Baker Bros. Advisors

Baker Bros. Advisors as of March 31, 2015

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 130 positions in its portfolio as reported in the March 2015 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Pharmacyclics 19.2 $2.3B 9.0M 255.95
Incyte Corporation (INCY) 11.3 $1.4B 15M 91.66
Synageva Biopharma 9.5 $1.1B 12M 97.53
Seattle Genetics 8.5 $1.0B 29M 35.35
Salix Pharmaceuticals Inc note 2.750% 5/1 6.7 $802M 216M 3.71
ACADIA Pharmaceuticals (ACAD) 5.5 $668M 21M 32.59
BioMarin Pharmaceutical (BMRN) 4.3 $524M 4.2M 124.62
Incyte Corp Ltd conv 4.2 $508M 275M 1.85
Incyte Corp Incy Cvt 144a 0.37 convert 3.9 $471M 259M 1.82
Incyte Corp note 4.750%10/0 3.5 $422M 40M 10.43
Genomic Health 3.5 $417M 14M 30.55
Anacor Pharmaceuticals In 2.0 $243M 4.2M 57.85
Biomarin Pharmaceutical Inc note 1.875% 4/2 1.1 $137M 22M 6.12
Invitae (NVTAQ) 0.9 $110M 6.6M 16.76
Spark Therapeutics 0.9 $103M 1.3M 77.50
Dyax 0.8 $101M 6.0M 16.76
Bellicum Pharma 0.8 $97M 4.2M 23.17
BioCryst Pharmaceuticals (BCRX) 0.8 $95M 11M 9.03
Gilead Sciences conv 0.8 $90M 21M 4.31
Medivation Inc note 2.625% 4/0 0.7 $85M 34M 2.51
Mirati Therapeutics 0.7 $82M 2.8M 29.32
Acorda Therap note 1.75% 6/15 0.5 $61M 60M 1.02
Cerus Corporation (CERS) 0.5 $57M 14M 4.17
XOMA CORP Common equity shares 0.5 $54M 15M 3.64
Versartis 0.5 $55M 3.0M 18.37
XenoPort 0.4 $46M 6.5M 7.12
Array BioPharma 0.3 $42M 5.7M 7.37
Slxp 1 1/2 03/15/19 0.3 $39M 15M 2.66
Heron Therapeutics (HRTX) 0.3 $38M 2.6M 14.55
Dbv Technologies S A (DBVT) 0.3 $36M 1.5M 23.36
Halozyme Therapeutics (HALO) 0.3 $32M 2.2M 14.28
Catalyst Pharmaceutical Partners (CPRX) 0.3 $33M 7.6M 4.33
Insmed (INSM) 0.3 $33M 1.6M 20.80
Tg Therapeutics (TGTX) 0.3 $32M 2.1M 15.48
Derma Sciences 0.2 $29M 3.5M 8.47
Progenics Pharmaceuticals 0.2 $26M 4.4M 5.98
Idera Pharmaceuticals 0.2 $26M 7.0M 3.71
Alder Biopharmaceuticals 0.2 $25M 880k 28.86
Gilead Sciences (GILD) 0.2 $25M 250k 98.13
Acorda Therapeutics 0.2 $25M 739k 33.28
Sangamo Biosciences (SGMO) 0.2 $22M 1.4M 15.68
Neurocrine Biosciences (NBIX) 0.2 $22M 542k 39.71
Kythera Biopharmaceuticals I 0.1 $18M 354k 50.15
Bluebird Bio (BLUE) 0.1 $18M 147k 120.77
Biomarin Pharmaceutical Inc note 0.750%10/1 0.1 $18M 12M 1.47
Vanda Pharmaceuticals (VNDA) 0.1 $16M 1.8M 9.30
Repros Therapeutics 0.1 $17M 2.0M 8.59
Foamix Pharmaceuticals 0.1 $17M 1.8M 9.25
Novavax 0.1 $16M 1.9M 8.27
Clovis Oncology 0.1 $15M 203k 74.23
Lion Biotechnologies 0.1 $16M 1.3M 12.11
Omeros Corporation (OMER) 0.1 $14M 637k 22.03
Agios Pharmaceuticals (AGIO) 0.1 $14M 150k 94.30
Xencor (XNCR) 0.1 $13M 872k 15.32
Threshold Pharmaceuticals 0.1 $12M 2.9M 4.06
Alcobra 0.1 $10M 1.8M 5.63
Macrogenics (MGNX) 0.1 $9.6M 305k 31.37
Aerie Pharmaceuticals 0.1 $9.4M 299k 31.34
Ultragenyx Pharmaceutical (RARE) 0.1 $9.2M 149k 62.09
Aquinox Pharmaceuticals 0.1 $9.8M 1.2M 8.22
Osiris Therapeutics 0.1 $8.8M 499k 17.58
ImmunoGen 0.1 $8.9M 1000k 8.95
