Baker Bros. Advisors

Baker Bros. Advisors as of March 31, 2012

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 63 positions in its portfolio as reported in the March 2012 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
41 Synageva Biopharma 6.5 $68M 7.5M 9.12
55 Incyte Genomics Notes 4.75% 10/1/2015 conv bonds 6.4 $67M 160M 0.42
45 Viropharma 6.0 $62M 12M 5.17
33 Pharmacyclics 5.7 $59M 9.3M 6.32
Medivation 4.9 $51M 683k 74.72
Ardea Biosciences 4.8 $50M 6.9M 7.29
60 Salix 2.75% 5/15/15 conv bonds 4.6 $48M 111M 0.43
Xoma 4.1 $43M 16M 2.77
61 Salix 144a 1.5% 3/15/19 conv bonds 4.0 $41M 230M 0.18
Biomarin Pharmaceutical Inc note 1.875% 4/2 3.9 $41M 23M 1.78
Intermune cv 5.0% 3.8 $40M 34M 1.18
Gilead Sciences (GILD) 3.8 $39M 800k 48.86
38 Seattle Genetics 3.5 $36M 21M 1.70
59 Salix 5.5% 8/15/28 conv bonds 2.7 $28M 22M 1.26
Gilead Sciences conv 2.6 $28M 22M 1.28
Medivation Inc note 2.625% 4/0 2.5 $26M 25M 1.06
Halozyme Therapeutics (HALO) 2.2 $23M 1.8M 12.76
Threshold Pharma 2.0 $21M 2.4M 8.80
BioCryst Pharmaceuticals (BCRX) 1.9 $20M 5.6M 3.63
Auxilium 1.9 $20M 6.5M 3.09
Intermune Inc note 2.500% 9/1 1.8 $19M 22M 0.86
Spectrum Pharmaceuticals 1.7 $18M 1.4M 12.63
Genomic Health 1.6 $17M 10M 1.62
Ym Biosciences 1.4 $15M 8.0M 1.86
Clovis Oncology 1.1 $12M 473k 25.45
9 Ariad Pharmaceuticals 1.1 $12M 7.0M 1.65
ACADIA Pharmaceuticals (ACAD) 1.1 $11M 5.2M 2.15
Exelixis (EXEL) 1.0 $11M 2.1M 5.18
31 Incyte 1.0 $11M 16M 0.67
D Tranzyme 0.9 $9.8M 3.8M 2.57
Onyx Pharmaceuticals 0.8 $8.1M 215k 37.68
Aegerion Pharmaceuticals 0.7 $7.3M 527k 13.83
Derma Sciences 0.7 $7.2M 744k 9.62
BioDelivery Sciences International 0.6 $6.3M 2.6M 2.42
Chelsea Therapeutics International 0.6 $5.9M 2.3M 2.56
Dendreon Corp cnv 0.6 $5.7M 7.1M 0.80
Salix Pharmaceuticals 0.5 $5.6M 107k 52.50
Dendreon Corporation 0.5 $4.8M 455k 10.66
Alere Inc note 3.000% 5/1 0.4 $4.5M 4.5M 1.01
Targacept 0.4 $4.2M 825k 5.12
Amicus Therapeutics (FOLD) 0.4 $4.0M 765k 5.28
XenoPort 0.3 $3.6M 809k 4.50
AVEO Pharmaceuticals 0.3 $3.7M 296k 12.41
Array BioPharma 0.3 $3.4M 1.0M 3.40
Anacor Pharmaceuticals 0.3 $3.3M 568k 5.89
Discovery Laboratories 0.3 $2.7M 1.0M 2.68
Sequenom 0.2 $2.4M 588k 4.07
ZIOPHARM Oncology 0.2 $2.2M 400k 5.40
Alere 0.2 $2.0M 75k 26.01
Anthera Pharmaceuticals 0.2 $1.7M 758k 2.21
AVANIR Pharmaceuticals 0.2 $1.7M 500k 3.42
32 Infinity Pharmaceuticals 0.2 $1.7M 138k 11.96
Ligand Pharmaceuticals 0.1 $1.2M 73k 15.95
Rigel Pharmaceuticals 0.1 $796k 99k 8.05
INC Ventrus Biosciences 0.1 $789k 79k 9.96
ArQule 0.1 $604k 86k 7.01
Raptor Pharmaceutical 0.1 $676k 100k 6.76
Idera Pharmaceuticals 0.1 $499k 288k 1.73
Chemocentryx 0.1 $533k 50k 10.66
Cubist Pharmaceuticals 0.0 $216k 5.0k 43.20
Cumberland Pharmaceuticals (CPIX) 0.0 $177k 24k 7.49
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $53k 21k 2.53
Aradigm Corporation (ARDM) 0.0 $16k 100k 0.16