Siren as of Sept. 30, 2025
Portfolio Holdings for Siren
Siren holds 115 positions in its portfolio as reported in the September 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 13.5 | $345M | 9.3M | 37.24 | |
| Kymera Therapeutics (KYMR) | 7.6 | $194M | 3.4M | 56.60 | |
| BeOne Medicines Sponsored Ads (ONC) | 6.6 | $168M | 493k | 340.70 | |
| Arrowhead Pharmaceuticals (ARWR) | 3.6 | $92M | 2.7M | 34.49 | |
| Bicara Therapeutics (BCAX) | 3.2 | $82M | 5.2M | 15.79 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 3.1 | $78M | 3.2M | 24.25 | |
| Crinetics Pharmaceuticals In (CRNX) | 2.8 | $70M | 1.7M | 41.65 | |
| Edgewise Therapeutics (EWTX) | 2.5 | $63M | 3.9M | 16.22 | |
| Disc Medicine (IRON) | 2.4 | $60M | 913k | 66.08 | |
| Dyne Therapeutics (DYN) | 2.3 | $60M | 4.7M | 12.65 | |
| Apellis Pharmaceuticals (APLS) | 2.3 | $58M | 2.6M | 22.63 | |
| Avidity Biosciences Ord (RNA) | 2.2 | $56M | 1.3M | 43.57 | |
| Stoke Therapeutics (STOK) | 2.1 | $53M | 2.2M | 23.50 | |
| Lexicon Pharmaceuticals Com New (LXRX) | 2.1 | $53M | 39M | 1.35 | |
| Rhythm Pharmaceuticals (RYTM) | 2.0 | $51M | 500k | 100.99 | |
| Tango Therapeutics (TNGX) | 1.9 | $49M | 5.9M | 8.40 | |
| Revolution Medicines (RVMD) | 1.9 | $49M | 1.0M | 46.70 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 1.8 | $47M | 236k | 198.81 | |
| Rezolute Com New (RZLT) | 1.8 | $46M | 4.9M | 9.40 | |
| Solid Biosciences Com New (SLDB) | 1.8 | $46M | 7.4M | 6.17 | |
| Septerna (SEPN) | 1.6 | $41M | 2.2M | 18.81 | |
| Arcus Biosciences Incorporated (RCUS) | 1.5 | $40M | 2.9M | 13.60 | |
| Taysha Gene Therapies Com Shs (TSHA) | 1.4 | $36M | 11M | 3.27 | |
| Taboola.com Ord Shs (TBLA) | 1.3 | $34M | 10M | 3.41 | |
| Xenon Pharmaceuticals (XENE) | 1.3 | $33M | 813k | 40.15 | |
| Soleno Therapeutics (SLNO) | 1.2 | $32M | 467k | 67.60 | |
| Rapport Therapeutics (RAPP) | 1.2 | $31M | 1.1M | 29.70 | |
| Structure Therapeutics Sponsored Ads (GPCR) | 1.1 | $29M | 1.0M | 28.00 | |
| WAVE Life Sciences SHS (WVE) | 1.1 | $27M | 3.7M | 7.32 | |
| Remitly Global (RELY) | 1.0 | $26M | 1.6M | 16.30 | |
| Cogent Biosciences (COGT) | 1.0 | $25M | 1.7M | 14.36 | |
| Trevi Therapeutics (TRVI) | 0.9 | $23M | 2.5M | 9.15 | |
| NewAmsterdam Pharma Company NV Ordinary Shares (NAMS) | 0.9 | $22M | 766k | 28.44 | |
| Korro Bio (KRRO) | 0.8 | $20M | 419k | 47.89 | |
| Erasca (ERAS) | 0.7 | $19M | 8.8M | 2.18 | |
| IHS Holding Ord Shs (IHS) | 0.6 | $16M | 2.4M | 6.82 | |
