Siren as of June 30, 2025
Portfolio Holdings for Siren
Siren holds 110 positions in its portfolio as reported in the June 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 17.0 | $328M | 9.3M | 35.42 | |
| Kymera Therapeutics (KYMR) | 7.7 | $150M | 3.4M | 43.64 | |
| BeOne Medicines Sponsored Ads (ONC) | 6.4 | $124M | 510k | 242.07 | |
| Disc Medicine (IRON) | 3.0 | $58M | 1.1M | 52.96 | |
| Crinetics Pharmaceuticals In (CRNX) | 2.5 | $49M | 1.7M | 28.76 | |
| Bicara Therapeutics (BCAX) | 2.5 | $49M | 5.2M | 9.29 | |
| Dyne Therapeutics (DYN) | 2.4 | $46M | 4.8M | 9.52 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 2.4 | $46M | 3.5M | 13.14 | |
| Merus N V (MRUS) | 2.3 | $45M | 854k | 52.60 | |
| Apellis Pharmaceuticals (APLS) | 2.3 | $45M | 2.6M | 17.31 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 2.2 | $42M | 246k | 172.60 | |
| Arrowhead Pharmaceuticals (ARWR) | 2.2 | $42M | 2.7M | 15.80 | |
| Edgewise Therapeutics (EWTX) | 2.1 | $41M | 3.2M | 13.11 | |
| Soleno Therapeutics (SLNO) | 2.0 | $39M | 467k | 83.78 | |
| Lexicon Pharmaceuticals Com New (LXRX) | 1.9 | $37M | 39M | 0.95 | |
| Taboola.com Ord Shs (TBLA) | 1.9 | $37M | 10M | 3.66 | |
| Solid Biosciences Com New (SLDB) | 1.9 | $36M | 7.4M | 4.87 | |
| Revolution Medicines (RVMD) | 1.8 | $35M | 939k | 36.79 | |
| Avidity Biosciences Ord (RNA) | 1.6 | $32M | 1.1M | 28.40 | |
| Rhythm Pharmaceuticals (RYTM) | 1.3 | $26M | 410k | 63.19 | |
| Apogee Therapeutics (APGE) | 1.3 | $26M | 595k | 43.43 | |
| Stoke Therapeutics (STOK) | 1.3 | $26M | 2.2M | 11.35 | |
| Taysha Gene Therapies Com Shs (TSHA) | 1.3 | $25M | 11M | 2.31 | |
| Xenon Pharmaceuticals (XENE) | 1.3 | $25M | 813k | 31.30 | |
| WAVE Life Sciences SHS (WVE) | 1.2 | $24M | 3.7M | 6.50 | |
| MoonLake Immunotherapeutics Class A Ord (MLTX) | 1.2 | $24M | 508k | 47.20 | |
| Septerna (SEPN) | 1.2 | $23M | 2.2M | 10.57 | |
| NewAmsterdam Pharma Company NV Ordinary Shares (NAMS) | 1.1 | $22M | 1.2M | 18.11 | |
| Trevi Therapeutics (TRVI) | 1.1 | $22M | 3.9M | 5.47 | |
| Tango Therapeutics (TNGX) | 0.9 | $17M | 3.4M | 5.12 | |
| Akero Therapeutics (AKRO) | 0.9 | $17M | 319k | 53.36 | |
| Silence Therapeutics Ads (SLN) | 0.9 | $17M | 2.9M | 5.80 | |
| Arrivent Biopharma (AVBP) | 0.8 | $15M | 700k | 21.77 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.7 | $14M | 2.0M | 6.95 | |
| Arcus Biosciences Incorporated (RCUS) | 0.7 | $13M | 1.6M | 8.14 | |
| IHS Holding Ord Shs (IHS) | 0.7 | $13M | 2.4M | 5.56 | |
| Amazon (AMZN) | 0.6 | $12M | 57k | 219.39 | |
| Denali Therapeutics (DNLI) | 0.6 | $12M | 822k | 13.99 | |
| Erasca (ERAS) | 0.6 | $11M | 8.8M | 1.27 | |
| Oric Pharmaceuticals (ORIC) | 0.5 | $10M | 1.0M | 10.15 | |
| Remitly Global (RELY) | 0.5 | $9.7M | 515k | 18.77 | |
| Vaxcyte (PCVX) | 0.5 | $9.6M | 296k | 32.51 | |
| CrowdStrike Holdings Cl A (CRWD) | 0.5 | $9.4M | 19k | 509.31 | |
| Cullinan Oncology (CGEM) | 0.5 | $9.0M | 1.2M | 7.53 | |
| Alphabet Cap Stk Cl A (GOOGL) | 0.5 | $8.9M | 51k | 176.20 | |
| Upstream Bio (UPB) | 0.4 | $8.7M | 789k | 10.98 | |
| Seer Com Cl A (SEER) | 0.4 | $8.6M | 4.0M | 2.14 | |
| Microsoft Corporation (MSFT) | 0.4 | $8.0M | 16k | 497.41 | |
| NVIDIA Corporation (NVDA) | 0.4 | $7.9M | 50k | 157.99 | |
| Ionq Inc Pipe (IONQ) | 0.4 | $7.3M | 170k | 42.97 | |
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.4 | $6.9M | 31k | 226.49 | |
| Gossamer Bio (GOSS) | 0.3 | $6.4M | 5.2M | 1.23 | |
| salesforce (CRM) | 0.3 | $6.2M | 23k | 272.69 | |
| Cogent Biosciences (COGT) | 0.3 | $6.1M | 854k | 7.18 | |
