Baker Bros. Advisors

Baker Bros. Advisors as of March 31, 2014

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 108 positions in its portfolio as reported in the March 2014 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Seattle Genetics 12.0 $945M 21M 45.56
Synageva Biopharma 11.2 $884M 11M 82.97
Pharmacyclics 11.1 $876M 8.7M 100.22
Incyte Corporation (INCY) 10.1 $794M 15M 53.52
ACADIA Pharmaceuticals (ACAD) 6.3 $498M 21M 24.33
Salix Pharmaceuticals Inc note 2.750% 5/1 6.2 $492M 219M 2.24
Genomic Health 4.6 $360M 14M 26.34
Incyte Corp Ltd conv 4.5 $351M 275M 1.28
Incyte Corp Incy Cvt 144a 0.37 convert 4.2 $326M 259M 1.26
Incyte Corp note 4.750%10/0 3.1 $246M 40M 6.08
InterMune 1.8 $145M 4.3M 33.47
BioMarin Pharmaceutical (BMRN) 1.6 $129M 1.9M 68.21
Auxilium Pharmaceuticals note 1.6 $128M 98M 1.31
XOMA CORP Common equity shares 1.5 $120M 23M 5.21
Itmn 2 1/2 12/15/17 1.4 $108M 41M 2.63
Intercept Pharmaceuticals In 1.1 $85M 256k 329.79
Biomarin Pharmaceutical Inc note 1.875% 4/2 1.0 $77M 23M 3.37
Vanda Pharmaceuticals (VNDA) 0.9 $72M 4.4M 16.25
Halozyme Therapeutics (HALO) 0.9 $72M 5.7M 12.70
Gilead Sciences conv 0.8 $67M 22M 3.11
BioCryst Pharmaceuticals (BCRX) 0.8 $62M 5.9M 10.58
Anacor Pharmaceuticals In 0.8 $62M 3.1M 20.01
Medivation Inc note 2.625% 4/0 0.7 $57M 40M 1.43
Repros Therapeutics 0.6 $49M 2.8M 17.74
Questcor Pharmaceuticals 0.6 $47M 718k 64.93
Mirati Therapeutics 0.6 $45M 2.4M 19.07
Derma Sciences 0.6 $45M 3.5M 12.68
Cerus Corporation (CERS) 0.5 $41M 8.5M 4.80
Gilead Sciences (GILD) 0.5 $39M 556k 70.86
Acorda Therapeutics 0.5 $38M 1.0M 37.91
Chelsea Therapeutics International 0.5 $37M 6.8M 5.52
Clovis Oncology 0.5 $37M 530k 69.27
Intermune cv 5.0% 0.4 $31M 17M 1.81
Heron Therapeutics (HRTX) 0.4 $30M 2.2M 13.91
Slxp 1 1/2 03/15/19 0.3 $25M 15M 1.69
Aegerion Pharmaceuticals 0.3 $24M 514k 46.12
Dyax 0.3 $23M 2.5M 8.98
XenoPort 0.3 $21M 4.0M 5.17
AVANIR Pharmaceuticals 0.3 $21M 5.8M 3.67
Progenics Pharmaceuticals 0.2 $18M 4.4M 4.09
Aquinox Pharmaceuticals 0.2 $15M 1.2M 12.73
Tg Therapeutics (TGTX) 0.2 $15M 2.2M 6.90
Biomarin Pharmaceutical Inc note 0.750%10/1 0.2 $14M 13M 1.10
Kythera Biopharmaceuticals I 0.2 $12M 311k 39.76
Arrowhead Research 0.1 $12M 732k 16.42
Tekmira Pharmaceuticals Corporation 0.1 $10M 484k 21.49
Insmed (INSM) 0.1 $11M 554k 19.04
Sangamo Biosciences (SGMO) 0.1 $9.5M 523k 18.08
Omeros Corporation (OMER) 0.1 $9.1M 754k 12.07
Synergy Pharmaceuticals 0.1 $9.3M 1.8M 5.31
