Baker Bros. Advisors

Baker Bros. Advisors as of June 30, 2014

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 106 positions in its portfolio as reported in the June 2014 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Synageva Biopharma 13.7 $1.1B 11M 104.80
Pharmacyclics 10.5 $861M 9.6M 89.71
Seattle Genetics 10.5 $860M 23M 38.25
Incyte Corporation (INCY) 10.3 $838M 15M 56.44
Salix Pharmaceuticals Inc note 2.750% 5/1 7.2 $586M 219M 2.67
ACADIA Pharmaceuticals (ACAD) 5.7 $463M 21M 22.59
Genomic Health 4.6 $374M 14M 27.40
Incyte Corp Ltd conv 4.5 $371M 275M 1.35
Incyte Corp Incy Cvt 144a 0.37 convert 4.2 $347M 259M 1.34
Incyte Corp note 4.750%10/0 3.2 $259M 40M 6.41
InterMune 2.5 $209M 4.7M 44.15
Itmn 2 1/2 12/15/17 1.7 $141M 41M 3.44
BioCryst Pharmaceuticals (BCRX) 1.7 $139M 11M 12.75
BioMarin Pharmaceutical (BMRN) 1.4 $119M 1.9M 62.21
XOMA CORP Common equity shares 1.3 $106M 23M 4.59
AVANIR Pharmaceuticals 1.3 $105M 19M 5.64
Gilead Sciences conv 1.0 $78M 22M 3.64
Vanda Pharmaceuticals (VNDA) 0.9 $71M 4.4M 16.18
Biomarin Pharmaceutical Inc note 1.875% 4/2 0.9 $71M 23M 3.08
Anacor Pharmaceuticals In 0.7 $58M 3.2M 17.73
Medivation Inc note 2.625% 4/0 0.7 $55M 35M 1.59
Dyax 0.7 $55M 5.7M 9.60
Repros Therapeutics 0.6 $48M 2.8M 17.30
Mirati Therapeutics 0.6 $48M 2.4M 20.00
Questcor Pharmaceuticals 0.6 $46M 500k 92.49
Cerus Corporation (CERS) 0.5 $43M 10M 4.15
Derma Sciences 0.5 $41M 3.5M 11.56
Intermune cv 5.0% 0.5 $40M 17M 2.36
Versartis 0.4 $35M 1.2M 28.04
Clovis Oncology 0.4 $33M 793k 41.41
Heron Therapeutics (HRTX) 0.4 $32M 2.6M 12.32
Acorda Therapeutics 0.4 $31M 906k 33.71
Slxp 1 1/2 03/15/19 0.4 $29M 15M 1.96
Halozyme Therapeutics (HALO) 0.3 $27M 2.8M 9.88
Gilead Sciences (GILD) 0.3 $21M 256k 82.91
Arrowhead Research 0.2 $21M 1.4M 14.31
Tg Therapeutics (TGTX) 0.2 $20M 2.2M 9.39
XenoPort 0.2 $20M 4.0M 4.83
Progenics Pharmaceuticals 0.2 $19M 4.4M 4.31
Salix Pharmaceuticals Ltd cmn 0.2 $15M 125k 123.35
Aegerion Pharmaceuticals 0.2 $13M 414k 32.09
Omeros Corporation (OMER) 0.2 $13M 754k 17.40
Biomarin Pharmaceutical Inc note 0.750%10/1 0.2 $13M 13M 1.03
Kythera Biopharmaceuticals I 0.1 $12M 311k 38.37
Aquinox Pharmaceuticals 0.1 $11M 1.2M 9.37
Qlt 0.1 $9.5M 1.5M 6.18
Agios Pharmaceuticals (AGIO) 0.1 $9.2M 200k 45.82
Osiris Therapeutics 0.1 $8.0M 511k 15.62
Sangamo Biosciences (SGMO) 0.1 $8.0M 523k 15.27
Neurocrine Biosciences (NBIX) 0.1 $8.2M 555k 14.84
