Hambrecht & Quist Capital Management

Tekla Capital Management as of Dec. 31, 2018

Portfolio Holdings for Tekla Capital Management

Tekla Capital Management holds 203 positions in its portfolio as reported in the December 2018 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Johnson & Johnson (JNJ) 5.7 $133M 1.0M 129.05
Amgen (AMGN) 5.7 $132M 678k 194.67
Biogen Idec (BIIB) 5.1 $119M 395k 300.92
Gilead Sciences (GILD) 5.1 $118M 1.9M 62.55
UnitedHealth (UNH) 4.0 $94M 375k 249.12
Celgene Corporation 3.8 $89M 1.4M 64.09
Illumina (ILMN) 3.4 $79M 262k 299.93
Vertex Pharmaceuticals Incorporated (VRTX) 3.0 $71M 426k 165.71
Pfizer (PFE) 2.8 $66M 1.5M 43.65
Merck & Co (MRK) 2.4 $56M 738k 76.41
Regeneron Pharmaceuticals (REGN) 2.2 $51M 136k 373.50
Alexion Pharmaceuticals 2.1 $48M 496k 97.36
Abbvie (ABBV) 1.9 $45M 492k 92.19
Medtronic (MDT) 1.9 $44M 481k 90.96
Thermo Fisher Scientific (TMO) 1.8 $43M 192k 223.79
Incyte Corporation (INCY) 1.8 $41M 645k 63.59
Mylan Nv 1.6 $39M 1.4M 27.40
Anthem (ELV) 1.6 $37M 141k 262.63
Bristol Myers Squibb (BMY) 1.4 $34M 653k 51.98
Allergan 1.3 $31M 235k 133.66
CVS Caremark Corporation (CVS) 1.3 $30M 461k 65.52
Abbott Laboratories (ABT) 1.2 $28M 392k 72.33
Stryker Corporation (SYK) 1.1 $25M 160k 156.75
Eli Lilly & Co. (LLY) 1.1 $25M 216k 115.72
Novartis (NVS) 1.1 $25M 292k 85.81
Danaher Corporation (DHR) 0.9 $22M 209k 103.12
Zoetis Inc Cl A (ZTS) 0.9 $22M 251k 85.54
Sarepta Therapeutics (SRPT) 0.9 $21M 192k 109.13
Humana (HUM) 0.8 $20M 69k 286.48
Centene Corporation (CNC) 0.8 $19M 167k 115.30
Teva Pharmaceutical Industries (TEVA) 0.8 $19M 1.2M 15.42
Intuitive Surgical (ISRG) 0.8 $19M 39k 478.93
BioMarin Pharmaceutical (BMRN) 0.8 $18M 207k 85.15
AstraZeneca (AZN) 0.7 $16M 428k 37.98
Boston Scientific Corporation (BSX) 0.7 $16M 445k 35.34
Becton, Dickinson and (BDX) 0.7 $16M 70k 225.31
Neurocrine Biosciences (NBIX) 0.7 $15M 216k 71.41
Jazz Pharmaceuticals (JAZZ) 0.6 $14M 115k 123.96
Novo Nordisk A/S (NVO) 0.6 $14M 302k 46.07
Omega Healthcare Investors (OHI) 0.6 $13M 380k 35.15
Seattle Genetics 0.6 $13M 226k 56.66
Cigna Corp (CI) 0.5 $12M 64k 189.92
Beigene (BGNE) 0.5 $12M 86k 140.26
Baxter International (BAX) 0.5 $11M 161k 65.82
SPDR S&P Biotech (XBI) 0.4 $10M 144k 71.75
Bluebird Bio (BLUE) 0.4 $9.8M 98k 99.20
Fibrogen (FGEN) 0.4 $9.8M 213k 46.28
