Siren as of Dec. 31, 2024
Portfolio Holdings for Siren
Siren holds 117 positions in its portfolio as reported in the December 2024 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 17.7 | $400M | 9.3M | 43.22 | |
| Beigene Sponsored Adr (ONC) | 5.3 | $121M | 654k | 184.71 | |
| Kymera Therapeutics (KYMR) | 5.3 | $120M | 3.0M | 40.23 | |
| Apellis Pharmaceuticals (APLS) | 4.0 | $90M | 2.8M | 31.91 | |
| Crinetics Pharmaceuticals In (CRNX) | 3.6 | $82M | 1.6M | 51.13 | |
| argenx SE Sponsored Adr (ARGX) | 3.1 | $71M | 115k | 615.00 | |
| Bicara Therapeutics (BCAX) | 2.5 | $57M | 3.3M | 17.42 | |
| Arrowhead Pharmaceuticals (ARWR) | 2.4 | $55M | 2.9M | 18.80 | |
| NewAmsterdam Pharma Company NV Ordinary Shares (NAMS) | 2.4 | $54M | 2.1M | 25.70 | |
| Septerna (SEPN) | 2.2 | $50M | 2.2M | 22.90 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 2.2 | $50M | 3.0M | 16.75 | |
| Springworks Therapeutics (SWTX) | 2.2 | $50M | 1.4M | 36.13 | |
| Neumora Therapeutics (NMRA) | 2.1 | $47M | 4.4M | 10.60 | |
| WAVE Life Sciences SHS (WVE) | 2.0 | $46M | 3.8M | 12.37 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 1.8 | $41M | 297k | 137.67 | |
| Madrigal Pharmaceuticals (MDGL) | 1.7 | $39M | 126k | 308.57 | |
| Taboola.com Ord Shs (TBLA) | 1.6 | $36M | 10M | 3.65 | |
| Apogee Therapeutics (APGE) | 1.5 | $34M | 747k | 45.30 | |
| Merus N V (MRUS) | 1.5 | $33M | 784k | 42.05 | |
| Avidity Biosciences Ord (RNA) | 1.4 | $33M | 1.1M | 29.08 | |
| Vera Therapeutics Cl A (VERA) | 1.4 | $32M | 759k | 42.29 | |
| Dyne Therapeutics (DYN) | 1.4 | $32M | 1.3M | 23.56 | |
| Xenon Pharmaceuticals (XENE) | 1.3 | $29M | 744k | 39.20 | |
| Lexicon Pharmaceuticals Com New (LXRX) | 1.3 | $29M | 39M | 0.74 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 1.1 | $26M | 1.8M | 14.00 | |
| Revolution Medicines (RVMD) | 1.1 | $25M | 572k | 43.74 | |
| Vaxcyte (PCVX) | 1.1 | $25M | 300k | 81.86 | |
| Arcus Biosciences Incorporated (RCUS) | 1.1 | $24M | 1.6M | 14.89 | |
| Erasca (ERAS) | 1.0 | $22M | 8.9M | 2.51 | |
| Stoke Therapeutics (STOK) | 1.0 | $22M | 2.0M | 11.03 | |
| Igm Biosciences (IGMS) | 0.9 | $20M | 3.3M | 6.11 | |
| Edgewise Therapeutics (EWTX) | 0.9 | $20M | 734k | 26.70 | |
| Silence Therapeutics Ads (SLN) | 0.9 | $20M | 2.8M | 6.88 | |
| Cytokinetics Com New (CYTK) | 0.8 | $19M | 402k | 47.04 | |
| Denali Therapeutics (DNLI) | 0.8 | $17M | 834k | 20.38 | |
| Korro Bio (KRRO) | 0.7 | $16M | 419k | 38.07 | |
| Soleno Therapeutics (SLNO) | 0.7 | $16M | 352k | 44.95 | |
