HighVista Strategies
Latest statistics and disclosures from HighVista Strategies's latest quarterly 13F-HR filing:
- Top 5 stock holdings are DBC, ABVX, MRUS, VRDN, RVMD, and represent 19.34% of HighVista Strategies's stock portfolio.
- Added to shares of these 10 stocks: ABVX (+$11M), CDTX (+$6.8M), INSM (+$5.5M), AGIO (+$5.0M), RVMD (+$5.0M), ACLX, PTGX, GPCR, MRUS, NUVL.
- Started 29 new stock positions in MELI, NBIS, AURA, BEKE, FN, CDTX, INBX, LITE, ADMA, CZR.
- Reduced shares in these 10 stocks: , , WDC, , AMED, STX, VRNA, SNPS, LYFT, CLF.
- Sold out of its positions in ADBE, AMED, ANSS, CME, CLF, CGEM, DAL, IRON, DYN, ETNB.
- HighVista Strategies was a net buyer of stock by $86M.
- HighVista Strategies has $408M in assets under management (AUM), dropping by 49.91%.
- Central Index Key (CIK): 0001335325
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Portfolio Holdings for HighVista Strategies
HighVista Strategies holds 148 positions in its portfolio as reported in the September 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Invesco Db Commdy Indx Trck Unit (DBC) | 7.9 | $32M | 1.4M | 22.53 |
|
|
| Abivax Sa Sponsored Ads (ABVX) | 3.8 | $16M | +260% | 185k | 84.90 |
|
| Merus N V (MRUS) | 3.1 | $13M | +48% | 133k | 94.15 |
|
| Miragen Therapeutics (VRDN) | 2.5 | $10M | -3% | 469k | 21.58 |
|
| Revolution Medicines (RVMD) | 2.0 | $8.2M | +157% | 175k | 46.70 |
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| Protagonist Therapeutics (PTGX) | 2.0 | $8.1M | +110% | 122k | 66.43 |
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| Nuvalent Inc-a (NUVL) | 2.0 | $8.1M | +84% | 93k | 86.48 |
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| Mineralys Therapeutics (MLYS) | 2.0 | $8.0M | +39% | 210k | 37.92 |
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| Arcellx Common Stock (ACLX) | 1.9 | $7.9M | +169% | 96k | 82.10 |
|
| Agios Pharmaceuticals (AGIO) | 1.9 | $7.8M | +178% | 195k | 40.14 |
|
| Cytokinetics Com New (CYTK) | 1.8 | $7.3M | +93% | 133k | 54.96 |
|
| Insmed Com Par $.01 (INSM) | 1.8 | $7.2M | +330% | 50k | 144.01 |
|
| Cidara Therapeutics Com New (CDTX) | 1.7 | $6.8M | NEW | 71k | 95.76 |
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| Cogent Biosciences (COGT) | 1.6 | $6.6M | +63% | 462k | 14.36 |
|
| Structure Therapeutics Sponsored Ads (GPCR) | 1.6 | $6.6M | +172% | 236k | 28.00 |
|
| Amazon (AMZN) | 1.4 | $5.8M | +39% | 26k | 219.57 |
|
| Sandisk Corp (SNDK) | 1.3 | $5.3M | +19% | 48k | 112.20 |
|
| Enliven Therapeutics (ELVN) | 1.3 | $5.3M | +83% | 259k | 20.47 |
|
| Akero Therapeutics (AKRO) | 1.3 | $5.2M | +83% | 110k | 47.48 |
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| Praxis Precision Medicines I Com New (PRAX) | 1.2 | $5.0M | +41% | 95k | 53.00 |
|
| Microsoft Corporation (MSFT) | 1.2 | $4.9M | -7% | 9.5k | 517.95 |
|
| Olema Pharmaceuticals (OLMA) | 1.0 | $4.3M | +57% | 437k | 9.79 |
|
| Bridgebio Pharma (BBIO) | 1.0 | $4.3M | +21% | 82k | 51.94 |
|
| Apogee Therapeutics (APGE) | 1.0 | $4.3M | +137% | 107k | 39.73 |
|
| Immunovant (IMVT) | 1.0 | $4.1M | +38% | 253k | 16.12 |
|
| Xoma Royalty Corporation Com New (XOMA) | 1.0 | $4.1M | -7% | 106k | 38.54 |
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| Guardant Health (GH) | 1.0 | $4.0M | +128% | 65k | 62.48 |
