Hambrecht & Quist Capital Management

Tekla Capital Management as of Sept. 30, 2015

Portfolio Holdings for Tekla Capital Management

Tekla Capital Management holds 135 positions in its portfolio as reported in the September 2015 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Gilead Sciences (GILD) 7.8 $218M 2.2M 98.19
Celgene Corporation 7.0 $196M 1.8M 108.17
Biogen Idec (BIIB) 4.9 $136M 467k 291.81
Incyte Corporation (INCY) 3.9 $108M 974k 110.33
Vertex Pharmaceuticals Incorporated (VRTX) 3.8 $105M 1.0M 104.14
Alexion Pharmaceuticals 3.7 $102M 655k 156.39
Allergan 3.5 $96M 353k 271.81
Johnson & Johnson (JNJ) 3.2 $88M 941k 93.35
Mylan Nv 3.1 $87M 2.2M 40.26
Teva Pharmaceutical Industries (TEVA) 2.8 $78M 1.4M 56.46
Alkermes (ALKS) 2.8 $78M 1.3M 58.67
Regeneron Pharmaceuticals (REGN) 2.6 $72M 154k 465.14
BioMarin Pharmaceutical (BMRN) 2.3 $64M 606k 105.32
Pfizer (PFE) 2.0 $57M 1.8M 31.41
Illumina (ILMN) 1.9 $53M 301k 175.82
UnitedHealth (UNH) 1.7 $47M 402k 116.01
Aetna 1.6 $46M 416k 109.41
Amgen (AMGN) 1.6 $45M 322k 138.32
Bristol Myers Squibb (BMY) 1.5 $42M 712k 59.20
Aegerion Pharmaceuticals 2% Du cvbond 1.3 $37M 13M 2.83
Merck & Co (MRK) 1.2 $34M 681k 49.39
Humana (HUM) 1.2 $34M 188k 179.00
Alnylam Pharmaceuticals (ALNY) 0.9 $25M 311k 80.36
Akorn 0.9 $24M 850k 28.50
Molina Healthcare (MOH) 0.9 $24M 348k 68.85
United Therapeutics Corporation (UTHR) 0.9 $24M 183k 131.24
Medicines Company 0.8 $24M 624k 37.96
Endo International (ENDPQ) 0.8 $22M 320k 69.28
Allscripts Healthcare Solutions (MDRX) 0.8 $22M 1.8M 12.40
Agilent Technologies Inc C ommon (A) 0.8 $22M 636k 34.33
Ventas (VTR) 0.7 $21M 369k 56.06
CIGNA Corporation 0.7 $20M 149k 135.02
Medtronic (MDT) 0.7 $19M 290k 66.94
Hca Holdings (HCA) 0.7 $19M 243k 77.36
ACADIA Pharmaceuticals (ACAD) 0.7 $19M 563k 33.07
Physicians Realty Trust 0.7 $19M 1.2M 15.09
Medical Properties Trust (MPW) 0.7 $18M 1.6M 11.06
iShares NASDAQ Biotechnology Index (IBB) 0.6 $18M 58k 303.33
Novo Nordisk A/S (NVO) 0.6 $16M 295k 54.24
Anacor Pharmaceuticals In 0.6 $15M 131k 117.71
Neurocrine Biosciences (NBIX) 0.5 $15M 376k 39.79
Alere 0.5 $14M 298k 48.15
Omega Healthcare Investors (OHI) 0.5 $15M 413k 35.15
Paratek Pharmaceuticals 0.5 $15M 763k 19.00
Bluebird Bio (BLUE) 0.5 $14M 161k 85.55
Corsicanto Ltd conv bnd 0.5 $14M 15M 0.92
Karyopharm Therapeutics (KPTI) 0.5 $13M 1.2M 10.53
McKesson Corporation (MCK) 0.5 $13M 68k 185.04
Impax Laboratories 0.4 $12M 345k 35.21
Gw Pharmaceuticals Plc ads 0.4 $12M 135k 91.37
Welltower Inc 6.50% pfd prepet 0.4 $12M 200k 60.73
Stryker Corporation (SYK) 0.4 $12M 124k 94.10
Ardelyx (ARDX) 0.4 $11M 640k 17.28
GlaxoSmithKline 0.4 $11M 285k 38.45
Senior Housing Properties Trust 0.4 $11M 671k 16.20
Baxter International (BAX) 0.4 $11M 320k 32.85
Thermo Fisher Scientific (TMO) 0.4 $11M 86k 122.28
Sabra Health Care REIT (SBRA) 0.4 $11M 456k 23.18
Puma Biotechnology (PBYI) 0.4 $11M 141k 75.36
Shire 0.4 $10M 50k 205.24
St. Jude Medical 0.4 $10M 162k 63.09
LTC Properties (LTC) 0.4 $10M 237k 42.67
Baxalta Incorporated 0.4 $10M 320k 31.51
IDEXX Laboratories (IDXX) 0.3 $9.8M 132k 74.25
