Baker Bros. Advisors as of Dec. 31, 2022
Portfolio Holdings for Baker Bros. Advisors
Baker Bros. Advisors holds 113 positions in its portfolio as reported in the December 2022 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Seagen | 36.2 | $6.0B | 47M | 128.51 | |
| Incyte Corporation (INCY) | 17.4 | $2.9B | 36M | 80.32 | |
| BeiGene Sponsored Adr (BGNE) | 15.4 | $2.6B | 12M | 219.94 | |
| BioMarin Pharmaceutical (BMRN) | 4.7 | $789M | 7.6M | 103.49 | |
| ACADIA Pharmaceuticals (ACAD) | 4.0 | $667M | 42M | 15.92 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 3.6 | $605M | 5.0M | 122.13 | |
| Madrigal Pharmaceuticals (MDGL) | 2.7 | $449M | 1.5M | 290.25 | |
| Rhythm Pharmaceuticals (RYTM) | 1.1 | $185M | 6.4M | 29.12 | |
| BioCryst Pharmaceuticals (BCRX) | 0.9 | $146M | 13M | 11.48 | |
| Immunocore Holdings Ads (IMCR) | 0.9 | $144M | 2.5M | 57.07 | |
| Akero Therapeutics (AKRO) | 0.8 | $130M | 2.4M | 54.80 | |
| Replimune Group (REPL) | 0.7 | $125M | 4.6M | 27.20 | |
| Kodiak Sciences (KOD) | 0.7 | $124M | 17M | 7.16 | |
| Horizon Therapeutics Public SHS | 0.7 | $110M | 970k | 113.80 | |
| argenx SE Sponsored Adr (ARGX) | 0.6 | $106M | 280k | 378.83 | |
| Abcellera Biologics (ABCL) | 0.6 | $106M | 11M | 10.13 | |
| Kymera Therapeutics (KYMR) | 0.4 | $72M | 2.9M | 24.96 | |
| Chinook Therapeutics | 0.4 | $66M | 2.5M | 26.20 | |
| Entrada Therapeutics (TRDA) | 0.4 | $66M | 4.9M | 13.52 | |
| Mirati Therapeutics | 0.4 | $64M | 1.4M | 45.31 | |
| Prelude Therapeutics (PRLD) | 0.4 | $61M | 10M | 6.04 | |
| Cerus Corporation (CERS) | 0.4 | $59M | 16M | 3.65 | |
| Aerovate Therapeutics (AVTE) | 0.3 | $58M | 2.0M | 29.30 | |
| Igm Biosciences (IGMS) | 0.3 | $54M | 3.2M | 17.01 | |
| Immatics SHS (IMTX) | 0.3 | $45M | 5.2M | 8.71 | |
| Nurix Therapeutics (NRIX) | 0.3 | $43M | 3.9M | 10.98 | |
| Kiniksa Pharmaceuticals Com Cl A | 0.3 | $42M | 2.8M | 14.98 | |
| Springworks Therapeutics (SWTX) | 0.2 | $40M | 1.5M | 26.01 | |
| Ideaya Biosciences (IDYA) | 0.2 | $30M | 1.7M | 18.17 | |
| Denali Therapeutics (DNLI) | 0.2 | $30M | 1.1M | 27.81 | |
| Xenon Pharmaceuticals (XENE) | 0.2 | $30M | 752k | 39.43 | |
| Verve Therapeutics (VERV) | 0.2 | $27M | 1.4M | 19.35 | |
| Dice Therapeutics | 0.2 | $27M | 862k | 31.20 | |
