Baker Bros. Advisors

Baker Bros. Advisors as of June 30, 2012

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 68 positions in its portfolio as reported in the June 2012 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
38 Seattle Genetics 8.0 $91M 19M 4.69
Genomic Health 6.5 $74M 11M 6.62
Viropharma 6.0 $69M 11M 6.06
Auxilium 6.0 $68M 6.3M 10.90
60 Salix 2.75% 5/15/15 conv bonds 4.4 $50M 111M 0.45
Biomarin Pharmaceutical Inc note 1.875% 4/2 4.1 $47M 23M 2.04
XOMA CORP Common equity shares 4.1 $46M 16M 2.98
Vertex Pharmaceuticals Incorporated (VRTX) 4.0 $45M 811k 55.92
Medivation 3.9 $44M 483k 91.40
Spectrum Pharmaceuticals 3.4 $39M 2.5M 15.56
Gilead Sciences (GILD) 3.3 $38M 740k 51.28
61 Salix 144a 1.5% 3/15/19 conv bonds 3.3 $38M 222M 0.17
Intermune cv 5.0% 3.2 $37M 34M 1.08
31 Incyte 3.2 $36M 15M 2.44
59 Salix 5.5% 8/15/28 conv bonds 2.9 $33M 22M 1.46
Medivation Inc note 2.625% 4/0 2.6 $29M 25M 1.19
Gilead Sciences conv 2.5 $28M 22M 1.30
Clovis Oncology 2.2 $25M 1.2M 21.68
37 Pharmacyclics 2.2 $25M 11M 2.18
BioCryst Pharmaceuticals (BCRX) 1.9 $22M 5.6M 3.97
61 Incyte Genomics Notes 4.75% 10/1/2015 conv bonds 1.5 $17M 158M 0.11
Intermune Inc note 2.500% 9/1 1.5 $17M 22M 0.80
Threshold Pharma 1.5 $17M 2.2M 7.40
Vertex Pharmaceuticals Inc note 3.350%10/0 1.4 $16M 13M 1.30
D Tranzyme 1.3 $15M 3.8M 3.76
Onyx Pharmaceuticals 1.2 $14M 215k 66.45
Halozyme Therapeutics (HALO) 1.0 $12M 1.3M 8.86
Ym Biosciences 1.0 $12M 5.9M 1.99
BioDelivery Sciences International 1.0 $12M 2.6M 4.48
Derma Sciences 1.0 $12M 1.2M 9.52
Exelixis (EXEL) 1.0 $11M 2.0M 5.53
ACADIA Pharmaceuticals (ACAD) 0.8 $9.2M 5.2M 1.76
Aegerion Pharmaceuticals 0.8 $9.1M 615k 14.84
BioMarin Pharmaceutical (BMRN) 0.7 $7.9M 200k 39.58
Synergy Pharmaceuticals 0.5 $5.3M 1.1M 4.75
XenoPort 0.4 $4.9M 809k 6.04
Chelsea Therapeutics International 0.4 $4.5M 3.0M 1.48
Cerus Corporation (CERS) 0.4 $4.2M 1.3M 3.32
Amicus Therapeutics (FOLD) 0.4 $4.2M 765k 5.50
Alere Inc note 3.000% 5/1 0.4 $4.0M 4.5M 0.90
Anacor Pharmaceuticals 0.3 $3.7M 568k 6.49
Array BioPharma 0.3 $3.5M 1.0M 3.47
Repros Therapeutics 0.3 $3.5M 385k 9.08
Alere 0.3 $3.4M 175k 19.44
45 Synageva Biopharma 0.3 $3.3M 7.5M 0.44
Qlt 0.2 $2.7M 352k 7.62
Sequenom 0.2 $2.4M 588k 4.06
ZIOPHARM Oncology 0.2 $2.4M 400k 5.95
Discovery Laboratories 0.2 $2.4M 1.0M 2.32
AVEO Pharmaceuticals 0.2 $2.1M 171k 12.16
INC Ventrus Biosciences 0.2 $2.1M 481k 4.27
AVANIR Pharmaceuticals 0.2 $2.0M 500k 3.92
32 Infinity Pharmaceuticals 0.2 $1.9M 138k 13.56
Synta Pharmaceuticals 0.1 $1.7M 313k 5.47
Targacept 0.1 $1.7M 407k 4.30
Biodel 0.1 $1.4M 540k 2.58
Ligand Pharmaceuticals 0.1 $1.2M 73k 16.93
Rigel Pharmaceuticals 0.1 $920k 99k 9.30
Anthera Pharmaceuticals 0.1 $815k 1.2M 0.68
Chemocentryx 0.1 $750k 50k 15.00
Raptor Pharmaceutical 0.1 $558k 100k 5.58
ArQule 0.0 $511k 86k 5.93
Idera Pharmaceuticals 0.0 $306k 288k 1.06
Cubist Pharmaceuticals 0.0 $190k 5.0k 38.00
9 Ariad Pharmaceuticals 0.0 $175k 5.8M 0.03
Cumberland Pharmaceuticals (CPIX) 0.0 $153k 24k 6.48
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $52k 21k 2.48
Aradigm Corporation (ARDM) 0.0 $12k 100k 0.12