Baker Bros. Advisors

Baker Bros. Advisors as of Dec. 31, 2010

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 56 positions in its portfolio as reported in the December 2010 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Alere 12.7 $70M 1.9M 36.60
Ardea Biosciences 8.5 $47M 5.6M 8.29
Genomic Health 8.0 $44M 6.7M 6.49
Halozyme Therapeutics (HALO) 5.7 $31M 3.9M 7.92
Pharmasset 5.5 $30M 693k 43.56
BioCryst Pharmaceuticals (BCRX) 5.2 $29M 5.6M 5.17
Salix Pharmaceuticals 4.9 $27M 570k 46.96
Auxilium 4.7 $26M 6.0M 4.33
Ym Biosciences 3.9 $21M 9.1M 2.33
Micromet 3.8 $21M 2.5M 8.12
Dendreon Corporation 3.2 $18M 506k 34.92
Inspire Pharmaceuticals 3.1 $17M 2.0M 8.40
Acorda Therapeutics 2.5 $14M 508k 27.26
BioMarin Pharmaceutical (BMRN) 2.5 $14M 505k 26.93
Pharmacyclics 2.2 $12M 2.0M 6.08
InterMune 1.7 $9.1M 249k 36.40
Trimeris 1.6 $8.5M 3.5M 2.46
Adolor Corporation (ADLR) 1.5 $8.4M 6.9M 1.21
Medivation 1.4 $7.6M 500k 15.17
Chelsea Therapeutics International 1.3 $7.2M 965k 7.50
Human Genome cv 2.25% 1.3 $7.2M 4.5M 1.60
XenoPort 1.2 $6.8M 800k 8.52
Anacor Pharmaceuticals In 1.2 $6.4M 1.2M 5.37
Amylin Pharmaceuticals Inc note 2.500% 4/1 1.1 $6.3M 6.3M 1.00
Achillion Pharmaceuticals 1.1 $6.1M 1.5M 4.15
Biomarin Pharmaceutical Inc note 1.875% 4/2 1.0 $5.7M 3.9M 1.45
Amicus Therapeutics (FOLD) 1.0 $5.5M 1.2M 4.70
ZIOPHARM Oncology 0.9 $4.9M 1.0M 4.66
GTx 0.8 $4.6M 1.7M 2.65
Threshold Pharma 0.8 $4.2M 3.1M 1.35
Exelixis (EXEL) 0.8 $4.1M 500k 8.21
Anthera Pharmaceuticals 0.7 $3.9M 800k 4.88
Alere Inc note 3.000% 5/1 0.7 $3.7M 3.5M 1.06
A.P. Pharma (APPA) 0.6 $3.1M 6.9M 0.45
Inhibitex 0.4 $2.3M 872k 2.60
AVANIR Pharmaceuticals 0.4 $2.0M 500k 4.08
Cypress Bioscience (CYPB) 0.3 $1.9M 300k 6.48
Infinity Pharmaceuticals (INFIQ) 0.2 $1.2M 199k 5.93
DepoMed 0.2 $1.2M 183k 6.36
Amylin Pharmaceuticals 0.2 $1.1M 76k 14.71
Lexicon Pharmaceuticals 0.2 $1.1M 750k 1.44
Bristol Myers Squibb (BMY) 0.2 $1.1M 40k 26.48
Idera Pharmaceuticals 0.1 $834k 288k 2.89
Ligand Pharmaceuticals 0.1 $746k 84k 8.92
Cornerstone Biopharma 0.1 $650k 112k 5.79
Cumberland Pharmaceuticals (CPIX) 0.1 $577k 96k 5.99
Anadys Pharmaceuticals (ANDS) 0.1 $343k 241k 1.42
Cadence Pharmaceuticals 0.1 $292k 39k 7.54
Sucampo Pharmaceuticals 0.1 $247k 64k 3.84
ACADIA Pharmaceuticals (ACAD) 0.0 $211k 176k 1.20
Pozen 0.0 $142k 21k 6.64
Alere 0.0 $183k 732.00 250.00
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $85k 22k 3.80
AutoImmune (AIMM) 0.0 $7.0k 13k 0.54
Aradigm Corporation (ARDM) 0.0 $17k 100k 0.17
VIA Pharmaceuticals (VIAP) 0.0 $4.1k 103k 0.04