Siren as of June 30, 2026
Portfolio Holdings for Siren
Siren holds 116 positions in its portfolio as reported in the June 2026 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price |
|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 10.7 | $527M | 9.6M | 55.00 | |
| Kymera Therapeutics (KYMR) | 6.8 | $337M | 2.9M | 114.67 | |
| Erasca (ERAS) | 4.2 | $209M | 11M | 18.32 | |
| Veradermics Common Stock (MANE) | 4.1 | $204M | 1.7M | 122.94 | |
| Tango Therapeutics (TNGX) | 3.9 | $193M | 6.2M | 31.26 | |
| Revolution Medicines (RVMD) | 3.4 | $169M | 900k | 187.28 | |
| Bicara Therapeutics (BCAX) | 3.4 | $166M | 5.6M | 29.69 | |
| Arrowhead Pharmaceuticals (ARWR) | 2.8 | $140M | 1.7M | 81.51 | |
| BeOne Medicines Sponsored Ads (ONC) | 2.7 | $133M | 465k | 284.97 | |
| Edgewise Therapeutics (EWTX) | 2.6 | $129M | 3.2M | 40.63 | |
| Rhythm Pharmaceuticals (RYTM) | 2.6 | $126M | 1.1M | 111.03 | |
| Lexicon Pharmaceuticals Com New (LXRX) | 2.2 | $106M | 44M | 2.40 | |
| Enliven Therapeutics (ELVN) | 1.8 | $90M | 1.8M | 50.75 | |
| Spyre Therapeutics Com New (SYRE) | 1.7 | $86M | 969k | 88.78 | |
| Parabilis Medicines | 1.7 | $82M | 3.0M | 27.37 | |
| Xenon Pharmaceuticals (XENE) | 1.6 | $80M | 1.3M | 60.36 | |
| Solid Biosciences Com New (SLDB) | 1.6 | $77M | 7.7M | 9.99 | |
| Abivax SA Sponsored Ads (ABVX) | 1.6 | $77M | 576k | 133.26 | |
| Hemab Therapeutics Holdings Com Shs | 1.6 | $77M | 2.1M | 36.73 | |
| Arcus Biosciences Incorporated (RCUS) | 1.5 | $75M | 2.4M | 30.83 | |
| Cogent Biosciences (COGT) | 1.5 | $72M | 1.9M | 38.70 | |
| Relay Therapeutics (RLAY) | 1.4 | $68M | 3.7M | 18.71 | |
| Taysha Gene Therapies Com Shs (TSHA) | 1.4 | $67M | 9.8M | 6.81 | |
| Definium Therapeutics Com Shs (DFTX) | 1.4 | $67M | 1.4M | 47.04 | |
| Stoke Therapeutics (STOK) | 1.3 | $65M | 2.0M | 32.72 | |
| Disc Medicine (IRON) | 1.3 | $65M | 888k | 73.14 | |
| Cytokinetics Com New (CYTK) | 1.3 | $65M | 759k | 85.19 | |
| Septerna (SEPN) | 1.3 | $64M | 1.9M | 33.49 | |
| Olema Pharmaceuticals (OLMA) | 1.2 | $61M | 4.9M | 12.51 | |
| Crinetics Pharmaceuticals In (CRNX) | 1.1 | $53M | 1.4M | 37.42 | |
| Kailera Therapeutics Common Stock | 1.0 | $49M | 2.2M | 22.03 | |
| Dyne Therapeutics (DYN) | 1.0 | $47M | 2.1M | 22.21 | |
| Structure Therapeutics Sponsored Ads (GPCR) | 0.9 | $47M | 873k | 53.67 | |
| Taboola.com Ord Shs (TBLA) | 0.9 | $42M | 8.4M | 5.00 | |
| Palvella Therapeutics Inc Ne (PVLA) | 0.8 | $39M | 258k | 152.82 | |
