Siren
Latest statistics and disclosures from Siren's latest quarterly 13F-HR filing:
- Top 5 stock holdings are SRRK, ONC, KYMR, BPMC, CRNX, and represent 36.25% of Siren's stock portfolio.
- Added to shares of these 10 stocks: BPMC (+$64M), IRON (+$53M), SLNO (+$27M), EWTX (+$21M), RYTM (+$15M), DYN (+$14M), SLDB (+$14M), SMMT (+$13M), MRUS (+$11M), KYMR (+$7.4M).
- Started 24 new stock positions in CRM, INFA, AGEN, SARO, IRON, Sailpoint, Sionna Therapeutics, BPMC, PEGA, TSLA. NKE, LPLA, Aadi Bioscience, Mestera, MDB, USB, ELDN, BILL, RDDT, Kalaris Therapeutics, GDS, SMMT, DECK, RYTM.
- Reduced shares in these 10 stocks: ARGX (-$71M), SWTX (-$50M), ONC (-$42M), MDGL (-$39M), CYTK (-$19M), KURA (-$12M), JANX (-$9.4M), IONS (-$8.7M), IOVA (-$8.2M), APGE (-$5.7M).
- Sold out of its positions in SLRN, ACHL, ALVR, APLT, ARGX, CYTK, DLTR, META, FCX, HCA.
- Siren was a net seller of stock by $-4.5M.
- Siren has $1.8B in assets under management (AUM), dropping by -21.68%.
- Central Index Key (CIK): 0002005245
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Portfolio Holdings for Siren
Siren holds 116 positions in its portfolio as reported in the March 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 16.8 | $297M | 9.3M | 32.15 |
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| Beigene Sponsored Ads (ONC) | 7.7 | $136M | -23% | 499k | 272.17 |
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| Kymera Therapeutics (KYMR) | 5.0 | $89M | +9% | 3.2M | 27.37 |
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| Blueprint Medicines (BPMC) | 3.6 | $64M | NEW | 726k | 88.51 |
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| Crinetics Pharmaceuticals In (CRNX) | 3.2 | $57M | +4% | 1.7M | 33.54 |
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| Apellis Pharmaceuticals (APLS) | 3.2 | $56M | -8% | 2.6M | 21.87 |
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| Disc Medicine (IRON) | 3.0 | $53M | NEW | 1.1M | 49.64 |
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| Soleno Therapeutics (SLNO) | 2.9 | $52M | +106% | 727k | 71.45 |
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| Ascendis Pharma A/S Sponsored Adr (ASND) | 2.5 | $45M | -3% | 287k | 155.86 |
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| Merus N V (MRUS) | 2.5 | $44M | +33% | 1.0M | 42.09 |
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| Bicara Therapeutics (BCAX) | 2.4 | $43M | 3.3M | 13.03 |
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| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 2.4 | $43M | 3.0M | 14.38 |
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| NewAmsterdam Pharma Company NV Ordinary Shares (NAMS) | 2.2 | $39M | -8% | 1.9M | 20.47 |
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| Edgewise Therapeutics (EWTX) | 2.1 | $37M | +131% | 1.7M | 22.00 |
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| Arrowhead Pharmaceuticals (ARWR) | 1.9 | $34M | -7% | 2.7M | 12.74 |
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| Avidity Biosciences Ord (RNA) | 1.8 | $33M | 1.1M | 29.52 |
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| WAVE Life Sciences SHS (WVE) | 1.7 | $30M | 3.7M | 8.08 |
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| Taboola.com Ord Shs (TBLA) | 1.7 | $29M | 10M | 2.95 |
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| Dyne Therapeutics (DYN) | 1.6 | $28M | +101% | 2.7M | 10.46 |
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| Solid Biosciences Com New (SLDB) | 1.5 | $27M | +97% | 7.4M | 3.70 |
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| Xenon Pharmaceuticals (XENE) | 1.4 | $25M | 733k | 33.55 |
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| Apogee Therapeutics (APGE) | 1.3 | $22M | -20% | 595k | 37.36 |
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| Revolution Medicines (RVMD) | 1.1 | $20M | 564k | 35.36 |
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| Trevi Therapeutics (TRVI) | 1.0 | $18M | 2.9M | 6.29 |
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| Vera Therapeutics Cl A (VERA) | 1.0 | $18M | 747k | 24.02 |
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| Lexicon Pharmaceuticals Com New (LXRX) | 1.0 | $18M | 39M | 0.46 |
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| Prothena Corporation SHS (PRTA) | 0.9 | $16M | +16% | 1.3M | 12.38 |
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| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.9 | $15M | 1.8M | 8.49 |
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| Stoke Therapeutics (STOK) | 0.8 | $15M | +12% | 2.2M | 6.65 |
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| Rhythm Pharmaceuticals (RYTM) | 0.8 | $15M | NEW | 278k | 52.97 |
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| Summit Therapeutics (SMMT) | 0.8 | $13M | NEW | 695k | 19.29 |
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| Septerna (SEPN) | 0.7 | $13M | 2.2M | 5.79 |
