeutics (TRVI) | 0.3 | $1.3M | NEW | 106k | 12.52 |
|
| Compass Therapeutics (CMPX) | 0.3 | $1.3M | NEW | 246k | 5.37 |
|
| Thermo Fisher Scientific (TMO) | 0.3 | $1.3M | NEW | 2.3k | 579.45 |
|
| Talen Energy Corp (TLN) | 0.3 | $1.3M | -31% | 3.5k | 374.84 |
|
| Booking Holdings (BKNG) | 0.3 | $1.3M | +54% | 243.00 | 5355.33 |
|
| Orthofix Medical (OFIX) | 0.3 | $1.3M | -8% | 85k | 15.16 |
|
| Enliven Therapeutics (ELVN) | 0.3 | $1.3M | -68% | 83k | 15.40 |
|
| Unity Software (U) | 0.3 | $1.3M | -57% | 29k | 44.17 |
|
| Newamsterdam Pharma Company Ordinary Shares (NAMS) | 0.3 | $1.2M | +11% | 36k | 35.08 |
|
| Reddit Cl A (RDDT) | 0.3 | $1.2M | -15% | 5.3k | 229.87 |
|
| Cg Oncology (CGON) | 0.3 | $1.2M | +12% | 29k | 41.52 |
|
| Ciena Corp Com New (CIEN) | 0.3 | $1.2M | NEW | 5.2k | 233.87 |
|
| RBC Bearings Incorporated (RBC) | 0.3 | $1.2M | -22% | 2.7k | 448.43 |
|
| KBR (KBR) | 0.3 | $1.2M | -15% | 30k | 40.20 |
|
| Intuit (INTU) | 0.3 | $1.2M | -16% | 1.8k | 662.42 |
|
| Api Group Corp Com Stk (APG) | 0.3 | $1.2M | -34% | 31k | 38.26 |
|
| Dyne Therapeutics (DYN) | 0.3 | $1.2M | NEW | 60k | 19.56 |
|
| Pure Storage Cl A (PSTG) | 0.3 | $1.2M | -14% | 17k | 67.01 |
|
| Acadia Healthcare (ACHC) | 0.3 | $1.2M | NEW | 82k | 14.19 |
|
| Ge Vernova (GEV) | 0.3 | $1.2M | +7% | 1.8k | 653.57 |
|
| Rxo Common Stock (RXO) | 0.3 | $1.1M | +12% | 91k | 12.64 |
|
| Immunocore Hldgs Ads (IMCR) | 0.3 | $1.1M | NEW | 33k | 34.71 |
|
| United Therapeutics Corporation (UTHR) | 0.3 | $1.1M | NEW | 2.3k | 487.25 |
|
| Qxo Com New (QXO) | 0.3 | $1.1M | -34% | 59k | 19.29 |
|
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.3 | $1.1M | -29% | 45k | 25.01 |
|
| Ptc (PTC) | 0.3 | $1.1M | -33% | 6.4k | 174.21 |
|
| MasTec (MTZ) | 0.3 | $1.1M | -24% | 5.0k | 217.37 |
|
| Charles Schwab Corporation (SCHW) | 0.3 | $1.1M | -24% | 11k | 99.91 |
|
| Nu Hldgs Ord Shs Cl A (NU) | 0.3 | $1.0M | -42% | 63k | 16.74 |
|
| Sandisk Corp (SNDK) | 0.3 | $1.0M | -90% | 4.4k | 237.38 |
|
| Pennymac Financial Services (PFSI) | 0.3 | $1.0M | -6% | 7.8k | 131.84 |
|
| Affirm Hldgs Com Cl A (AFRM) | 0.3 | $974k | +4% | 13k | 74.43 |
|
| Corporacion Amer Arpts S A (CAAP) | 0.2 | $966k | -47% | 37k | 26.00 |
|
| Amphenol Corp Cl A (APH) | 0.2 | $957k | -54% | 7.1k | 135.14 |
|
| Entergy Corporation (ETR) | 0.2 | $955k | +7% | 10k | 92.43 |
|
| Sea Sponsord Ads (SE) | 0.2 | $950k | +44% | 7.5k | 127.57 |
|
| Full Truck Alliance Sponsored Ads (YMM) | 0.2 | $940k | NEW | 88k | 10.73 |
|
| MercadoLibre (MELI) | 0.2 | $937k | -7% | 465.00 | 2014.26 |
|
| Core Scientific (CORZ) | 0.2 | $925k | -15% | 64k | 14.56 |
|
| Tyra Biosciences (TYRA) | 0.2 | $922k | -46% | 35k | 26.29 |
|
| Vistra Energy (VST) | 0.2 | $915k | NEW | 5.7k | 161.33 |
|
| Cytomx Therapeutics (CTMX) | 0.2 | $826k | -24% | 194k | 4.26 |