| Silence Therapeutics Ads (SLN) | 0.7 | $36M | 3.3M | 10.98 | |
| Denali Therapeutics (DNLI) | 0.7 | $36M | 1.4M | 25.72 | |
| Remitly Global (RELY) | 0.7 | $35M | 1.5M | 22.41 | |
| Cullinan Oncology (CGEM) | 0.7 | $35M | 1.9M | 18.21 | |
| Capital One Financial (COF) | 0.7 | $34M | 172k | 200.62 | |
| Trevi Therapeutics (TRVI) | 0.7 | $33M | 1.8M | 18.65 | |
| Oric Pharmaceuticals (ORIC) | 0.7 | $33M | 3.0M | 10.83 | |
| Alphabet Cap Stk Cl A (GOOGL) | 0.7 | $32M | 90k | 357.37 | |
| Dbv Technologies SA Sponsored Ads (DBVT) | 0.6 | $31M | 1.9M | 16.40 | |
| Absci Corp (ABSI) | 0.6 | $29M | 2.5M | 11.59 | |
| Sionna Therapeutics (SION) | 0.5 | $27M | 611k | 43.99 | |
| Rapport Therapeutics (RAPP) | 0.5 | $27M | 642k | 41.67 | |
| Amylyx Pharmaceuticals (AMLX) | 0.5 | $27M | 1.5M | 17.96 | |
| Annexon (ANNX) | 0.5 | $26M | 4.5M | 5.71 | |
| Monopar Therapeutics Com New (MNPR) | 0.5 | $25M | 270k | 92.59 | |
| Oruka Therapeutics (ORKA) | 0.5 | $24M | 250k | 95.17 | |
| Seaport Therapeutics Common Stock | 0.5 | $24M | 1.1M | 21.72 | |
| Damora Therapeutics Com New (DMRA) | 0.5 | $23M | 900k | 26.01 | |
| Tyra Biosciences (TYRA) | 0.5 | $23M | 725k | 31.94 | |
| Microsoft Corporation (MSFT) | 0.5 | $23M | 62k | 373.02 | |
| Zura Bio Class A Ord Shs (ZURA) | 0.4 | $22M | 3.7M | 5.90 | |
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.4 | $21M | 45k | 477.57 | |
| NVIDIA Corporation (NVDA) | 0.4 | $19M | 95k | 200.09 | |
| Rezolute Com New (RZLT) | 0.4 | $17M | 3.3M | 5.20 | |
| Maplight Therapeutics (MPLT) | 0.3 | $16M | 450k | 35.84 | |
| Neumora Therapeutics (NMRA) | 0.3 | $14M | 8.5M | 1.70 | |
| Nebius Group NV Shs Class A (NBIS) | 0.3 | $14M | 52k | 276.17 | |
| Cytomx Therapeutics (CTMX) | 0.3 | $13M | 3.5M | 3.75 | |
| Generate Biomedicines Com Shs (GENB) | 0.3 | $12M | 736k | 16.87 | |
| Inhibikase Therapeutics Com New (IKT) | 0.2 | $12M | 5.9M | 2.03 | |
| Adagene Ads (ADAG) | 0.2 | $11M | 2.7M | 4.20 | |
| Engene Therapeutics (ENGN) | 0.2 | $11M | 6.3M | 1.73 | |
| Aadi Bioscience (WHWK) | 0.2 | $11M | 2.3M | 4.58 | |
| Datadog Cl A Com (DDOG) | 0.2 | $10M | 40k | 260.36 | |
| Servicenow (NOW) | 0.2 | $9.9M | 100k | 99.28 | |
| Broadcom (AVGO) | 0.2 | $9.4M | 25k | 377.75 | |
| Ionq Inc Pipe (IONQ) | 0.2 | $9.1M | 170k | 53.26 | |
| Jfrog Ord Shs (FROG) | 0.2 | $8.7M | 96k | 90.88 | |
| Oculis Holding Ordinary Shares (OCS) | 0.2 | $8.7M | 625k | 13.87 | |
| Iren Ordinary Shares (IREN) | 0.2 | $8.0M | 175k | 45.73 | |
| Amazon (AMZN) | 0.2 | $7.7M | 33k | 238.34 | |