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| Arcus Biosciences Incorporated (RCUS) | 0.7 | $13M | 1.6M | 7.85 |
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| IHS Holding Ord Shs (IHS) | 0.7 | $12M | 2.4M | 5.22 |
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| Erasca (ERAS) | 0.7 | $12M | 8.8M | 1.37 |
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| Denali Therapeutics (DNLI) | 0.6 | $11M | 822k | 13.60 |
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| Vaxcyte (PCVX) | 0.6 | $11M | 296k | 37.76 |
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| Amazon (AMZN) | 0.6 | $11M | +54% | 57k | 190.26 |
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| Microsoft Corporation (MSFT) | 0.6 | $11M | +23% | 29k | 375.39 |
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| Remitly Global (RELY) | 0.6 | $10M | 490k | 20.80 |
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| Taysha Gene Therapies Com Shs (TSHA) | 0.5 | $9.1M | 6.5M | 1.39 |
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| Cullinan Oncology (CGEM) | 0.5 | $9.0M | 1.2M | 7.57 |
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| CrowdStrike Holdings Cl A (CRWD) | 0.5 | $8.8M | +4% | 25k | 352.58 |
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| Silence Therapeutics Ads (SLN) | 0.4 | $7.9M | 2.8M | 2.82 |
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| Alphabet Cap Stk Cl A (GOOGL) | 0.4 | $7.8M | +624% | 51k | 154.64 |
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| Cartesian Therapeutics Com New (RNAC) | 0.4 | $7.4M | 563k | 13.18 |
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| Adobe Systems Incorporated (ADBE) | 0.4 | $7.4M | +119% | 19k | 383.53 |
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| Korro Bio (KRRO) | 0.4 | $7.3M | 419k | 17.41 |
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| Servicenow (NOW) | 0.4 | $7.3M | +62% | 9.1k | 796.14 |
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| Seer Com Cl A (SEER) | 0.4 | $6.8M | 4.0M | 1.69 |
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| PDD Holdings Sponsored Ads (PDD) | 0.4 | $6.3M | 53k | 118.35 |
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| Spyre Therapeutics Com New (SYRE) | 0.3 | $5.9M | 369k | 16.14 |
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| Gossamer Bio (GOSS) | 0.3 | $5.7M | -3% | 5.2M | 1.10 |
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| Oric Pharmaceuticals (ORIC) | 0.3 | $5.6M | 1.0M | 5.58 |
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| Upstream Bio (UPB) | 0.3 | $4.8M | 789k | 6.12 |
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| NVIDIA Corporation (NVDA) | 0.3 | $4.8M | -9% | 44k | 108.38 |
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| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.3 | $4.7M | +90% | 29k | 166.00 |
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| Datadog Cl A Com (DDOG) | 0.3 | $4.7M | +55% | 47k | 99.21 |
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| Neumora Therapeutics (NMRA) | 0.2 | $4.4M | 4.4M | 1.00 |
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| Jfrog Ord Shs (FROG) | 0.2 | $4.2M | +9% | 132k | 32.00 |
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| Dynatrace Com New (DT) | 0.2 | $4.1M | +6% | 88k | 47.15 |
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| Mestera | 0.2 | $4.1M | NEW | 150k | 27.22 |
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| Rocket Pharmaceuticals (RCKT) | 0.2 | $3.9M | 591k | 6.67 |
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| salesforce (CRM) | 0.2 | $3.9M | NEW | 15k | 268.36 |
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| New Oriental Education & Technology Group Spon Adr (EDU) | 0.2 | $3.8M | +16% | 80k | 47.81 |
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| Rapport Therapeutics (RAPP) | 0.2 | $3.8M | 379k | 10.03 |
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| Ionq Inc Pipe (IONQ) | 0.2 | $3.8M | 170k | 22.07 |
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| Igm Biosciences (IGMS) | 0.2 | $3.7M | -2% | 3.3M | 1.15 |
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| Aadi Bioscience | 0.2 | $3.7M | NEW | 2.1M | 1.78 |
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| Instil Bio Com New (TIL) | 0.2 | $3.5M | +5% | 204k | 17.36 |
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| Tango Therapeutics (TNGX) | 0.2 | $3.5M | 2.6M | 1.37 |
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| Vigil Neuroscience (VIGL) | 0.2 | $3.5M | 2.0M | 1.78 |
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| Sionna Therapeutics | 0.2 | $3.4M | NEW | 325k | 10.46 |
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| Nebius Group NV Shs Class A (NBIS) | 0.2 | $3.0M | +16% | 140k | 21.11 |
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| Foghorn Therapeutics (FHTX) | 0.1 | $2.6M | 721k | 3.65 |
