Baker Bros. Advisors

Baker Bros. Advisors as of Dec. 31, 2020

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 126 positions in its portfolio as reported in the December 2020 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Seagen 31.2 $8.3B 47M 175.14
BeiGene Sponsored Adr (BGNE) 11.4 $3.0B 12M 258.39
Incyte Corporation (INCY) 10.5 $2.8B 32M 86.98
ACADIA Pharmaceuticals (ACAD) 8.4 $2.2B 42M 53.46
Kodiak Sciences (KOD) 7.7 $2.0B 14M 146.91
Alexion Pharmaceuticals 5.2 $1.4B 8.8M 156.24
Prelude Therapeutics (PRLD) 2.7 $724M 10M 71.55
BioMarin Pharmaceutical (BMRN) 2.5 $666M 7.6M 87.69
Invitae (NVTAQ) 2.5 $654M 16M 41.81
Ascendis Pharma A/S Sponsored Adr (ASND) 2.2 $590M 3.5M 166.78
Abcellera Biologics (ABCL) 1.6 $421M 11M 40.24
Mirati Therapeutics 1.2 $310M 1.4M 219.64
argenx SE Sponsored Adr (ARGX) 1.1 $300M 1.0M 294.09
Igm Biosciences (IGMS) 1.0 $278M 3.1M 88.29
Madrigal Pharmaceuticals (MDGL) 0.6 $167M 1.5M 111.17
Amarin Corporation Sponsored Adr (AMRN) 0.5 $137M 28M 4.89
Heron Therapeutics (HRTX) 0.5 $127M 6.0M 21.16
Kymera Therapeutics (KYMR) 0.5 $122M 2.0M 62.00
Allakos (ALLK) 0.4 $100M 714k 140.00
Cerus Corporation (CERS) 0.4 $95M 14M 6.92
BioCryst Pharmaceuticals (BCRX) 0.4 $95M 13M 7.45
Pacific Biosciences of California (PACB) 0.3 $83M 3.2M 25.94
Zymeworks 0.3 $81M 1.7M 47.26
Insmed Incorporated Com Par $.01 (INSM) 0.3 $72M 2.2M 33.29
Forma Therapeutics Holdings SHS 0.3 $71M 2.0M 34.90
Rhythm Pharmaceuticals (RYTM) 0.3 $69M 2.3M 29.73
Neurocrine Biosciences (NBIX) 0.2 $65M 677k 95.85
Axsome Therapeutics (AXSM) 0.2 $64M 779k 81.47
Ultragenyx Pharmaceutical (RARE) 0.2 $62M 444k 138.43
Nurix Therapeutics (NRIX) 0.2 $59M 1.8M 32.88
Atreca Cl A Com (BCEL) 0.2 $57M 3.5M 16.15
Neoleukin Therapeutics 0.2 $54M 3.8M 14.10
Adaptimmune Therapeutics Sponsored Adr (ADAP) 0.2 $53M 9.8M 5.39
Apellis Pharmaceuticals (APLS) 0.2 $51M 897k 57.20
Kiniksa Pharmaceuticals Com Cl A (KNSA) 0.2 $50M 2.8M 17.67
ADC Therapeutics SA SHS (ADCT) 0.2 $45M 1.4M 32.01
Aligos Therapeutics (ALGS) 0.2 $45M 1.6M 27.65
Horizon Therapeutics Public SHS 0.2 $44M 599k 73.15
Krystal Biotech (KRYS) 0.2 $42M 699k 60.00
Chemocentryx 0.2 $41M 657k 61.92
Global Blood Therapeutics In 0.2 $40M 920k 43.31
DBV Technologies Sponsored Adr (DBVT) 0.1 $38M 15M 2.62
Opthea Sponsored Ads (OPT) 0.1 $37M 3.3M 11.21
Merus N V (MRUS) 0.1 $36M 2.0M 17.53
Alkermes SHS (ALKS) 0.1 $31M 1.5M 19.95
Frequency Therapeutics 0.1 $30M 857k 35.26
Protagonist Therapeutics (PTGX) 0.1 $29M 1.4M 20.16
Bioatla (BCAB) 0.1 $28M 825k 34.01
Reata Pharmaceuticals Cl A 0.1 $28M 224k 123.62
Athira Pharma (ATHA) 0.1 $28M 806k 34.25
Aeglea Biotherapeutics 0.1 $27M 3.4M 7.87
Fulgent Genetics (FLGT) 0.1 $26M 496k 52.10
Adaptive Biotechnologies Cor (ADPT) 0.1 $23M 380k 59.13
Verastem 0.1 $22M 10M 2.13
Mereo BioPharma Group Ads (MREO) 0.1 $22M 6.0M 3.58
Altimmune (ALT) 0.1 $21M 1.9M 11.28
Aurinia Pharmaceuticals (AUPH) 0.1 $20M 1.4M 13.83
Immatics SHS (IMTX) 0.1 $20M 1.8M 10.79
Novavax (NVAX) 0.1 $19M 170k 111.51
Idera Pharmaceuticals Com Par 0.1 $17M 4.6M 3.67