| CrowdStrike Holdings Cl A (CRWD) | 0.2 | $7.6M | 10k | 763.14 | |
| Design Therapeutics (DSGN) | 0.2 | $7.6M | 523k | 14.47 | |
| PDD Holdings Sponsored Ads (PDD) | 0.1 | $7.2M | 95k | 76.28 | |
| Satellos Bioscience (MSLE) | 0.1 | $6.9M | 892k | 7.78 | |
| Dynatrace Com New (DT) | 0.1 | $6.8M | 155k | 43.91 | |
| Apple Call Option (AAPL) | 0.1 | $6.7M | 23k | 289.36 | |
| Tenax Therapeutics Com New (TENX) | 0.1 | $6.2M | 427k | 14.55 | |
| vTv Therapeutics Cl A New (VTVT) | 0.1 | $6.1M | 163k | 37.65 | |
| Eloxx Pharmaceuticals Com New | 0.1 | $5.6M | 400k | 13.88 | |
| Agomab Therapeutics NV Sponsored Ads (AGMB) | 0.1 | $5.3M | 411k | 12.98 | |
| Alibaba Group Holding Sponsored Ads (BABA) | 0.1 | $4.8M | 50k | 95.98 | |
| Korro Bio (KRRO) | 0.1 | $4.6M | 348k | 13.18 | |
| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $4.5M | 312k | 14.60 | |
| Adagio Therapeutics (IVVD) | 0.1 | $4.4M | 5.0M | 0.87 | |
| Ouster Com New (OUST) | 0.1 | $4.2M | 68k | 62.52 | |
| Palisade Bio (PALI) | 0.1 | $4.2M | 2.0M | 2.09 | |
| Aeva Technologies Com New (AEVA) | 0.1 | $4.2M | 146k | 28.72 | |
| Seer Com Cl A (SEER) | 0.1 | $4.1M | 2.5M | 1.66 | |
| NovaBridge Biosciences Sponsored Ads (NBP) | 0.1 | $3.9M | 2.0M | 1.95 | |
| GitLab Class A Com (GTLB) | 0.1 | $3.8M | 125k | 30.53 | |
| Odyssey Therapeutics Common Stock | 0.1 | $3.7M | 200k | 18.71 | |
| Foghorn Therapeutics (FHTX) | 0.1 | $3.5M | 721k | 4.88 | |
| Agenus Com New (AGEN) | 0.1 | $3.3M | 1.1M | 3.06 | |
| monday.com SHS (MNDY) | 0.1 | $3.1M | 43k | 72.39 | |
| Zoetis Cl A (ZTS) | 0.1 | $2.5M | 35k | 71.86 | |
| Workiva Com Cl A (WK) | 0.0 | $2.2M | 45k | 48.51 | |
| Netflix (NFLX) | 0.0 | $1.8M | 25k | 71.40 | |
| Kalaris Therapeutics (KLRS) | 0.0 | $1.8M | 436k | 4.07 | |
| Quantinuum Cl A Com | 0.0 | $1.6M | 20k | 81.74 | |
| Rani Therapeutics Holdings Com Cl A (RANI) | 0.0 | $1.5M | 2.0M | 0.76 | |
| Tesla Motors (TSLA) | 0.0 | $1.5M | 3.5k | 420.60 | |
| KE Holdings Sponsored Ads (BEKE) | 0.0 | $1.5M | 100k | 14.53 | |
| Entera Bio SHS (ENTX) | 0.0 | $1.3M | 737k | 1.77 | |
| Medline Com Cl A (MDLN) | 0.0 | $986k | 25k | 39.44 | |
| Lumentum Hldgs (LITE) | 0.0 | $905k | 1.1k | 858.06 | |
| Figma Class A Com Stk (FIG) | 0.0 | $905k | 50k | 18.09 | |
| Gossamer Bio (GOSS) | 0.0 | $857k | 5.2M | 0.16 | |
| Fox Corp Cl A Com (FOXA) | 0.0 | $522k | 10k | 52.16 | |
| At&t (T) | 0.0 | $518k | 25k | 20.70 | |
| Nu Holdings Ord Shs Cl A (NU) | 0.0 | $334k | 25k | 13.36 |