Infinity Pharmaceuticals (INFIQ) 0.1 $8.0M 624k 12.74
Threshold Pharmaceuticals 0.1 $7.2M 1.8M 3.96
Synergy Pharmaceuticals 0.1 $7.2M 1.8M 4.07
Bluebird Bio (BLUE) 0.1 $7.6M 198k 38.57
Aerie Pharmaceuticals 0.1 $7.4M 299k 24.77
Array BioPharma 0.1 $6.5M 1.4M 4.56
Ironwood Pharmaceuticals (IRWD) 0.1 $6.8M 446k 15.33
Discovery Laboratories 0.1 $6.5M 3.7M 1.78
Tekmira Pharmaceuticals Corporation 0.1 $6.3M 484k 13.06
Epizyme 0.1 $6.7M 214k 31.12
Macrogenics (MGNX) 0.1 $6.8M 312k 21.73
Xencor (XNCR) 0.1 $6.3M 542k 11.62
Novavax 0.1 $5.7M 1.2M 4.62
Catalyst Pharmaceutical Partners (CPRX) 0.1 $5.6M 2.2M 2.53
Insmed (INSM) 0.1 $6.1M 304k 19.98
Cytrx 0.1 $5.6M 1.4M 4.18
Idera Pharmaceuticals 0.1 $4.7M 1.6M 2.90
BioDelivery Sciences International 0.1 $5.1M 421k 12.07
Ligand Pharmaceuticals In (LGND) 0.1 $4.6M 73k 62.29
Zogenix 0.1 $4.7M 2.4M 2.01
D Stemline Therapeutics 0.1 $5.0M 339k 14.67
Ambit Bioscience 0.1 $5.2M 748k 6.91
Ignyta 0.1 $5.2M 571k 9.09
Galectin Therapeutics (GALT) 0.1 $4.1M 300k 13.81
Karyopharm Therapeutics (KPTI) 0.1 $4.4M 94k 46.55
Ultragenyx Pharmaceutical (RARE) 0.1 $4.5M 100k 44.89
Concert Pharmaceuticals I equity 0.1 $4.0M 399k 10.10
Celsus Therapeutics Plc sponsored adr ne 0.1 $3.7M 674k 5.50
ISIS Pharmaceuticals 0.0 $3.3M 96k 34.45
Achillion Pharmaceuticals 0.0 $3.3M 438k 7.57
Biota Pharmaceuticals 0.0 $3.2M 1.1M 2.85
Enanta Pharmaceuticals (ENTA) 0.0 $3.2M 75k 43.07
Alder Biopharmaceuticals 0.0 $3.1M 153k 20.07
Lipocine 0.0 $3.1M 500k 6.10
Synta Pharmaceuticals 0.0 $2.0M 500k 4.09
Foundation Medicine 0.0 $2.1M 78k 26.96
Regado Biosciences 0.0 $2.7M 400k 6.79
Mediwound Ltd cmn 0.0 $2.6M 225k 11.38
Geron Corporation (GERN) 0.0 $1.3M 403k 3.21
Rigel Pharmaceuticals (RIGL) 0.0 $1.7M 482k 3.63
OraSure Technologies (OSUR) 0.0 $2.0M 235k 8.61
Amicus Therapeutics (FOLD) 0.0 $1.6M 482k 3.34
Ophthotech 0.0 $1.6M 37k 42.31
La Jolla Pharmaceuticl Com Par 0.0 $2.0M 222k 9.18
Achaogen 0.0 $1.4M 100k 13.96
Mast Therapeutics 0.0 $1.9M 3.0M 0.63
Salix Pharmaceuticals 0.0 $1.1M 8.6k 123.30
Alnylam Pharmaceuticals (ALNY) 0.0 $733k 12k 63.19
ZIOPHARM Oncology 0.0 $986k 245k 4.03
Tesaro 0.0 $971k 31k 31.10
Receptos 0.0 $1.0M 24k 42.59
Acceleron Pharma 0.0 $977k 29k 33.96
Uniqure Nv (QURE) 0.0 $417k 31k 13.60
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $108k 13k 8.15
Chemocentryx 0.0 $293k 50k 5.86
Five Prime Therapeutics 0.0 $308k 20k 15.54