Cymabay Therapeutics 0.1 $17M 2.9M 5.74
Invitae Corporation Note 2.0% 9/1/2024 (Principal) 0.1 $16M 10M 1.60
Xencor (XNCR) 0.1 $16M 369k 43.63
BioMarin Pharmaceutical Note 0.599% 8/1/2024 (Principal) 0.1 $16M 15M 1.07
Albireo Pharma 0.1 $16M 413k 37.51
Sangamo Biosciences (SGMO) 0.1 $13M 857k 15.61
GW Pharmaceuticals Ads 0.0 $13M 113k 115.41
Gamida Cell SHS (GMDA) 0.0 $13M 1.5M 8.39
Chinook Therapeutics 0.0 $12M 749k 15.86
Five Prime Therapeutics 0.0 $11M 668k 17.01
Mirum Pharmaceuticals (MIRM) 0.0 $11M 647k 17.46
Silverback Therapeutics (SPRY) 0.0 $11M 238k 46.34
Xenon Pharmaceuticals (XENE) 0.0 $11M 687k 15.38
Bluebird Bio (BLUE) 0.0 $9.8M 227k 43.27
Iveric Bio 0.0 $9.7M 1.4M 6.91
Assembly Biosciences 0.0 $9.3M 1.5M 6.05
Anaptysbio Inc Common (ANAB) 0.0 $9.2M 427k 21.50
Crinetics Pharmaceuticals In (CRNX) 0.0 $8.7M 617k 14.11
Vaxart (VXRT) 0.0 $8.0M 1.4M 5.71
Cabaletta Bio (CABA) 0.0 $7.9M 636k 12.48
Hookipa Pharma Inc equity (HOOK) 0.0 $7.8M 701k 11.09
Syros Pharmaceuticals 0.0 $7.5M 690k 10.85
Denali Therapeutics (DNLI) 0.0 $7.4M 89k 83.76
Karuna Therapeutics Ord 0.0 $7.1M 70k 101.59
Autolus Therapeutics Sponsored Ads (AUTL) 0.0 $7.0M 782k 8.94
Harmony Biosciences Hldgs In (HRMY) 0.0 $6.5M 180k 36.15
Genetron Holdings Ads 0.0 $6.4M 455k 14.00
Intellia Therapeutics (NTLA) 0.0 $6.1M 111k 54.40
Passage Bio (PASG) 0.0 $6.0M 235k 25.57
Replimune Group (REPL) 0.0 $5.9M 154k 38.15
Iteos Therapeutics (ITOS) 0.0 $5.1M 150k 33.82
Protara Therapeutics Com Stk (TARA) 0.0 $4.8M 200k 24.21
Burning Rock Biotech Sponsored Ads (BNR) 0.0 $4.8M 209k 23.10
Gossamer Bio (GOSS) 0.0 $4.6M 481k 9.67
Macrogenics (MGNX) 0.0 $4.6M 201k 22.86
Tricida 0.0 $4.4M 629k 7.05
Inflarx Nv (IFRX) 0.0 $4.3M 856k 5.03
Alector (ALEC) 0.0 $3.6M 239k 15.13
Logicbio Therapeutics 0.0 $3.4M 452k 7.63
Tcr2 Therapeutics Inc cs 0.0 $3.4M 111k 30.93
Constellation Pharmceticls I 0.0 $3.3M 115k 28.80
Legend Biotech Corporation Sponsored Ads (LEGN) 0.0 $3.3M 116k 28.16
Ngm Biopharmaceuticals (NGM) 0.0 $3.2M 107k 30.30
Chiasma 0.0 $3.2M 742k 4.35
Akero Therapeutics (AKRO) 0.0 $3.1M 118k 25.80
Acceleron Pharma 0.0 $2.9M 22k 127.95
Dicerna Pharmaceuticals 0.0 $2.3M 102k 22.03
Ovid Therapeutics (OVID) 0.0 $2.2M 956k 2.31
Inozyme Pharma (INZY) 0.0 $2.2M 107k 20.64
Viking Therapeutics (VKTX) 0.0 $2.0M 364k 5.63
Arcus Biosciences Incorporated (RCUS) 0.0 $1.9M 73k 25.97
Orchard Therapeutics Ads 0.0 $1.4M 333k 4.32
Leap Therapeutics 0.0 $1.3M 560k 2.25
Molecular Templates 0.0 $1.3M 134k 9.39
Oyster Point Pharma 0.0 $1.2M 61k 18.82
Galapagos NV Sponsored Adr (GLPG) 0.0 $1.1M 11k 99.02
Infinity Pharmaceuticals (INFIQ) 0.0 $1.1M 522k 2.12
Evofem Biosciences 0.0 $991k 411k 2.41
Affimed Therapeutics B V 0.0 $958k 165k 5.82
Bellicum Pharmaceuticals 0.0 $879k 249k 3.53
Kezar Life Sciences (KZR) 0.0 $729k 140k 5.22
Adamas Pharmaceuticals 0.0 $641k 148k 4.33
Galmed Pharmaceuticals SHS 0.0 $575k 185k 3.11
uniQure SHS (QURE) 0.0 $244k 6.7k 36.20
Sunesis Pharmaceuticals 0.0 $106k 53k 2.00
Genfit SA Ads (GNFT) 0.0 $71k 15k 4.82