| Uniqure NV SHS (QURE) | 0.6 | $16M | 275k | 58.37 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.6 | $16M | 2.0M | 7.74 | |
| Silence Therapeutics Ads (SLN) | 0.6 | $15M | 2.9M | 5.19 | |
| RAPT Therapeutics Com New (RAPT) | 0.6 | $15M | 581k | 25.79 | |
| Upstream Bio (UPB) | 0.6 | $15M | 789k | 18.81 | |
| Gossamer Bio (GOSS) | 0.5 | $14M | 5.2M | 2.63 | |
| Arrivent Biopharma (AVBP) | 0.5 | $13M | 700k | 18.45 | |
| Amazon (AMZN) | 0.5 | $13M | 59k | 219.57 | |
| Oric Pharmaceuticals (ORIC) | 0.5 | $12M | 1.0M | 12.00 | |
| Denali Therapeutics (DNLI) | 0.5 | $12M | 822k | 14.52 | |
| Ionq Inc Pipe (IONQ) | 0.4 | $11M | 170k | 61.50 | |
| Sionna Therapeutics (SION) | 0.4 | $9.6M | 325k | 29.41 | |
| CrowdStrike Holdings Cl A (CRWD) | 0.4 | $9.1M | 19k | 490.38 | |
| Microsoft Corporation (MSFT) | 0.3 | $8.9M | 17k | 517.95 | |
| Seer Com Cl A (SEER) | 0.3 | $8.7M | 4.0M | 2.17 | |
| Nebius Group NV Shs Class A (NBIS) | 0.3 | $8.2M | 73k | 112.27 | |
| Neumora Therapeutics (NMRA) | 0.3 | $7.9M | 4.4M | 1.82 | |
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.3 | $7.9M | 28k | 279.29 | |
| salesforce (CRM) | 0.3 | $7.1M | 30k | 237.00 | |
| Cullinan Oncology (CGEM) | 0.3 | $7.1M | 1.2M | 5.93 | |
| NVIDIA Corporation (NVDA) | 0.3 | $7.0M | 38k | 186.57 | |
| Servicenow (NOW) | 0.3 | $6.6M | 7.1k | 920.28 | |
| Spyre Therapeutics Com New (SYRE) | 0.2 | $6.2M | 369k | 16.76 | |
| Cartesian Therapeutics Com New (RNAC) | 0.2 | $5.8M | 563k | 10.22 | |
| PDD Holdings Sponsored Ads (PDD) | 0.2 | $5.7M | 43k | 132.17 | |
| Eledon Pharmaceuticals (ELDN) | 0.2 | $5.4M | 2.1M | 2.59 | |
| Adobe Systems Incorporated (ADBE) | 0.2 | $5.3M | 15k | 352.75 | |
| Alphabet Cap Stk Cl A (GOOGL) | 0.2 | $5.2M | 21k | 243.10 | |
| Jfrog Ord Shs (FROG) | 0.2 | $5.1M | 107k | 47.33 | |
| Sagimet Biosciences Com Ser A (SGMT) | 0.2 | $5.0M | 725k | 6.86 | |
| Dynatrace Com New (DT) | 0.2 | $4.9M | 100k | 48.45 | |
| Datadog Cl A Com (DDOG) | 0.2 | $4.7M | 33k | 142.40 | |
| I-Mab Sponsored Ads (NBP) | 0.2 | $4.4M | 1.2M | 3.78 | |
| Agenus Com New (AGEN) | 0.2 | $4.1M | 1.1M | 3.85 | |
| Lexeo Therapeutics (LXEO) | 0.2 | $4.0M | 603k | 6.64 | |
| Black Diamond Therapeutics (BDTX) | 0.2 | $4.0M | 1.0M | 3.79 | |
| Aadi Bioscience (WHWK) | 0.2 | $4.0M | 2.1M | 1.90 | |
| vTv Therapeutics Cl A New (VTVT) | 0.1 | $3.8M | 163k | 23.35 | |
| Instil Bio Com New (TIL) | 0.1 | $3.6M | 204k | 17.86 | |
| Foghorn Therapeutics (FHTX) | 0.1 | $3.5M | 721k | 4.89 | |
