Rock Springs Capital Management as of Sept. 30, 2025
Portfolio Holdings for Rock Springs Capital Management
Rock Springs Capital Management holds 92 positions in its portfolio as reported in the September 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Argenx Se Sponsored Adr (ARGX) | 6.2 | $105M | 143k | 737.56 | |
| Eli Lilly & Co. (LLY) | 4.7 | $80M | 105k | 763.00 | |
| Rhythm Pharmaceuticals (RYTM) | 4.2 | $72M | 717k | 100.99 | |
| Madrigal Pharmaceuticals (MDGL) | 3.7 | $63M | 138k | 458.66 | |
| Revolution Medicines (RVMD) | 3.6 | $62M | 1.3M | 46.70 | |
| Merus N V (MRUS) | 3.3 | $56M | 597k | 94.15 | |
| Mirum Pharmaceuticals (MIRM) | 3.3 | $56M | 761k | 73.31 | |
| Insmed Com Par $.01 (INSM) | 3.2 | $55M | 385k | 144.01 | |
| Travere Therapeutics (TVTX) | 3.0 | $52M | 2.2M | 23.90 | |
| Ascendis Pharma A/s Sponsored Adr (ASND) | 2.5 | $43M | 215k | 198.81 | |
| Irhythm Technologies (IRTC) | 2.4 | $40M | 235k | 171.99 | |
| Agios Pharmaceuticals (AGIO) | 2.2 | $39M | 959k | 40.14 | |
| Ultragenyx Pharmaceutical (RARE) | 2.2 | $38M | 1.2M | 30.08 | |
| Intuitive Surgical Com New (ISRG) | 2.1 | $37M | 82k | 447.23 | |
| Boston Scientific Corporation (BSX) | 2.1 | $35M | 360k | 97.63 | |
| Xenon Pharmaceuticals (XENE) | 2.0 | $34M | 852k | 40.15 | |
| Alnylam Pharmaceuticals (ALNY) | 2.0 | $34M | 74k | 456.00 | |
| EXACT Sciences Corporation (EXAS) | 1.9 | $33M | 594k | 54.71 | |
| Penumbra (PEN) | 1.8 | $31M | 121k | 253.32 | |
| Akero Therapeutics (AKRO) | 1.7 | $30M | 627k | 47.48 | |
| Scholar Rock Hldg Corp (SRRK) | 1.7 | $30M | 794k | 37.24 | |
| Zai Lab Adr (ZLAB) | 1.6 | $27M | 791k | 33.89 | |
| Structure Therapeutics Sponsored Ads (GPCR) | 1.6 | $27M | 951k | 28.00 | |
| Kymera Therapeutics (KYMR) | 1.5 | $26M | 450k | 56.60 | |
| Tenet Healthcare Corp Com New (THC) | 1.5 | $25M | 125k | 203.04 | |
| Evolent Health Cl A (EVH) | 1.5 | $25M | 3.0M | 8.46 | |
| Caris Life Sciences (CAI) | 1.4 | $24M | 794k | 30.25 | |
| Cidara Therapeutics Com New (CDTX) | 1.4 | $24M | 249k | 95.76 | |
| Dex (DXCM) | 1.2 | $21M | 317k | 67.29 | |
| Omada Health (OMDA) | 1.2 | $20M | 920k | 22.11 | |
| Celldex Therapeutics Com New (CLDX) | 1.1 | $19M | 722k | 25.87 | |
| Vera Therapeutics Cl A (VERA) | 1.0 | $18M | 617k | 29.06 | |
| Newamsterdam Pharma Company Ordinary Shares Call Option (NAMS) | 1.0 | $18M | 628k | 28.44 | |
| Phreesia (PHR) | 1.0 | $18M | 749k | 23.52 | |
| Tarsus Pharmaceuticals (TARS) | 1.0 | $17M | 288k | 59.43 | |
| Compass Therapeutics (CMPX) | 0.9 | $16M | 4.5M | 3.50 | |
| Pharvaris N V (PHVS) | 0.9 | $16M | 623k | 24.95 | |
| Brooks Automation (AZTA) | 0.9 | $16M | 540k | 28.72 | |
| Mineralys Therapeutics (MLYS) | 0.9 | $16M | 408k | 37.92 | |
| Amicus Therapeutics (FOLD) | 0.9 | $15M | 1.9M | 7.88 | |
| Spdr Series Trust S&p Biotech (XBI) | 0.9 | $15M | 152k | 100.20 | |
| Arcellx Common Stock (ACLX) | 0.9 | $15M | 179k | 82.10 | |
| Summit Therapeutics (SMMT) | 0.9 | $15M | 710k | 20.66 | |
