Hambrecht & Quist Capital Management

Tekla Capital Management as of Dec. 31, 2015

Portfolio Holdings for Tekla Capital Management

Tekla Capital Management holds 134 positions in its portfolio as reported in the December 2015 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Gilead Sciences (GILD) 8.6 $236M 2.3M 101.19
Celgene Corporation 7.4 $205M 1.7M 119.76
Biogen Idec (BIIB) 5.0 $138M 451k 306.35
Vertex Pharmaceuticals Incorporated (VRTX) 4.7 $130M 1.0M 125.83
Allergan 4.6 $128M 410k 312.50
Alexion Pharmaceuticals 4.4 $122M 637k 190.75
Johnson & Johnson (JNJ) 3.5 $97M 941k 102.72
Incyte Corporation (INCY) 3.5 $96M 881k 108.45
Teva Pharmaceutical Industries (TEVA) 3.2 $88M 1.3M 65.64
Regeneron Pharmaceuticals (REGN) 3.0 $84M 154k 542.87
Illumina (ILMN) 3.0 $83M 434k 191.95
BioMarin Pharmaceutical (BMRN) 2.3 $63M 596k 104.76
Pfizer (PFE) 2.1 $58M 1.8M 32.28
Amgen (AMGN) 1.9 $52M 322k 162.33
UnitedHealth (UNH) 1.8 $48M 409k 117.64
Alkermes (ALKS) 1.5 $41M 510k 79.38
Merck & Co (MRK) 1.3 $36M 681k 52.82
Shire 1.3 $35M 172k 205.00
Medivation 1.2 $32M 667k 48.34
Agilent Technologies Inc C ommon (A) 1.1 $31M 729k 41.81
Hca Holdings (HCA) 1.1 $30M 449k 67.63
Mylan Nv 1.0 $29M 531k 54.07
Humana (HUM) 0.8 $23M 129k 178.51
ACADIA Pharmaceuticals (ACAD) 0.8 $23M 638k 35.65
Ventas (VTR) 0.8 $21M 369k 56.43
Molina Healthcare (MOH) 0.8 $21M 348k 60.13
Physicians Realty Trust 0.8 $21M 1.2M 16.86
Puma Biotechnology (PBYI) 0.7 $20M 260k 78.40
iShares NASDAQ Biotechnology Index (IBB) 0.7 $20M 58k 338.32
Medical Properties Trust (MPW) 0.7 $18M 1.6M 11.51
Neurocrine Biosciences (NBIX) 0.6 $18M 312k 56.57
Endo International (ENDPQ) 0.6 $18M 286k 61.22
Novo Nordisk A/S (NVO) 0.6 $17M 295k 58.08
McKesson Corporation (MCK) 0.6 $16M 83k 197.23
Horizon Pharma 0.6 $16M 750k 21.67
St. Jude Medical 0.6 $16M 256k 61.77
Medicines Company 0.5 $15M 402k 37.34
Impax Laboratories 0.5 $15M 345k 42.76
United Therapeutics Corporation (UTHR) 0.5 $15M 93k 156.61
Omega Healthcare Investors (OHI) 0.5 $15M 413k 34.98
Paratek Pharmaceuticals 0.5 $15M 763k 18.97
Bristol Myers Squibb (BMY) 0.5 $14M 203k 68.79
Corsicanto Ltd conv bnd 0.5 $13M 15M 0.91
Sanofi-Aventis SA (SNY) 0.5 $13M 305k 42.65
Alnylam Pharmaceuticals (ALNY) 0.5 $13M 138k 94.14
Anacor Pharmaceuticals In 0.5 $12M 110k 112.97
Baxalta Incorporated 0.5 $13M 320k 39.03
Baxter International (BAX) 0.4 $12M 320k 38.15
Thermo Fisher Scientific (TMO) 0.4 $12M 86k 141.85
Cepheid 0.4 $12M 334k 36.53
Welltower Inc 6.50% pfd prepet 0.4 $12M 200k 60.91
GlaxoSmithKline 0.4 $12M 285k 40.35
Stryker Corporation (SYK) 0.4 $12M 124k 92.94
Alere 0.4 $12M 298k 39.09
Ardelyx (ARDX) 0.4 $12M 639k 18.12
Zimmer Holdings (ZBH) 0.4 $11M 102k 102.59
LTC Properties (LTC) 0.4 $10M 237k 43.14
Intra Cellular Therapies (ITCI) 0.4 $10M 188k 53.79
Senior Housing Properties Trust 0.4 $10M 671k 14.84
Ultragenyx Pharmaceutical (RARE) 0.4 $9.9M 88k 112.18
IDEXX Laboratories (IDXX) 0.3 $9.7M 132k 72.92
Medtronic (MDT) 0.3 $9.6M 124k 76.92
Natera (NTRA) 0.3 $9.5M 882k 10.80
