Baker Bros. Advisors as of Dec. 31, 2024
Portfolio Holdings for Baker Bros. Advisors
Baker Bros. Advisors holds 95 positions in its portfolio as reported in the December 2024 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Incyte Corporation (INCY) | 22.7 | $2.1B | 31M | 69.07 | |
| BeiGene Sponsored Adr (ONC) | 18.8 | $1.8B | 9.5M | 184.71 | |
| ACADIA Pharmaceuticals (ACAD) | 8.4 | $787M | 43M | 18.35 | |
| Madrigal Pharmaceuticals (MDGL) | 6.5 | $609M | 2.0M | 308.57 | |
| Summit Therapeutics (SMMT) | 4.7 | $436M | 24M | 17.84 | |
| Revolution Medicines (RVMD) | 3.7 | $347M | 7.9M | 43.74 | |
| Insmed Incorporated Com Par $.01 (INSM) | 3.7 | $346M | 5.0M | 69.04 | |
| Rhythm Pharmaceuticals (RYTM) | 3.6 | $341M | 6.1M | 55.98 | |
| Kymera Therapeutics (KYMR) | 2.6 | $241M | 6.0M | 40.23 | |
| Kodiak Sciences (KOD) | 1.8 | $172M | 17M | 9.95 | |
| Edgewise Therapeutics (EWTX) | 1.8 | $164M | 6.2M | 26.70 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 1.6 | $152M | 11M | 14.00 | |
| Replimune Group (REPL) | 1.4 | $134M | 11M | 12.11 | |
| Alkermes SHS (ALKS) | 1.3 | $120M | 4.2M | 28.76 | |
| Insmed Incorporated Note 0.75% 6/1/2028 (Principal) | 1.0 | $93M | 43M | 2.17 | |
| Entrada Therapeutics (TRDA) | 0.9 | $84M | 4.9M | 17.29 | |
| Abcellera Biologics (ABCL) | 0.9 | $81M | 28M | 2.93 | |
| Denali Therapeutics (DNLI) | 0.8 | $76M | 3.7M | 20.38 | |
| Nurix Therapeutics (NRIX) | 0.8 | $73M | 3.9M | 18.84 | |
| argenx SE Sponsored Adr (ARGX) | 0.7 | $69M | 112k | 615.00 | |
| Ultragenyx Pharmaceutical (RARE) | 0.7 | $66M | 1.6M | 42.07 | |
| Kiniksa Pharmaceuticals International Ord Shs Cl A (KNSA) | 0.6 | $56M | 2.8M | 19.78 | |
| Immatics SHS (IMTX) | 0.6 | $52M | 7.3M | 7.11 | |
| CRISPR Therapeutics Namen Akt (CRSP) | 0.5 | $52M | 1.3M | 39.36 | |
| Stoke Therapeutics (STOK) | 0.5 | $51M | 4.6M | 11.03 | |
| Immunocore Holdings Ads (IMCR) | 0.5 | $45M | 1.5M | 29.50 | |
| Roivant Sciences SHS (ROIV) | 0.5 | $45M | 3.8M | 11.83 | |
| Sera Prognostics Class A Com (SERA) | 0.5 | $44M | 5.4M | 8.14 | |
| Immunovant (IMVT) | 0.5 | $42M | 1.7M | 24.77 | |
| Xenon Pharmaceuticals (XENE) | 0.4 | $39M | 994k | 39.20 | |
| Celcuity (CELC) | 0.4 | $35M | 2.7M | 13.09 | |
| Monte Rosa Therapeutics (GLUE) | 0.4 | $34M | 4.9M | 6.94 | |
| Akero Therapeutics (AKRO) | 0.3 | $31M | 1.1M | 27.82 | |
| Cerus Corporation (CERS) | 0.3 | $30M | 20M | 1.54 | |
| Ionis Pharmaceuticals Note 1.75% 6/15/2028 (Principal) | 0.3 | $30M | 30M | 0.98 | |
| Grail (GRAL) | 0.3 | $29M | 1.6M | 17.85 | |
| Ideaya Biosciences (IDYA) | 0.3 | $27M | 1.1M | 25.70 | |
| Krystal Biotech (KRYS) | 0.3 | $27M | 170k | 156.66 | |
| Candel Therapeutics (CADL) | 0.3 | $26M | 3.0M | 8.68 | |
| Praxis Precision Medicines I (PRAX) | 0.3 | $26M | 332k | 76.96 | |
| Igm Biosciences (IGMS) | 0.3 | $25M | 4.1M | 6.11 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.2 | $21M | 1.2M | 16.75 | |
| Merus N V (MRUS) | 0.2 | $19M | 450k | 42.05 | |
| Dyne Therapeutics (DYN) | 0.2 | $16M | 672k | 23.56 | |
| Neurogene (NGNE) | 0.2 | $15M | 675k | 22.86 | |