| Cogent Biosciences (COGT) | 0.8 | $15M | 1.0M | 14.36 | |
| Enliven Therapeutics (ELVN) | 0.8 | $14M | 686k | 20.47 | |
| Zenas Biopharma (ZBIO) | 0.8 | $13M | 581k | 22.20 | |
| Neurocrine Biosciences (NBIX) | 0.7 | $13M | 90k | 140.38 | |
| Ardelyx (ARDX) | 0.7 | $13M | 2.3M | 5.51 | |
| Danaher Corporation (DHR) | 0.7 | $12M | 62k | 198.26 | |
| Lenz Therapeutics (LENZ) | 0.6 | $11M | 236k | 46.58 | |
| Soleno Therapeutics (SLNO) | 0.6 | $10M | 155k | 67.60 | |
| Dyne Therapeutics (DYN) | 0.6 | $10M | 824k | 12.65 | |
| Mereo Biopharma Group Spon Ads (MREO) | 0.6 | $9.4M | 4.6M | 2.06 | |
| Aclaris Therapeutics (ACRS) | 0.5 | $8.8M | 4.6M | 1.90 | |
| Gossamer Bio (GOSS) | 0.5 | $8.6M | 3.3M | 2.63 | |
| Heartflow Inc/Sh | 0.5 | $8.4M | 250k | 33.66 | |
| Inspire Med Sys (INSP) | 0.5 | $8.2M | 111k | 74.20 | |
| Agilon Health (AGL) | 0.4 | $7.2M | 7.0M | 1.03 | |
| Edwards Lifesciences (EW) | 0.4 | $6.8M | 88k | 77.77 | |
| Amylyx Pharmaceuticals (AMLX) | 0.4 | $6.8M | 500k | 13.59 | |
| Gossamer Bio Note 5.000% 6/0 (Principal) | 0.4 | $6.7M | 9.6M | 0.70 | |
| Regeneron Pharmaceuticals (REGN) | 0.4 | $6.4M | 11k | 562.27 | |
| Bicara Therapeutics (BCAX) | 0.3 | $5.9M | 371k | 15.79 | |
| Janux Therapeutics (JANX) | 0.3 | $5.1M | 210k | 24.44 | |
| Mbx Biosciences (MBX) | 0.3 | $4.9M | 283k | 17.50 | |
| Thermo Fisher Scientific (TMO) | 0.3 | $4.9M | 10k | 485.02 | |
| Bridgebio Pharma (BBIO) | 0.3 | $4.4M | 85k | 51.94 | |
| Alphatec Hldgs Com New (ATEC) | 0.3 | $4.4M | 303k | 14.54 | |
| Acadia Healthcare (ACHC) | 0.2 | $4.2M | 170k | 24.76 | |
| Ocular Therapeutix (OCUL) | 0.2 | $3.5M | 300k | 11.69 | |
| Talphera Com New (TLPH) | 0.2 | $3.2M | 3.6M | 0.89 | |
| Alkermes SHS (ALKS) | 0.2 | $3.2M | 107k | 30.00 | |
| Sionna Therapeutics (SION) | 0.2 | $2.9M | 99k | 29.41 | |
| Edap Tms S A Sponsored Adr (EDAP) | 0.2 | $2.9M | 1.3M | 2.29 | |
| Jasper Therapeutics Com New (JSPR) | 0.2 | $2.6M | 1.1M | 2.38 | |
| West Pharmaceutical Services (WST) | 0.1 | $2.6M | 9.8k | 262.33 | |
| Apellis Pharmaceuticals (APLS) | 0.1 | $2.1M | 92k | 22.63 | |
| Neurogene (NGNE) | 0.1 | $1.8M | 104k | 17.33 | |
| Korro Bio (KRRO) | 0.1 | $1.7M | 36k | 47.89 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 0.1 | $1.7M | 69k | 24.25 | |
| Perspective Therapeutics Com New (CATX) | 0.1 | $1.5M | 444k | 3.43 | |
| Applied Therapeutics (APLT) | 0.1 | $1.3M | 2.1M | 0.60 | |
| Mersana Therapeutics (MRSN) | 0.1 | $1.2M | 153k | 7.76 | |
| Immunovant (IMVT) | 0.1 | $1.2M | 73k | 16.12 | |
| Eyepoint Pharmaceuticals Com New (EYPT) | 0.0 | $451k | 32k | 14.24 | |
| Charles River Laboratories (CRL) | 0.0 | $422k | 2.7k | 156.46 | |
| Vaxcyte (PCVX) | 0.0 | $400k | 11k | 36.02 | |
| Novavax Com New (NVAX) | 0.0 | $390k | 45k | 8.67 | |
| Prothena Corp SHS (PRTA) | 0.0 | $248k | 25k | 9.76 | |
| Moonlake Immunotherapeutics Class A Ord (MLTX) | 0.0 | $202k | 28k | 7.17 | |
| Nuvation Bio *w Exp 02/10/202 (NUVB.WS) | 0.0 | $27k | 134k | 0.20 | |
| Compugen Ord (CGEN) | 0.0 | $20k | 13k | 1.47 |
