Siren as of Dec. 31, 2025
Portfolio Holdings for Siren
Siren holds 113 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 14.2 | $477M | 11M | 44.05 | |
| Kymera Therapeutics (KYMR) | 7.6 | $256M | 3.3M | 77.81 | |
| BeOne Medicines Sponsored Ads (ONC) | 4.5 | $152M | 500k | 303.81 | |
| Edgewise Therapeutics (EWTX) | 3.4 | $112M | 4.5M | 24.82 | |
| Revolution Medicines (RVMD) | 3.2 | $106M | 1.3M | 79.65 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 3.0 | $101M | 4.0M | 25.01 | |
| Arrowhead Pharmaceuticals (ARWR) | 3.0 | $100M | 1.5M | 66.39 | |
| Bicara Therapeutics (BCAX) | 2.6 | $88M | 5.2M | 16.83 | |
| Olema Pharmaceuticals (OLMA) | 2.5 | $83M | 3.3M | 25.00 | |
| Disc Medicine (IRON) | 2.3 | $79M | 988k | 79.41 | |
| Structure Therapeutics Sponsored Ads (GPCR) | 2.2 | $75M | 1.1M | 69.55 | |
| Tango Therapeutics (TNGX) | 2.2 | $72M | 8.2M | 8.86 | |
| Arcus Biosciences Incorporated (RCUS) | 2.1 | $72M | 3.0M | 23.83 | |
| Stoke Therapeutics (STOK) | 2.1 | $71M | 2.2M | 31.74 | |
| Crinetics Pharmaceuticals In (CRNX) | 2.1 | $70M | 1.5M | 46.55 | |
| Dyne Therapeutics (DYN) | 2.0 | $69M | 3.5M | 19.56 | |
| Apellis Pharmaceuticals (APLS) | 1.9 | $65M | 2.6M | 25.12 | |
| Cogent Biosciences (COGT) | 1.7 | $58M | 1.6M | 35.52 | |
| Septerna (SEPN) | 1.7 | $56M | 2.0M | 27.88 | |
| Taysha Gene Therapies Com Shs (TSHA) | 1.7 | $56M | 10M | 5.50 | |
| Rhythm Pharmaceuticals (RYTM) | 1.6 | $54M | 500k | 107.04 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 1.5 | $50M | 236k | 213.24 | |
| RAPT Therapeutics Com New (RAPT) | 1.4 | $47M | 1.4M | 33.87 | |
| Taboola.com Ord Shs (TBLA) | 1.4 | $46M | 10M | 4.61 | |
| Lexicon Pharmaceuticals Com New (LXRX) | 1.3 | $45M | 39M | 1.15 | |
| Zymeworks Del (ZYME) | 1.3 | $44M | 1.7M | 26.33 | |
| Solid Biosciences Com New (SLDB) | 1.3 | $43M | 7.7M | 5.64 | |
| WAVE Life Sciences SHS (WVE) | 1.2 | $42M | 2.5M | 17.00 | |
| Xenon Pharmaceuticals (XENE) | 1.1 | $36M | 813k | 44.82 | |
| Dbv Technologies SA Sponsored Ads (DBVT) | 1.1 | $36M | 1.9M | 19.17 | |
| Erasca (ERAS) | 1.0 | $33M | 8.8M | 3.72 | |
| Engene Holdings (ENGN) | 0.9 | $30M | 3.3M | 9.03 | |
| Trevi Therapeutics (TRVI) | 0.9 | $29M | 2.3M | 12.52 | |
| Spyre Therapeutics Com New (SYRE) | 0.8 | $27M | 819k | 32.76 | |
| Mineralys Therapeutics (MLYS) | 0.8 | $25M | 700k | 36.29 | |
| Denali Therapeutics (DNLI) | 0.7 | $23M | 1.4M | 16.51 | |
