Siren
Latest statistics and disclosures from Siren's latest quarterly 13F-HR filing:
- Top 5 stock holdings are SRRK, KYMR, ERAS, EWTX, ONC, and represent 34.85% of Siren's stock portfolio.
- Added to shares of these 10 stocks: MANE (+$95M), CYTK (+$41M), ERAS (+$40M), XENE (+$29M), ELVN (+$29M), ORIC (+$25M), DMRA (+$23M), PVLA (+$23M), ANNX (+$22M), OLMA (+$22M).
- Started 19 new stock positions in GENB, DMRA, ANNX, ABSI, MANE, QURE, CTMX, AS, NU, MU. ELVN, MSLE, AGMB, CYTK, RZLT, AEVA, DFTX, FPS, AMLX.
- Reduced shares in these 10 stocks: Centessa Pharmaceuticals (-$118M), Apellis Pharmaceuticals (-$65M), TNGX (-$53M), Ascendis Pharma A S (-$50M), RAPT (-$47M), ZYME (-$44M), MLYS (-$25M), DYN (-$23M), RVMD (-$22M), IHS (-$18M).
- Sold out of its positions in ADBE, ALMS, Apellis Pharmaceuticals, ARM, Ascendis Pharma A S, BNTC, BLLN, BDTX, CRBU, CMPS.
- Siren was a net buyer of stock by $2.4M.
- Siren has $3.6B in assets under management (AUM), dropping by 7.61%.
- Central Index Key (CIK): 0002005245
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Portfolio Holdings for Siren
Siren holds 100 positions in its portfolio as reported in the March 2026 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 14.8 | $532M | 11M | 49.16 |
|
|
| Kymera Therapeutics (KYMR) | 7.4 | $265M | -3% | 3.2M | 83.29 |
|
| Erasca (ERAS) | 5.0 | $182M | +28% | 11M | 16.18 |
|
| Edgewise Therapeutics (EWTX) | 3.9 | $140M | -2% | 4.4M | 31.50 |
|
| BeOne Medicines Sponsored Ads (ONC) | 3.8 | $138M | -7% | 465k | 296.97 |
|
| Tango Therapeutics (TNGX) | 3.3 | $118M | -30% | 5.7M | 20.92 |
|
| Bicara Therapeutics (BCAX) | 3.2 | $115M | +11% | 5.8M | 19.89 |
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| Revolution Medicines (RVMD) | 3.0 | $108M | -16% | 1.1M | 97.25 |
|
| Arrowhead Pharmaceuticals (ARWR) | 2.8 | $101M | +7% | 1.6M | 62.70 |
|
| Veradermics Common Stock (MANE) | 2.6 | $95M | NEW | 1.5M | 63.15 |
|
| Xenon Pharmaceuticals (XENE) | 2.1 | $77M | +62% | 1.3M | 58.15 |
|
| Olema Pharmaceuticals (OLMA) | 2.0 | $71M | +44% | 4.8M | 14.91 |
|
| Crinetics Pharmaceuticals In (CRNX) | 1.9 | $69M | +26% | 1.9M | 36.32 |
|
| Lexicon Pharmaceuticals Com New (LXRX) | 1.9 | $69M | +13% | 44M | 1.56 |
|
| Cogent Biosciences (COGT) | 1.8 | $66M | +4% | 1.7M | 38.49 |
|
| Stoke Therapeutics (STOK) | 1.8 | $65M | -11% | 2.0M | 32.56 |
|
| Arcus Biosciences Incorporated (RCUS) | 1.8 | $65M | 3.0M | 21.60 |
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| Structure Therapeutics Sponsored Ads (GPCR) | 1.8 | $64M | +23% | 1.3M | 48.20 |
|
| Disc Medicine (IRON) | 1.8 | $63M | 988k | 63.94 |
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| Rhythm Pharmaceuticals (RYTM) | 1.7 | $63M | +45% | 726k | 86.97 |
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| Solid Biosciences Com New (SLDB) | 1.5 | $55M | 7.7M | 7.20 |
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| Septerna (SEPN) | 1.3 | $48M | 2.0M | 24.03 |
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| Centessa Pharmaceuticals Sponsored Ads | 1.2 | $42M | -73% | 1.1M | 39.72 |
|
| Spyre Therapeutics Com New (SYRE) | 1.1 | $41M | 819k | 50.44 |
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|
| Cytokinetics Com New (CYTK) | 1.1 | $41M | NEW | 614k | 65.91 |
|
| Dyne Therapeutics (DYN) | 1.1 | $40M | -36% | 2.2M | 18.13 |
|
| Taysha Gene Therapies Com Shs (TSHA) | 1.1 | $40M | -12% | 8.8M | 4.47 |
|
| Dbv Technologies SA Sponsored Ads (DBVT) | 1.1 | $39M | 1.9M | 20.89 |
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| Oric Pharmaceuticals (ORIC) | 1.1 | $38M | +197% | 3.0M | 12.67 |
|
| Engene Holdings | 1.0 | $36M | +57% | 5.3M | 6.81 |
|
| Palvella Therapeutics Inc Ne (PVLA) | 0.9 | $32M | +243% | 258k | 124.65 |
|
| Taboola.com Ord Shs (TBLA) | 0.9 | $31M | 10M | 3.10 |
|
|
| Enliven Therapeutics (ELVN) | 0.8 | $29M | NEW | 746k | 39.20 |
