Baker Bros. Advisors as of Dec. 31, 2021
Portfolio Holdings for Baker Bros. Advisors
Baker Bros. Advisors holds 121 positions in its portfolio as reported in the December 2021 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Seagen | 35.3 | $7.2B | 47M | 154.60 | |
| BeiGene Sponsored Adr (BGNE) | 15.4 | $3.2B | 12M | 270.93 | |
| Incyte Corporation (INCY) | 12.0 | $2.5B | 34M | 73.40 | |
| Kodiak Sciences (KOD) | 6.1 | $1.2B | 15M | 84.78 | |
| ACADIA Pharmaceuticals (ACAD) | 4.8 | $978M | 42M | 23.34 | |
| BioMarin Pharmaceutical (BMRN) | 3.3 | $673M | 7.6M | 88.35 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 3.0 | $611M | 4.5M | 134.53 | |
| argenx SE Sponsored Adr (ARGX) | 1.9 | $392M | 1.1M | 350.19 | |
| Mirati Therapeutics | 1.0 | $207M | 1.4M | 146.69 | |
| BioCryst Pharmaceuticals (BCRX) | 0.9 | $176M | 13M | 13.85 | |
| Kymera Therapeutics (KYMR) | 0.7 | $151M | 2.4M | 63.49 | |
| Invitae (NVTAQ) | 0.7 | $151M | 9.9M | 15.27 | |
| Abcellera Biologics (ABCL) | 0.7 | $149M | 11M | 14.30 | |
| Madrigal Pharmaceuticals (MDGL) | 0.6 | $127M | 1.5M | 84.74 | |
| Prelude Therapeutics (PRLD) | 0.6 | $126M | 10M | 12.45 | |
| Legend Biotech Corporation Sponsored Ads (LEGN) | 0.6 | $116M | 2.5M | 46.61 | |
| Pacific Biosciences of California (PACB) | 0.5 | $111M | 5.4M | 20.46 | |
| Global Blood Therapeutics In | 0.5 | $97M | 3.3M | 29.27 | |
| Cerus Corporation (CERS) | 0.5 | $93M | 14M | 6.81 | |
| Igm Biosciences (IGMS) | 0.5 | $93M | 3.2M | 29.33 | |
| Immunocore Holdings Ads (IMCR) | 0.4 | $86M | 2.5M | 34.24 | |
| Travere Therapeutics (TVTX) | 0.4 | $83M | 2.7M | 31.04 | |
| Entrada Therapeutics (TRDA) | 0.4 | $81M | 4.7M | 17.12 | |
| Heron Therapeutics (HRTX) | 0.4 | $74M | 8.1M | 9.13 | |
| Amarin Corporation Sponsored Adr (AMRN) | 0.3 | $71M | 21M | 3.37 | |
| Nurix Therapeutics (NRIX) | 0.3 | $71M | 2.5M | 28.95 | |
| Instil Bio | 0.3 | $67M | 3.9M | 17.11 | |
| Merus N V (MRUS) | 0.3 | $65M | 2.0M | 31.80 | |
| Horizon Therapeutics Public SHS | 0.3 | $65M | 599k | 107.76 | |
| Immatics SHS (IMTX) | 0.3 | $60M | 4.4M | 13.44 | |
| Chemocentryx | 0.3 | $59M | 1.6M | 36.41 | |
| Insmed Incorporated Com Par $.01 (INSM) | 0.3 | $59M | 2.2M | 27.24 | |
| Neurocrine Biosciences (NBIX) | 0.3 | $58M | 677k | 85.17 | |
| Krystal Biotech (KRYS) | 0.3 | $57M | 808k | 69.95 | |
| Verve Therapeutics (VERV) | 0.3 | $52M | 1.4M | 36.87 | |
| Apellis Pharmaceuticals Note 3.5% 9/15/2026 (Principal) | 0.2 | $48M | 32M | 1.51 | |
| Verastem | 0.2 | $44M | 22M | 2.05 | |