Qlt 0.1 $8.5M 1.5M 5.56
Threshold Pharmaceuticals 0.1 $8.7M 1.8M 4.76
Prothena (PRTA) 0.1 $8.8M 230k 38.31
Discovery Laboratories 0.1 $7.9M 3.7M 2.15
Galectin Therapeutics (GALT) 0.1 $7.7M 500k 15.31
Agios Pharmaceuticals (AGIO) 0.1 $7.8M 200k 39.15
Array BioPharma 0.1 $6.7M 1.4M 4.70
Neurocrine Biosciences (NBIX) 0.1 $7.2M 448k 16.10
Infinity Pharmaceuticals (INFIQ) 0.1 $7.4M 624k 11.89
Zogenix 0.1 $6.7M 2.4M 2.85
Biota Pharmaceuticals 0.1 $6.8M 1.1M 6.11
D Stemline Therapeutics 0.1 $6.9M 339k 20.36
Ambit Bioscience 0.1 $6.8M 748k 9.12
Idera Pharmaceuticals 0.1 $6.6M 1.6M 4.08
Aerie Pharmaceuticals 0.1 $6.3M 299k 21.19
Xencor (XNCR) 0.1 $6.4M 542k 11.73
Novavax 0.1 $5.5M 1.2M 4.53
Ironwood Pharmaceuticals (IRWD) 0.1 $5.5M 446k 12.32
Osiris Therapeutics 0.1 $4.7M 362k 13.13
Ligand Pharmaceuticals In (LGND) 0.1 $4.9M 73k 67.26
Cytrx 0.1 $4.7M 1.4M 3.49
Epizyme 0.1 $4.9M 214k 22.77
Portola Pharmaceuticals 0.1 $4.7M 183k 25.90
Bluebird Bio (BLUE) 0.1 $4.5M 198k 22.74
Regado Biosciences 0.1 $5.0M 400k 12.52
Ultragenyx Pharmaceutical (RARE) 0.1 $4.9M 100k 48.89
Ignyta 0.1 $4.7M 571k 8.30
Celsus Therapeutics Plc sponsored adr ne 0.1 $4.4M 674k 6.49
ISIS Pharmaceuticals 0.1 $4.2M 96k 43.21
BioDelivery Sciences International 0.1 $3.6M 421k 8.44
Retrophin 0.1 $4.2M 197k 21.27
Furiex Pharmaceuticals 0.0 $3.5M 40k 87.00
Enanta Pharmaceuticals (ENTA) 0.0 $3.2M 81k 39.98
Synta Pharmaceuticals 0.0 $2.2M 500k 4.31
Mast Therapeutics 0.0 $2.0M 3.0M 0.68
Macrogenics (MGNX) 0.0 $2.7M 96k 27.83
La Jolla Pharmaceuticl Com Par 0.0 $2.4M 222k 10.80
Auxilium Pharmaceuticals 0.0 $1.6M 59k 27.18
Rigel Pharmaceuticals (RIGL) 0.0 $1.9M 482k 3.88
OraSure Technologies (OSUR) 0.0 $1.9M 235k 7.97
Achillion Pharmaceuticals 0.0 $1.4M 438k 3.29
Catalyst Pharmaceutical Partners (CPRX) 0.0 $1.3M 570k 2.26
Ophthotech 0.0 $1.3M 37k 35.73
Karyopharm Therapeutics (KPTI) 0.0 $1.8M 59k 30.88
Achaogen 0.0 $1.5M 100k 15.46
Geron Corporation (GERN) 0.0 $838k 403k 2.08
Alnylam Pharmaceuticals (ALNY) 0.0 $779k 12k 67.16
Amicus Therapeutics (FOLD) 0.0 $997k 482k 2.07
ZIOPHARM Oncology 0.0 $1.1M 245k 4.58
INC Ventrus Biosciences 0.0 $535k 418k 1.28
Tesaro 0.0 $920k 31k 29.47
Receptos 0.0 $1.0M 24k 41.92
Acceleron Pharma 0.0 $992k 29k 34.49
Uniqure Nv (QURE) 0.0 $477k 31k 15.55
Salix Pharmaceuticals 0.0 $375k 3.6k 103.56
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $113k 13k 8.53
Chemocentryx 0.0 $332k 50k 6.64
Five Prime Therapeutics 0.0 $390k 20k 19.67