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| Reddit Cl A (RDDT) | 0.1 | $2.5M | NEW | 24k | 104.90 |
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| Lpl Financial Holdings (LPLA) | 0.1 | $2.5M | NEW | 7.5k | 327.14 |
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| Sagimet Biosciences Com Ser A (SGMT) | 0.1 | $2.4M | 725k | 3.26 |
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| Eledon Pharmaceuticals (ELDN) | 0.1 | $2.3M | NEW | 690k | 3.39 |
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| Tesla Motors (TSLA) | 0.1 | $2.3M | NEW | 9.0k | 259.16 |
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| Kalaris Therapeutics | 0.1 | $2.3M | NEW | 283k | 8.03 |
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| Marvell Technology (MRVL) | 0.1 | $2.3M | +636% | 37k | 61.57 |
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| Qualcomm (QCOM) | 0.1 | $2.2M | -6% | 14k | 153.61 |
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| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $2.1M | +75% | 105k | 20.09 |
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| Lexeo Therapeutics (LXEO) | 0.1 | $2.1M | 603k | 3.47 |
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| ProQR Therapeutics NV Shs Euro (PRQR) | 0.1 | $2.1M | 1.6M | 1.33 |
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| Palo Alto Networks (PANW) | 0.1 | $2.0M | +91% | 12k | 170.64 |
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| Sailpoint | 0.1 | $1.8M | NEW | 95k | 18.75 |
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| Black Diamond Therapeutics (BDTX) | 0.1 | $1.6M | 1.0M | 1.55 |
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| Standardaero (SARO) | 0.1 | $1.5M | NEW | 57k | 26.64 |
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| Bioage Labs (BIOA) | 0.1 | $1.4M | 382k | 3.76 |
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| Tourmaline Bio (TRML) | 0.1 | $1.4M | 91k | 15.21 |
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| Workiva Com Cl A (WK) | 0.1 | $1.3M | +75% | 18k | 75.91 |
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| Bill Com Holdings Ord (BILL) | 0.1 | $1.3M | NEW | 29k | 45.89 |
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| Paypal Holdings (PYPL) | 0.1 | $1.3M | +33% | 20k | 65.25 |
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| Generation Bio (GBIO) | 0.1 | $1.2M | 3.0M | 0.41 |
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| SEMrush Holdings Cl A Com (SEMR) | 0.1 | $1.2M | +257% | 125k | 9.33 |
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| Pegasystems (PEGA) | 0.1 | $1.1M | NEW | 17k | 69.52 |
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| MongoDB Cl A (MDB) | 0.1 | $965k | NEW | 5.5k | 175.40 |
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| Nike CL B (NKE) | 0.1 | $952k | NEW | 15k | 63.48 |
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| Intel Corporation (INTC) | 0.1 | $908k | 40k | 22.71 |
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| Informatica Com Cl A (INFA) | 0.0 | $873k | NEW | 50k | 17.45 |
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| Boeing Company (BA) | 0.0 | $853k | -80% | 5.0k | 170.55 |
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| Couchbase (BASE) | 0.0 | $785k | -16% | 50k | 15.75 |
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| Agenus Com New (AGEN) | 0.0 | $753k | NEW | 500k | 1.50 |
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| Kronos Bio (KRON) | 0.0 | $695k | 843k | 0.82 |
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| Procore Technologies (PCOR) | 0.0 | $660k | -50% | 10k | 66.02 |
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| Ferrari Nv Ord (RACE) | 0.0 | $636k | -25% | 1.5k | 424.24 |
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| HOOKIPA Pharma Com New (HOOK) | 0.0 | $612k | 567k | 1.08 |
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| Deckers Outdoor Corporation (DECK) | 0.0 | $559k | NEW | 5.0k | 111.81 |
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| US Bancorp Com New (USB) | 0.0 | $528k | NEW | 13k | 42.22 |
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| Occidental Petroleum Corporation (OXY) | 0.0 | $494k | -33% | 10k | 49.36 |
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| GDS Holdings Sponsored Ads (GDS) | 0.0 | $317k | NEW | 13k | 25.33 |
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| Cyclerion Therapeutics (CYCN) | 0.0 | $290k | 116k | 2.50 |
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| Ironwood Pharmaceuticals Com Cl A (IRWD) | 0.0 | $163k | 111k | 1.47 |
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| Caribou Biosciences (CRBU) | 0.0 | $96k | 105k | 0.91 |
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Past Filings by Siren
SEC 13F filings are viewable for Siren going back to 2024
- Siren 2025 Q1 restated filed May 23, 2025
- Siren 2025 Q1 filed May 14, 2025
- Siren 2024 Q4 filed Feb. 14, 2025
- Siren 2024 Q3 filed Nov. 13, 2024