|
| Liquidia Corporation Com New (LQDA) | 1.0 | $4.0M | +46% | 177k | 22.74 |
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| Rhythm Pharmaceuticals (RYTM) | 0.9 | $3.8M | +33% | 38k | 100.99 |
|
| Spyre Therapeutics Com New (SYRE) | 0.9 | $3.6M | +91% | 216k | 16.76 |
|
| Celldex Therapeutics Com New (CLDX) | 0.9 | $3.5M | +26% | 135k | 25.87 |
|
| Gh Research Ordinary Shares (GHRS) | 0.8 | $3.5M | +362% | 242k | 14.30 |
|
| Edgewise Therapeutics (EWTX) | 0.8 | $3.4M | +198% | 208k | 16.22 |
|
| Broadcom (AVGO) | 0.8 | $3.4M | -20% | 10k | 329.91 |
|
| Meta Platforms Cl A (META) | 0.8 | $3.3M | +45% | 4.5k | 734.38 |
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| Xenon Pharmaceuticals (XENE) | 0.8 | $3.3M | +80% | 82k | 40.15 |
|
| Apellis Pharmaceuticals (APLS) | 0.8 | $3.3M | +68% | 146k | 22.63 |
|
| Vaxcyte (PCVX) | 0.8 | $3.1M | +159% | 87k | 36.02 |
|
| salesforce (CRM) | 0.7 | $3.1M | +15% | 13k | 237.00 |
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| Argenx Se Sponsored Adr (ARGX) | 0.7 | $3.0M | +68% | 4.1k | 737.56 |
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| Avidity Biosciences Ord (RNA) | 0.7 | $2.9M | +60% | 66k | 43.57 |
|
| Advanced Micro Devices (AMD) | 0.7 | $2.8M | +11% | 17k | 161.79 |
|
| Xpo Logistics Inc equity (XPO) | 0.7 | $2.7M | 21k | 129.27 |
|
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| Unity Software (U) | 0.7 | $2.7M | +17% | 67k | 40.04 |
|
| Visa Com Cl A (V) | 0.7 | $2.7M | +22% | 7.9k | 341.38 |
|
| Vera Therapeutics Cl A (VERA) | 0.6 | $2.6M | +125% | 91k | 29.06 |
|
| Constellation Energy (CEG) | 0.6 | $2.5M | -8% | 7.6k | 329.07 |
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| NVIDIA Corporation (NVDA) | 0.6 | $2.5M | -14% | 13k | 186.58 |
|
| Hewlett Packard Enterprise (HPE) | 0.6 | $2.4M | +14% | 99k | 24.56 |
|
| Mastercard Incorporated Cl A (MA) | 0.6 | $2.4M | +5% | 4.2k | 568.81 |
|
| Alphabet Cap Stk Cl C (GOOG) | 0.6 | $2.4M | NEW | 9.8k | 243.55 |
|
| CRH Ord (CRH) | 0.6 | $2.3M | NEW | 19k | 119.90 |
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| Scholar Rock Hldg Corp (SRRK) | 0.5 | $2.2M | +90% | 60k | 37.24 |
|
| Ferguson Enterprises Common Stock New (FERG) | 0.5 | $2.2M | -2% | 9.7k | 224.58 |
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| Talen Energy Corp (TLN) | 0.5 | $2.2M | -13% | 5.1k | 425.38 |
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| Quanta Services (PWR) | 0.5 | $2.2M | -18% | 5.2k | 414.42 |
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| Avantor (AVTR) | 0.5 | $2.2M | NEW | 172k | 12.48 |
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| Dianthus Therapeutics (DNTH) | 0.5 | $2.1M | +241% | 54k | 39.35 |
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| Clean Harbors (CLH) | 0.5 | $2.1M | NEW | 9.1k | 232.22 |
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| Lumentum Hldgs (LITE) | 0.5 | $2.1M | NEW | 13k | 162.71 |
|
| Flowserve Corporation (FLS) | 0.5 | $2.1M | NEW | 39k | 53.14 |
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| Capital One Financial (COF) | 0.5 | $2.1M | NEW | 9.7k | 212.58 |
|
| Compania De Minas Buenaventu Sponsored Adr (BVN) | 0.5 | $2.0M | +9% | 83k | 24.33 |
|