| Cartesian Therapeutics Com New (RNAC) | 0.3 | $5.9M | 563k | 10.39 | |
| Vera Therapeutics Cl A (VERA) | 0.3 | $5.8M | 247k | 23.56 | |
| Adobe Systems Incorporated (ADBE) | 0.3 | $5.8M | 15k | 386.88 | |
| Sionna Therapeutics (SION) | 0.3 | $5.6M | 325k | 17.35 | |
| PDD Holdings Sponsored Ads (PDD) | 0.3 | $5.5M | 53k | 104.66 | |
| Sagimet Biosciences Com Ser A (SGMT) | 0.3 | $5.5M | 725k | 7.62 | |
| Spyre Therapeutics Com New (SYRE) | 0.3 | $5.5M | 369k | 14.97 | |
| Pacira Pharmaceuticals (PCRX) | 0.3 | $5.4M | 225k | 23.90 | |
| Servicenow (NOW) | 0.3 | $5.3M | 5.1k | 1028.08 | |
| Korro Bio (KRRO) | 0.3 | $5.2M | 419k | 12.49 | |
| Datadog Cl A Com (DDOG) | 0.3 | $5.2M | 38k | 134.33 | |
| Agenus Com New (AGEN) | 0.3 | $4.9M | 1.1M | 4.57 | |
| Jfrog Ord Shs (FROG) | 0.2 | $4.7M | 107k | 43.88 | |
| Rapport Therapeutics (RAPP) | 0.2 | $4.3M | 379k | 11.37 | |
| Instil Bio Com New (TIL) | 0.2 | $4.2M | 204k | 20.83 | |
| Dynatrace Com New (DT) | 0.2 | $4.2M | 75k | 55.21 | |
| Aadi Bioscience (WHWK) | 0.2 | $3.9M | 2.1M | 1.87 | |
| New Oriental Education & Technology Group Spon Adr (EDU) | 0.2 | $3.9M | 72k | 53.95 | |
| Igm Biosciences (IGMS) | 0.2 | $3.6M | 3.3M | 1.12 | |
| Foghorn Therapeutics (FHTX) | 0.2 | $3.4M | 721k | 4.70 | |
| Vigil Neuroscience (VIGL) | 0.2 | $3.3M | 411k | 7.95 | |
| Neumora Therapeutics (NMRA) | 0.2 | $3.2M | 4.4M | 0.73 | |
| ProQR Therapeutics NV Shs Euro (PRQR) | 0.2 | $3.2M | 1.6M | 2.04 | |
| Nebius Group NV Shs Class A (NBIS) | 0.1 | $2.8M | 51k | 55.33 | |
| Black Diamond Therapeutics (BDTX) | 0.1 | $2.6M | 1.0M | 2.48 | |
| Lexeo Therapeutics (LXEO) | 0.1 | $2.4M | 603k | 4.02 | |
| Palo Alto Networks (PANW) | 0.1 | $2.4M | 12k | 204.64 | |
| Qualcomm (QCOM) | 0.1 | $2.2M | 14k | 159.26 | |
| Workiva Com Cl A (WK) | 0.1 | $1.9M | 28k | 68.45 | |
| Eledon Pharmaceuticals (ELDN) | 0.1 | $1.9M | 690k | 2.71 | |
| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $1.9M | 105k | 17.74 | |
| Hubspot (HUBS) | 0.1 | $1.7M | 3.0k | 556.63 | |
| UnitedHealth (UNH) | 0.1 | $1.6M | 5.1k | 311.97 | |
| Bioage Labs (BIOA) | 0.1 | $1.6M | 382k | 4.13 | |
| GitLab Class A Com (GTLB) | 0.1 | $1.6M | 35k | 45.11 | |
| Tourmaline Bio (TRML) | 0.1 | $1.5M | 91k | 15.99 | |
| Rocket Pharmaceuticals (RCKT) | 0.1 | $1.4M | 591k | 2.45 | |
| Tesla Motors (TSLA) | 0.1 | $1.3M | 4.0k | 317.66 | |
| Birkenstock Holding Com Shs (BIRK) | 0.1 | $1.2M | 25k | 49.18 | |
| Sailpoint (SAIL) | 0.1 | $1.1M | 50k | 22.86 | |
| SEMrush Holdings Cl A Com (SEMR) | 0.1 | $1.1M | 125k | 9.05 | |
| Primo Brands Corp Class A Com Shs (PRMB) | 0.1 | $1.1M | 38k | 29.62 | |
| Cellebrite DI Ordinary Shares (CLBT) | 0.0 | $960k | 60k | 16.00 | |
| Generation Bio | 0.0 | $950k | 3.0M | 0.32 | |
| Kalaris Therapeutics (KLRS) | 0.0 | $755k | 283k | 2.67 | |
| HOOKIPA Pharma Com New (HOOK) | 0.0 | $711k | 567k | 1.25 | |
| Atlassian Corp Cl A (TEAM) | 0.0 | $711k | 3.5k | 203.09 | |
| Procore Technologies (PCOR) | 0.0 | $684k | 10k | 68.42 | |
| Ccc Intelligent Solutions Holdings (CCC) | 0.0 | $471k | 50k | 9.41 | |
| PG&E Corporation (PCG) | 0.0 | $349k | 25k | 13.94 | |
| Cyclerion Therapeutics (CYCN) | 0.0 | $338k | 116k | 2.91 | |
| Reddit Cl A (RDDT) | 0.0 | $301k | 2.0k | 150.57 | |
| Vertiv Holdings Com Cl A (VRT) | 0.0 | $257k | 2.0k | 128.41 | |
| Deckers Outdoor Corporation (DECK) | 0.0 | $206k | 2.0k | 103.07 | |
| Caribou Biosciences (CRBU) | 0.0 | $133k | 105k | 1.26 | |
| Ironwood Pharmaceuticals Com Cl A (IRWD) | 0.0 | $80k | 111k | 0.72 |
