Siren as of March 31, 2025
Portfolio Holdings for Siren
Siren holds 116 positions in its portfolio as reported in the March 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 16.8 | $297M | 9.3M | 32.15 | |
| Beigene Sponsored Ads (ONC) | 7.7 | $136M | 499k | 272.17 | |
| Kymera Therapeutics (KYMR) | 5.0 | $89M | 3.2M | 27.37 | |
| Blueprint Medicines (BPMC) | 3.6 | $64M | 726k | 88.51 | |
| Crinetics Pharmaceuticals In (CRNX) | 3.2 | $57M | 1.7M | 33.54 | |
| Apellis Pharmaceuticals (APLS) | 3.2 | $56M | 2.6M | 21.87 | |
| Disc Medicine (IRON) | 3.0 | $53M | 1.1M | 49.64 | |
| Soleno Therapeutics (SLNO) | 2.9 | $52M | 727k | 71.45 | |
| Ascendis Pharma A/S Sponsored Adr (ASND) | 2.5 | $45M | 287k | 155.86 | |
| Merus N V (MRUS) | 2.5 | $44M | 1.0M | 42.09 | |
| Bicara Therapeutics (BCAX) | 2.4 | $43M | 3.3M | 13.03 | |
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 2.4 | $43M | 3.0M | 14.38 | |
| NewAmsterdam Pharma Company NV Ordinary Shares (NAMS) | 2.2 | $39M | 1.9M | 20.47 | |
| Edgewise Therapeutics (EWTX) | 2.1 | $37M | 1.7M | 22.00 | |
| Arrowhead Pharmaceuticals (ARWR) | 1.9 | $34M | 2.7M | 12.74 | |
| Avidity Biosciences Ord (RNA) | 1.8 | $33M | 1.1M | 29.52 | |
| WAVE Life Sciences SHS (WVE) | 1.7 | $30M | 3.7M | 8.08 | |
| Taboola.com Ord Shs (TBLA) | 1.7 | $29M | 10M | 2.95 | |
| Dyne Therapeutics (DYN) | 1.6 | $28M | 2.7M | 10.46 | |
| Solid Biosciences Com New (SLDB) | 1.5 | $27M | 7.4M | 3.70 | |
| Xenon Pharmaceuticals (XENE) | 1.4 | $25M | 733k | 33.55 | |
| Apogee Therapeutics (APGE) | 1.3 | $22M | 595k | 37.36 | |
| Revolution Medicines (RVMD) | 1.1 | $20M | 564k | 35.36 | |
| Trevi Therapeutics (TRVI) | 1.0 | $18M | 2.9M | 6.29 | |
| Vera Therapeutics Cl A (VERA) | 1.0 | $18M | 747k | 24.02 | |
| Lexicon Pharmaceuticals Com New (LXRX) | 1.0 | $18M | 39M | 0.46 | |
| Prothena Corporation SHS (PRTA) | 0.9 | $16M | 1.3M | 12.38 | |
| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.9 | $15M | 1.8M | 8.49 | |
| Stoke Therapeutics (STOK) | 0.8 | $15M | 2.2M | 6.65 | |
| Rhythm Pharmaceuticals (RYTM) | 0.8 | $15M | 278k | 52.97 | |
| Summit Therapeutics (SMMT) | 0.8 | $13M | 695k | 19.29 | |
| Septerna (SEPN) | 0.7 | $13M | 2.2M | 5.79 | |
| Arcus Biosciences Incorporated (RCUS) | 0.7 | $13M | 1.6M | 7.85 | |
| IHS Holding Ord Shs (IHS) | 0.7 | $12M | 2.4M | 5.22 | |
| Erasca (ERAS) | 0.7 | $12M | 8.8M | 1.37 | |
| Denali Therapeutics (DNLI) | 0.6 | $11M | 822k | 13.60 | |