|
| Compania De Minas Buenaventu Sponsored Adr (BVN) | 0.2 | $825k | -64% | 30k | 27.83 |
|
| Shift4 Pmts Cl A (FOUR) | 0.2 | $818k | +3% | 13k | 62.97 |
|
| Hdfc Bank Sponsored Ads (HDB) | 0.2 | $809k | -32% | 22k | 36.54 |
|
| Icici Bank Adr (IBN) | 0.2 | $783k | -29% | 26k | 29.80 |
|
| Ascendis Pharma A/s Sponsored Adr (ASND) | 0.2 | $781k | -48% | 3.7k | 213.24 |
|
| Trip Com Group Ads (TCOM) | 0.2 | $766k | +9% | 11k | 71.91 |
|
| Alkermes SHS (ALKS) | 0.2 | $739k | -40% | 26k | 27.98 |
|
| Gitlab Class A Com (GTLB) | 0.2 | $725k | NEW | 19k | 37.53 |
|
| New Oriental Ed & Technology Spon Adr (EDU) | 0.2 | $705k | NEW | 13k | 55.03 |
|
| Roblox Corp Cl A (RBLX) | 0.2 | $683k | -3% | 8.4k | 81.03 |
|
| Alcon Ord Shs (ALC) | 0.2 | $661k | +32% | 10k | 63.28 |
|
| Urogen Pharma (URGN) | 0.2 | $656k | -12% | 28k | 23.42 |
|
| Cnx Resources Corporation (CNX) | 0.2 | $648k | -43% | 18k | 36.77 |
|
| Banco Bradesco S A Sp Adr Pfd New (BBD) | 0.2 | $634k | -63% | 190k | 3.33 |
|
| 3M Company (MMM) | 0.2 | $632k | -48% | 4.0k | 160.10 |
|
| Autoliv (ALV) | 0.2 | $622k | -39% | 5.2k | 118.70 |
|
| Petroleo Brasileiro Sa Petro Sp Adr Non Vtg (PBR.A) | 0.2 | $622k | -60% | 55k | 11.27 |
|
| Xcel Energy (XEL) | 0.2 | $595k | NEW | 8.1k | 73.86 |
|
| Argan (AGX) | 0.2 | $594k | -73% | 1.9k | 313.32 |
|
| Coupang Cl A (CPNG) | 0.2 | $585k | +3% | 25k | 23.59 |
|
| Janux Therapeutics (JANX) | 0.1 | $572k | -24% | 41k | 13.80 |
|
| Kymera Therapeutics (KYMR) | 0.1 | $532k | -56% | 6.8k | 77.81 |
|
| Jd.com Spon Ads Cl A (JD) | 0.1 | $501k | -25% | 18k | 28.70 |
|
| Nektar Therapeutics Com New (NKTR) | 0.1 | $497k | NEW | 12k | 42.28 |
|
| Kanzhun Sponsored Ads (BZ) | 0.1 | $420k | +8% | 21k | 20.38 |
|
| Nokia Corp Sponsored Adr (NOK) | 0.1 | $385k | -28% | 60k | 6.47 |
|
| Dbv Technologies S A Sponsored Ads (DBVT) | 0.1 | $304k | NEW | 16k | 19.17 |
|
Past Filings by HighVista Strategies
SEC 13F filings are viewable for HighVista Strategies going back to 2010
- HighVista Strategies 2025 Q4 filed Feb. 17, 2026
- HighVista Strategies 2025 Q3 filed Nov. 14, 2025
- HighVista Strategies 2025 Q2 filed Aug. 14, 2025
- HighVista Strategies 2025 Q1 filed May 15, 2025
- HighVista Strategies 2024 Q4 filed Feb. 14, 2025
- HighVista Strategies 2024 Q3 filed Nov. 14, 2024
- HighVista Strategies 2024 Q2 filed Aug. 14, 2024
- HighVista Strategies 2024 Q1 filed May 15, 2024
- HighVista Strategies 2023 Q3 filed Nov. 14, 2023
- HighVista Strategies 2023 Q2 filed Aug. 14, 2023
- HighVista Strategies 2023 Q1 filed May 15, 2023
- HighVista Strategies 2022 Q4 filed Feb. 14, 2023
- HighVista Strategies 2022 Q3 filed Nov. 14, 2022
- HighVista Strategies 2022 Q2 filed Aug. 15, 2022
- HighVista Strategies 2022 Q1 filed May 16, 2022
- HighVista Strategies 2021 Q4 filed Feb. 14, 2022