Siren
Latest statistics and disclosures from Siren's latest quarterly 13F-HR filing:
- Top 5 stock holdings are SRRK, KYMR, ERAS, MANE, TNGX, and represent 29.72% of Siren's stock portfolio.
- Added to shares of these 10 stocks: Parabilis Medicines (+$82M), ABVX (+$77M), Hemab Therapeutics Holdings (+$77M), RLAY (+$68M), ELVN (+$52M), Kailera Therapeutics (+$49M), RYTM (+$46M), COF (+$34M), ORKA (+$24M), Seaport Therapeutics (+$24M).
- Started 26 new stock positions in ENTX, TYRA, RLAY, Odyssey Therapeutics, DSGN, T, COF, ADAG, ZTS, ENGN.
- Reduced shares in these 10 stocks: SRRK (-$69M), EWTX (-$51M), Centessa Pharmaceuticals (-$42M), RVMD (-$40M), Engene Holdings (-$36M), KYMR (-$29M), GPCR (-$25M), RCUS (-$18M), CRNX (-$18M), FULC (-$18M).
- Sold out of its positions in BCYC, Centessa Pharmaceuticals, Engene Holdings, FPS, FULC, MU, PRMB, AS, QURE, WVE.
- Siren was a net buyer of stock by $354M.
- Siren has $4.9B in assets under management (AUM), dropping by 36.98%.
- Central Index Key (CIK): 0002005245
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Portfolio Holdings for Siren
Siren holds 116 positions in its portfolio as reported in the June 2026 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 10.7 | $527M | -11% | 9.6M | 55.00 |
|
| Kymera Therapeutics (KYMR) | 6.8 | $337M | -7% | 2.9M | 114.67 |
|
| Erasca (ERAS) | 4.2 | $209M | 11M | 18.32 |
|
|
| Veradermics Common Stock (MANE) | 4.1 | $204M | +9% | 1.7M | 122.94 |
|
| Tango Therapeutics (TNGX) | 3.9 | $193M | +9% | 6.2M | 31.26 |
|
| Revolution Medicines (RVMD) | 3.4 | $169M | -18% | 900k | 187.28 |
|
| Bicara Therapeutics (BCAX) | 3.4 | $166M | -3% | 5.6M | 29.69 |
|
| Arrowhead Pharmaceuticals (ARWR) | 2.8 | $140M | +6% | 1.7M | 81.51 |
|
| BeOne Medicines Sponsored Ads (ONC) | 2.7 | $133M | 465k | 284.97 |
|
|
| Edgewise Therapeutics (EWTX) | 2.6 | $129M | -28% | 3.2M | 40.63 |
|
| Rhythm Pharmaceuticals (RYTM) | 2.6 | $126M | +56% | 1.1M | 111.03 |
|
| Lexicon Pharmaceuticals Com New (LXRX) | 2.2 | $106M | 44M | 2.40 |
|
|
| Enliven Therapeutics (ELVN) | 1.8 | $90M | +137% | 1.8M | 50.75 |
|
| Spyre Therapeutics Com New (SYRE) | 1.7 | $86M | +18% | 969k | 88.78 |
|
| Parabilis Medicines | 1.7 | $82M | NEW | 3.0M | 27.37 |
|
| Xenon Pharmaceuticals (XENE) | 1.6 | $80M | 1.3M | 60.36 |
|
|
| Solid Biosciences Com New (SLDB) | 1.6 | $77M | 7.7M | 9.99 |
|
|
| Abivax SA Sponsored Ads (ABVX) | 1.6 | $77M | NEW | 576k | 133.26 |