| Travere Therapeutics (TVTX) | 0.2 | $26M | 1.2M | 21.03 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.1 | $25M | 844k | 29.60 | |
| Anaptysbio Inc Common (ANAB) | 0.1 | $24M | 776k | 30.99 | |
| Krystal Biotech (KRYS) | 0.1 | $24M | 303k | 79.22 | |
| DBV Technologies Sponsored Adr | 0.1 | $22M | 15M | 1.53 | |
| Fibrogen (FGEN) | 0.1 | $22M | 1.4M | 16.02 | |
| Ultragenyx Pharmaceutical (RARE) | 0.1 | $22M | 471k | 46.33 | |
| Heron Therapeutics (HRTX) | 0.1 | $20M | 8.1M | 2.50 | |
| 2seventy Bio (TSVT) | 0.1 | $19M | 2.1M | 9.37 | |
| Insmed Incorporated Note 0.75% 6/1/2028 (Principal) | 0.1 | $19M | 24M | 0.82 | |
| Prime Medicine (PRME) | 0.1 | $19M | 1.0M | 18.58 | |
| Biomea Fusion (BMEA) | 0.1 | $18M | 2.1M | 8.43 | |
| Bluebird Bio (BLUE) | 0.1 | $17M | 2.5M | 6.92 | |
| Silverback Therapeutics (SPRY) | 0.1 | $17M | 2.0M | 8.53 | |
| Invitae (NVTAQ) | 0.1 | $16M | 8.4M | 1.86 | |
| Opthea Sponsored Ads (OPT) | 0.1 | $14M | 2.7M | 5.36 | |
| Adaptimmune Therapeutics Sponsored Adr (ADAP) | 0.1 | $14M | 9.8M | 1.46 | |
| Cymabay Therapeutics | 0.1 | $14M | 2.2M | 6.27 | |
| Zymeworks Del (ZYME) | 0.1 | $13M | 1.7M | 7.86 | |
| Aadi Bioscience (AADI) | 0.1 | $13M | 990k | 12.83 | |
| Cabaletta Bio (CABA) | 0.1 | $12M | 1.3M | 9.25 | |
| Verastem | 0.1 | $11M | 27M | 0.40 | |
| Altimmune (ALT) | 0.1 | $11M | 654k | 16.45 | |
| Stoke Therapeutics (STOK) | 0.1 | $10M | 1.1M | 9.23 | |
| Cincor Pharma | 0.1 | $9.9M | 807k | 12.29 | |
| Vor Biopharma (VOR) | 0.1 | $9.7M | 1.5M | 6.65 | |
| Avidity Biosciences Ord (RNA) | 0.1 | $9.6M | 435k | 22.19 | |
| Pacific Biosciences of California (PACB) | 0.1 | $9.2M | 1.1M | 8.18 | |
| Point Biopharma Global | 0.1 | $8.5M | 1.2M | 7.29 | |
| Reata Pharmaceuticals Cl A | 0.1 | $8.5M | 224k | 37.99 | |
| Summit Therapeutics (SMMT) | 0.1 | $8.5M | 2.0M | 4.25 | |
| Female Health (VERU) | 0.1 | $8.5M | 1.6M | 5.28 | |
| Affimed Therapeutics B V | 0.0 | $8.2M | 6.6M | 1.24 | |
| Invitae Corporation Note 2.0% 9/1/2024 (Principal) | 0.0 | $8.1M | 10M | 0.78 | |
| Compass Therapeutics (CMPX) | 0.0 | $7.8M | 1.6M | 5.03 | |
| Design Therapeutics (DSGN) | 0.0 | $7.1M | 692k | 10.26 | |
| Biohaven (BHVN) | 0.0 | $6.6M | 476k | 13.88 | |
| Vera Therapeutics Cl A (VERA) | 0.0 | $6.4M | 333k | 19.35 | |
| Alector (ALEC) | 0.0 | $6.3M | 682k | 9.23 | |
| Macrogenics (MGNX) | 0.0 | $6.0M | 893k | 6.71 | |
