Opaleye Management as of March 31, 2026
Portfolio Holdings for Opaleye Management
Opaleye Management holds 54 positions in its portfolio as reported in the March 2026 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Harrow Health (HROW) | 13.2 | $100M | 2.8M | 35.26 | |
| Liquidia Corporation Com New (LQDA) | 11.7 | $89M | 2.5M | 34.90 | |
| Eton Pharmaceuticals (ETON) | 9.3 | $71M | 2.9M | 24.68 | |
| Sol-gel Technologies Shs New (SLGL) | 5.2 | $40M | 500k | 79.22 | |
| Rhythm Pharmaceuticals (RYTM) | 4.7 | $35M | 123k | 287.18 | |
| Apogee Therapeutics (APGE) | 4.3 | $33M | 390k | 84.17 | |
| Disc Medicine (IRON) | 3.5 | $27M | 421k | 63.94 | |
| Urogen Pharma (URGN) | 3.4 | $26M | 1.4M | 17.98 | |
| Crescent Biopharma (CBIO) | 3.2 | $24M | 1.3M | 18.37 | |
| Stoke Therapeutics (STOK) | 3.0 | $23M | 700k | 32.56 | |
| Perspective Therapeutics Com New (CATX) | 2.6 | $20M | 4.7M | 4.17 | |
| Rezolute Com New (RZLT) | 2.5 | $19M | 6.3M | 3.05 | |
| Meiragtx Holdings (MGTX) | 2.4 | $18M | 2.1M | 8.66 | |
| Tg Therapeutics (TGTX) | 2.3 | $18M | 535k | 33.22 | |
| Sanuwave Health (SNWV) | 2.2 | $17M | 981k | 17.29 | |
| Edgewise Therapeutics (EWTX) | 2.1 | $16M | 500k | 31.50 | |
| Alpha Cognition Com New (ACOG) | 1.9 | $14M | 2.6M | 5.49 | |
| Annexon (ANNX) | 1.7 | $13M | 2.3M | 5.54 | |
| Alumis (ALMS) | 1.6 | $12M | 550k | 22.03 | |
| Codexis (CDXS) | 1.5 | $11M | 6.8M | 1.63 | |
| Protagonist Therapeutics (PTGX) | 1.4 | $11M | 100k | 105.40 | |
| Revolution Medicines (RVMD) | 1.3 | $9.7M | 100k | 97.25 | |
| Xoma Royalty Corporation Com New (XOMA) | 1.2 | $9.4M | 300k | 31.37 | |
| Q32 Bio (QTTB) | 1.1 | $8.1M | 1.3M | 6.42 | |
| Mbx Biosciences (MBX) | 1.0 | $7.8M | 260k | 29.85 | |
| Relmada Therapeutics (RLMD) | 0.9 | $6.5M | 935k | 6.96 | |
| Cg Oncology (CGON) | 0.8 | $6.4M | 95k | 67.68 | |
| Jade Biosciences Com New (JBIO) | 0.8 | $6.0M | 428k | 14.05 | |
| Ocular Therapeutix (OCUL) | 0.7 | $5.1M | 600k | 8.47 | |
| Assertio Holdings Com New (ASRT) | 0.7 | $5.1M | 266k | 19.06 | |
| Editas Medicine (EDIT) | 0.6 | $4.8M | 1.9M | 2.47 | |
| Sutro Biopharma Com Shs (STRO) | 0.6 | $4.7M | 191k | 24.91 | |
| Journey Med Corp (DERM) | 0.6 | $4.5M | 960k | 4.69 | |
| Voyager Therapeutics (VYGR) | 0.6 | $4.4M | 1.2M | 3.86 | |
| Trevi Therapeutics (TRVI) | 0.5 | $4.1M | 345k | 11.93 | |
| Tectonic Therapeutic (TECX) | 0.5 | $3.8M | 123k | 30.91 | |
| Cabaletta Bio (CABA) | 0.5 | $3.7M | 1.4M | 2.69 | |
| Biodesix (BDSX) | 0.5 | $3.5M | 238k | 14.50 | |
| Rocket Pharmaceuticals (RCKT) | 0.5 | $3.4M | 955k | 3.58 | |
| Zentalis Pharmaceuticals (ZNTL) | 0.4 | $3.3M | 1.4M | 2.34 | |
| Intellia Therapeutics (NTLA) | 0.4 | $3.1M | 245k | 12.82 | |
| Fortress Biotech Com New (FBIO) | 0.4 | $2.9M | 1.0M | 2.79 | |
| Ocuphire Pharma (IRD) | 0.3 | $2.3M | 1.1M | 2.01 | |
| Rigel Pharmaceuticals (RIGL) | 0.2 | $1.9M | 70k | 27.04 | |
| Atea Pharmaceuticals (AVIR) | 0.2 | $1.7M | 323k | 5.38 | |
| Lyell Immunopharma Com New (LYEL) | 0.2 | $1.6M | 79k | 20.06 | |
| Enanta Pharmaceuticals (ENTA) | 0.2 | $1.6M | 125k | 12.63 | |
| Nextcure Com New (NXTC) | 0.2 | $1.5M | 141k | 10.68 | |
| 4d Molecular Therapeutics In (FDMT) | 0.1 | $1.0M | 112k | 9.31 | |
| Perspective Therapeutics Call | 0.1 | $834k | 200k | 4.17 | |
| Protalix Biotherapeutics (PLX) | 0.1 | $738k | 340k | 2.17 | |
| Bridgebio Oncology Therapeut Com New (BBOT) | 0.1 | $477k | 53k | 8.95 | |
| Lb Pharmaceuticals Com Shs (LBRX) | 0.0 | $358k | 15k | 24.66 | |
| Adagio Med Hldgs (ADGM) | 0.0 | $21k | 18k | 1.15 |