|
| Hemab Therapeutics Holdings Com Shs | 1.6 | $77M | NEW | 2.1M | 36.73 |
|
| Arcus Biosciences Incorporated (RCUS) | 1.5 | $75M | -19% | 2.4M | 30.83 |
|
| Cogent Biosciences (COGT) | 1.5 | $72M | +8% | 1.9M | 38.70 |
|
| Relay Therapeutics (RLAY) | 1.4 | $68M | NEW | 3.7M | 18.71 |
|
| Taysha Gene Therapies Com Shs (TSHA) | 1.4 | $67M | +11% | 9.8M | 6.81 |
|
| Definium Therapeutics Com Shs (DFTX) | 1.4 | $67M | +54% | 1.4M | 47.04 |
|
| Stoke Therapeutics (STOK) | 1.3 | $65M | 2.0M | 32.72 |
|
|
| Disc Medicine (IRON) | 1.3 | $65M | -10% | 888k | 73.14 |
|
| Cytokinetics Com New (CYTK) | 1.3 | $65M | +23% | 759k | 85.19 |
|
| Septerna (SEPN) | 1.3 | $64M | -5% | 1.9M | 33.49 |
|
| Olema Pharmaceuticals (OLMA) | 1.2 | $61M | +2% | 4.9M | 12.51 |
|
| Crinetics Pharmaceuticals In (CRNX) | 1.1 | $53M | -25% | 1.4M | 37.42 |
|
| Kailera Therapeutics Common Stock | 1.0 | $49M | NEW | 2.2M | 22.03 |
|
| Dyne Therapeutics (DYN) | 1.0 | $47M | -4% | 2.1M | 22.21 |
|
| Structure Therapeutics Sponsored Ads (GPCR) | 0.9 | $47M | -34% | 873k | 53.67 |
|
| Taboola.com Ord Shs (TBLA) | 0.9 | $42M | -15% | 8.4M | 5.00 |
|
| Palvella Therapeutics Inc Ne (PVLA) | 0.8 | $39M | 258k | 152.82 |
|
|
| Silence Therapeutics Ads (SLN) | 0.7 | $36M | +13% | 3.3M | 10.98 |
|
| Denali Therapeutics (DNLI) | 0.7 | $36M | 1.4M | 25.72 |
|
|
| Remitly Global (RELY) | 0.7 | $35M | 1.5M | 22.41 |
|
|
| Cullinan Oncology (CGEM) | 0.7 | $35M | +58% | 1.9M | 18.21 |
|
| Capital One Financial (COF) | 0.7 | $34M | NEW | 172k | 200.62 |
|
| Trevi Therapeutics (TRVI) | 0.7 | $33M | 1.8M | 18.65 |
|
|
| Oric Pharmaceuticals (ORIC) | 0.7 | $33M | 3.0M | 10.83 |
|
|
| Alphabet Cap Stk Cl A (GOOGL) | 0.7 | $32M | +36% | 90k | 357.37 |
|
| Dbv Technologies SA Sponsored Ads (DBVT) | 0.6 | $31M | 1.9M | 16.40 |
|
|
| Absci Corp (ABSI) | 0.6 | $29M | +37% | 2.5M | 11.59 |
|
| Sionna Therapeutics (SION) | 0.5 | $27M | +103% | 611k | 43.99 |
|
| Rapport Therapeutics (RAPP) | 0.5 | $27M | 642k | 41.67 |
|
|
| Amylyx Pharmaceuticals (AMLX) | 0.5 | $27M | +20% | 1.5M | 17.96 |
|
| Annexon (ANNX) | 0.5 | $26M | +12% | 4.5M | 5.71 |
|
| Monopar Therapeutics Com New (MNPR) | 0.5 | $25M | 270k | 92.59 |
|
|
| Oruka Therapeutics (ORKA) | 0.5 | $24M | NEW | 250k | 95.17 |
|
| Seaport Therapeutics Common Stock | 0.5 | $24M | NEW | 1.1M | 21.72 |
|
| Damora Therapeutics Com New (DMRA) | 0.5 | $23M | 900k | 26.01 |
|
|