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| Denali Therapeutics (DNLI) | 0.7 | $27M | 1.4M | 19.20 |
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| Remitly Global (RELY) | 0.7 | $24M | -4% | 1.5M | 15.67 |
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| Damora Therapeutics Com New (DMRA) | 0.6 | $23M | NEW | 900k | 25.90 |
|
| Zura Bio Class A Ord Shs (ZURA) | 0.6 | $22M | +187% | 3.7M | 5.95 |
|
| Annexon (ANNX) | 0.6 | $22M | NEW | 4.0M | 5.54 |
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| Trevi Therapeutics (TRVI) | 0.6 | $21M | -21% | 1.8M | 11.93 |
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| Rapport Therapeutics (RAPP) | 0.6 | $20M | -9% | 642k | 31.29 |
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| Alphabet Cap Stk Cl A (GOOGL) | 0.5 | $19M | +217% | 66k | 287.56 |
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| Fulcrum Therapeutics (FULC) | 0.5 | $18M | +20% | 2.4M | 7.67 |
|
| WAVE Life Sciences SHS (WVE) | 0.5 | $18M | 2.5M | 7.25 |
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| Definium Therapeutics Com Shs (DFTX) | 0.5 | $17M | NEW | 920k | 18.90 |
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| Amylyx Pharmaceuticals (AMLX) | 0.5 | $17M | NEW | 1.2M | 13.90 |
|
| Cullinan Oncology (CGEM) | 0.5 | $17M | 1.2M | 14.21 |
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| Neumora Therapeutics (NMRA) | 0.5 | $17M | +35% | 8.5M | 1.95 |
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| Uniqure NV SHS (QURE) | 0.5 | $16M | NEW | 1.0M | 16.35 |
|
| Cytomx Therapeutics (CTMX) | 0.5 | $16M | NEW | 3.5M | 4.70 |
|
| NVIDIA Corporation (NVDA) | 0.4 | $16M | +137% | 89k | 174.40 |
|
| Silence Therapeutics Ads (SLN) | 0.4 | $15M | 2.9M | 5.27 |
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| Microsoft Corporation (MSFT) | 0.4 | $15M | +175% | 41k | 370.17 |
|
| Monopar Therapeutics Com New (MNPR) | 0.4 | $15M | +27% | 270k | 54.79 |
|
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.4 | $14M | +52% | 42k | 337.95 |
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| Sionna Therapeutics (SION) | 0.3 | $12M | 300k | 40.09 |
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| Nebius Group NV Shs Class A (NBIS) | 0.3 | $12M | +49% | 114k | 103.76 |
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| Rezolute Com New (RZLT) | 0.3 | $10M | NEW | 3.3M | 3.05 |
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| Inhibikase Therapeutics Com New (IKT) | 0.3 | $9.8M | 5.9M | 1.68 |
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| Amazon (AMZN) | 0.3 | $9.7M | -9% | 47k | 208.27 |
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| Generate Biomedicines Com Shs (GENB) | 0.3 | $9.2M | NEW | 736k | 12.50 |
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| Maplight Therapeutics (MPLT) | 0.3 | $9.1M | 450k | 20.33 |
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| Servicenow (NOW) | 0.3 | $9.1M | +144% | 87k | 104.55 |
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| CrowdStrike Holdings Cl A (CRWD) | 0.2 | $9.0M | +39% | 23k | 390.41 |
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| PDD Holdings Sponsored Ads (PDD) | 0.2 | $8.5M | +31% | 83k | 102.18 |
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| Tesla Motors (TSLA) | 0.2 | $8.0M | +1333% | 22k | 371.75 |
|
| NovaBridge Biosciences Sponsored Ads (NBP) | 0.2 | $7.4M | 3.0M | 2.46 |
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| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.2 | $7.2M | -22% | 1.6M | 4.64 |
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| Aadi Bioscience (WHWK) | 0.2 | $7.2M | 2.1M | 3.45 |
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| Tenax Therapeutics Com New (TENX) | 0.2 | $6.8M | 427k | 15.99 |
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| vTv Therapeutics Cl A New (VTVT) | 0.2 | $6.5M | 163k | 39.66 |