| Insmed Incorporated Note 0.75% 6/1/2028 (Principal) | 0.2 | $43M | 40M | 1.08 | |
| Sarepta Therapeutics DBCV 1.5% 11/15/2024 (Principal) | 0.2 | $43M | 29M | 1.46 | |
| Rhythm Pharmaceuticals (RYTM) | 0.2 | $39M | 3.9M | 9.98 | |
| Chinook Therapeutics | 0.2 | $38M | 2.3M | 16.31 | |
| Ultragenyx Pharmaceutical (RARE) | 0.2 | $37M | 444k | 84.09 | |
| Adaptimmune Therapeutics Sponsored Adr (ADAP) | 0.2 | $37M | 9.8M | 3.75 | |
| Alkermes SHS (ALKS) | 0.2 | $35M | 1.5M | 23.26 | |
| Kiniksa Pharmaceuticals Com Cl A (KNSA) | 0.2 | $33M | 2.8M | 11.77 | |
| Design Therapeutics (DSGN) | 0.1 | $31M | 1.4M | 21.41 | |
| Talis Biomedical Corp | 0.1 | $31M | 7.6M | 4.01 | |
| Forma Therapeutics Holdings SHS | 0.1 | $29M | 2.0M | 14.22 | |
| Zymeworks | 0.1 | $28M | 1.7M | 16.39 | |
| Bluebird Bio (BLUE) | 0.1 | $25M | 2.5M | 9.99 | |
| Aligos Therapeutics (ALGS) | 0.1 | $25M | 2.1M | 11.87 | |
| Opthea Sponsored Ads (OPT) | 0.1 | $24M | 3.2M | 7.54 | |
| Crinetics Pharmaceuticals In (CRNX) | 0.1 | $24M | 828k | 28.41 | |
| Xenon Pharmaceuticals (XENE) | 0.1 | $24M | 752k | 31.24 | |
| DBV Technologies Sponsored Adr (DBVT) | 0.1 | $23M | 15M | 1.60 | |
| Axsome Therapeutics (AXSM) | 0.1 | $23M | 611k | 37.78 | |
| Aerovate Therapeutics (AVTE) | 0.1 | $22M | 1.8M | 11.79 | |
| 2seventy bio Common Stock (TSVT) | 0.1 | $21M | 833k | 25.63 | |
| Fulgent Genetics (FLGT) | 0.1 | $20M | 201k | 100.59 | |
| Neoleukin Therapeutics | 0.1 | $18M | 3.8M | 4.82 | |
| Otonomy | 0.1 | $16M | 7.8M | 2.08 | |
| Aeglea Biotherapeutics | 0.1 | $16M | 3.4M | 4.75 | |
| Bioatla (BCAB) | 0.1 | $16M | 825k | 19.63 | |
| Surrozen | 0.1 | $16M | 2.5M | 6.44 | |
| Replimune Group (REPL) | 0.1 | $16M | 593k | 27.10 | |
| Dice Therapeutics | 0.1 | $15M | 588k | 25.31 | |
| Anaptysbio Inc Common (ANAB) | 0.1 | $15M | 427k | 34.75 | |
| Tricida Note 3.5% 5/15/2027 (Principal) | 0.1 | $15M | 28M | 0.54 | |
| Affimed Therapeutics B V | 0.1 | $15M | 2.7M | 5.52 | |
| Achilles Therapeutics Sponsored Ads (ACHL) | 0.1 | $13M | 2.6M | 5.01 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.1 | $13M | 1.1M | 11.26 | |
| Tricida | 0.1 | $12M | 1.3M | 9.56 | |
| Relmada Therapeutics (RLMD) | 0.1 | $11M | 495k | 22.53 | |
| Sarepta Therapeutics (SRPT) | 0.1 | $11M | 124k | 90.05 | |
| Atreca Cl A Com (BCEL) | 0.1 | $11M | 3.5M | 3.03 | |
| Athira Pharma (ATHA) | 0.1 | $11M | 806k | 13.03 | |
| Altimmune (ALT) | 0.0 | $9.8M | 1.1M | 9.16 | |
| Invitae Corporation Note 2.0% 9/1/2024 (Principal) | 0.0 | $9.6M | 10M | 0.93 | |