| Workday Cl A (WDAY) | 0.5 | $2.0M | +34% | 8.2k | 240.73 |
|
| Ptc (PTC) | 0.5 | $1.9M | -5% | 9.5k | 203.02 |
|
| Argan (AGX) | 0.5 | $1.9M | +24% | 7.1k | 270.05 |
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| Dynavax Technologies Corp Com New (DVAX) | 0.5 | $1.9M | +60% | 193k | 9.93 |
|
| Amphenol Corp Cl A (APH) | 0.5 | $1.9M | -18% | 15k | 123.75 |
|
| Fabrinet SHS (FN) | 0.5 | $1.9M | NEW | 5.1k | 364.62 |
|
| Banco Bradesco S A Sp Adr Pfd New (BBD) | 0.4 | $1.8M | +17% | 520k | 3.38 |
|
| Nu Hldgs Ord Shs Cl A (NU) | 0.4 | $1.8M | +8% | 109k | 16.01 |
|
| Qxo Com New (QXO) | 0.4 | $1.7M | +6% | 90k | 19.06 |
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| Western Digital (WDC) | 0.4 | $1.7M | -71% | 14k | 120.06 |
|
| Pure Storage Cl A (PSTG) | 0.4 | $1.7M | NEW | 20k | 83.81 |
|
| KBR (KBR) | 0.4 | $1.7M | NEW | 36k | 47.29 |
|
| Petroleo Brasileiro Sa Petro Sp Adr Non Vtg (PBR.A) | 0.4 | $1.6M | +31% | 138k | 11.82 |
|
| Seagate Technology Hldngs Pl Ord Shs (STX) | 0.4 | $1.6M | -68% | 6.9k | 236.06 |
|
| Api Group Corp Com Stk (APG) | 0.4 | $1.6M | +88% | 47k | 34.37 |
|
| Madrigal Pharmaceuticals (MDGL) | 0.4 | $1.6M | +53% | 3.5k | 458.66 |
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| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.4 | $1.5M | +55% | 63k | 24.25 |
|
| Core & Main Cl A (CNM) | 0.4 | $1.5M | NEW | 28k | 53.83 |
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| Roivant Sciences SHS (ROIV) | 0.4 | $1.5M | +61% | 99k | 15.13 |
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| Corbus Pharmaceuticals Hldgs Com New (CRBP) | 0.4 | $1.5M | +56% | 118k | 12.65 |
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| Cisco Systems (CSCO) | 0.4 | $1.5M | -7% | 22k | 68.42 |
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| Intuit (INTU) | 0.4 | $1.5M | -33% | 2.2k | 682.91 |
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| Tarsus Pharmaceuticals (TARS) | 0.4 | $1.5M | +112% | 25k | 59.43 |
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| Entegris (ENTG) | 0.4 | $1.5M | -24% | 16k | 92.46 |
|
| Reddit Cl A (RDDT) | 0.4 | $1.4M | NEW | 6.3k | 229.99 |
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| MasTec (MTZ) | 0.3 | $1.4M | -39% | 6.7k | 212.81 |
|
| Bank of America Corporation (BAC) | 0.3 | $1.4M | -15% | 28k | 51.59 |
|
| Ascendis Pharma A/s Sponsored Adr (ASND) | 0.3 | $1.4M | +138% | 7.1k | 198.81 |
|
| Adma Biologics (ADMA) | 0.3 | $1.4M | NEW | 95k | 14.66 |
|
| Evolus (EOLS) | 0.3 | $1.4M | +289% | 226k | 6.14 |
|
| RBC Bearings Incorporated (RBC) | 0.3 | $1.4M | -5% | 3.5k | 390.29 |
|
| Orthofix Medical (OFIX) | 0.3 | $1.4M | -12% | 93k | 14.64 |
|
| Progressive Corporation (PGR) | 0.3 | $1.4M | -6% | 5.5k | 246.95 |
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| Janux Therapeutics (JANX) | 0.3 | $1.4M | -11% | 55k | 24.44 |
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| Core Scientific (CORZ) | 0.3 | $1.3M | -58% | 75k | 17.94 |
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| Charles Schwab Corporation (SCHW) | 0.3 | $1.3M | -13% | 14k | 95.47 |
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| Alkermes SHS (ALKS) | 0.3 | $1.3M | -16% | 44k | 30.00 |
