Rtw Investments
Latest statistics and disclosures from Rtw Investments's latest quarterly 13F-HR filing:
- Top 5 stock holdings are MDGL, INSM, PTCT, ARGX, PTGX, and represent 36.07% of Rtw Investments's stock portfolio.
- Added to shares of these 10 stocks: INSM (+$306M), IRTC (+$210M), APLS (+$193M), RGEN (+$174M), COGT (+$147M), PODD (+$92M), ZLAB (+$82M), CSTL (+$82M), IMVT (+$81M), RDNT (+$80M).
- Started 29 new stock positions in PODD, CELC, IVA, TNGX, HNGE, IMVT, KYMR, CAPR, FLGT, KOD.
- Reduced shares in these 10 stocks: RNA (-$496M), AKRO (-$260M), MRUS (-$191M), NTRA (-$115M), SYK (-$86M), PTGX (-$61M), ISRG (-$57M), , TSHA (-$44M), AXSM (-$42M).
- Sold out of its positions in ABVX, ADGM, AKRO, ALEC, RNA, CTMX, DYN, GEHC, LENZ, PEPG. DGX, MRUS.
- Rtw Investments was a net buyer of stock by $368M.
- Rtw Investments has $10B in assets under management (AUM), dropping by 23.01%.
- Central Index Key (CIK): 0001493215
Tip: Access up to 7 years of quarterly data
Positions held by Rtw Investments consolidated in one spreadsheet with up to 7 years of data
Download as csv
Download as Excel
Portfolio Holdings for Rtw Investments
Rtw Investments holds 91 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Madrigal Pharmaceuticals (MDGL) | 11.6 | $1.2B | 2.0M | 582.34 |
|
|
| Insmed Com Par $.01 (INSM) | 8.4 | $843M | +57% | 4.8M | 174.04 |
|
| Ptc Therapeutics I (PTCT) | 5.9 | $588M | 7.7M | 75.96 |
|
|
| Argenx Se Sponsored Adr (ARGX) | 5.7 | $566M | 674k | 840.95 |
|
|
| Protagonist Therapeutics (PTGX) | 4.4 | $442M | -12% | 5.1M | 87.34 |
|
| Natera (NTRA) | 3.4 | $344M | -25% | 1.5M | 229.09 |
|
| RadNet (RDNT) | 2.8 | $281M | +39% | 3.9M | 71.35 |
|
| Tarsus Pharmaceuticals (TARS) | 2.7 | $273M | +4% | 3.3M | 81.88 |
|
| Cogent Biosciences (COGT) | 2.7 | $270M | +118% | 7.6M | 35.52 |
|
| Penumbra (PEN) | 2.7 | $269M | 867k | 310.91 |
|
|
| Irhythm Technologies (IRTC) | 2.1 | $210M | NEW | 1.2M | 177.44 |
|
| Apogee Therapeutics (APGE) | 2.1 | $205M | 2.7M | 75.48 |
|
|
| Apellis Pharmaceuticals (APLS) | 1.9 | $193M | NEW | 7.7M | 25.12 |
|
| ACADIA Pharmaceuticals (ACAD) | 1.9 | $191M | 7.1M | 26.71 |
|
|
| Establishment Labs Holdings Ord (ESTA) | 1.9 | $189M | 2.6M | 72.88 |
|
|
| Stoke Therapeutics (STOK) | 1.8 | $176M | +8% | 5.5M | 31.74 |
|
| Repligen Corporation (RGEN) | 1.7 | $174M | NEW | 1.1M | 163.86 |
|
| Cytokinetics Com New (CYTK) | 1.7 | $173M | 2.7M | 63.54 |
|
|
| Immunocore Hldgs Ads (IMCR) | 1.7 | $169M | 4.9M | 34.71 |
|
|
| Axsome Therapeutics (AXSM) | 1.6 | $162M | -20% | 888k | 182.64 |
|
| Guardant Health (GH) | 1.5 | $151M | 1.5M | 102.14 |
|
|
| Neurocrine Biosciences (NBIX) | 1.5 | $151M | 1.1M | 141.83 |
|
|