| Prothena Corporation SHS (PRTA) | 0.7 | $15M | 1.1M | 13.85 | |
| Solid Biosciences Com New (SLDB) | 0.7 | $15M | 3.7M | 4.00 | |
| Cullinan Oncology (CGEM) | 0.7 | $15M | 1.2M | 12.18 | |
| Upstream Bio (UPB) | 0.6 | $13M | 800k | 16.44 | |
| Trevi Therapeutics (TRVI) | 0.5 | $12M | 2.9M | 4.12 | |
| Kura Oncology (KURA) | 0.5 | $12M | 1.3M | 8.71 | |
| Taysha Gene Therapies Com Shs (TSHA) | 0.5 | $11M | 6.6M | 1.73 | |
| Remitly Global (RELY) | 0.5 | $11M | 490k | 22.57 | |
| Cartesian Therapeutics Com New (RNAC) | 0.5 | $10M | 572k | 17.91 | |
| Microsoft Corporation (MSFT) | 0.4 | $9.7M | 23k | 421.50 | |
| Janux Therapeutics (JANX) | 0.4 | $9.4M | 175k | 53.54 | |
| Seer Com Cl A (SEER) | 0.4 | $9.2M | 4.0M | 2.31 | |
| Ionis Pharmaceuticals (IONS) | 0.4 | $8.7M | 250k | 34.96 | |
| Spyre Therapeutics Com New (SYRE) | 0.4 | $8.7M | 374k | 23.28 | |
| CrowdStrike Holdings Cl A (CRWD) | 0.4 | $8.2M | 24k | 342.16 | |
| Iovance Biotherapeutics (IOVA) | 0.4 | $8.2M | 1.1M | 7.40 | |
| Oric Pharmaceuticals (ORIC) | 0.4 | $8.1M | 1.0M | 8.07 | |
| Tango Therapeutics (TNGX) | 0.4 | $8.0M | 2.6M | 3.09 | |
| Amazon (AMZN) | 0.4 | $8.0M | 37k | 219.39 | |
| Rocket Pharmaceuticals (RCKT) | 0.3 | $7.5M | 600k | 12.57 | |
| Ionq Inc Pipe (IONQ) | 0.3 | $7.1M | 170k | 41.77 | |
| IHS Holding Ord Shs (IHS) | 0.3 | $6.9M | 2.4M | 2.92 | |
| Rapport Therapeutics (RAPP) | 0.3 | $6.8M | 384k | 17.74 | |
| NVIDIA Corporation (NVDA) | 0.3 | $6.6M | 49k | 134.29 | |
| Servicenow (NOW) | 0.3 | $5.9M | 5.6k | 1060.12 | |
| Acelyrin | 0.2 | $5.4M | 1.7M | 3.14 | |
| PDD Holdings Sponsored Ads (PDD) | 0.2 | $5.1M | 53k | 96.99 | |
| Gossamer Bio Call Option (GOSS) | 0.2 | $4.9M | 5.4M | 0.90 | |
| Dynatrace Com New (DT) | 0.2 | $4.5M | 83k | 54.35 | |
| Boeing Company (BA) | 0.2 | $4.4M | 25k | 177.00 | |
| New Oriental Education & Technology Group Spon Adr (EDU) | 0.2 | $4.4M | 69k | 64.18 | |
| Datadog Cl A Com (DDOG) | 0.2 | $4.3M | 30k | 142.89 | |
| ProQR Therapeutics NV Shs Euro (PRQR) | 0.2 | $4.2M | 1.6M | 2.65 | |
| Lexeo Therapeutics (LXEO) | 0.2 | $4.0M | 603k | 6.58 | |
| Adobe Systems Incorporated (ADBE) | 0.2 | $3.9M | 8.8k | 444.68 | |
| Phathom Pharmaceuticals (PHAT) | 0.2 | $3.7M | 461k | 8.12 | |
| Instil Bio Com New (TIL) | 0.2 | $3.7M | 192k | 19.09 | |
| Jfrog Ord Shs (FROG) | 0.2 | $3.5M | 120k | 29.41 | |
| Foghorn Therapeutics (FHTX) | 0.2 | $3.4M | 721k | 4.72 | |
| Vigil Neuroscience (VIGL) | 0.1 | $3.4M | 2.0M | 1.70 | |