| Cyteir Therapeutics | 0.0 | $9.2M | 813k | 11.37 | |
| Karuna Therapeutics Ord | 0.0 | $9.2M | 70k | 131.01 | |
| Tango Therapeutics (TNGX) | 0.0 | $8.2M | 750k | 10.94 | |
| Fibrogen (FGEN) | 0.0 | $8.2M | 580k | 14.10 | |
| Edgewise Therapeutics (EWTX) | 0.0 | $7.6M | 500k | 15.28 | |
| Cymabay Therapeutics | 0.0 | $7.3M | 2.2M | 3.38 | |
| Macrogenics (MGNX) | 0.0 | $7.1M | 443k | 16.05 | |
| Iteos Therapeutics (ITOS) | 0.0 | $7.0M | 150k | 46.56 | |
| Novavax (NVAX) | 0.0 | $6.9M | 48k | 143.06 | |
| Allakos (ALLK) | 0.0 | $6.9M | 703k | 9.79 | |
| Tscan Therapeutics (TCRX) | 0.0 | $6.4M | 1.4M | 4.50 | |
| Reata Pharmaceuticals Cl A | 0.0 | $5.9M | 224k | 26.37 | |
| Revolution Medicines (RVMD) | 0.0 | $5.6M | 222k | 25.17 | |
| Harmony Biosciences Hldgs In (HRMY) | 0.0 | $5.3M | 124k | 42.64 | |
| Ngm Biopharmaceuticals (NGM) | 0.0 | $5.2M | 292k | 17.71 | |
| Alector (ALEC) | 0.0 | $4.9M | 239k | 20.65 | |
| Atyr Pharma (LIFE) | 0.0 | $4.7M | 625k | 7.47 | |
| Kura Oncology (KURA) | 0.0 | $4.3M | 304k | 14.00 | |
| Denali Therapeutics (DNLI) | 0.0 | $4.0M | 89k | 44.60 | |
| Biomea Fusion (BMEA) | 0.0 | $3.9M | 525k | 7.45 | |
| Tcr2 Therapeutics Inc cs | 0.0 | $3.5M | 753k | 4.66 | |
| Genetron Holdings Ads | 0.0 | $2.8M | 455k | 6.10 | |
| Cabaletta Bio (CABA) | 0.0 | $2.5M | 662k | 3.79 | |
| Akero Therapeutics (AKRO) | 0.0 | $2.5M | 118k | 21.15 | |
| Vincera Pharma (VINC) | 0.0 | $2.5M | 241k | 10.19 | |
| Albireo Pharma | 0.0 | $2.4M | 105k | 23.29 | |
| Syndax Pharmaceuticals (SNDX) | 0.0 | $2.4M | 111k | 21.89 | |
| Kezar Life Sciences (KZR) | 0.0 | $2.3M | 140k | 16.72 | |
| Burning Rock Biotech Sponsored Ads (BNR) | 0.0 | $2.0M | 209k | 9.53 | |
| Leap Therapeutics | 0.0 | $1.8M | 560k | 3.24 | |
| Hookipa Pharma Inc equity (HOOK) | 0.0 | $1.6M | 701k | 2.33 | |
| Gamida Cell SHS (GMDA) | 0.0 | $1.6M | 611k | 2.54 | |
| Sera Prognostics Class A Com (SERA) | 0.0 | $1.4M | 202k | 6.87 | |
| Neximmune | 0.0 | $1.4M | 294k | 4.61 | |
| Protara Therapeutics Com Stk (TARA) | 0.0 | $1.3M | 200k | 6.75 | |
| Oyster Point Pharma | 0.0 | $1.1M | 61k | 18.27 | |
| Logicbio Therapeutics | 0.0 | $1.0M | 452k | 2.31 | |
| Foghorn Therapeutics (FHTX) | 0.0 | $1.0M | 45k | 22.88 | |
| Evofem Biosciences | 0.0 | $1.0M | 2.7M | 0.38 | |
| Surrozen W Exp 8/11/2026 (SRZNW) | 0.0 | $958k | 833k | 1.15 | |
| Passage Bio (PASG) | 0.0 | $744k | 117k | 6.35 | |
| Inozyme Pharma (INZY) | 0.0 | $730k | 107k | 6.82 | |
| Bellicum Pharmaceuticals | 0.0 | $371k | 249k | 1.49 |