| Vaxcyte (PCVX) | 0.6 | $11M | 296k | 37.76 | |
| Amazon (AMZN) | 0.6 | $11M | 57k | 190.26 | |
| Microsoft Corporation (MSFT) | 0.6 | $11M | 29k | 375.39 | |
| Remitly Global (RELY) | 0.6 | $10M | 490k | 20.80 | |
| Taysha Gene Therapies Com Shs (TSHA) | 0.5 | $9.1M | 6.5M | 1.39 | |
| Cullinan Oncology (CGEM) | 0.5 | $9.0M | 1.2M | 7.57 | |
| CrowdStrike Holdings Cl A (CRWD) | 0.5 | $8.8M | 25k | 352.58 | |
| Silence Therapeutics Ads (SLN) | 0.4 | $7.9M | 2.8M | 2.82 | |
| Alphabet Cap Stk Cl A (GOOGL) | 0.4 | $7.8M | 51k | 154.64 | |
| Cartesian Therapeutics Com New (RNAC) | 0.4 | $7.4M | 563k | 13.18 | |
| Adobe Systems Incorporated (ADBE) | 0.4 | $7.4M | 19k | 383.53 | |
| Korro Bio (KRRO) | 0.4 | $7.3M | 419k | 17.41 | |
| Servicenow (NOW) | 0.4 | $7.3M | 9.1k | 796.14 | |
| Seer Com Cl A (SEER) | 0.4 | $6.8M | 4.0M | 1.69 | |
| PDD Holdings Sponsored Ads (PDD) | 0.4 | $6.3M | 53k | 118.35 | |
| Spyre Therapeutics Com New (SYRE) | 0.3 | $5.9M | 369k | 16.14 | |
| Gossamer Bio (GOSS) | 0.3 | $5.7M | 5.2M | 1.10 | |
| Oric Pharmaceuticals (ORIC) | 0.3 | $5.6M | 1.0M | 5.58 | |
| Upstream Bio (UPB) | 0.3 | $4.8M | 789k | 6.12 | |
| NVIDIA Corporation (NVDA) | 0.3 | $4.8M | 44k | 108.38 | |
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.3 | $4.7M | 29k | 166.00 | |
| Datadog Cl A Com (DDOG) | 0.3 | $4.7M | 47k | 99.21 | |
| Neumora Therapeutics (NMRA) | 0.2 | $4.4M | 4.4M | 1.00 | |
| Jfrog Ord Shs (FROG) | 0.2 | $4.2M | 132k | 32.00 | |
| Dynatrace Com New (DT) | 0.2 | $4.1M | 88k | 47.15 | |
| Mestera (MTSR) | 0.2 | $4.1M | 150k | 27.22 | |
| Rocket Pharmaceuticals (RCKT) | 0.2 | $3.9M | 591k | 6.67 | |
| salesforce (CRM) | 0.2 | $3.9M | 15k | 268.36 | |
| New Oriental Education & Technology Group Spon Adr (EDU) | 0.2 | $3.8M | 80k | 47.81 | |
| Rapport Therapeutics (RAPP) | 0.2 | $3.8M | 379k | 10.03 | |
| Ionq Inc Pipe (IONQ) | 0.2 | $3.8M | 170k | 22.07 | |
| Igm Biosciences (IGMS) | 0.2 | $3.7M | 3.3M | 1.15 | |
| Aadi Bioscience (WHWK) | 0.2 | $3.7M | 2.1M | 1.78 | |
| Instil Bio Com New (TIL) | 0.2 | $3.5M | 204k | 17.36 | |
| Tango Therapeutics (TNGX) | 0.2 | $3.5M | 2.6M | 1.37 | |
| Vigil Neuroscience (VIGL) | 0.2 | $3.5M | 2.0M | 1.78 | |
| Sionna Therapeutics (SION) | 0.2 | $3.4M | 325k | 10.46 | |
| Nebius Group NV Shs Class A (NBIS) | 0.2 | $3.0M | 140k | 21.11 | |
| Foghorn Therapeutics (FHTX) | 0.1 | $2.6M | 721k | 3.65 | |
| Reddit Cl A (RDDT) | 0.1 | $2.5M | 24k | 104.90 | |
