Opaleye Management as of Dec. 31, 2025
Portfolio Holdings for Opaleye Management
Opaleye Management holds 54 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Harrow Health (HROW) | 25.2 | $191M | 3.9M | 49.00 | |
| Liquidia Corporation Com New (LQDA) | 11.2 | $85M | 2.4M | 34.90 | |
| Eton Pharmaceuticals (ETON) | 6.4 | $48M | 2.9M | 16.91 | |
| Rhythm Pharmaceuticals (RYTM) | 4.7 | $35M | 330k | 107.04 | |
| Apogee Therapeutics (APGE) | 3.9 | $29M | 388k | 75.48 | |
| Sanuwave Health (SNWV) | 3.9 | $29M | 981k | 29.84 | |
| Stoke Therapeutics (STOK) | 2.9 | $22M | 695k | 31.74 | |
| Ocular Therapeutix (OCUL) | 2.6 | $19M | 1.6M | 12.14 | |
| Sol Gel Technologies Shs New (SLGL) | 2.5 | $19M | 454k | 42.14 | |
| Cg Oncology (CGON) | 2.2 | $17M | 410k | 41.52 | |
| Tg Therapeutics (TGTX) | 2.1 | $16M | 535k | 29.81 | |
| Disc Medicine (IRON) | 2.1 | $16M | 200k | 79.41 | |
| Rezolute Com New (RZLT) | 2.0 | $15M | 6.3M | 2.36 | |
| Crescent Biopharma (CBIO) | 1.8 | $14M | 1.2M | 11.86 | |
| Alkermes SHS (ALKS) | 1.8 | $14M | 490k | 27.98 | |
| Alpha Cognition Com New (ACOG) | 1.8 | $14M | 2.1M | 6.50 | |
| Annexon (ANNX) | 1.7 | $13M | 2.6M | 5.02 | |
| Edgewise Therapeutics (EWTX) | 1.6 | $12M | 500k | 24.82 | |
| Codexis (CDXS) | 1.5 | $11M | 6.8M | 1.63 | |
| Protagonist Therapeutics (PTGX) | 1.2 | $9.2M | 105k | 87.34 | |
| Gossamer Bio (GOSS) | 1.1 | $8.4M | 2.7M | 3.10 | |
| Mbx Biosciences (MBX) | 1.1 | $8.2M | 260k | 31.54 | |
| Revolution Medicines (RVMD) | 1.1 | $8.0M | 100k | 79.65 | |
| Xoma Corp Del Com New (XOMA) | 1.0 | $7.8M | 293k | 26.59 | |
| Journey Med Corp (DERM) | 1.0 | $7.5M | 975k | 7.71 | |
| Karyopharm Therapeutics Com New (KPTI) | 0.9 | $6.8M | 930k | 7.36 | |
| Jade Biosciences Com New (JBIO) | 0.9 | $6.6M | 428k | 15.43 | |
| Urogen Pharma (URGN) | 0.8 | $6.3M | 268k | 23.42 | |
| Alumis (ALMS) | 0.7 | $5.2M | 535k | 9.76 | |
| Perspective Therapeutics (CATX) | 0.7 | $5.0M | 1.2M | 4.21 | |
| Voyager Therapeutics (VYGR) | 0.6 | $4.7M | 1.2M | 3.93 | |
| Relmada Therapeutics (RLMD) | 0.6 | $4.5M | 935k | 4.83 | |
| Tectonic Therapeutic (TECX) | 0.6 | $4.5M | 215k | 20.86 | |
| Protalix Biotherapeutics (PLX) | 0.6 | $4.5M | 2.5M | 1.80 | |
| Trevi Therapeutics (TRVI) | 0.6 | $4.3M | 345k | 12.52 | |
| Fortress Biotech Com New (FBIO) | 0.5 | $4.0M | 1.1M | 3.66 | |
| Rocket Pharmaceuticals (RCKT) | 0.4 | $3.4M | 955k | 3.51 | |
| Meiragtx Holdings (MGTX) | 0.4 | $3.1M | 391k | 7.95 | |
| Rigel Pharmaceuticals (RIGL) | 0.4 | $3.0M | 70k | 42.83 | |
| Zymeworks Del (ZYME) | 0.4 | $2.9M | 109k | 26.33 | |
| Assertio Holdings Com New | 0.3 | $2.6M | 285k | 9.07 | |
| Ventyx Biosciences (VTYX) | 0.3 | $2.3M | 252k | 9.03 | |
| Ocuphire Pharma (IRD) | 0.3 | $2.3M | 1.1M | 2.01 | |
| Sutro Biopharma Com Shs (STRO) | 0.3 | $2.2M | 191k | 11.57 | |
| Cabaletta Bio (CABA) | 0.3 | $2.0M | 900k | 2.19 | |
| Zentalis Pharmaceuticals (ZNTL) | 0.2 | $1.9M | 1.4M | 1.35 | |
| Generation Bio Com New (GBIO) | 0.2 | $1.8M | 310k | 5.68 | |
| Bridgebio Pharma (BBIO) | 0.2 | $1.4M | 18k | 76.49 | |
| Enanta Pharmaceuticals (ENTA) | 0.2 | $1.2M | 75k | 15.77 | |
| Q32 Bio (QTTB) | 0.1 | $708k | 213k | 3.32 | |
| Atea Pharmaceuticals (AVIR) | 0.1 | $642k | 180k | 3.57 | |
| Silence Therapeutics Ads (SLN) | 0.1 | $480k | 79k | 6.08 | |
| Rapt Therapeutics Com New (RAPT) | 0.0 | $213k | 150k | 1.42 | |
| Adagio Med Hldgs (ADGM) | 0.0 | $115k | 111k | 1.04 |