| ProQR Therapeutics NV Shs Euro (PRQR) | 0.1 | $3.3M | 1.6M | 2.13 | |
| New Oriental Education & Technology Group Spon Adr (EDU) | 0.1 | $3.3M | 62k | 53.07 | |
| CoreWeave Com Cl A (CRWV) | 0.1 | $3.3M | 24k | 136.85 | |
| Pepgen (PEPG) | 0.1 | $3.2M | 700k | 4.62 | |
| GitLab Class A Com (GTLB) | 0.1 | $2.9M | 64k | 45.08 | |
| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $2.8M | 145k | 19.00 | |
| Palo Alto Networks (PANW) | 0.1 | $2.7M | 14k | 203.62 | |
| Tenax Therapeutics Com New (TENX) | 0.1 | $2.7M | 352k | 7.61 | |
| Workiva Com Cl A (WK) | 0.1 | $2.6M | 30k | 86.08 | |
| Qualcomm (QCOM) | 0.1 | $2.3M | 14k | 166.36 | |
| Bioage Labs (BIOA) | 0.1 | $2.2M | 382k | 5.88 | |
| Keurig Dr Pepper (KDP) | 0.1 | $2.0M | 77k | 25.51 | |
| Hubspot (HUBS) | 0.1 | $1.9M | 4.0k | 467.80 | |
| Chipotle Mexican Grill (CMG) | 0.1 | $1.9M | 48k | 39.19 | |
| Kalaris Therapeutics (KLRS) | 0.1 | $1.8M | 318k | 5.78 | |
| Generation Bio Com New (GBIO) | 0.1 | $1.8M | 297k | 6.12 | |
| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $1.7M | 90k | 18.53 | |
| Primo Brands Corp Class A Com Shs (PRMB) | 0.1 | $1.7M | 75k | 22.10 | |
| Spotify Technology SA SHS (SPOT) | 0.1 | $1.5M | 2.2k | 698.00 | |
| NIQ Global Intelligence Ordinary Shares (NIQ) | 0.1 | $1.5M | 95k | 15.70 | |
| monday.com SHS (MNDY) | 0.1 | $1.4M | 7.0k | 193.69 | |
| Sailpoint (SAIL) | 0.0 | $1.1M | 50k | 22.08 | |
| Elastic NV Ord Shs (ESTC) | 0.0 | $1.1M | 13k | 84.49 | |
| Iren Ordinary Shares (IREN) | 0.0 | $938k | 20k | 46.91 | |
| SEMrush Holdings Cl A Com (SEMR) | 0.0 | $885k | 125k | 7.08 | |
| Amer Sports Com Shs (AS) | 0.0 | $869k | 25k | 34.75 | |
| Pinterest Cl A (PINS) | 0.0 | $804k | 25k | 32.17 | |
| Figma Class A Com Stk (FIG) | 0.0 | $778k | 15k | 51.87 | |
| Confluent Class A Com (CFLT) | 0.0 | $743k | 38k | 19.80 | |
| Procore Technologies (PCOR) | 0.0 | $729k | 10k | 72.92 | |
| Astera Labs (ALAB) | 0.0 | $685k | 3.5k | 195.80 | |
| Tesla Motors (TSLA) | 0.0 | $667k | 1.5k | 444.72 | |
| Chime Financial Com Shs Cl A (CHYM) | 0.0 | $504k | 25k | 20.17 | |
| Ccc Intelligent Solutions Holdings (CCC) | 0.0 | $456k | 50k | 9.11 | |
| Kenvue (KVUE) | 0.0 | $406k | 25k | 16.23 | |
| Vertiv Holdings Com Cl A (VRT) | 0.0 | $302k | 2.0k | 150.86 | |
| Cyclerion Therapeutics (CYCN) | 0.0 | $267k | 116k | 2.30 | |
| Caribou Biosciences (CRBU) | 0.0 | $246k | 105k | 2.33 | |
| Ironwood Pharmaceuticals Com Cl A (IRWD) | 0.0 | $145k | 111k | 1.31 |