| Remitly Global (RELY) | 0.7 | $22M | 1.6M | 13.80 | |
| Fulcrum Therapeutics (FULC) | 0.7 | $22M | 2.0M | 11.31 | |
| Rapport Therapeutics (RAPP) | 0.6 | $22M | 709k | 30.34 | |
| Silence Therapeutics Ads (SLN) | 0.5 | $18M | 2.9M | 6.08 | |
| IHS Holding Ord Shs (IHS) | 0.5 | $18M | 2.4M | 7.46 | |
| Gossamer Bio (GOSS) | 0.5 | $16M | 5.2M | 3.10 | |
| Upstream Bio (UPB) | 0.5 | $16M | 589k | 27.15 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.4 | $14M | 2.0M | 7.08 | |
| Monopar Therapeutics Com New (MNPR) | 0.4 | $14M | 212k | 65.30 | |
| Cullinan Oncology (CGEM) | 0.4 | $12M | 1.2M | 10.35 | |
| Sionna Therapeutics (SION) | 0.4 | $12M | 300k | 41.14 | |
| Inhibikase Therapeutics Com New (IKT) | 0.4 | $12M | 5.9M | 2.05 | |
| NovaBridge Biosciences Sponsored Ads (NBP) | 0.4 | $12M | 3.0M | 3.98 | |
| Amazon (AMZN) | 0.4 | $12M | 52k | 230.82 | |
| Neumora Therapeutics (NMRA) | 0.3 | $11M | 6.3M | 1.79 | |
| Mind Medicine Com New (MNMD) | 0.3 | $11M | 800k | 13.39 | |
| Benitec Biopharma Com New (BNTC) | 0.3 | $10M | 775k | 13.47 | |
| Adagio Therapeutics (IVVD) | 0.3 | $9.9M | 4.0M | 2.47 | |
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.3 | $8.4M | 28k | 303.89 | |
| Oric Pharmaceuticals (ORIC) | 0.2 | $8.2M | 1.0M | 8.18 | |
| Maplight Therapeutics (MPLT) | 0.2 | $7.9M | 450k | 17.57 | |
| Palvella Therapeutics Inc Ne (PVLA) | 0.2 | $7.9M | 75k | 104.67 | |
| CrowdStrike Holdings Cl A (CRWD) | 0.2 | $7.7M | 17k | 468.76 | |
| Ionq Inc Pipe (IONQ) | 0.2 | $7.6M | 170k | 44.87 | |
| Seer Com Cl A (SEER) | 0.2 | $7.3M | 4.0M | 1.83 | |
| Microsoft Corporation (MSFT) | 0.2 | $7.3M | 15k | 483.62 | |
| PDD Holdings Sponsored Ads (PDD) | 0.2 | $7.2M | 63k | 113.39 | |
| Lexeo Therapeutics (LXEO) | 0.2 | $7.2M | 721k | 9.93 | |
| NVIDIA Corporation (NVDA) | 0.2 | $7.0M | 38k | 186.50 | |
| salesforce (CRM) | 0.2 | $6.9M | 26k | 264.91 | |
| Compass Pathways Sponsored Ads (CMPS) | 0.2 | $6.9M | 1.0M | 6.90 | |
| BillionToOne Cl A (BLLN) | 0.2 | $6.9M | 84k | 81.84 | |
| Workiva Com Cl A (WK) | 0.2 | $6.8M | 79k | 86.25 | |
| Zura Bio Class A Ord Shs (ZURA) | 0.2 | $6.8M | 1.3M | 5.24 | |
| vTv Therapeutics Cl A New (VTVT) | 0.2 | $6.5M | 163k | 39.99 | |
| Alphabet Cap Stk Cl A (GOOGL) | 0.2 | $6.5M | 21k | 313.00 | |
| Nebius Group NV Shs Class A (NBIS) | 0.2 | $6.4M | 76k | 83.70 | |
| Savara (SVRA) | 0.2 | $6.0M | 1.0M | 6.03 | |