Sunesis Pharmaceuticals 0.1 $7.8M 3.2M 2.45
Arrowhead Research 0.1 $8.7M 1.3M 6.76
Proqr Thrapeutics N V shs euro (PRQR) 0.1 $8.8M 400k 21.88
Karyopharm Therapeutics (KPTI) 0.1 $6.6M 217k 30.61
La Jolla Pharmaceuticl Com Par 0.1 $7.5M 412k 18.30
Celladon 0.1 $6.9M 367k 18.94
Concert Pharmaceuticals I equity 0.1 $7.5M 496k 15.15
Ligand Pharmaceuticals In (LGND) 0.1 $5.7M 73k 77.11
Foundation Medicine 0.1 $6.0M 124k 48.11
Ignyta 0.1 $5.7M 571k 9.95
Juno Therapeutics 0.1 $6.1M 100k 60.66
Infinity Pharmaceuticals (INFIQ) 0.0 $4.3M 305k 13.98
Amarin Corporation (AMRN) 0.0 $5.2M 2.2M 2.34
Transition Therapeutics 0.0 $5.3M 769k 6.83
Discovery Laboratories 0.0 $4.2M 3.6M 1.19
Cytrx 0.0 $4.4M 1.3M 3.37
D Stemline Therapeutics 0.0 $4.8M 334k 14.47
Epizyme 0.0 $4.4M 233k 18.78
Chimerix (CMRX) 0.0 $4.3M 115k 37.69
ISIS Pharmaceuticals 0.0 $3.6M 57k 63.67
Zogenix 0.0 $3.1M 2.3M 1.37
Tekmira Pharmaceuticals Corporation 0.0 $3.2M 181k 17.46
Array Biopharma Inc note 3.000% 6/0 0.0 $3.8M 3.0M 1.25
Receptos 0.0 $3.9M 24k 164.90
Zafgen 0.0 $3.8M 95k 39.61
Lipocine 0.0 $3.4M 489k 6.90
Sage Therapeutics (SAGE) 0.0 $3.8M 75k 50.23
Aurinia Pharmaceuticals (AUPH) 0.0 $3.1M 712k 4.38
Assembly Biosciences 0.0 $3.3M 250k 13.24
Neuroderm Ltd F 0.0 $3.4M 250k 13.42
Bellerophon Therapeutics 0.0 $3.2M 350k 9.18
BioDelivery Sciences International 0.0 $2.7M 256k 10.50
Ironwood Pharmaceuticals (IRWD) 0.0 $2.7M 169k 16.00
Achillion Pharmaceuticals 0.0 $2.1M 214k 9.86
ZIOPHARM Oncology 0.0 $2.0M 189k 10.77
Palatin Technologies 0.0 $2.1M 2.1M 1.02
Biota Pharmaceuticals 0.0 $2.0M 863k 2.30
Enanta Pharmaceuticals (ENTA) 0.0 $2.3M 75k 30.61
Mast Therapeutics 0.0 $2.3M 4.7M 0.48
Auspex Pharmaceuticals 0.0 $2.5M 25k 100.28
Intra Cellular Therapies (ITCI) 0.0 $2.5M 104k 23.88
Vitae Pharmaceuticals 0.0 $2.2M 188k 11.71
Affimed Therapeutics B V 0.0 $2.5M 400k 6.30
Protalix Biotherapeutics Inc note 4.500% 9/1 0.0 $2.6M 3.5M 0.75
Proteon Therapeutics 0.0 $2.0M 173k 11.63
Synta Pharmaceuticals 0.0 $949k 489k 1.94
Rigel Pharmaceuticals (RIGL) 0.0 $1.3M 357k 3.57
OraSure Technologies (OSUR) 0.0 $1.5M 229k 6.54
Alnylam Pharmaceuticals (ALNY) 0.0 $1.2M 11k 104.41
Ohr Pharmaceutical 0.0 $941k 370k 2.54
Acceleron Pharma 0.0 $1.1M 29k 38.07
Ophthotech 0.0 $1.7M 36k 46.54
Achaogen 0.0 $976k 100k 9.76
Uniqure Nv (QURE) 0.0 $730k 30k 24.33
Mediwound Ltd cmn 0.0 $1.6M 225k 7.24
Aldeyra Therapeutics (ALDX) 0.0 $1.4M 142k 10.18
Loxo Oncology 0.0 $1.2M 100k 12.45
Marinus Pharmaceuticals 0.0 $1.8M 200k 8.99
Dermira 0.0 $1.5M 100k 15.35
Cellectis S A (CLLS) 0.0 $1.7M 50k 34.58
Ascendis Pharma A S (ASND) 0.0 $1.7M 100k 17.35
Aegerion Pharmaceuticals 0.0 $374k 14k 26.15
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $86k 13k 6.49
Chemocentryx 0.0 $370k 49k 7.54
Biodel 0.0 $36k 30k 1.19
Five Prime Therapeutics 0.0 $440k 19k 22.86
Biotime Inc wts oct 1 18 0.0 $40k 20k 1.99
Aptose Biosciences 0.0 $181k 33k 5.42