Baker Bros. Advisors

Baker Bros. Advisors as of Dec. 31, 2011

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 55 positions in its portfolio as reported in the December 2011 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Onyx Pharmaceuticals 4.4 $9.4M 215k 43.95
55 Intermune Inc Notes 5% 3/1/15 conv bonds 4.2 $9.0M 19M 0.48
Aegerion Pharmaceuticals 4.1 $8.8M 527k 16.74
10 Auxilium 4.1 $8.8M 6.5M 1.36
33 Pharmacyclics 4.0 $8.7M 8.0M 1.09
31 Micromet 4.0 $8.6M 4.0M 2.16
23 Gilead Sciences 3.8 $8.2M 2.9M 2.83
Dendreon Corp cnv 3.4 $7.3M 11M 0.69
23 Halozyme Therapeutics 3.2 $7.0M 1.8M 3.92
14 Biomarin 3.1 $6.8M 488k 13.87
9 Ariad Pharmaceuticals 2.9 $6.2M 5.4M 1.15
Exelixis (EXEL) 2.8 $6.1M 1.3M 4.74
54 Intermune Inc Notes 2.5% 9/15/18 conv bonds 2.8 $6.0M 22M 0.28
D Tranzyme 2.7 $5.8M 2.0M 2.89
Chelsea Therapeutics International 2.6 $5.7M 1.1M 5.13
ACADIA Pharmaceuticals (ACAD) 2.6 $5.7M 5.2M 1.08
Dendreon Corporation 2.4 $5.2M 682k 7.60
Salix Pharmaceuticals 2.4 $5.1M 107k 47.85
Clovis Oncology 2.3 $4.9M 350k 14.09
28 Inhibitex 2.3 $4.9M 2.3M 2.15
Anthera Pharmaceuticals 2.1 $4.7M 758k 6.14
40 Synageva 2.1 $4.6M 6.2M 0.75
52 Gilead 1.625% 5/1/16 conv bonds 2.1 $4.5M 22M 0.21
Threshold Pharma 2.1 $4.5M 3.7M 1.22
38 Seattle Genetics 2.0 $4.3M 21M 0.21
Alere Inc note 3.000% 5/1 2.0 $4.3M 4.5M 0.95
46 Biomarin Pharmaceuticals Notes 1.875% 4/23/2017 conv bonds 1.9 $4.0M 7.9M 0.51
12 Biocryst Pharmaceuticals 1.7 $3.7M 5.6M 0.67
Derma Sciences 1.7 $3.6M 476k 7.58
27 Incyte 1.6 $3.4M 16M 0.22
Spectrum Pharmaceuticals 1.5 $3.3M 910k 3.64
43 Ym Biosciences 1.5 $3.2M 8.0M 0.40
Amicus Therapeutics (FOLD) 1.4 $3.1M 913k 3.44
XenoPort 1.4 $3.1M 809k 3.81
22 Genomic Health 1.4 $3.0M 8.8M 0.34
Anacor Pharmaceuticals 1.3 $2.9M 468k 6.20
Raptor Pharmaceutical 1.3 $2.8M 452k 6.26
Medivation 1.1 $2.3M 483k 4.73
BioDelivery Sciences International 1.0 $2.1M 2.6M 0.80
Targacept 0.9 $2.0M 358k 5.57
56 Salix 5.5% 8/15/28 conv bonds 0.8 $1.8M 45M 0.04
34 Pharmasset 0.6 $1.2M 1.6M 0.79
8 Ardea Biosciences 0.5 $1.1M 6.0M 0.18
AVANIR Pharmaceuticals 0.5 $1.0M 500k 2.05
Rigel Pharmaceuticals 0.4 $894k 113k 7.89
Ligand Pharmaceuticals In (LGND) 0.4 $871k 73k 11.87
Xoma 0.2 $461k 400k 1.15
24 Gtx 0.2 $370k 3.1M 0.12
Idera Pharmaceuticals 0.1 $303k 288k 1.05
INC Ventrus Biosciences 0.1 $195k 24k 8.02
Cumberland Pharmaceuticals (CPIX) 0.1 $127k 24k 5.38
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $60k 21k 2.86
ADVENTRX Pharmaceuticals 0.0 $38k 65k 0.59
Aradigm Corporation (ARDM) 0.0 $11k 100k 0.11
45 Viropharma 0.0 $0 12M 0.00