Aegerion Pharmaceuticals 2% Du cvbond 0.4 $9.8M 13M 0.75
IDEXX Laboratories (IDXX) 0.4 $9.6M 52k 186.02
Zimmer Holdings (ZBH) 0.4 $9.3M 89k 103.72
Hca Holdings (HCA) 0.4 $9.3M 74k 124.45
Sage Therapeutics (SAGE) 0.4 $9.4M 98k 95.79
Alnylam Pharmaceuticals (ALNY) 0.4 $9.2M 126k 72.91
Galapagos Nv- (GLPG) 0.4 $9.2M 100k 91.74
Amarin Corporation (AMRN) 0.4 $8.9M 654k 13.61
Sabra Health Care REIT (SBRA) 0.4 $8.9M 543k 16.48
Edwards Lifesciences (EW) 0.4 $8.7M 57k 153.17
McKesson Corporation (MCK) 0.4 $8.7M 79k 110.47
AmerisourceBergen (COR) 0.4 $8.3M 112k 74.40
GlaxoSmithKline 0.4 $8.4M 219k 38.21
Amicus Therapeutics (FOLD) 0.4 $8.4M 875k 9.58
Medicines Company 0.3 $8.2M 429k 19.14
Sanofi-Aventis SA (SNY) 0.3 $7.8M 180k 43.41
LTC Properties (LTC) 0.3 $7.4M 179k 41.68
Acceleron Pharma 0.3 $7.4M 171k 43.55
Smith & Nephew (SNN) 0.3 $6.9M 186k 37.38
ResMed (RMD) 0.3 $6.7M 59k 113.87
Exelixis (EXEL) 0.3 $6.7M 339k 19.67
Diplomat Pharmacy 0.3 $6.8M 506k 13.46
Blueprint Medicines (BPMC) 0.3 $6.7M 125k 53.91
Medical Properties Trust (MPW) 0.3 $6.7M 414k 16.08
Esperion Therapeutics (ESPR) 0.3 $6.5M 142k 46.00
Pra Health Sciences 0.3 $6.5M 71k 91.97
Shire 0.3 $6.3M 36k 174.04
Align Technology (ALGN) 0.3 $6.3M 30k 209.44
Physicians Realty Trust 0.3 $6.3M 391k 16.03
Immunomedics 0.3 $6.2M 432k 14.27
Gw Pharmaceuticals Plc ads 0.3 $6.2M 63k 97.39
Ventas (VTR) 0.2 $5.8M 99k 58.59
Quest Diagnostics Incorporated (DGX) 0.2 $5.5M 67k 83.26
Pieris Pharmaceuticals (PIRS) 0.2 $5.6M 2.1M 2.66
Array BioPharma 0.2 $5.2M 364k 14.25
Endo International (ENDPQ) 0.2 $5.2M 717k 7.30
Steris 0.2 $5.1M 48k 106.85
Merus N V (MRUS) 0.2 $5.1M 368k 14.00
Crispr Therapeutics (CRSP) 0.2 $5.1M 178k 28.57
Dentsply Sirona (XRAY) 0.2 $4.7M 126k 37.21
United Therapeutics Corporation (UTHR) 0.2 $4.5M 41k 108.89
Senior Housing Properties Trust 0.2 $4.4M 377k 11.72
Alkermes (ALKS) 0.2 $4.5M 151k 29.51
Acadia Healthcare (ACHC) 0.2 $4.5M 173k 25.71
Ionis Pharmaceuticals (IONS) 0.2 $4.5M 83k 54.06
Iqvia Holdings (IQV) 0.2 $4.5M 39k 116.16
Anaptysbio Inc Common (ANAB) 0.2 $4.2M 66k 63.79
Abiomed 0.2 $4.0M 12k 325.02
Cellectis S A (CLLS) 0.2 $3.9M 237k 16.65
Zogenix 0.2 $4.0M 111k 36.46
Global Blood Therapeutics In 0.2 $3.9M 94k 41.05
Laboratory Corp. of America Holdings (LH) 0.2 $3.7M 29k 126.36
