Baker Bros. Advisors

Baker Bros. Advisors as of Dec. 31, 2012

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 68 positions in its portfolio as reported in the December 2012 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
BioMarin Pharmaceutical (BMRN) 3.7 $9.9M 200k 49.20
Medivation 3.5 $9.5M 967k 9.78
BioDelivery Sciences International 3.4 $9.2M 2.1M 4.31
Xoma 3.2 $8.7M 20M 0.43
Synergy Pharmaceuticals 3.2 $8.6M 1.6M 5.26
Exelisis 4.25% 8/15/2019 conv bonds 3.2 $8.6M 19M 0.45
XenoPort 3.0 $8.0M 1.0M 7.77
Gilead 0.625% 5/1/13 conv bonds 3.0 $8.0M 25M 0.32
BioCryst Pharmaceuticals (BCRX) 2.9 $7.9M 5.6M 1.42
Clovis Oncology 2.9 $7.8M 1.1M 7.03
Seattle Genetics 2.9 $7.7M 19M 0.40
Synageva Biopharma 2.6 $7.1M 8.4M 0.85
Intermune 2.6 $7.1M 1.8M 4.01
Mei Pharma 2.6 $7.0M 1.0M 7.00
Spectrum Pharmaceuticals 2.5 $6.8M 1.5M 4.52
Gilead Sciences (GILD) 2.5 $6.8M 92k 73.45
Threshold Pharma 2.5 $6.7M 1.6M 4.21
Cerus Corporation (CERS) 2.5 $6.7M 2.1M 3.16
Genomic Health 2.5 $6.7M 12M 0.54
Biomarin Pharmaceuticals Notes 1.875% 4/23/2017 conv bonds 2.5 $6.6M 23M 0.29
Gilead 1.625% 5/1/16 conv bonds 2.3 $6.2M 22M 0.29
Incyte 2.3 $6.1M 15M 0.41
Aegerion Pharmaceuticals 2.1 $5.6M 615k 9.11
Array BioPharma 2.1 $5.6M 1.5M 3.72
Viropharma 2.0 $5.4M 9.0M 0.60
Derma Sciences 1.9 $5.1M 1.4M 3.75
Kythera Biopharmaceuticals I 1.9 $5.0M 165k 30.34
Anacor Pharmaceuticals 1.5 $4.0M 777k 5.20
Intermune Inc Notes 5% 3/1/15 conv bonds 1.4 $3.7M 34M 0.11
ArQule 1.3 $3.6M 1.3M 2.79
Repros Therapeutics 1.3 $3.6M 1.5M 2.40
Synta Pharmaceuticals 1.2 $3.2M 1.5M 2.18
Intercept Pharmaceuticals In 1.1 $2.8M 375k 7.57
54 Intermune Inc Notes 2.5% 9/15/18 conv bonds 1.0 $2.8M 17M 0.17
Salix Pharmaceuticals 1.0 $2.7M 67k 40.47
Progenics Pharmaceuticals 1.0 $2.7M 900k 2.98
United Therapeutics Notes 1% 9/15/16 144a conv bonds 1.0 $2.7M 18M 0.15
Zogenix 1.0 $2.7M 2.0M 1.33
Acadia Pharmaceuticals 1.0 $2.7M 16M 0.17
INC Ventrus Biosciences 1.0 $2.6M 1.2M 2.16
D Tranzyme 0.9 $2.4M 4.4M 0.54
Chelsea Therapeutics International 0.9 $2.3M 3.0M 0.76
Onyx Pharmaceuticals 0.8 $2.1M 160k 12.90
Amicus Therapeutics (FOLD) 0.8 $2.1M 765k 2.68
23 Halozyme Therapeutics 0.7 $1.9M 1.8M 1.06
Cytrx 0.7 $1.9M 1.0M 1.87
Vanda Pharmaceuticals (VNDA) 0.7 $1.9M 500k 3.70
Discovery Laboratories 0.7 $1.8M 853k 2.11
Insmed (INSM) 0.6 $1.6M 240k 6.69
Ligand Pharmaceuticals 0.6 $1.5M 73k 20.74
Qlt 0.6 $1.5M 1.5M 1.01
Geron Corporation (GERN) 0.5 $1.4M 1.0M 1.41
Vertex Pharmaceuticals Notes 3.35% 10/1/15 conv bonds 0.5 $1.4M 28M 0.05
Durata Therapeutics 0.5 $1.3M 169k 7.64
Biodel 0.5 $1.3M 540k 2.35
Pharmacyclics 0.5 $1.3M 11M 0.11
Infinity Pharmaceuticals 0.5 $1.2M 1.2M 1.06
Medivation 2.625% 4/1/17 conv bonds 0.5 $1.2M 25M 0.05
ZIOPHARM Oncology 0.4 $1.1M 254k 4.16
Auxilium 0.4 $1.0M 4.4M 0.24
Lpath 0.4 $1.0M 200k 5.05
Ariad Pharmaceuticals 0.3 $830k 2.1M 0.39
Chemocentryx 0.2 $547k 50k 10.94
Cubist Pharmaceuticals 0.1 $210k 5.0k 42.00
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $105k 21k 5.01
Idera Pharmaceuticals 0.0 $79k 89k 0.89
Sequenom 0.0 $61k 13k 4.73
Aradigm Corporation (ARDM) 0.0 $13k 100k 0.13