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| Keros Therapeutics (KROS) | 0.3 | $1.3M | +57% | 83k | 15.82 |
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| Corporacion Amer Arpts S A (CAAP) | 0.3 | $1.3M | +15% | 71k | 18.12 |
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| Soleno Therapeutics (SLNO) | 0.3 | $1.3M | +44% | 19k | 67.60 |
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| Relay Therapeutics (RLAY) | 0.3 | $1.3M | +60% | 241k | 5.22 |
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| Ocular Therapeutix (OCUL) | 0.3 | $1.2M | +19% | 107k | 11.69 |
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| Rxo Common Stock (RXO) | 0.3 | $1.2M | +4% | 81k | 15.38 |
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| Johnson Ctls Intl SHS (JCI) | 0.3 | $1.2M | NEW | 11k | 109.95 |
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| Roblox Corp Cl A (RBLX) | 0.3 | $1.2M | NEW | 8.7k | 138.52 |
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| Nextera Energy (NEE) | 0.3 | $1.2M | NEW | 16k | 75.49 |
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| 3M Company (MMM) | 0.3 | $1.2M | -47% | 7.6k | 155.18 |
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| MercadoLibre (MELI) | 0.3 | $1.2M | NEW | 500.00 | 2336.94 |
|
| Caesars Entertainment (CZR) | 0.3 | $1.2M | NEW | 43k | 27.02 |
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| Axsome Therapeutics (AXSM) | 0.3 | $1.1M | -14% | 9.3k | 121.45 |
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| Icici Bank Adr (IBN) | 0.3 | $1.1M | +27% | 37k | 30.23 |
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| Hdfc Bank Sponsored Ads (HDB) | 0.3 | $1.1M | +146% | 33k | 34.16 |
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| Autoliv (ALV) | 0.3 | $1.1M | +2% | 8.7k | 123.50 |
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| Natera (NTRA) | 0.3 | $1.1M | +63% | 6.6k | 160.97 |
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| Cg Oncology (CGON) | 0.3 | $1.0M | +152% | 26k | 40.28 |
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| Pennymac Financial Services (PFSI) | 0.3 | $1.0M | -33% | 8.3k | 123.88 |
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| Magnera Corp Com Shs (MAGN) | 0.3 | $1.0M | -12% | 87k | 11.72 |
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| Ge Vernova (GEV) | 0.2 | $1.0M | -58% | 1.7k | 614.90 |
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| Cnx Resources Corporation (CNX) | 0.2 | $1.0M | -15% | 31k | 32.12 |
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| Shift4 Pmts Cl A (FOUR) | 0.2 | $968k | +10% | 13k | 77.40 |
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| Tyra Biosciences (TYRA) | 0.2 | $921k | +163% | 66k | 13.99 |
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| Sea Sponsord Ads (SE) | 0.2 | $919k | -42% | 5.1k | 178.73 |
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| Affirm Hldgs Com Cl A (AFRM) | 0.2 | $914k | NEW | 13k | 73.08 |
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| Newamsterdam Pharma Company Ordinary Shares (NAMS) | 0.2 | $905k | +65% | 32k | 28.44 |
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| Entergy Corporation (ETR) | 0.2 | $895k | -37% | 9.6k | 93.19 |
