Baker Bros. Advisors

Baker Bros. Advisors as of Dec. 31, 2013

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 95 positions in its portfolio as reported in the December 2013 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Pharmacyclics 13.0 $922M 8.7M 105.78
Seattle Genetics 11.7 $827M 21M 39.89
Incyte Corporation (INCY) 10.6 $750M 15M 50.63
Synageva Biopharma 9.4 $665M 10M 64.72
ACADIA Pharmaceuticals (ACAD) 7.0 $499M 20M 24.99
Salix Pharmaceuticals Inc note 2.750% 5/1 6.1 $432M 219M 1.97
Genomic Health 5.6 $400M 14M 29.27
Incyte Corp Ltd conv 4.7 $332M 275M 1.21
Incyte Corp Incy Cvt 144a 0.37 convert 4.4 $311M 259M 1.20
Incyte Genomics Notes 4.75% 10/1/2015 conv bonds 3.3 $233M 40M 5.76
XOMA CORP Common equity shares 2.2 $155M 23M 6.73
BioMarin Pharmaceutical (BMRN) 1.9 $137M 1.9M 70.35
Auxilium Pharmaceuticals note 1.4 $97M 87M 1.11
Halozyme Therapeutics (HALO) 1.3 $94M 6.3M 14.99
Biomarin Pharmaceutical Inc note 1.875% 4/2 1.1 $80M 23M 3.47
Gilead Sciences conv 1.0 $71M 22M 3.30
Vanda Pharmaceuticals (VNDA) 0.8 $60M 4.8M 12.41
Medivation Inc note 2.625% 4/0 0.8 $58M 40M 1.46
Itmn 2 1/2 12/15/17 0.8 $56M 41M 1.37
Cerus Corporation (CERS) 0.8 $55M 8.5M 6.45
BioCryst Pharmaceuticals (BCRX) 0.7 $51M 6.7M 7.60
Repros Therapeutics 0.7 $51M 2.8M 18.30
Questcor Pharmaceuticals 0.6 $42M 776k 54.45
Gilead Sciences (GILD) 0.6 $42M 556k 75.10
Anacor Pharmaceuticals In 0.6 $42M 2.5M 16.78
Mirati Therapeutics 0.6 $40M 2.4M 16.63
Aegerion Pharmaceuticals 0.5 $36M 500k 70.96
Arrowhead Research 0.5 $34M 3.1M 10.85
Clovis Oncology 0.5 $32M 531k 60.27
Derma Sciences 0.4 $28M 2.6M 10.82
Medivation 0.4 $25M 398k 63.82
Chelsea Therapeutics International 0.4 $26M 5.8M 4.44
Intercept Pharmaceuticals In 0.3 $25M 363k 68.28
Progenics Pharmaceuticals 0.3 $22M 4.2M 5.33
Slxp 1 1/2 03/15/19 0.3 $22M 15M 1.49
Intermune cv 5.0% 0.3 $20M 17M 1.16
AVANIR Pharmaceuticals 0.3 $18M 5.4M 3.36
Dyax 0.2 $15M 2.0M 7.54
Idera Pharmaceuticals 0.2 $15M 3.2M 4.63
Synergy Pharmaceuticals 0.2 $15M 2.6M 5.63
Insmed (INSM) 0.2 $14M 796k 17.00
D Stemline Therapeutics 0.2 $13M 675k 19.60
Biomarin Pharmaceutical Inc note 0.750%10/1 0.2 $13M 13M 1.06
Kythera Biopharmaceuticals I 0.2 $12M 313k 37.35
ISIS Pharmaceuticals 0.1 $9.8M 247k 39.84
Zogenix 0.1 $9.5M 2.8M 3.44
32 Infinity Pharmaceuticals 0.1 $8.9M 643k 13.81
Prothena (PRTA) 0.1 $8.9M 337k 26.52
Qlt 0.1 $8.6M 1.5M 5.57
Threshold Pharmaceuticals 0.1 $8.7M 1.9M 4.67
Discovery Laboratories 0.1 $8.4M 3.7M 2.25
Tg Therapeutics (TGTX) 0.1 $8.6M 2.2M 3.90
Array BioPharma 0.1 $7.5M 1.5M 5.01
Omeros Corporation (OMER) 0.1 $6.9M 608k 11.29
Ambit Bioscience 0.1 $7.2M 748k 9.64
Osiris Therapeutics 0.1 $6.0M 375k 16.08
Novavax 0.1 $6.6M 1.3M 5.12
Ironwood Pharmaceuticals (IRWD) 0.1 $6.3M 546k 11.61
XenoPort 0.1 $5.9M 1.0M 5.75
Sangamo Biosciences (SGMO) 0.1 $5.9M 424k 13.89
Portola Pharmaceuticals 0.1 $5.8M 224k 25.75
Aerie Pharmaceuticals 0.1 $5.4M 300k 17.96
BioDelivery Sciences International 0.1 $5.0M 846k 5.89
INC Ventrus Biosciences 0.1 $4.6M 1.2M 3.82
Biota Pharmaceuticals 0.1 $4.7M 1.1M 4.19
Agios Pharmaceuticals (AGIO) 0.1 $4.9M 206k 23.95
Xencor (XNCR) 0.1 $5.0M 550k 9.14
Tekmira Pharmaceuticals Corporation 0.1 $4.0M 500k 7.97
Epizyme 0.1 $4.6M 220k 20.80
Gw Pharmaceuticals Plc ads 0.1 $3.9M 94k 41.54
Ligand Pharmaceuticals 0.1 $3.9M 73k 52.60
Ophthotech 0.1 $3.3M 103k 32.35
Synta Pharmaceuticals 0.0 $2.6M 500k 5.24
Puma Biotechnology (PBYI) 0.0 $2.6M 25k 103.52
Enanta Pharmaceuticals (ENTA) 0.0 $3.0M 109k 27.28
Receptos 0.0 $2.9M 100k 28.99
Macrogenics (MGNX) 0.0 $2.7M 100k 27.43
InterMune 0.0 $2.2M 150k 14.73
United Therapeutics Corporation (UTHR) 0.0 $2.3M 20k 113.10
Geron Corporation (GERN) 0.0 $1.9M 403k 4.74
Bluebird Bio (BLUE) 0.0 $2.4M 115k 20.98
Rigel Pharmaceuticals (RIGL) 0.0 $1.4M 500k 2.85
OraSure Technologies (OSUR) 0.0 $1.5M 244k 6.29
Amicus Therapeutics (FOLD) 0.0 $1.2M 515k 2.35
Achillion Pharmaceuticals 0.0 $1.5M 455k 3.32
ZIOPHARM Oncology 0.0 $1.1M 254k 4.34
Acceleron Pharma 0.0 $1.2M 30k 39.60
Karyopharm Therapeutics (KPTI) 0.0 $1.4M 61k 22.93
Galectin Therapeutics (GALT) 0.0 $813k 101k 8.08
Tesaro 0.0 $882k 31k 28.25
Foundation Medicine 0.0 $476k 20k 23.80
Salix Pharmaceuticals 0.0 $326k 3.6k 90.03
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $193k 21k 9.20
Chemocentryx 0.0 $290k 50k 5.80
Five Prime Therapeutics 0.0 $333k 20k 16.80