Sio Capital Management
Latest statistics and disclosures from Sio Capital Management's latest quarterly 13F-HR filing:
- Top 5 stock holdings are CELC, CI, SNY, MMS, ZBH, and represent 34.59% of Sio Capital Management's stock portfolio.
- Added to shares of these 10 stocks: CI (+$47M), ZBH (+$35M), RYTM (+$28M), OGN (+$25M), ICLR (+$23M), WAY (+$20M), LIVN (+$20M), SNY (+$20M), BHVN (+$14M), GPCR (+$14M).
- Started 27 new stock positions in CCRN, WAY, ICLR, COR, ELTX, BHVN, KYMR, CRL, XLO, BTSG.
- Reduced shares in these 10 stocks: CELC (-$31M), IRON (-$18M), ALKS (-$16M), , HSIC (-$15M), GSK (-$12M), DRUG (-$8.5M), HAE (-$8.4M), KALV (-$8.3M), NVCR (-$5.3M).
- Sold out of its positions in APRE, ERAS, GSK, KALV, MRK, HSIC, Senseonics Hldgs, SEPN, SLP, NVCR.
- Sio Capital Management was a net buyer of stock by $166M.
- Sio Capital Management has $636M in assets under management (AUM), dropping by 60.88%.
- Central Index Key (CIK): 0001482416
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Portfolio Holdings for Sio Capital Management
Sio Capital Management holds 68 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Celcuity (CELC) | 7.5 | $48M | -39% | 477k | 99.74 |
|
| Cigna Corp (CI) | 7.5 | $47M | NEW | 172k | 275.23 |
|
| Sanofi Sa Sponsored Adr (SNY) | 7.4 | $47M | +72% | 972k | 48.46 |
|
| Maximus (MMS) | 6.8 | $43M | -10% | 500k | 86.32 |
|
| Zimmer Holdings (ZBH) | 5.5 | $35M | NEW | 386k | 89.92 |
|
| Rhythm Pharmaceuticals Put Option (RYTM) | 4.5 | $28M | NEW | 266k | 107.04 |
|
| Kenvue (KVUE) | 4.0 | $25M | +73% | 1.5M | 17.25 |
|
| Organon & Co Common Stock (OGN) | 3.9 | $25M | NEW | 3.4M | 7.17 |
|
| Icon SHS (ICLR) | 3.6 | $23M | NEW | 127k | 182.22 |
|
| Waystar Holding Corp (WAY) | 3.2 | $20M | NEW | 614k | 32.75 |
|
| Livanova SHS (LIVN) | 3.1 | $20M | NEW | 322k | 61.53 |
|
| Dianthus Therapeutics (DNTH) | 3.1 | $20M | -17% | 475k | 41.21 |
|
| Biohaven (BHVN) | 2.2 | $14M | NEW | 1.2M | 11.29 |
|
| Structure Therapeutics Sponsored Ads (GPCR) | 2.2 | $14M | NEW | 202k | 69.55 |
|
| BioMarin Pharmaceutical (BMRN) | 2.2 | $14M | +3% | 233k | 59.43 |
|
| Tyra Biosciences (TYRA) | 2.2 | $14M | +2% | 526k | 26.29 |
|
| Brightspring Health Svcs (BTSG) | 1.8 | $12M | NEW | 308k | 37.45 |
|
| Centene Corporation (CNC) | 1.8 | $11M | -29% | 274k | 41.15 |
|
| Charles River Laboratories (CRL) | 1.7 | $11M | NEW | 55k | 199.48 |
|
| Teleflex Incorporated (TFX) | 1.7 | $11M | +116% | 87k | 122.04 |
|
| Anteris Technologies Global (AVR) | 1.5 | $9.4M | +5% | 1.9M | 4.99 |
|
| Protara Therapeutics Com Stk (TARA) | 1.4 | $9.1M | NEW | 1.7M | 5.33 |
|
| Cross Country Healthcare (CCRN) | 1.4 | $8.7M | NEW | 1.1M | 8.10 |
|
| Haemonetics Corporation (HAE) | 1.2 | $7.4M | -53% | 93k | 80.15 |
|
| Biosante Pharmaceuticals (ANIP) | 1.1 | $6.9M | +56% | 87k | 78.94 |
|
| Aquestive Therapeutics (AQST) | 1.0 | $6.4M | -33% | 993k | 6.46 |
|
| Bright Minds Biosciences Com New (DRUG) | 1.0 | $6.4M | -57% | 82k | 78.04 |
|
| Edgewise Therapeutics (EWTX) | 0.9 | $5.9M | -22% | 238k | 24.82 |
|
| Abivax Sa Sponsored Ads (ABVX) | 0.9 | $5.8M | NEW | 43k | 134.85 |
|
| Crinetics Pharmaceuticals In (CRNX) | 0.9 | $5.8M | -28% | 125k | 46.55 |
|
| Rapport Therapeutics (RAPP) | 0.9 | $5.6M | 185k | 30.34 |
|
|
| AmerisourceBergen (COR) | 0.8 | $5.4M | NEW | 16k | 337.75 |
|