| Spyre Therapeutics Com New (SYRE) | 1.4 | $137M | +15% | 4.2M | 32.76 |
|
| Zai Lab Adr (ZLAB) | 1.2 | $123M | +203% | 7.0M | 17.64 |
|
| Immatics SHS (IMTX) | 1.2 | $120M | +29% | 11M | 10.50 |
|
| Belite Bio Sponsored Ads (BLTE) | 1.1 | $114M | +128% | 715k | 159.96 |
|
| Urogen Pharma (URGN) | 1.1 | $106M | 4.5M | 23.42 |
|
|
| Xencor (XNCR) | 1.0 | $104M | +8% | 6.8M | 15.31 |
|
| Insulet Corporation (PODD) | 0.9 | $92M | NEW | 325k | 284.24 |
|
| Taysha Gene Therapies Com Shs (TSHA) | 0.9 | $90M | -32% | 16M | 5.50 |
|
| Masimo Corporation (MASI) | 0.9 | $89M | 683k | 130.06 |
|
|
| Uniqure Nv SHS (QURE) | 0.9 | $89M | -16% | 3.7M | 23.93 |
|
| Stryker Corporation (SYK) | 0.9 | $86M | -50% | 245k | 351.47 |
|
| Cg Oncology (CGON) | 0.8 | $84M | +18% | 2.0M | 41.52 |
|
| Castle Biosciences (CSTL) | 0.8 | $82M | NEW | 2.1M | 38.90 |
|
| Immunovant (IMVT) | 0.8 | $81M | NEW | 3.2M | 25.42 |
|
| Beta Bionics (BBNX) | 0.8 | $76M | -24% | 2.5M | 30.47 |
|
| Gh Research Ordinary Shares (GHRS) | 0.8 | $75M | +6% | 5.9M | 12.70 |
|
| Replimune Group (REPL) | 0.7 | $69M | +11% | 7.1M | 9.72 |
|
| Ultragenyx Pharmaceutical (RARE) | 0.7 | $69M | -7% | 3.0M | 23.00 |
|
| Crinetics Pharmaceuticals In (CRNX) | 0.6 | $63M | +54% | 1.4M | 46.55 |
|
| Oruka Therapeutics (ORKA) | 0.6 | $62M | +5% | 2.1M | 30.31 |
|
| Rocket Pharmaceuticals (RCKT) | 0.6 | $62M | 18M | 3.51 |
|
|
| Compass Pathways Sponsored Ads (CMPS) | 0.6 | $60M | 8.8M | 6.90 |
|
|
| Intuitive Surgical Com New (ISRG) | 0.6 | $57M | -50% | 101k | 566.36 |
|
| Rapt Therapeutics Com New (RAPT) | 0.6 | $56M | +11% | 1.6M | 33.87 |
|
| Celcuity (CELC) | 0.5 | $55M | NEW | 550k | 99.74 |
|
| Verastem Com New (VSTM) | 0.5 | $51M | +21% | 6.6M | 7.72 |
|
| Alkermes SHS (ALKS) | 0.5 | $47M | 1.7M | 27.98 |
|
|
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.4 | $45M | -21% | 1.8M | 25.01 |
|
| Kodiak Sciences (KOD) | 0.4 | $42M | NEW | 1.5M | 27.96 |
|
| Aquestive Therapeutics (AQST) | 0.4 | $40M | 6.3M | 6.46 |
|
|
| Arrowhead Pharmaceuticals (ARWR) | 0.4 | $39M | NEW | 585k | 66.39 |
|
| Savara (SVRA) | 0.4 | $36M | NEW | 6.0M | 6.03 |
|
| Health Sciences Acq Corp 2 (OBIO) | 0.3 | $35M | 8.3M | 4.15 |
|
|
| Neurogene (NGNE) | 0.3 | $28M | 1.4M | 20.60 |
|
|
| Wave Life Sciences SHS (WVE) | 0.2 | $23M | +50% | 1.4M | 17.00 |
|
| Jade Biosciences Com New (JBIO) | 0.2 | $22M | 1.4M | 15.43 |
|
|
| Evommune Com Shs (EVMN) | 0.2 | $22M | NEW | 1.3M | 17.12 |
|
| Kymera Therapeutics (KYMR) | 0.2 | $19M | NEW | 240k | 77.81 |
|
| Fulgent Genetics (FLGT) | 0.2 | $19M | NEW | 705k | 26.27 |
|
| Cullinan Oncology (CGEM) | 0.2 | $18M | 1.7M | 10.35 |
|
|
| Hinge Health Cl A (HNGE) | 0.2 | $16M | NEW | 354k | 46.45 |
|