| Athira Pharma (ATHA) | 0.0 | $6.0M | 1.9M | 3.17 | |
| Century Therapeutics (IPSC) | 0.0 | $5.9M | 1.1M | 5.13 | |
| Roivant Sciences SHS (ROIV) | 0.0 | $5.7M | 717k | 7.99 | |
| Tango Therapeutics (TNGX) | 0.0 | $5.4M | 750k | 7.25 | |
| Revolution Medicines (RVMD) | 0.0 | $5.3M | 222k | 23.82 | |
| Edgewise Therapeutics (EWTX) | 0.0 | $4.5M | 500k | 8.94 | |
| Praxis Precision Medicines I | 0.0 | $4.4M | 1.8M | 2.38 | |
| Tscan Therapeutics (TCRX) | 0.0 | $4.3M | 2.8M | 1.55 | |
| Aravive | 0.0 | $4.3M | 3.3M | 1.32 | |
| Cyteir Therapeutics | 0.0 | $4.1M | 2.5M | 1.65 | |
| Natera (NTRA) | 0.0 | $4.0M | 100k | 40.17 | |
| Talis Biomedical Corp | 0.0 | $3.4M | 7.6M | 0.45 | |
| Instil Bio | 0.0 | $3.3M | 5.3M | 0.63 | |
| Xencor (XNCR) | 0.0 | $3.2M | 123k | 26.04 | |
| Iteos Therapeutics (ITOS) | 0.0 | $2.9M | 150k | 19.53 | |
| Kala Pharmaceuticals (KALA) | 0.0 | $2.9M | 77k | 38.15 | |
| Atreca Cl A Com (BCEL) | 0.0 | $2.8M | 3.5M | 0.80 | |
| Hookipa Pharma Inc equity | 0.0 | $2.8M | 3.5M | 0.81 | |
| Pmv Pharmaceuticals (PMVP) | 0.0 | $2.8M | 322k | 8.70 | |
| Atara Biotherapeutics | 0.0 | $2.4M | 744k | 3.28 | |
| Nkarta (NKTX) | 0.0 | $2.4M | 400k | 5.99 | |
| Vaxcyte (PCVX) | 0.0 | $2.3M | 49k | 47.95 | |
| Achilles Therapeutics Sponsored Ads (ACHL) | 0.0 | $2.3M | 2.6M | 0.90 | |
| Fate Therapeutics (FATE) | 0.0 | $2.2M | 216k | 10.09 | |
| Aligos Therapeutics (ALGS) | 0.0 | $2.0M | 2.1M | 0.95 | |
| Neoleukin Therapeutics | 0.0 | $1.9M | 3.8M | 0.51 | |
| Kronos Bio (KRON) | 0.0 | $1.9M | 1.2M | 1.62 | |
| Aeglea Biotherapeutics | 0.0 | $1.5M | 3.4M | 0.45 | |
| Tcr2 Therapeutics Inc cs | 0.0 | $752k | 753k | 1.00 | |
| Protara Therapeutics Com Stk (TARA) | 0.0 | $535k | 200k | 2.68 | |
| Genetron Holdings Ads | 0.0 | $510k | 455k | 1.12 | |
| Kezar Life Sciences (KZR) | 0.0 | $436k | 62k | 7.04 | |
| Insmed Incorporated Com Par $.01 (INSM) | 0.0 | $399k | 20k | 19.98 | |
| Foghorn Therapeutics (FHTX) | 0.0 | $287k | 45k | 6.38 | |
| Sera Prognostics Class A Com (SERA) | 0.0 | $254k | 202k | 1.26 | |
| Leap Therapeutics | 0.0 | $252k | 560k | 0.45 | |
| Vincera Pharma (VINC) | 0.0 | $246k | 241k | 1.02 | |
| Bellicum Pharmaceuticals | 0.0 | $179k | 249k | 0.72 | |
| Surrozen W Exp 8/11/2026 (SRZNW) | 0.0 | $46k | 833k | 0.06 | |
| Atyr Pharma (ATYR) | 0.0 | $19k | 8.6k | 2.19 |