| Tyra Biosciences (TYRA) | 0.5 | $23M | NEW | 725k | 31.94 |
|
| Microsoft Corporation (MSFT) | 0.5 | $23M | +48% | 62k | 373.02 |
|
| Zura Bio Class A Ord Shs (ZURA) | 0.4 | $22M | 3.7M | 5.90 |
|
|
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.4 | $21M | +5% | 45k | 477.57 |
|
| NVIDIA Corporation (NVDA) | 0.4 | $19M | +6% | 95k | 200.09 |
|
| Rezolute Com New (RZLT) | 0.4 | $17M | 3.3M | 5.20 |
|
|
| Maplight Therapeutics (MPLT) | 0.3 | $16M | 450k | 35.84 |
|
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| Neumora Therapeutics (NMRA) | 0.3 | $14M | 8.5M | 1.70 |
|
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| Nebius Group NV Shs Class A (NBIS) | 0.3 | $14M | -54% | 52k | 276.17 |
|
| Cytomx Therapeutics (CTMX) | 0.3 | $13M | 3.5M | 3.75 |
|
|
| Generate Biomedicines Com Shs (GENB) | 0.3 | $12M | 736k | 16.87 |
|
|
| Inhibikase Therapeutics Com New (IKT) | 0.2 | $12M | 5.9M | 2.03 |
|
|
| Adagene Ads (ADAG) | 0.2 | $11M | NEW | 2.7M | 4.20 |
|
| Engene Therapeutics (ENGN) | 0.2 | $11M | NEW | 6.3M | 1.73 |
|
| Aadi Bioscience (WHWK) | 0.2 | $11M | +12% | 2.3M | 4.58 |
|
| Datadog Cl A Com (DDOG) | 0.2 | $10M | -26% | 40k | 260.36 |
|
| Servicenow (NOW) | 0.2 | $9.9M | +14% | 100k | 99.28 |
|
| Broadcom (AVGO) | 0.2 | $9.4M | +66% | 25k | 377.75 |
|
| Ionq Inc Pipe (IONQ) | 0.2 | $9.1M | 170k | 53.26 |
|
|
| Jfrog Ord Shs (FROG) | 0.2 | $8.7M | -25% | 96k | 90.88 |
|
| Oculis Holding Ordinary Shares (OCS) | 0.2 | $8.7M | NEW | 625k | 13.87 |
|
| Iren Ordinary Shares (IREN) | 0.2 | $8.0M | +306% | 175k | 45.73 |
|
| Amazon (AMZN) | 0.2 | $7.7M | -30% | 33k | 238.34 |
|
| CrowdStrike Holdings Cl A (CRWD) | 0.2 | $7.6M | -56% | 10k | 763.14 |
|
| Design Therapeutics (DSGN) | 0.2 | $7.6M | NEW | 523k | 14.47 |
|
| PDD Holdings Sponsored Ads (PDD) | 0.1 | $7.2M | +13% | 95k | 76.28 |
|
| Satellos Bioscience (MSLE) | 0.1 | $6.9M | 892k | 7.78 |
|
|
| Dynatrace Com New (DT) | 0.1 | $6.8M | +3% | 155k | 43.91 |
|
| Apple Call Option (AAPL) | 0.1 | $6.7M | NEW | 23k | 289.36 |
|
| Tenax Therapeutics Com New (TENX) | 0.1 | $6.2M | 427k | 14.55 |
|
|
| vTv Therapeutics Cl A New (VTVT) | 0.1 | $6.1M | 163k | 37.65 |
|
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| Eloxx Pharmaceuticals Com New | 0.1 | $5.6M | NEW | 400k | 13.88 |
|
| Agomab Therapeutics NV Sponsored Ads (AGMB) | 0.1 | $5.3M | 411k | 12.98 |
|
|
| Alibaba Group Holding Sponsored Ads (BABA) | 0.1 | $4.8M | NEW | 50k | 95.98 |