Sabra Health Care REIT (SBRA) 0.3 $9.2M 456k 20.23
Icon (ICLR) 0.3 $8.9M 115k 77.70
Cepheid conv 0.3 $8.9M 10M 0.89
Pieris Pharmaceuticals (PIRS) 0.3 $8.8M 3.8M 2.29
Aegerion Pharmaceuticals 2% Du cvbond 0.3 $8.6M 13M 0.66
Universal Health Services (UHS) 0.3 $8.4M 70k 119.49
Novartis (NVS) 0.3 $8.0M 93k 86.04
Community Health Systems (CYH) 0.3 $8.1M 305k 26.53
Centene Corporation (CNC) 0.3 $7.9M 120k 65.81
Juno Therapeutics 0.3 $8.0M 182k 43.97
Eli Lilly & Co. (LLY) 0.3 $7.2M 86k 84.26
WellCare Health Plans 0.2 $6.9M 89k 78.20
Cytomx Therapeutics (CTMX) 0.2 $6.8M 328k 20.87
Merrimack Pharmaceuticals In 0.2 $6.7M 854k 7.90
Karyopharm Therapeutics (KPTI) 0.2 $6.6M 500k 13.25
Dynavax Technologies (DVAX) 0.2 $6.6M 275k 24.16
Retrophin 0.2 $6.4M 330k 19.29
Cellectis S A (CLLS) 0.2 $6.4M 207k 31.03
Auris Med Hldg 0.2 $6.2M 1.3M 4.89
Exelixis (EXEL) 0.2 $5.8M 1.0M 5.64
Flamel Technologies 0.2 $5.8M 474k 12.21
Accelr8 Technology 0.2 $5.7M 265k 21.49
Heron Therapeutics (HRTX) 0.2 $5.8M 219k 26.70
Sage Therapeutics (SAGE) 0.2 $5.7M 98k 58.30
Akorn 0.2 $5.4M 145k 37.31
Endologix 0.2 $5.5M 551k 9.90
Perrigo Company (PRGO) 0.2 $5.4M 37k 144.69
Healthcare Realty Trust Incorporated 0.2 $5.3M 187k 28.32
Foamix Pharmaceuticals 0.2 $5.3M 652k 8.11
Supernus Pharmaceuticals note 7.500 5/0 0.2 $5.4M 2.0M 2.68
Allergan Plc pfd conv ser a 0.2 $5.2M 5.0k 1030.20
Tenet Healthcare Corporation (THC) 0.2 $5.0M 165k 30.30
Sagent Pharmaceuticals 0.2 $4.6M 287k 15.91
Mallinckrodt Pub 0.2 $4.6M 62k 74.64
Inotek Pharmaceuticals 0.2 $4.8M 425k 11.33
Arca Biopharma 0.1 $3.8M 811k 4.65
DepoMed 0.1 $3.6M 200k 18.13
Halozyme Therapeutics (HALO) 0.1 $3.5M 200k 17.33
Alliqua 0.1 $3.5M 1.7M 2.14
Adaptimmune Therapeutics (ADAP) 0.1 $3.6M 297k 12.06
Novavax 0.1 $3.0M 358k 8.39
Bluebird Bio (BLUE) 0.1 $3.2M 49k 64.22
Uniqure Nv (QURE) 0.1 $2.9M 176k 16.54
Flex Pharma 0.1 $2.9M 233k 12.45
Allscripts Healthcare Solutions (MDRX) 0.1 $2.7M 174k 15.38
Insmed (INSM) 0.1 $2.8M 157k 18.15
Grifols S A Sponsored Adr R (GRFS) 0.1 $2.7M 83k 32.40
Lexicon Pharmaceuticals (LXRX) 0.1 $2.6M 198k 13.31
Cynapsus Therapeutics 0.1 $2.8M 180k 15.44
Kite Pharma 0.1 $2.5M 41k 61.61
Forward Pharma A/s 0.1 $2.6M 137k 19.00
Dbv Technologies S A (DBVT) 0.1 $2.4M 66k 36.31
Care Cap Properties 0.1 $2.6M 84k 30.58
Momenta Pharmaceuticals 0.1 $2.3M 154k 14.84
Gw Pharmaceuticals Plc ads 0.1 $2.1M 30k 69.43
Esperion Therapeutics (ESPR) 0.1 $2.3M 103k 22.26
Merrimack Pharmaceuticals In note 4.500% 7/1 0.1 $2.2M 1.5M 1.48
Affimed Therapeutics B V 0.1 $2.1M 294k 7.12
Tetraphase Pharmaceuticals 0.1 $1.9M 192k 10.03
Celldex Therapeutics 0.1 $1.7M 106k 15.68
Nevro (NVRO) 0.1 $1.7M 25k 67.52
Galapagos Nv- (GLPG) 0.1 $1.3M 20k 62.90
Bellicum Pharma 0.0 $1.2M 60k 20.27
GenMark Diagnostics 0.0 $724k 93k 7.76
Cidara Therapeutics Inc Common Stock Usd 0.0001 (CDTX) 0.0 $901k 53k 17.16
Chimerix (CMRX) 0.0 $428k 48k 8.95
Xencor (XNCR) 0.0 $292k 20k 14.60
Abbvie (ABBV) 0.0 $9.0k 156.00 57.69
Zafgen 0.0 $84k 13k 6.31
Rmr Group Inc cl a (RMR) 0.0 $107k 7.4k 14.38
Gilead Sciences 0.0 $27k 278.00 97.12