| Xencor (XNCR) | 0.2 | $15M | 670k | 22.98 | |
| Bicara Therapeutics (BCAX) | 0.2 | $15M | 833k | 17.42 | |
| Prelude Therapeutics (PRLD) | 0.1 | $13M | 10M | 1.27 | |
| Ionis Pharmaceuticals (IONS) | 0.1 | $13M | 358k | 34.96 | |
| Alumis (ALMS) | 0.1 | $12M | 1.6M | 7.86 | |
| Neumora Therapeutics (NMRA) | 0.1 | $11M | 1.0M | 10.60 | |
| Design Therapeutics (DSGN) | 0.1 | $11M | 1.7M | 6.17 | |
| Structure Therapeutics Sponsored Ads (GPCR) | 0.1 | $9.8M | 362k | 27.12 | |
| Verve Therapeutics (VERV) | 0.1 | $9.5M | 1.7M | 5.64 | |
| Opthea Sponsored Ads (OPT) | 0.1 | $8.5M | 2.2M | 3.93 | |
| Tscan Therapeutics (TCRX) | 0.1 | $8.5M | 2.8M | 3.04 | |
| Kala Pharmaceuticals (KALA) | 0.1 | $8.3M | 1.2M | 6.94 | |
| Vir Biotechnology (VIR) | 0.1 | $8.0M | 1.1M | 7.34 | |
| Mirum Pharmaceuticals (MIRM) | 0.1 | $7.9M | 191k | 41.35 | |
| Arvinas Ord (ARVN) | 0.1 | $7.8M | 406k | 19.17 | |
| Intellia Therapeutics (NTLA) | 0.1 | $7.5M | 644k | 11.66 | |
| 2seventy bio Common Stock | 0.1 | $7.3M | 2.5M | 2.94 | |
| Taysha Gene Therapies Com Shs (TSHA) | 0.1 | $6.9M | 4.0M | 1.73 | |
| Celldex Therapeutics (CLDX) | 0.1 | $6.3M | 248k | 25.27 | |
| Biomea Fusion (BMEA) | 0.1 | $5.6M | 1.5M | 3.88 | |
| Fate Therapeutics (FATE) | 0.1 | $5.4M | 3.3M | 1.65 | |
| BioNTech SE Sponsored Ads (BNTX) | 0.1 | $5.1M | 45k | 113.95 | |
| Disc Medicine (IRON) | 0.1 | $4.9M | 77k | 63.40 | |
| Relay Therapeutics (RLAY) | 0.1 | $4.8M | 1.2M | 4.12 | |
| Contineum Therapeutics Cl A (CTNM) | 0.0 | $4.6M | 313k | 14.65 | |
| DBV Technologies Sponsored Ads (DBVT) | 0.0 | $4.5M | 1.5M | 3.09 | |
| Sagimet Biosciences Com Ser A (SGMT) | 0.0 | $4.3M | 953k | 4.50 | |
| Wave Life Sciences SHS (WVE) | 0.0 | $4.3M | 344k | 12.37 | |
| Skye Bioscience (SKYE) | 0.0 | $4.1M | 1.5M | 2.83 | |
| Vaxcyte (PCVX) | 0.0 | $4.0M | 49k | 81.86 | |
| Sana Biotechnology (SANA) | 0.0 | $3.9M | 2.4M | 1.63 | |
| Leap Therapeutics (LPTX) | 0.0 | $3.4M | 1.2M | 2.88 | |
| Aligos Therapeutics (ALGS) | 0.0 | $3.3M | 83k | 39.84 | |
| Prime Medicine (PRME) | 0.0 | $3.0M | 1.0M | 2.92 | |
| Protara Therapeutics Com Stk (TARA) | 0.0 | $2.8M | 537k | 5.28 | |
| Enliven Therapeutics (ELVN) | 0.0 | $2.6M | 115k | 22.50 | |
| Arcturus Therapeutics Hldg I (ARCT) | 0.0 | $2.6M | 151k | 16.97 | |
| Compass Therapeutics (CMPX) | 0.0 | $2.3M | 1.6M | 1.45 | |
| Generation Bio | 0.0 | $2.1M | 1.9M | 1.06 | |
| Hookipa Pharma (HOOK) | 0.0 | $1.6M | 813k | 2.01 | |
| Mersana Therapeutics | 0.0 | $1.6M | 1.1M | 1.43 | |
| vTv Therapeutics Cl A (VTVT) | 0.0 | $1.3M | 97k | 13.81 | |
| Rocket Pharmaceuticals (RCKT) | 0.0 | $1.2M | 97k | 12.57 | |
| Ptc Therapeutics I (PTCT) | 0.0 | $921k | 20k | 45.14 | |
| Century Therapeutics (IPSC) | 0.0 | $805k | 798k | 1.01 | |
| Pmv Pharmaceuticals (PMVP) | 0.0 | $486k | 322k | 1.51 | |
| Acrivon Therapeutics Common Stock (ACRV) | 0.0 | $318k | 53k | 6.02 | |
| Foghorn Therapeutics (FHTX) | 0.0 | $213k | 45k | 4.72 | |
| Tyra Biosciences (TYRA) | 0.0 | $147k | 11k | 13.90 | |
| Surrozen W Exp 8/11/2026 (SRZNW) | 0.0 | $18k | 833k | 0.02 |