Wright Medical Group Nv 0.2 $3.6M 133k 27.22
Ligand Pharmaceuticals In (LGND) 0.1 $3.6M 27k 135.69
Loxo Oncology 0.1 $3.4M 25k 140.07
Bausch Health Companies (BHC) 0.1 $3.5M 192k 18.47
Ultragenyx Pharmaceutical (RARE) 0.1 $3.3M 77k 43.48
Welltower Inc Com reit (WELL) 0.1 $3.2M 46k 69.40
Koninklijke Philips Electronics NV (PHG) 0.1 $3.0M 85k 35.11
WellCare Health Plans 0.1 $3.1M 13k 236.08
Varian Medical Systems 0.1 $3.0M 26k 113.32
Nektar Therapeutics (NKTR) 0.1 $3.1M 94k 32.87
Albireo Pharma 0.1 $3.1M 125k 24.53
Sangamo Biosciences (SGMO) 0.1 $2.8M 242k 11.48
Coherus Biosciences (CHRS) 0.1 $2.9M 315k 9.05
Innoviva (INVA) 0.1 $2.8M 162k 17.45
Charles River Laboratories (CRL) 0.1 $2.6M 23k 113.19
Nevro (NVRO) 0.1 $2.7M 69k 38.89
Inovalon Holdings Inc Cl A 0.1 $2.5M 176k 14.18
Ascendis Pharma A S (ASND) 0.1 $2.7M 42k 62.64
Verona Pharma Plc ads (VRNA) 0.1 $2.5M 275k 9.00
Tenet Healthcare Corporation (THC) 0.1 $2.4M 141k 17.14
Epizyme 0.1 $2.4M 386k 6.16
Portola Pharmaceuticals 0.1 $2.3M 115k 19.52
Ptc Therapeutics I (PTCT) 0.1 $2.4M 69k 34.32
Agios Pharmaceuticals (AGIO) 0.1 $2.3M 49k 46.12
Waters Corporation (WAT) 0.1 $2.0M 11k 188.61
Xencor (XNCR) 0.1 $2.0M 56k 36.16
Marinus Pharmaceuticals 0.1 $2.2M 756k 2.87
Foamix Pharmaceuticals 0.1 $2.2M 601k 3.59
Intellia Therapeutics (NTLA) 0.1 $2.1M 150k 13.65
Flamel Technologies Sa (AVDL) 0.1 $2.1M 815k 2.58
Arena Pharmaceuticals 0.1 $2.0M 52k 38.96
Sutro Biopharma (STRO) 0.1 $2.1M 230k 9.02
Healthcare Realty Trust Incorporated 0.1 $1.9M 68k 28.44
Mettler-Toledo International (MTD) 0.1 $2.0M 3.5k 565.71
Masimo Corporation (MASI) 0.1 $1.8M 17k 107.34
Myokardia 0.1 $1.9M 39k 48.86
Iovance Biotherapeutics (IOVA) 0.1 $1.9M 217k 8.85
Teleflex Incorporated (TFX) 0.1 $1.6M 6.4k 258.50
Puma Biotechnology (PBYI) 0.1 $1.7M 83k 20.35
Inogen (INGN) 0.1 $1.7M 14k 124.15
Editas Medicine (EDIT) 0.1 $1.7M 77k 22.75
Ac Immune Sa (ACIU) 0.1 $1.6M 172k 9.45
Dr. Reddy's Laboratories (RDY) 0.1 $1.4M 37k 37.70
NuVasive 0.1 $1.4M 29k 49.56
Clovis Oncology 0.1 $1.4M 75k 17.96
Intercept Pharmaceuticals In 0.1 $1.3M 13k 100.76
Perrigo Company (PRGO) 0.1 $1.4M 37k 38.74
Aerie Pharmaceuticals 0.1 $1.4M 39k 36.11
New Senior Inv Grp 0.1 $1.3M 315k 4.12
Adaptimmune Therapeutics (ADAP) 0.1 $1.3M 229k 5.75
Protagonist Therapeutics (PTGX) 0.1 $1.3M 197k 6.73
