HighVista Strategies

HighVista Strategies as of Dec. 31, 2025

Portfolio Holdings for HighVista Strategies

HighVista Strategies holds 145 positions in its portfolio as reported in the December 2025 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Invesco Db Commdy Indx Trck Unit (DBC) 6.1 $24M 1.1M 22.36
Structure Therapeutics Sponsored Ads (GPCR) 3.5 $13M 193k 69.55
Cogent Biosciences (COGT) 3.1 $12M 337k 35.52
Miragen Therapeutics (VRDN) 3.0 $12M 373k 31.12
Abivax Sa Sponsored Ads (ABVX) 2.5 $9.7M 72k 134.85
Revolution Medicines (RVMD) 2.5 $9.6M 120k 79.65
Praxis Precision Medicines I Com New (PRAX) 2.0 $7.6M 26k 294.74
Nuvalent Inc-a (NUVL) 1.9 $7.4M 73k 100.59
Cytokinetics Com New (CYTK) 1.9 $7.3M 115k 63.54
Terns Pharmaceuticals (TERN) 1.8 $7.1M 176k 40.40
Maze Therapeatics (MAZE) 1.8 $7.1M 170k 41.43
Insmed Com Par $.01 (INSM) 1.8 $6.9M 39k 174.04
Apogee Therapeutics (APGE) 1.7 $6.7M 89k 75.48
Protagonist Therapeutics (PTGX) 1.7 $6.4M 74k 87.34
Soleno Therapeutics (SLNO) 1.6 $6.3M 135k 46.30
Spyre Therapeutics Com New (SYRE) 1.6 $6.2M 188k 32.76
Bridgebio Pharma (BBIO) 1.6 $6.1M 80k 76.49
Olema Pharmaceuticals (OLMA) 1.6 $6.0M 242k 25.00
Immunovant (IMVT) 1.5 $5.6M 222k 25.42
Liquidia Corporation Com New (LQDA) 1.4 $5.4M 156k 34.49
Vaxcyte (PCVX) 1.4 $5.3M 114k 46.14
Cidara Therapeutics Com New (CDTX) 1.3 $5.1M 23k 220.89
Arcellx Common Stock (ACLX) 1.3 $4.9M 75k 65.20
Relay Therapeutics (RLAY) 1.2 $4.6M 545k 8.46
Rhythm Pharmaceuticals (RYTM) 1.2 $4.6M 43k 107.04
Mineralys Therapeutics (MLYS) 1.2 $4.5M 125k 36.29
Pharvaris N V (PHVS) 1.2 $4.5M 162k 27.75
Tarsus Pharmaceuticals (TARS) 1.1 $4.4M 54k 81.88
Edgewise Therapeutics (EWTX) 1.1 $4.2M 171k 24.82
Ocular Therapeutix (OCUL) 1.1 $4.2M 344k 12.14
Agios Pharmaceuticals (AGIO) 1.0 $4.0M 148k 27.22
Amazon (AMZN) 1.0 $4.0M 17k 230.82
Apellis Pharmaceuticals (APLS) 1.0 $3.8M 151k 25.12
Guardant Health (GH) 1.0 $3.8M 37k 102.14
Stoke Therapeutics (STOK) 0.9 $3.7M 116k 31.74
Compass Pathways Sponsored Ads (CMPS) 0.9 $3.4M 499k 6.90
Microsoft Corporation (MSFT) 0.8 $3.2M 6.5k 483.62
Lb Pharmaceuticals Com Shs (LBRX) 0.8 $3.1M 140k 22.26
Palisade Bio (PALI) 0.8 $3.1M 1.3M 2.35
Gh Research Ordinary Shares (GHRS) 0.8 $3.1M 241k 12.70
Argenx Se Sponsored Adr (ARGX) 0.8 $3.0M 3.6k 840.95
Xoma Royalty Corporation Com New (XOMA) 0.8 $3.0M 113k 26.59
TransDigm Group Incorporated (TDG) 0.7 $2.9M 2.2k 1329.85