| Nebius Group NV Shs Class A (NBIS) | 0.1 | $3.3M | 120k | 27.70 | |
| Sagimet Biosciences Com Ser A (SGMT) | 0.1 | $3.3M | 725k | 4.50 | |
| Generation Bio | 0.1 | $3.2M | 3.0M | 1.06 | |
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.1 | $3.0M | 15k | 197.49 | |
| Freeport-McMoRan CL B (FCX) | 0.1 | $2.9M | 75k | 38.08 | |
| Allovir (ALVR) | 0.1 | $2.8M | 6.6M | 0.42 | |
| Ovid Therapeutics (OVID) | 0.1 | $2.7M | 2.9M | 0.93 | |
| Sea Sponsored Ads (SE) | 0.1 | $2.7M | 25k | 106.10 | |
| Elastic NV Ord Shs (ESTC) | 0.1 | $2.5M | 25k | 99.08 | |
| Qualcomm (QCOM) | 0.1 | $2.3M | 15k | 153.62 | |
| Bioage Labs (BIOA) | 0.1 | $2.2M | 388k | 5.79 | |
| Black Diamond Therapeutics (BDTX) | 0.1 | $2.2M | 1.0M | 2.14 | |
| Regenxbio Inc equity us cm (RGNX) | 0.1 | $2.2M | 284k | 7.73 | |
| Tourmaline Bio (TRML) | 0.1 | $1.9M | 91k | 20.28 | |
| Procore Technologies (PCOR) | 0.1 | $1.5M | 20k | 74.93 | |
| Applied Therapeutics (APLT) | 0.1 | $1.4M | 1.6M | 0.86 | |
| Alphabet Cap Stk Cl A (GOOGL) | 0.1 | $1.3M | 7.0k | 189.30 | |
| Paypal Holdings (PYPL) | 0.1 | $1.3M | 15k | 85.35 | |
| HOOKIPA Pharma Com New (HOOK) | 0.1 | $1.1M | 567k | 2.01 | |
| Hca Holdings (HCA) | 0.0 | $1.1M | 3.8k | 300.15 | |
| Ke Holdings Sponsored Ads (BEKE) | 0.0 | $1.1M | 60k | 18.42 | |
| Workiva Com Cl A (WK) | 0.0 | $1.1M | 10k | 109.50 | |
| Palo Alto Networks (PANW) | 0.0 | $1.1M | 6.0k | 181.96 | |
| Omega Therapeutics Common Stock (OMGAQ) | 0.0 | $987k | 1.3M | 0.75 | |
| Couchbase | 0.0 | $935k | 60k | 15.59 | |
| Achilles Therapeutics Sponsored Ads (ACHL) | 0.0 | $861k | 755k | 1.14 | |
| Ferrari Nv Ord (RACE) | 0.0 | $855k | 2.0k | 427.25 | |
| Intel Corporation (INTC) | 0.0 | $802k | 40k | 20.05 | |
| Kronos Bio | 0.0 | $801k | 843k | 0.95 | |
| Dollar Tree (DLTR) | 0.0 | $749k | 10k | 74.94 | |
| Occidental Petroleum Corporation (OXY) | 0.0 | $741k | 15k | 49.41 | |
| Meta Platforms Cl A (META) | 0.0 | $586k | 1.0k | 585.51 | |
| Marvell Technology (MRVL) | 0.0 | $552k | 5.0k | 110.45 | |
| Nu Holdings Ord Shs Cl A (NU) | 0.0 | $518k | 50k | 10.36 | |
| Ironwood Pharmaceuticals Com Cl A (IRWD) | 0.0 | $490k | 111k | 4.43 | |
| Monday.Com SHS (MNDY) | 0.0 | $471k | 2.0k | 235.44 | |
| SEMrush Holdings Cl A Com (SEMR) | 0.0 | $416k | 35k | 11.88 | |
| Cyclerion Therapeutics (CYCN) | 0.0 | $374k | 116k | 3.22 | |
| Kanzhun Sponsored Ads (BZ) | 0.0 | $345k | 25k | 13.80 | |
| Caribou Biosciences (CRBU) | 0.0 | $168k | 105k | 1.59 |
