Baker Bros. Advisors

Latest statistics and disclosures from Baker Bros. Advisors's latest quarterly 13F-HR filing:

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Positions held by Baker Bros. Advisors consolidated in one spreadsheet with up to 7 years of data

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Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 118 positions in its portfolio as reported in the March 2022 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Seagen (SGEN) 38.8 $6.8B 47M 144.05
Incyte Corporation (INCY) 16.5 $2.9B +7% 36M 79.42
BeiGene Sponsored Adr (BGNE) 12.6 $2.2B 12M 188.60
ACADIA Pharmaceuticals (ACAD) 5.8 $1.0B 42M 24.22
BioMarin Pharmaceutical (BMRN) 3.4 $588M 7.6M 77.10
Ascendis Pharma A/S Sponsored Adr (ASND) 3.1 $533M 4.5M 117.36
argenx SE Sponsored Adr (ARGX) 2.0 $353M 1.1M 315.31
BioCryst Pharmaceuticals (BCRX) 1.2 $207M 13M 16.26
Madrigal Pharmaceuticals (MDGL) 0.8 $147M 1.5M 98.12
Kodiak Sciences (KOD) 0.7 $123M +8% 16M 7.72
Mirati Therapeutics (MRTX) 0.7 $116M 1.4M 82.22
Global Blood Therapeutics In (GBT) 0.7 $115M 3.3M 34.64
Abcellera Biologics (ABCL) 0.6 $102M 11M 9.75
Kymera Therapeutics (KYMR) 0.6 $101M 2.4M 42.32