Avidity Biosciences Ord 0.7 $2.9M 40k 72.13
Amylyx Pharmaceuticals (AMLX) 0.7 $2.9M 239k 12.08
Bridgebio Oncology Therapeut Com New (BBOT) 0.7 $2.9M 229k 12.52
NVIDIA Corporation (NVDA) 0.7 $2.7M 14k 186.50
salesforce (CRM) 0.6 $2.3M 8.6k 264.91
Visa Com Cl A (V) 0.6 $2.2M 6.3k 350.71
Septerna (SEPN) 0.6 $2.2M 79k 27.88
Axsome Therapeutics (AXSM) 0.5 $2.0M 11k 182.64
Dianthus Therapeutics (DNTH) 0.5 $2.0M 49k 41.21
Alphabet Cap Stk Cl C (GOOG) 0.5 $2.0M 6.3k 313.80
Broadcom (AVGO) 0.5 $2.0M 5.6k 346.10
Rocket Cos Com Cl A (RKT) 0.5 $1.9M 97k 19.36
Union Pacific Corporation (UNP) 0.5 $1.9M 8.1k 231.32
Hewlett Packard Enterprise (HPE) 0.5 $1.8M 76k 24.02
Amrize SHS (AMRZ) 0.5 $1.8M 34k 54.08
Avalo Therapeutics Com New (AVTX) 0.4 $1.7M 96k 18.16
Flowserve Corporation (FLS) 0.4 $1.7M 25k 69.38
Xpo Logistics Inc equity (XPO) 0.4 $1.7M 13k 135.91
Constellation Energy (CEG) 0.4 $1.7M 4.8k 353.27
Meta Platforms Cl A (META) 0.4 $1.7M 2.6k 660.09
Applovin Corp Com Cl A (APP) 0.4 $1.7M 2.5k 673.82
Madrigal Pharmaceuticals (MDGL) 0.4 $1.7M 2.8k 582.34
Celcuity (CELC) 0.4 $1.6M 17k 99.74
Lumentum Hldgs (LITE) 0.4 $1.6M 4.3k 368.59
Mastercard Incorporated Cl A (MA) 0.4 $1.6M 2.8k 570.88
Cleveland-cliffs (CLF) 0.4 $1.6M 119k 13.28
Ferguson Enterprises Common Stock New (FERG) 0.4 $1.6M 7.0k 222.63
Nextera Energy (NEE) 0.4 $1.5M 19k 80.28
UniFirst Corporation (UNF) 0.4 $1.5M 7.7k 192.90
Clean Harbors (CLH) 0.4 $1.5M 6.2k 234.48
EQT Corporation (EQT) 0.4 $1.5M 27k 53.60
Celldex Therapeutics Com New (CLDX) 0.4 $1.4M 52k 27.16
Workday Cl A (WDAY) 0.4 $1.4M 6.5k 214.78
Trevi Therapeutics (TRVI) 0.3 $1.3M 106k 12.52
Compass Therapeutics (CMPX) 0.3 $1.3M 246k 5.37
Thermo Fisher Scientific (TMO) 0.3 $1.3M 2.3k 579.45
Talen Energy Corp (TLN) 0.3 $1.3M 3.5k 374.84
Booking Holdings (BKNG) 0.3 $1.3M 243.00 5355.33
Orthofix Medical (OFIX) 0.3 $1.3M 85k 15.16
Enliven Therapeutics (ELVN) 0.3 $1.3M 83k 15.40
Unity Software (U) 0.3 $1.3M 29k 44.17
Newamsterdam Pharma Company Ordinary Shares (NAMS) 0.3 $1.2M 36k 35.08
Reddit Cl A (RDDT) 0.3 $1.2M 5.3k 229.87
Cg Oncology (CGON) 0.3 $1.2M 29k 41.52
Ciena Corp Com New (CIEN) 0.3 $1.2M 5.2k 233.87
RBC Bearings Incorporated (RBC) 0.3 $1.2M 2.7k 448.43
KBR (KBR) 0.3 $1.2M 30k 40.20
Intuit (INTU) 0.3 $1.2M 1.8k 662.42
Api Group Corp Com Stk (APG) 0.3 $1.2M 31k 38.26
Dyne Therapeutics (DYN) 0.3 $1.2M 60k 19.56
Pure Storage Cl A (PSTG) 0.3 $1.2M 17k 67.01
Acadia Healthcare (ACHC) 0.3 $1.2M 82k 14.19