| Lpl Financial Holdings (LPLA) | 0.1 | $2.5M | 7.5k | 327.14 | |
| Sagimet Biosciences Com Ser A (SGMT) | 0.1 | $2.4M | 725k | 3.26 | |
| Eledon Pharmaceuticals (ELDN) | 0.1 | $2.3M | 690k | 3.39 | |
| Tesla Motors (TSLA) | 0.1 | $2.3M | 9.0k | 259.16 | |
| Kalaris Therapeutics (KLRS) | 0.1 | $2.3M | 283k | 8.03 | |
| Marvell Technology (MRVL) | 0.1 | $2.3M | 37k | 61.57 | |
| Qualcomm (QCOM) | 0.1 | $2.2M | 14k | 153.61 | |
| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $2.1M | 105k | 20.09 | |
| Lexeo Therapeutics (LXEO) | 0.1 | $2.1M | 603k | 3.47 | |
| ProQR Therapeutics NV Shs Euro (PRQR) | 0.1 | $2.1M | 1.6M | 1.33 | |
| Palo Alto Networks (PANW) | 0.1 | $2.0M | 12k | 170.64 | |
| Sailpoint (SAIL) | 0.1 | $1.8M | 95k | 18.75 | |
| Black Diamond Therapeutics (BDTX) | 0.1 | $1.6M | 1.0M | 1.55 | |
| Standardaero (SARO) | 0.1 | $1.5M | 57k | 26.64 | |
| Bioage Labs (BIOA) | 0.1 | $1.4M | 382k | 3.76 | |
| Tourmaline Bio (TRML) | 0.1 | $1.4M | 91k | 15.21 | |
| Workiva Com Cl A (WK) | 0.1 | $1.3M | 18k | 75.91 | |
| Bill Com Holdings Ord (BILL) | 0.1 | $1.3M | 29k | 45.89 | |
| Paypal Holdings (PYPL) | 0.1 | $1.3M | 20k | 65.25 | |
| Generation Bio | 0.1 | $1.2M | 3.0M | 0.41 | |
| SEMrush Holdings Cl A Com (SEMR) | 0.1 | $1.2M | 125k | 9.33 | |
| Pegasystems (PEGA) | 0.1 | $1.1M | 17k | 69.52 | |
| MongoDB Cl A (MDB) | 0.1 | $965k | 5.5k | 175.40 | |
| Nike CL B (NKE) | 0.1 | $952k | 15k | 63.48 | |
| Intel Corporation (INTC) | 0.1 | $908k | 40k | 22.71 | |
| Informatica Com Cl A (INFA) | 0.0 | $873k | 50k | 17.45 | |
| Boeing Company (BA) | 0.0 | $853k | 5.0k | 170.55 | |
| Couchbase | 0.0 | $785k | 50k | 15.75 | |
| Agenus Com New (AGEN) | 0.0 | $753k | 500k | 1.50 | |
| Kronos Bio | 0.0 | $695k | 843k | 0.82 | |
| Procore Technologies (PCOR) | 0.0 | $660k | 10k | 66.02 | |
| Ferrari Nv Ord (RACE) | 0.0 | $636k | 1.5k | 424.24 | |
| HOOKIPA Pharma Com New (HOOK) | 0.0 | $612k | 567k | 1.08 | |
| Deckers Outdoor Corporation (DECK) | 0.0 | $559k | 5.0k | 111.81 | |
| US Bancorp Com New (USB) | 0.0 | $528k | 13k | 42.22 | |
| Occidental Petroleum Corporation (OXY) | 0.0 | $494k | 10k | 49.36 | |
| GDS Holdings Sponsored Ads (GDS) | 0.0 | $317k | 13k | 25.33 | |
| Cyclerion Therapeutics (CYCN) | 0.0 | $290k | 116k | 2.50 | |
| Ironwood Pharmaceuticals Com Cl A (IRWD) | 0.0 | $163k | 111k | 1.47 | |
| Caribou Biosciences (CRBU) | 0.0 | $96k | 105k | 0.91 |