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Horizon Therapeutics Public SHS (HZNP) 0.5 $95M +50% 899k 105.21
Travere Therapeutics (TVTX) 0.5 $85M +23% 3.3M 25.77
Igm Biosciences (IGMS) 0.5 $84M 3.2M 26.73
Invitae (NVTA) 0.5 $79M 9.9M 7.97
Immunocore Holdings Ads (IMCR) 0.4 $75M 2.5M 29.90
Cerus Corporation (CERS) 0.4 $75M 14M 5.49
Legend Biotech Corporation Sponsored Ads (LEGN) 0.4 $73M -19% 2.0M 36.34
Prelude Therapeutics (PRLD) 0.4 $70M 10M 6.90
Amarin Corporation Sponsored Adr (AMRN) 0.4 $70M 21M 3.29
Neurocrine Biosciences (NBIX) 0.4 $64M 677k 93.75
Merus N V (MRUS) 0.3 $54M 2.0M 26.44
Krystal Biotech (KRYS) 0.3 $54M 808k 66.54
Insmed Incorporated Com Par $.01 (INSM) 0.3 $51M 2.2M 23.50
Pacific Biosciences of California (PACB) 0.3 $50M 5.4M 9.10
Rhythm Pharmaceuticals (RYTM) 0.3 $48M +6% 4.1M 11.52
Heron Therapeutics (HRTX) 0.3 $47M 8.1M 5.72
Entrada Therapeutics (TRDA) 0.3 $44M 4.7M 9.39
Instil Bio (TIL) 0.2 $42M 3.9M 10.75
Alkermes SHS (ALKS) 0.2 $40M 1.5M 26.31
Insmed Incorporated Note 0.75% 6/1/2028 (Principal) 0.2 $39M 40M 0.97
Sarepta Therapeutics DBCV 1.5% 11/15/2024 (Principal) 0.2 $38M 29M 1.31
Chinook Therapeutics (KDNY) 0.2 $38M 2.3M 16.36
Verastem (VSTM) 0.2 $38M +25% 27M 1.41
Aerovate Therapeutics (AVTE) 0.2 $38M +13% 2.1M 18.33
Immatics SHS (IMTX) 0.2 $35M 4.4M 7.99
2seventy bio Common Stock (TSVT) 0.2 $35M +147% 2.1M 17.06
Nurix Therapeutics (NRIX) 0.2 $34M 2.5M 14.01
Verve Therapeutics (VERV) 0.2 $32M 1.4M 22.82
Ultragenyx Pharmaceutical (RARE) 0.2 $32M 444k 72.62
Kiniksa Pharmaceuticals Com Cl A (KNSA) 0.2 $28M 2.8M 9.94
Replimune Group (REPL) 0.2 $27M +171% 1.6M 16.98
Axsome Therapeutics (AXSM) 0.1 $25M 611k 41.39
DBV Technologies Sponsored Adr (DBVT) 0.1 $23M 15M 1.59
Design Therapeutics (DSGN) 0.1 $23M 1.4M 16.15
Chemocentryx (CCXI) 0.1 $23M -43% 917k 25.07
Xenon Pharmaceuticals (XENE) 0.1 $23M 752k 30.57
Affimed Therapeutics B V (AFMD) 0.1 $23M +94% 5.2M 4.37
Adaptimmune Therapeutics Sponsored Adr (ADAP) 0.1 $20M 9.8M 2.06
Forma Therapeutics Holdings SHS (FMTX) 0.1 $19M 2.0M 9.30
Otonomy (OTIC) 0.1 $19M 7.8M 2.40
Opthea Sponsored Ads (OPT) 0.1 $19M -15% 2.7M 6.86
Crinetics Pharmaceuticals In (CRNX) 0.1 $18M 828k 21.95
Tricida (TCDA) 0.1 $14M +34% 1.7M 8.22
Relmada Therapeutics (RLMD) 0.1 $13M 495k 26.99
Fulgent Genetics (FLGT) 0.1 $13M 201k 62.41
Bluebird Bio (BLUE) 0.1 $12M 2.5M 4.85
Dice Therapeutics (DICE) 0.1 $11M 588k 19.13
Atreca Cl A Com (BCEL) 0.1 $11M 3.5M 3.17
Zymeworks (ZYME) 0.1 $11M 1.7M 6.55
Athira Pharma (ATHA) 0.1 $11M 806k 13.50
Talis Biomedical Corp (TLIS) 0.1 $11M 7.6M 1.41
Anaptysbio Inc Common (ANAB) 0.1 $11M 427k 24.74
Centessa Pharmaceuticals Sponsored Ads (CNTA) 0.1 $10M 1.1M 8.97
Sarepta Therapeutics (SRPT) 0.1 $9.6M 124k 78.12
Karuna Therapeutics Ord (KRTX) 0.1 $8.9M 70k 126.79
Invitae Corporation Note 2.0% 9/1/2024 (Principal) 0.0 $8.4M 10M 0.81
Aeglea Biotherapeutics (AGLE) 0.0 $7.8M 3.4M 2.30
Vera Therapeutics Cl A (VERA) 0.0 $7.8M NEW 333k 23.49
Achilles Therapeutics Sponsored Ads (ACHL) 0.0 $7.6M 2.6M 2.94
Surrozen (SRZN) 0.0 $7.5M 2.5M 3.01
Reata Pharmaceuticals Cl A (RETA) 0.0 $7.3M 224k 32.76
Neoleukin Therapeutics (NLTX) 0.0 $7.2M 3.8M 1.88
Fibrogen (FGEN) 0.0 $7.0M 582k 12.02
Biomea Fusion (BMEA) 0.0 $6.9M +195% 1.6M 4.46
Cymabay Therapeutics (CBAY) 0.0 $6.7M 2.2M 3.11
Altimmune (ALT) 0.0 $6.5M 1.1M 6.09
Harmony Biosciences Hldgs In (HRMY) 0.0 $6.0M 124k 48.65
Tango Therapeutics (TNGX) 0.0 $5.7M 750k 7.58
Revolution Medicines (RVMD) 0.0 $5.7M 222k 25.51
Hookipa Pharma Inc equity (HOOK) 0.0 $5.5M +242% 2.4M 2.28
Edgewise Therapeutics (EWTX) 0.0 $4.9M 500k 9.70
Iteos Therapeutics (ITOS) 0.0 $4.8M 150k 32.18
Aligos Therapeutics (ALGS) 0.0 $4.5M 2.1M 2.15
Ngm Biopharmaceuticals (NGM) 0.0 $4.4M 292k 15.25
Kura Oncology (KURA) 0.0 $4.4M -9% 275k 16.08
Bioatla (BCAB) 0.0 $4.1M 825k 5.00
Allakos (ALLK) 0.0 $4.0M 703k 5.70
Tscan Therapeutics (TCRX) 0.0 $4.0M 1.4M 2.80
Macrogenics (MGNX) 0.0 $3.9M 443k 8.81
Novavax (NVAX) 0.0 $3.5M 48k 73.66
Alector (ALEC) 0.0 $3.4M 239k 14.25
Atyr Pharma (LIFE) 0.0 $3.3M 625k 5.35
Cyteir Therapeutics (CYT) 0.0 $3.1M 813k 3.77
Denali Therapeutics (DNLI) 0.0 $2.9M 89k 32.17
Kezar Life Sciences (KZR) 0.0 $2.3M 140k 16.62
Tcr2 Therapeutics Inc cs (TCRR) 0.0 $2.1M 753k 2.76
Burning Rock Biotech Sponsored Ads (BNR) 0.0 $1.9M 209k 9.29
Syndax Pharmaceuticals (SNDX) 0.0 $1.9M 111k 17.38
Akero Therapeutics (AKRO) 0.0 $1.7M 118k 14.19
Cabaletta Bio (CABA) 0.0 $1.3M 662k 2.03
Neximmune (NEXI) 0.0 $1.2M 294k 4.21
Epizyme (EPZM) 0.0 $1.2M NEW 1.0M 1.15
Protara Therapeutics Com Stk (TARA) 0.0 $1.0M 200k 5.11
Genetron Holdings Ads (GTH) 0.0 $997k 455k 2.19
Leap Therapeutics (LPTX) 0.0 $979k 560k 1.75
Vincera Pharma (VINC) 0.0 $966k 241k 4.00
Sera Prognostics Class A Com (SERA) 0.0 $764k 202k 3.79
Oyster Point Pharma (OYST) 0.0 $715k 61k 11.64
Foghorn Therapeutics (FHTX) 0.0 $686k 45k 15.24
Bellicum Pharmaceuticals (BLCM) 0.0 $538k 249k 2.16
Inozyme Pharma (INZY) 0.0 $438k 107k 4.09
Passage Bio (PASG) 0.0 $363k 117k 3.10
Logicbio Therapeutics (LOGC) 0.0 $307k 452k 0.68
Surrozen W Exp 8/11/2026 (SRZNW) 0.0 $208k 833k 0.25

Past Filings by Baker Bros. Advisors

SEC 13F filings are viewable for Baker Bros. Advisors going back to 2010

View all past filings