Ge Vernova (GEV) 0.3 $1.2M 1.8k 653.57
Rxo Common Stock (RXO) 0.3 $1.1M 91k 12.64
Immunocore Hldgs Ads (IMCR) 0.3 $1.1M 33k 34.71
United Therapeutics Corporation (UTHR) 0.3 $1.1M 2.3k 487.25
Qxo Com New (QXO) 0.3 $1.1M 59k 19.29
Centessa Pharmaceuticals Sponsored Ads (CNTA) 0.3 $1.1M 45k 25.01
Ptc (PTC) 0.3 $1.1M 6.4k 174.21
MasTec (MTZ) 0.3 $1.1M 5.0k 217.37
Charles Schwab Corporation (SCHW) 0.3 $1.1M 11k 99.91
Nu Hldgs Ord Shs Cl A (NU) 0.3 $1.0M 63k 16.74
Sandisk Corp (SNDK) 0.3 $1.0M 4.4k 237.38
Pennymac Financial Services (PFSI) 0.3 $1.0M 7.8k 131.84
Affirm Hldgs Com Cl A (AFRM) 0.3 $974k 13k 74.43
Corporacion Amer Arpts S A (CAAP) 0.2 $966k 37k 26.00
Amphenol Corp Cl A (APH) 0.2 $957k 7.1k 135.14
Entergy Corporation (ETR) 0.2 $955k 10k 92.43
Sea Sponsord Ads (SE) 0.2 $950k 7.5k 127.57
Full Truck Alliance Sponsored Ads (YMM) 0.2 $940k 88k 10.73
MercadoLibre (MELI) 0.2 $937k 465.00 2014.26
Core Scientific (CORZ) 0.2 $925k 64k 14.56
Tyra Biosciences (TYRA) 0.2 $922k 35k 26.29
Vistra Energy (VST) 0.2 $915k 5.7k 161.33
Cytomx Therapeutics (CTMX) 0.2 $826k 194k 4.26
Compania De Minas Buenaventu Sponsored Adr (BVN) 0.2 $825k 30k 27.83
Shift4 Pmts Cl A (FOUR) 0.2 $818k 13k 62.97
Hdfc Bank Sponsored Ads (HDB) 0.2 $809k 22k 36.54
Icici Bank Adr (IBN) 0.2 $783k 26k 29.80
Ascendis Pharma A/s Sponsored Adr (ASND) 0.2 $781k 3.7k 213.24
Trip Com Group Ads (TCOM) 0.2 $766k 11k 71.91
Alkermes SHS (ALKS) 0.2 $739k 26k 27.98
Gitlab Class A Com (GTLB) 0.2 $725k 19k 37.53
New Oriental Ed & Technology Spon Adr (EDU) 0.2 $705k 13k 55.03
Roblox Corp Cl A (RBLX) 0.2 $683k 8.4k 81.03
Alcon Ord Shs (ALC) 0.2 $661k 10k 63.28
Urogen Pharma (URGN) 0.2 $656k 28k 23.42
Cnx Resources Corporation (CNX) 0.2 $648k 18k 36.77
Banco Bradesco S A Sp Adr Pfd New (BBD) 0.2 $634k 190k 3.33
3M Company (MMM) 0.2 $632k 4.0k 160.10
Autoliv (ALV) 0.2 $622k 5.2k 118.70
Petroleo Brasileiro Sa Petro Sp Adr Non Vtg (PBR.A) 0.2 $622k 55k 11.27
Xcel Energy (XEL) 0.2 $595k 8.1k 73.86
Argan (AGX) 0.2 $594k 1.9k 313.32
Coupang Cl A (CPNG) 0.2 $585k 25k 23.59
Janux Therapeutics (JANX) 0.1 $572k 41k 13.80
Kymera Therapeutics (KYMR) 0.1 $532k 6.8k 77.81
Jd.com Spon Ads Cl A (JD) 0.1 $501k 18k 28.70
Nektar Therapeutics Com New (NKTR) 0.1 $497k 12k 42.28
Kanzhun Sponsored Ads (BZ) 0.1 $420k 21k 20.38
Nokia Corp Sponsored Adr (NOK) 0.1 $385k 60k 6.47
Dbv Technologies S A Sponsored Ads (DBVT) 0.1 $304k 16k 19.17