| X4 Pharmaceuticals Com New (XFOR) | 0.2 | $6.0M | 1.5M | 4.00 | |
| Jfrog Ord Shs (FROG) | 0.2 | $5.8M | 94k | 62.46 | |
| Servicenow (NOW) | 0.2 | $5.5M | 36k | 153.19 | |
| Tenax Therapeutics Com New (TENX) | 0.2 | $5.2M | 427k | 12.19 | |
| Aadi Bioscience (WHWK) | 0.2 | $5.0M | 2.1M | 2.42 | |
| Dynatrace Com New (DT) | 0.1 | $5.0M | 115k | 43.34 | |
| Datadog Cl A Com (DDOG) | 0.1 | $5.0M | 36k | 135.99 | |
| Alumis (ALMS) | 0.1 | $4.9M | 500k | 9.76 | |
| Meta Platforms Cl A (META) | 0.1 | $4.7M | 7.2k | 660.09 | |
| Pepgen (PEPG) | 0.1 | $4.6M | 700k | 6.51 | |
| Sagimet Biosciences Com Ser A (SGMT) | 0.1 | $4.3M | 725k | 5.92 | |
| Adobe Systems Incorporated (ADBE) | 0.1 | $4.2M | 12k | 349.99 | |
| Foghorn Therapeutics (FHTX) | 0.1 | $3.9M | 721k | 5.40 | |
| GitLab Class A Com (GTLB) | 0.1 | $3.7M | 99k | 37.53 | |
| Kalaris Therapeutics (KLRS) | 0.1 | $3.7M | 436k | 8.44 | |
| New Oriental Education & Technology Group Spon Adr (EDU) | 0.1 | $3.4M | 62k | 55.03 | |
| Agenus Com New (AGEN) | 0.1 | $3.3M | 1.1M | 3.14 | |
| Medline Com Cl A (MDLN) | 0.1 | $3.2M | 75k | 42.00 | |
| Korro Bio (KRRO) | 0.1 | $2.8M | 348k | 8.01 | |
| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $2.7M | 150k | 18.04 | |
| Rani Therapeutics Holdings Com Cl A (RANI) | 0.1 | $2.7M | 2.0M | 1.35 | |
| Zscaler Incorporated (ZS) | 0.1 | $2.7M | 12k | 224.92 | |
| Black Diamond Therapeutics (BDTX) | 0.1 | $2.5M | 1.0M | 2.43 | |
| monday.com SHS (MNDY) | 0.1 | $2.5M | 17k | 147.56 | |
| Broadcom (AVGO) | 0.1 | $2.4M | 7.0k | 346.10 | |
| Qualcomm (QCOM) | 0.1 | $2.4M | 14k | 171.05 | |
| Arm Holdings Sponsored Ads (ARM) | 0.1 | $2.4M | 22k | 109.31 | |
| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $2.3M | 145k | 15.76 | |
| Instil Bio Com New (TIL) | 0.1 | $2.2M | 204k | 11.00 | |
| Palo Alto Networks (PANW) | 0.1 | $2.1M | 12k | 184.20 | |
| CoreWeave Com Cl A (CRWV) | 0.1 | $2.0M | 28k | 71.61 | |
| Iren Ordinary Shares (IREN) | 0.0 | $1.6M | 43k | 37.77 | |
| Varonis Sys (VRNS) | 0.0 | $1.2M | 38k | 32.80 | |
| Primo Brands Corp Class A Com Shs (PRMB) | 0.0 | $1.2M | 75k | 16.35 | |
| Generation Bio Com New (GBIO) | 0.0 | $1.1M | 201k | 5.68 | |
| Figma Class A Com Stk (FIG) | 0.0 | $934k | 25k | 37.37 | |
| Tesla Motors (TSLA) | 0.0 | $675k | 1.5k | 449.72 | |
| Caribou Biosciences (CRBU) | 0.0 | $168k | 105k | 1.59 | |
| Cyclerion Therapeutics (CYCN) | 0.0 | $147k | 116k | 1.27 |