Zimmer Holdings (ZBH) 0.3 $9.6M 102k 93.93
Community Health Systems (CYH) 0.3 $9.0M 210k 42.77
Abbvie (ABBV) 0.3 $8.9M 164k 54.41
Natera (NTRA) 0.3 $8.8M 814k 10.85
Novartis (NVS) 0.3 $8.5M 93k 91.92
Medivation 0.3 $8.7M 205k 42.50
Ultragenyx Pharmaceutical (RARE) 0.3 $8.5M 88k 96.31
WellCare Health Plans 0.3 $7.6M 89k 86.18
Sage Therapeutics (SAGE) 0.3 $7.6M 181k 42.32
Auris Med Hldg 0.3 $7.5M 2.1M 3.56
Juno Therapeutics 0.3 $7.4M 182k 40.69
Lexicon Pharmaceuticals (LXRX) 0.3 $7.6M 708k 10.74
Eli Lilly & Co. (LLY) 0.3 $7.2M 86k 83.68
Merrimack Pharmaceuticals In 0.3 $7.3M 854k 8.51
Pieris Pharmaceuticals (PIRS) 0.2 $7.0M 3.8M 1.83
Endologix 0.2 $6.8M 551k 12.26
Dynavax Technologies (DVAX) 0.2 $6.7M 275k 24.54
Centene Corporation (CNC) 0.2 $6.5M 120k 54.23
Sagent Pharmaceuticals 0.2 $6.3M 410k 15.33
Horizon Pharma 0.2 $6.5M 326k 19.82
Tenet Healthcare Corporation (THC) 0.2 $6.1M 165k 36.92
Intra Cellular Therapies (ITCI) 0.2 $6.0M 150k 40.04
ISIS Pharmaceuticals 0.2 $5.9M 147k 40.42
Supernus Pharmaceuticals note 7.500 5/0 0.2 $5.5M 2.0M 2.77
Alliqua 0.2 $5.2M 1.7M 3.17
Heron Therapeutics (HRTX) 0.2 $5.3M 219k 24.40
Icon (ICLR) 0.2 $5.1M 72k 70.97
Healthcare Realty Trust Incorporated 0.2 $4.7M 187k 24.85
Mallinckrodt Pub 0.2 $4.7M 73k 63.94
Esperion Therapeutics (ESPR) 0.2 $4.9M 206k 23.59
Allergan Plc pfd conv ser a 0.2 $4.7M 5.0k 943.40
Foamix Pharmaceuticals 0.2 $4.5M 614k 7.33
Spectrum Pharmaceuticals Inc conv 0.2 $4.5M 5.0M 0.89
Uniqure Nv (QURE) 0.1 $4.2M 206k 20.45
Cellectis S A (CLLS) 0.1 $4.2M 158k 26.36
Arca Biopharma 0.1 $4.0M 811k 4.97
DepoMed 0.1 $3.8M 200k 18.85
Achillion Pharmaceuticals 0.1 $3.8M 547k 6.91
Inotek Pharmaceuticals 0.1 $4.0M 425k 9.40
Celldex Therapeutics 0.1 $3.6M 338k 10.54
Wright Medical 0.1 $3.3M 156k 21.02
Epizyme 0.1 $3.3M 257k 12.86
Adaptimmune Therapeutics (ADAP) 0.1 $3.4M 282k 11.97
Trovagene 0.1 $3.1M 550k 5.69
Perrigo Company (PRGO) 0.1 $3.0M 19k 157.25
Forward Pharma A/s 0.1 $3.1M 132k 23.56
Aegerion Pharmaceuticals 0.1 $2.8M 206k 13.60
Flex Pharma 0.1 $2.8M 233k 12.01
Care Cap Properties 0.1 $2.8M 84k 32.94
Momenta Pharmaceuticals 0.1 $2.5M 154k 16.41
Grifols S A Sponsored Adr R (GRFS) 0.1 $2.5M 83k 30.40
Accelr8 Technology 0.1 $2.3M 145k 16.18
Merrimack Pharmaceuticals In note 4.500% 7/1 0.1 $2.3M 1.5M 1.57
Dbv Technologies S A (DBVT) 0.1 $2.3M 66k 35.59
Tetralogic Pharmaceuticals c note 8.000% 6/1 0.1 $2.3M 4.5M 0.52
Chimerix (CMRX) 0.1 $1.8M 48k 38.20
GenMark Diagnostics 0.1 $1.7M 215k 7.87
BioDelivery Sciences International 0.1 $1.4M 250k 5.56
Tetraphase Pharmaceuticals 0.1 $1.4M 192k 7.46
Affimed Therapeutics B V 0.1 $1.4M 228k 6.17
Abaxis 0.0 $988k 23k 43.98
Verastem 0.0 $895k 500k 1.79
Bellicum Pharma 0.0 $872k 60k 14.53
Trillium Therapeutics, Inc. Cmn 0.0 $847k 65k 13.03
Galapagos Nv- (GLPG) 0.0 $814k 20k 40.70
Cynapsus Therapeutics 0.0 $799k 49k 16.20
Zafgen 0.0 $425k 13k 31.94
Cidara Therapeutics Inc Common Stock Usd 0.0001 (CDTX) 0.0 $636k 50k 12.72
Macrogenics (MGNX) 0.0 $273k 13k 21.42
Xencor (XNCR) 0.0 $245k 20k 12.25
Kite Pharma 0.0 $351k 6.3k 55.71