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| Kymera Therapeutics (KYMR) | 0.2 | $890k | NEW | 16k | 56.60 |
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| Booking Holdings (BKNG) | 0.2 | $848k | -56% | 157.00 | 5399.27 |
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| Cytomx Therapeutics (CTMX) | 0.2 | $820k | NEW | 257k | 3.19 |
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| Jd.com Spon Ads Cl A (JD) | 0.2 | $818k | +21% | 23k | 34.98 |
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| Coupang Cl A (CPNG) | 0.2 | $774k | -44% | 24k | 32.20 |
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| Trip Com Group Ads (TCOM) | 0.2 | $734k | +15% | 9.8k | 75.20 |
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| Celcuity (CELC) | 0.2 | $676k | NEW | 14k | 49.40 |
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| Alibaba Group Hldg Sponsored Ads (BABA) | 0.2 | $672k | 3.8k | 178.73 |
|
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| Urogen Pharma (URGN) | 0.2 | $636k | NEW | 32k | 19.95 |
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| Nebius Group Shs Class A (NBIS) | 0.1 | $584k | NEW | 5.2k | 112.27 |
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| Alcon Ord Shs (ALC) | 0.1 | $466k | +28% | 7.9k | 59.26 |
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| Kanzhun Sponsored Ads (BZ) | 0.1 | $442k | -39% | 19k | 23.36 |
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| Wave Life Sciences SHS (WVE) | 0.1 | $434k | +64% | 59k | 7.32 |
|
| Nokia Corp Sponsored Adr (NOK) | 0.1 | $399k | 83k | 4.81 |
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| Avalo Therapeutics Com New (AVTX) | 0.1 | $353k | NEW | 28k | 12.71 |
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| Inhibrx Biosciences (INBX) | 0.1 | $257k | NEW | 7.6k | 33.68 |
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| Tal Education Group Sponsored Ads (TAL) | 0.1 | $220k | +8% | 20k | 11.20 |
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| Ke Hldgs Sponsored Ads (BEKE) | 0.1 | $217k | NEW | 11k | 19.00 |
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| Aura Biosciences (AURA) | 0.0 | $168k | NEW | 27k | 6.18 |
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| Moonlake Immunotherapeutics Class A Ord (MLTX) | 0.0 | $137k | -9% | 19k | 7.17 |
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Past Filings by HighVista Strategies
SEC 13F filings are viewable for HighVista Strategies going back to 2010
- HighVista Strategies 2025 Q3 filed Nov. 14, 2025
- HighVista Strategies 2025 Q2 filed Aug. 14, 2025
- HighVista Strategies 2025 Q1 filed May 15, 2025
- HighVista Strategies 2024 Q4 filed Feb. 14, 2025
- HighVista Strategies 2024 Q3 filed Nov. 14, 2024
- HighVista Strategies 2024 Q2 filed Aug. 14, 2024
- HighVista Strategies 2024 Q1 filed May 15, 2024
- HighVista Strategies 2023 Q3 filed Nov. 14, 2023
- HighVista Strategies 2023 Q2 filed Aug. 14, 2023
- HighVista Strategies 2023 Q1 filed May 15, 2023
- HighVista Strategies 2022 Q4 filed Feb. 14, 2023
- HighVista Strategies 2022 Q3 filed Nov. 14, 2022
- HighVista Strategies 2022 Q2 filed Aug. 15, 2022
- HighVista Strategies 2022 Q1 filed May 16, 2022
- HighVista Strategies 2021 Q4 filed Feb. 14, 2022
- HighVista Strategies 2021 Q3 filed Nov. 15, 2021