|
| Korro Bio (KRRO) | 0.1 | $4.6M | 348k | 13.18 |
|
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| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $4.5M | 312k | 14.60 |
|
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| Adagio Therapeutics (IVVD) | 0.1 | $4.4M | +25% | 5.0M | 0.87 |
|
| Ouster Com New (OUST) | 0.1 | $4.2M | NEW | 68k | 62.52 |
|
| Palisade Bio (PALI) | 0.1 | $4.2M | NEW | 2.0M | 2.09 |
|
| Aeva Technologies Com New (AEVA) | 0.1 | $4.2M | +32% | 146k | 28.72 |
|
| Seer Com Cl A (SEER) | 0.1 | $4.1M | 2.5M | 1.66 |
|
|
| NovaBridge Biosciences Sponsored Ads (NBP) | 0.1 | $3.9M | -33% | 2.0M | 1.95 |
|
| GitLab Class A Com (GTLB) | 0.1 | $3.8M | +25% | 125k | 30.53 |
|
| Odyssey Therapeutics Common Stock | 0.1 | $3.7M | NEW | 200k | 18.71 |
|
| Foghorn Therapeutics (FHTX) | 0.1 | $3.5M | 721k | 4.88 |
|
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| Agenus Com New (AGEN) | 0.1 | $3.3M | 1.1M | 3.06 |
|
|
| monday.com SHS (MNDY) | 0.1 | $3.1M | +70% | 43k | 72.39 |
|
| Zoetis Cl A (ZTS) | 0.1 | $2.5M | NEW | 35k | 71.86 |
|
| Workiva Com Cl A (WK) | 0.0 | $2.2M | -51% | 45k | 48.51 |
|
| Netflix (NFLX) | 0.0 | $1.8M | NEW | 25k | 71.40 |
|
| Kalaris Therapeutics (KLRS) | 0.0 | $1.8M | 436k | 4.07 |
|
|
| Quantinuum Cl A Com | 0.0 | $1.6M | NEW | 20k | 81.74 |
|
| Rani Therapeutics Holdings Com Cl A (RANI) | 0.0 | $1.5M | 2.0M | 0.76 |
|
|
| Tesla Motors (TSLA) | 0.0 | $1.5M | -83% | 3.5k | 420.60 |
|
| KE Holdings Sponsored Ads (BEKE) | 0.0 | $1.5M | 100k | 14.53 |
|
|
| Entera Bio SHS (ENTX) | 0.0 | $1.3M | NEW | 737k | 1.77 |
|
| Medline Com Cl A (MDLN) | 0.0 | $986k | 25k | 39.44 |
|
|
| Lumentum Hldgs (LITE) | 0.0 | $905k | NEW | 1.1k | 858.06 |
|
| Figma Class A Com Stk (FIG) | 0.0 | $905k | 50k | 18.09 |
|
|
| Gossamer Bio (GOSS) | 0.0 | $857k | 5.2M | 0.16 |
|
|
| Fox Corp Cl A Com (FOXA) | 0.0 | $522k | NEW | 10k | 52.16 |
|
| At&t (T) | 0.0 | $518k | NEW | 25k | 20.70 |
|
| Nu Holdings Ord Shs Cl A (NU) | 0.0 | $334k | 25k | 13.36 |
|
Past Filings by Siren
SEC 13F filings are viewable for Siren going back to 2024
- Siren 2026 Q2 filed Aug. 13, 2026
- Siren 2026 Q1 filed May 14, 2026
- Siren 2025 Q4 filed Feb. 13, 2026
- Siren 2025 Q3 filed Nov. 13, 2025
- Siren 2025 Q2 filed Aug. 13, 2025
- Siren 2025 Q1 restated filed May 23, 2025
- Siren 2025 Q1 filed May 14, 2025
- Siren 2024 Q4 filed Feb. 14, 2025
- Siren 2024 Q3 filed Nov. 13, 2024