Siren

Siren as of March 31, 2026

Portfolio Holdings for Siren

Siren holds 100 positions in its portfolio as reported in the March 2026 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Scholar Rock Hldg Corp (SRRK) 14.8 $532M 11M 49.16
Kymera Therapeutics (KYMR) 7.4 $265M 3.2M 83.29
Erasca (ERAS) 5.0 $182M 11M 16.18
Edgewise Therapeutics (EWTX) 3.9 $140M 4.4M 31.50
BeOne Medicines Sponsored Ads (ONC) 3.8 $138M 465k 296.97
Tango Therapeutics (TNGX) 3.3 $118M 5.7M 20.92
Bicara Therapeutics (BCAX) 3.2 $115M 5.8M 19.89
Revolution Medicines (RVMD) 3.0 $108M 1.1M 97.25
Arrowhead Pharmaceuticals (ARWR) 2.8 $101M 1.6M 62.70
Veradermics Common Stock (MANE) 2.6 $95M 1.5M 63.15
Xenon Pharmaceuticals (XENE) 2.1 $77M 1.3M 58.15
Olema Pharmaceuticals (OLMA) 2.0 $71M 4.8M 14.91
Crinetics Pharmaceuticals In (CRNX) 1.9 $69M 1.9M 36.32
Lexicon Pharmaceuticals Com New (LXRX) 1.9 $69M 44M 1.56
Cogent Biosciences (COGT) 1.8 $66M 1.7M 38.49
Stoke Therapeutics (STOK) 1.8 $65M 2.0M 32.56
Arcus Biosciences Incorporated (RCUS) 1.8 $65M 3.0M 21.60
Structure Therapeutics Sponsored Ads (GPCR) 1.8 $64M 1.3M 48.20
Disc Medicine (IRON) 1.8 $63M 988k 63.94
Rhythm Pharmaceuticals (RYTM) 1.7 $63M 726k 86.97
Solid Biosciences Com New (SLDB) 1.5 $55M 7.7M 7.20
Septerna (SEPN) 1.3 $48M 2.0M 24.03
Centessa Pharmaceuticals Sponsored Ads 1.2 $42M 1.1M 39.72
Spyre Therapeutics Com New (SYRE) 1.1 $41M 819k 50.44
Cytokinetics Com New (CYTK) 1.1 $41M 614k 65.91
Dyne Therapeutics (DYN) 1.1 $40M 2.2M 18.13
Taysha Gene Therapies Com Shs (TSHA) 1.1 $40M 8.8M 4.47
Dbv Technologies SA Sponsored Ads (DBVT) 1.1 $39M 1.9M 20.89
Oric Pharmaceuticals (ORIC) 1.1 $38M 3.0M 12.67
Engene Holdings 1.0 $36M 5.3M 6.81
Palvella Therapeutics Inc Ne (PVLA) 0.9 $32M 258k 124.65
Taboola.com Ord Shs (TBLA) 0.9 $31M 10M 3.10
Enliven Therapeutics (ELVN) 0.8 $29M 746k 39.20
Denali Therapeutics (DNLI) 0.7 $27M 1.4M 19.20
Remitly Global (RELY) 0.7 $24M 1.5M 15.67
Damora Therapeutics Com New (DMRA) 0.6 $23M 900k 25.90
Zura Bio Class A Ord Shs (ZURA) 0.6 $22M 3.7M 5.95
Annexon (ANNX) 0.6 $22M 4.0M 5.54
Trevi Therapeutics (TRVI) 0.6 $21M 1.8M 11.93
Rapport Therapeutics (RAPP) 0.6 $20M 642k 31.29
Alphabet Cap Stk Cl A (GOOGL) 0.5 $19M 66k 287.56
Fulcrum Therapeutics (FULC) 0.5 $18M 2.4M 7.67
WAVE Life Sciences SHS (WVE) 0.5 $18M 2.5M 7.25
Definium Therapeutics Com Shs (DFTX) 0.5 $17M 920k 18.90
Amylyx Pharmaceuticals (AMLX) 0.5 $17M 1.2M 13.90
Cullinan Oncology (CGEM) 0.5 $17M 1.2M 14.21
Neumora Therapeutics (NMRA) 0.5 $17M 8.5M 1.95
Uniqure NV SHS (QURE) 0.5 $16M 1.0M 16.35