| McKesson Corporation (MCK) | 0.8 | $5.2M | NEW | 6.4k | 820.29 |
|
| Disc Medicine (IRON) | 0.7 | $4.6M | -79% | 58k | 79.41 |
|
| Proqr Therapeutics N V Shs Euro (PRQR) | 0.7 | $4.4M | +4% | 2.2M | 2.02 |
|
| Fulcrum Therapeutics (FULC) | 0.7 | $4.3M | NEW | 382k | 11.31 |
|
| Savara (SVRA) | 0.6 | $3.7M | -15% | 614k | 6.03 |
|
| Oruka Therapeutics (ORKA) | 0.6 | $3.6M | NEW | 118k | 30.31 |
|
| Ventyx Biosciences (VTYX) | 0.6 | $3.5M | -53% | 388k | 9.03 |
|
| Pmv Pharmaceuticals (PMVP) | 0.5 | $3.3M | 2.6M | 1.25 |
|
|
| Shoulder Innovations Common Stock (SI) | 0.5 | $3.3M | -34% | 228k | 14.30 |
|
| Aligos Therapeutics Com New (ALGS) | 0.5 | $3.1M | 336k | 9.32 |
|
|
| Vir Biotechnology (VIR) | 0.5 | $2.9M | 478k | 6.03 |
|
|
| Alkermes SHS (ALKS) | 0.4 | $2.7M | -85% | 95k | 27.98 |
|
| Ideaya Biosciences (IDYA) | 0.4 | $2.6M | -39% | 76k | 34.57 |
|
| Kymera Therapeutics (KYMR) | 0.4 | $2.5M | NEW | 32k | 77.81 |
|
| Elicio Therapeutics Put Option (ELTX) | 0.4 | $2.4M | NEW | 297k | 7.96 |
|
| Ovid Therapeutics (OVID) | 0.4 | $2.3M | 1.4M | 1.63 |
|
|
| Context Therapeutics (CNTX) | 0.3 | $2.0M | 1.3M | 1.47 |
|
|
| Hyperfine Com Cl A (HYPR) | 0.3 | $2.0M | NEW | 2.0M | 0.98 |
|
| Outlook Therapeutics Put Option (OTLK) | 0.3 | $1.8M | NEW | 1.1M | 1.58 |
|
| Bridgebio Oncology Therapeut Com New (BBOT) | 0.3 | $1.6M | 131k | 12.52 |
|
|
| Ibio Com New (IBIO) | 0.2 | $1.4M | NEW | 740k | 1.93 |
|
| Xilio Therapeutics (XLO) | 0.2 | $1.4M | NEW | 2.1M | 0.64 |
|
| Adagio Med Hldgs (ADGM) | 0.2 | $1.3M | NEW | 1.3M | 1.04 |
|
| Avalo Therapeutics Com New (AVTX) | 0.2 | $1.3M | 72k | 18.16 |
|
|
| Neuroone Med Technologies Com New (NMTC) | 0.1 | $864k | -51% | 1.1M | 0.76 |
|
| Tela Bio (TELA) | 0.1 | $751k | 636k | 1.18 |
|
|
| Foghorn Therapeutics (FHTX) | 0.1 | $664k | 123k | 5.40 |
|
|
| Senseonics Hldgs (SENS) | 0.1 | $639k | NEW | 116k | 5.52 |
|
| Enanta Pharmaceuticals (ENTA) | 0.1 | $631k | NEW | 40k | 15.77 |
|
| Terns Pharmaceuticals (TERN) | 0.1 | $408k | 10k | 40.40 |
|
|
| Modular Med Com New (MODD) | 0.0 | $286k | 786k | 0.36 |
|
|
| Nyxoah S A SHS (NYXH) | 0.0 | $234k | 51k | 4.60 |
|
|
| Boundless Bio (BOLD) | 0.0 | $196k | 164k | 1.20 |
|
|
| Nextcure Com New (NXTC) | 0.0 | $155k | 11k | 14.19 |
|
|
| Rocket Pharmaceuticals *w Exp 09/02/202 (RCKTW) | 0.0 | $7.2k | 400k | 0.02 |
|
|
| Humacyte *w Exp 08/27/202 (HUMAW) | 0.0 | $4.9k | 50k | 0.10 |
|
Past Filings by Sio Capital Management
SEC 13F filings are viewable for Sio Capital Management going back to 2010
- Sio Capital Management 2025 Q4 filed Feb. 17, 2026
- Sio Capital Management 2025 Q3 filed Nov. 13, 2025
- Sio Capital Management 2025 Q2 filed Aug. 13, 2025
- Sio Capital Management 2025 Q1 filed May 15, 2025
- Sio Capital Management 2024 Q4 filed Feb. 14, 2025
- Sio Capital Management 2024 Q3 filed Nov. 14, 2024
- Sio Capital Management 2024 Q2 filed Aug. 14, 2024
- Sio Capital Management 2024 Q1 filed May 15, 2024
- Sio Capital Management 2023 Q3 filed Nov. 14, 2023
- Sio Capital Management 2023 Q2 filed Aug. 14, 2023
- Sio Capital Management 2023 Q1 filed May 12, 2023
- Sio Capital Management 2022 Q4 filed Feb. 13, 2023
- Sio Capital Management 2022 Q3 filed Nov. 14, 2022
- Sio Capital Management 2022 Q2 filed Aug. 15, 2022
- Sio Capital Management 2022 Q1 filed May 16, 2022
- Sio Capital Management 2021 Q4 filed Feb. 14, 2022