Aerpio Pharmaceuticals 0.1 $1.3M 765k 1.70
Genomic Health 0.1 $1.1M 17k 64.42
HCP 0.1 $1.3M 46k 27.93
Uniqure Nv (QURE) 0.1 $1.1M 38k 28.83
Intra Cellular Therapies (ITCI) 0.1 $1.3M 110k 11.39
Akebia Therapeutics (AKBA) 0.1 $1.2M 214k 5.53
Ardelyx (ARDX) 0.1 $1.1M 639k 1.79
Healthcare Tr Amer Inc cl a 0.1 $1.2M 46k 25.30
Dermira 0.1 $1.2M 162k 7.19
Audentes Therapeutics 0.1 $1.1M 53k 21.32
Ovid Therapeutics (OVID) 0.1 $1.2M 497k 2.42
Nightstar Therapeutics 0.1 $1.1M 99k 11.52
Novavax 0.0 $1.1M 571k 1.84
Spectrum Pharmaceuticals 0.0 $1.0M 115k 8.75
Tetraphase Pharmaceuticals 0.0 $971k 859k 1.13
Mallinckrodt Pub 0.0 $847k 54k 15.80
Evolent Health (EVH) 0.0 $841k 42k 19.95
Livanova Plc Ord (LIVN) 0.0 $1.0M 11k 91.49
Novocure Ltd ord (NVCR) 0.0 $820k 25k 33.47
Syndax Pharmaceuticals (SNDX) 0.0 $890k 200k 4.45
Hologic (HOLX) 0.0 $803k 20k 41.08
ArQule 0.0 $693k 250k 2.77
ImmunoGen 0.0 $807k 168k 4.80
LeMaitre Vascular (LMAT) 0.0 $642k 27k 23.65
Takeda Pharmaceutical foreign 0.0 $649k 19k 33.80
Affimed Therapeutics B V 0.0 $790k 254k 3.11
Trillium Therapeutics, Inc. Cmn 0.0 $763k 446k 1.71
Global Medical Reit (GMRE) 0.0 $653k 73k 8.90
Madrigal Pharmaceuticals (MDGL) 0.0 $752k 6.7k 112.74
Egalet Corporation note 5.50% 4/1/20 0.0 $700k 7.0M 0.10
Rhythm Pharmaceuticals (RYTM) 0.0 $669k 25k 26.88
Agilent Technologies Inc C ommon (A) 0.0 $553k 8.2k 67.44
Community Health Systems (CYH) 0.0 $575k 204k 2.82
Achillion Pharmaceuticals 0.0 $507k 319k 1.59
Mirati Therapeutics 0.0 $576k 14k 42.38
Concert Pharmaceuticals I equity 0.0 $569k 45k 12.54
Spark Therapeutics 0.0 $422k 11k 39.18
Lexicon Pharmaceuticals (LXRX) 0.0 $465k 70k 6.64
Cidara Therapeutics Inc Common Stock Usd 0.0001 (CDTX) 0.0 $373k 159k 2.35
Viking Therapeutics (VKTX) 0.0 $436k 57k 7.65
Arrowhead Pharmaceuticals (ARWR) 0.0 $381k 31k 12.41
Athenex 0.0 $578k 46k 12.69
Molecular Templates 0.0 $582k 144k 4.04
Eidos Therapeutics 0.0 $384k 28k 13.76
Cardinal Health (CAH) 0.0 $281k 6.3k 44.60
Bellicum Pharma 0.0 $175k 60k 2.92
Arca Biopharma 0.0 $268k 811k 0.33
Clearside Biomedical (CLSD) 0.0 $177k 165k 1.07
Nucana Plc american depositary shares (NCNA) 0.0 $142k 9.8k 14.46
Alliqua Biomedical 0.0 $278k 149k 1.87
Celldex Therapeutics 0.0 $21k 106k 0.20
Quorum Health 0.0 $69k 24k 2.91
Jounce Therapeutics 0.0 $34k 10k 3.36