Cytomx Therapeutics (CTMX) 0.5 $16M 3.5M 4.70
NVIDIA Corporation (NVDA) 0.4 $16M 89k 174.40
Silence Therapeutics Ads (SLN) 0.4 $15M 2.9M 5.27
Microsoft Corporation (MSFT) 0.4 $15M 41k 370.17
Monopar Therapeutics Com New (MNPR) 0.4 $15M 270k 54.79
Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) 0.4 $14M 42k 337.95
Sionna Therapeutics (SION) 0.3 $12M 300k 40.09
Nebius Group NV Shs Class A (NBIS) 0.3 $12M 114k 103.76
Rezolute Com New (RZLT) 0.3 $10M 3.3M 3.05
Inhibikase Therapeutics Com New (IKT) 0.3 $9.8M 5.9M 1.68
Amazon (AMZN) 0.3 $9.7M 47k 208.27
Generate Biomedicines Com Shs (GENB) 0.3 $9.2M 736k 12.50
Maplight Therapeutics (MPLT) 0.3 $9.1M 450k 20.33
Servicenow (NOW) 0.3 $9.1M 87k 104.55
CrowdStrike Holdings Cl A (CRWD) 0.2 $9.0M 23k 390.41
PDD Holdings Sponsored Ads (PDD) 0.2 $8.5M 83k 102.18
Tesla Motors (TSLA) 0.2 $8.0M 22k 371.75
NovaBridge Biosciences Sponsored Ads (NBP) 0.2 $7.4M 3.0M 2.46
Bicycle Therapeutics Sponsored Ads (BCYC) 0.2 $7.2M 1.6M 4.64
Aadi Bioscience (WHWK) 0.2 $7.2M 2.1M 3.45
Tenax Therapeutics Com New (TENX) 0.2 $6.8M 427k 15.99
vTv Therapeutics Cl A New (VTVT) 0.2 $6.5M 163k 39.66
Datadog Cl A Com (DDOG) 0.2 $6.4M 54k 118.05
Jfrog Ord Shs (FROG) 0.2 $6.0M 129k 46.93
Dynatrace Com New (DT) 0.2 $5.5M 150k 36.98
Workiva Com Cl A (WK) 0.2 $5.5M 93k 59.63
Absci Corp (ABSI) 0.1 $5.4M 1.8M 3.00
Adagio Therapeutics (IVVD) 0.1 $5.2M 4.0M 1.30
Satellos Bioscience (MSLE) 0.1 $5.0M 892k 5.63
Ionq Inc Pipe (IONQ) 0.1 $4.9M 170k 28.83
Broadcom (AVGO) 0.1 $4.6M 15k 309.51
Agomab Therapeutics NV Sponsored Ads (AGMB) 0.1 $4.3M 411k 10.49
Cellebrite DI Ordinary Shares (CLBT) 0.1 $4.3M 312k 13.78
Seer Com Cl A (SEER) 0.1 $4.1M 2.5M 1.68
Korro Bio (KRRO) 0.1 $3.9M 348k 11.32
Agenus Com New (AGEN) 0.1 $3.6M 1.1M 3.34
Foghorn Therapeutics (FHTX) 0.1 $3.4M 721k 4.78
Forgent Power Solutions Com Shs Cl A (FPS) 0.1 $2.9M 100k 29.27
Kalaris Therapeutics (KLRS) 0.1 $2.5M 436k 5.77
GitLab Class A Com (GTLB) 0.1 $2.2M 100k 21.64
Micron Technology (MU) 0.1 $2.0M 6.0k 337.84
monday.com SHS (MNDY) 0.0 $1.7M 25k 69.11
Gossamer Bio (GOSS) 0.0 $1.7M 5.2M 0.33
Amer Sports Com Shs (AS) 0.0 $1.6M 50k 32.92
KE Holdings Sponsored Ads (BEKE) 0.0 $1.5M 100k 14.97
Iren Ordinary Shares (IREN) 0.0 $1.5M 43k 34.28
Rani Therapeutics Holdings Com Cl A (RANI) 0.0 $1.5M 2.0M 0.73
Aeva Technologies Com New (AEVA) 0.0 $1.4M 110k 13.16
Medline Com Cl A (MDLN) 0.0 $1.1M 25k 44.50
Figma Class A Com Stk (FIG) 0.0 $1.1M 50k 21.14
Primo Brands Corp Class A Com Shs (PRMB) 0.0 $942k 50k 18.83
Nu Holdings Ord Shs Cl A (NU) 0.0 $359k 25k 14.37