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| Datadog Cl A Com (DDOG) | 0.2 | $6.4M | +49% | 54k | 118.05 |
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| Jfrog Ord Shs (FROG) | 0.2 | $6.0M | +37% | 129k | 46.93 |
|
| Dynatrace Com New (DT) | 0.2 | $5.5M | +30% | 150k | 36.98 |
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| Workiva Com Cl A (WK) | 0.2 | $5.5M | +16% | 93k | 59.63 |
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| Absci Corp (ABSI) | 0.1 | $5.4M | NEW | 1.8M | 3.00 |
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| Adagio Therapeutics (IVVD) | 0.1 | $5.2M | 4.0M | 1.30 |
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| Satellos Bioscience (MSLE) | 0.1 | $5.0M | NEW | 892k | 5.63 |
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| Ionq Inc Pipe (IONQ) | 0.1 | $4.9M | 170k | 28.83 |
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| Broadcom (AVGO) | 0.1 | $4.6M | +114% | 15k | 309.51 |
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| Agomab Therapeutics NV Sponsored Ads (AGMB) | 0.1 | $4.3M | NEW | 411k | 10.49 |
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| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $4.3M | +107% | 312k | 13.78 |
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| Seer Com Cl A (SEER) | 0.1 | $4.1M | -38% | 2.5M | 1.68 |
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| Korro Bio (KRRO) | 0.1 | $3.9M | 348k | 11.32 |
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| Agenus Com New (AGEN) | 0.1 | $3.6M | 1.1M | 3.34 |
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| Foghorn Therapeutics (FHTX) | 0.1 | $3.4M | 721k | 4.78 |
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| Forgent Power Solutions Com Shs Cl A (FPS) | 0.1 | $2.9M | NEW | 100k | 29.27 |
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| Kalaris Therapeutics (KLRS) | 0.1 | $2.5M | 436k | 5.77 |
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| GitLab Class A Com (GTLB) | 0.1 | $2.2M | 100k | 21.64 |
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| Micron Technology (MU) | 0.1 | $2.0M | NEW | 6.0k | 337.84 |
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| monday.com SHS (MNDY) | 0.0 | $1.7M | +47% | 25k | 69.11 |
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| Gossamer Bio (GOSS) | 0.0 | $1.7M | 5.2M | 0.33 |
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| Amer Sports Com Shs (AS) | 0.0 | $1.6M | NEW | 50k | 32.92 |
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| KE Holdings Sponsored Ads (BEKE) | 0.0 | $1.5M | -31% | 100k | 14.97 |
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| Iren Ordinary Shares (IREN) | 0.0 | $1.5M | 43k | 34.28 |
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| Rani Therapeutics Holdings Com Cl A (RANI) | 0.0 | $1.5M | 2.0M | 0.73 |
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| Aeva Technologies Com New (AEVA) | 0.0 | $1.4M | NEW | 110k | 13.16 |
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| Medline Com Cl A (MDLN) | 0.0 | $1.1M | -66% | 25k | 44.50 |
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| Figma Class A Com Stk (FIG) | 0.0 | $1.1M | +100% | 50k | 21.14 |
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| Primo Brands Corp Class A Com Shs (PRMB) | 0.0 | $942k | -33% | 50k | 18.83 |
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| Nu Holdings Ord Shs Cl A (NU) | 0.0 | $359k | NEW | 25k | 14.37 |
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Past Filings by Siren
SEC 13F filings are viewable for Siren going back to 2024
- Siren 2026 Q1 filed May 14, 2026
- Siren 2025 Q4 filed Feb. 13, 2026
- Siren 2025 Q3 filed Nov. 13, 2025
- Siren 2025 Q2 filed Aug. 13, 2025
- Siren 2025 Q1 restated filed May 23, 2025
- Siren 2025 Q1 filed May 14, 2025
- Siren 2024 Q4 filed Feb. 14, 2025
- Siren 2024 Q3 filed Nov. 13, 2024