| Beam Therapeutics (BEAM) | 0.2 | $16M | NEW | 570k | 27.72 |
|
| Heartflow Inc/Sh (HTFL) | 0.1 | $14M | 495k | 29.15 |
|
|
| Compass Therapeutics (CMPX) | 0.1 | $13M | 2.5M | 5.37 |
|
|
| Tango Therapeutics (TNGX) | 0.1 | $13M | NEW | 1.5M | 8.86 |
|
| Lumexa Imaging Holdings (LMRI) | 0.1 | $12M | NEW | 650k | 18.50 |
|
| Larimar Therapeutics (LRMR) | 0.1 | $12M | 3.1M | 3.81 |
|
|
| Tempus Ai Cl A (TEM) | 0.1 | $12M | 200k | 59.05 |
|
|
| Kalaris Therapeutics (KLRS) | 0.1 | $11M | NEW | 1.3M | 8.44 |
|
| Iqvia Holdings (IQV) | 0.1 | $10M | NEW | 46k | 225.41 |
|
| Perceptive Cap Solutions Cor Cl A Ord Shs (PCSC) | 0.1 | $9.7M | 743k | 13.03 |
|
|
| Atai Beckley Nv SHS | 0.1 | $8.2M | NEW | 2.0M | 4.09 |
|
| Allurion Technologies Common Stock (ALUR) | 0.1 | $7.2M | +131% | 5.9M | 1.23 |
|
| Capricor Therapeutics Com New (CAPR) | 0.1 | $7.2M | NEW | 250k | 28.86 |
|
| Structure Therapeutics Sponsored Ads (GPCR) | 0.1 | $7.0M | NEW | 100k | 69.55 |
|
| Inventiva Sa Ads (IVA) | 0.1 | $6.0M | NEW | 1.3M | 4.65 |
|
| Milestone Pharmaceuticals (MIST) | 0.1 | $5.1M | 2.5M | 2.02 |
|
|
| Exagen (XGN) | 0.0 | $4.8M | -53% | 791k | 6.08 |
|
| Tenax Therapeutics Com New (TENX) | 0.0 | $4.6M | 378k | 12.19 |
|
|
| Crescent Biopharma (CBIO) | 0.0 | $4.4M | NEW | 373k | 11.86 |
|
| Mind Medicine Mindmed Com New (MNMD) | 0.0 | $4.0M | NEW | 300k | 13.39 |
|
| 4d Molecular Therapeutics In (FDMT) | 0.0 | $3.6M | NEW | 476k | 7.50 |
|
| Corvus Pharmaceuticals (CRVS) | 0.0 | $3.4M | -83% | 448k | 7.70 |
|
| Omada Health (OMDA) | 0.0 | $3.2M | 200k | 15.78 |
|
|
| Medline Com Cl A (MDLN) | 0.0 | $2.9M | NEW | 70k | 42.00 |
|
| Disc Medicine (IRON) | 0.0 | $2.4M | NEW | 30k | 79.41 |
|
| Imagenebio (IMA) | 0.0 | $2.3M | 334k | 6.90 |
|
|
| Erasca (ERAS) | 0.0 | $546k | NEW | 147k | 3.72 |
|
| Rocket Pharmaceuticals *w Exp 09/02/202 (RCKTW) | 0.0 | $8.5k | 350k | 0.02 |
|
Past Filings by Rtw Investments
SEC 13F filings are viewable for Rtw Investments going back to 2014
- Rtw Investments 2025 Q4 filed Feb. 17, 2026
- Rtw Investments 2025 Q3 filed Nov. 14, 2025
- Rtw Investments 2025 Q2 filed Aug. 14, 2025
- Rtw Investments 2025 Q1 filed May 15, 2025
- Rtw Investments 2024 Q4 filed Feb. 14, 2025
- Rtw Investments 2024 Q3 filed Nov. 14, 2024
- Rtw Investments 2024 Q2 filed Aug. 14, 2024
- Rtw Investments 2024 Q1 filed May 15, 2024
- Rtw Investments 2023 Q4 filed Feb. 14, 2024
- Rtw Investments 2023 Q3 filed Nov. 14, 2023
- Rtw Investments 2023 Q2 filed Aug. 14, 2023
- Rtw Investments 2023 Q1 filed May 15, 2023
- Rtw Investments 2022 Q4 filed Feb. 14, 2023
- Rtw Investments 2022 Q3 filed Nov. 14, 2022
- Rtw Investments 2022 Q2 filed Aug. 15, 2022
- Rtw Investments 2022 Q1 filed May 16, 2022