Baker Bros. Advisors

Baker Bros. Advisors as of June 30, 2015

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 126 positions in its portfolio as reported in the June 2015 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Incyte Corporation (INCY) 13.6 $1.5B 15M 104.21
Seattle Genetics 13.1 $1.5B 31M 48.40
Alexion Pharmaceuticals 10.4 $1.2B 6.5M 180.77
Abbvie (ABBV) 8.5 $966M 14M 67.19
ACADIA Pharmaceuticals (ACAD) 7.5 $858M 21M 41.88
Incyte Corporation Notes 1.25% 11/15/2020 144A Conv Bonds (Principal) 5.0 $568M 275M 2.07
BioMarin Pharmaceutical (BMRN) 4.9 $560M 4.1M 136.78
Incyte Corporation Notes 0.375% 11/15/2018 144A Conv Bonds (Principal) 4.6 $530M 259M 2.04
Incyte Corporation Notes 4.75% 10/1/2015 144A Conv Bonds (Principal) 4.2 $479M 40M 11.84
Genomic Health 3.3 $380M 14M 27.79
Anacor Pharmaceuticals In 2.5 $281M 3.6M 77.43
Dyax 1.8 $210M 7.9M 26.50
BioCryst Pharmaceuticals (BCRX) 1.5 $173M 12M 14.93
BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 Conv Bonds (Principal) 1.3 $150M 22M 6.70
Gilead, Inc. 1.625% 5/1/16 Conv Bonds (Principal) 0.9 $108M 21M 5.15
Invitae (NVTAQ) 0.9 $98M 6.6M 14.88
Bellicum Pharma 0.8 $89M 4.2M 21.27
Mirati Therapeutics 0.8 $88M 2.8M 31.47
Heron Therapeutics (HRTX) 0.8 $88M 2.8M 31.16
Spark Therapeutics 0.7 $76M 1.3M 60.27
Medivation, Inc. 2.625% 4/1/17 Conv Bonds (Principal) 0.7 $75M 34M 2.21
Cerus Corporation (CERS) 0.6 $70M 14M 5.19
Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 Conv Bonds (Principal) 0.5 $60M 60M 1.01
XOMA CORP Common equity shares 0.5 $57M 15M 3.88
DBV Technologies Sponsored Adr 0.5 $56M 1.9M 29.78
Versartis 0.5 $52M 3.4M 15.22
Alder Biopharmaceuticals 0.4 $47M 892k 52.97
Halozyme Therapeutics (HALO) 0.4 $44M 1.9M 22.58
Atyr Pharma Inc Common Stock Usd 0.001 0.4 $43M 2.3M 18.52
XenoPort 0.3 $40M 6.5M 6.13
Array BioPharma 0.3 $40M 5.5M 7.21
Insmed (INSM) 0.3 $39M 1.6M 24.42
Sangamo Biosciences (SGMO) 0.3 $36M 3.2M 11.09
ImmunoGen 0.3 $33M 2.3M 14.38
Tg Therapeutics (TGTX) 0.3 $33M 2.0M 16.59
Progenics Pharmaceuticals 0.3 $33M 4.4M 7.46
Catalyst Pharmaceutical Partners (CPRX) 0.3 $30M 7.3M 4.13
Gilead Sciences (GILD) 0.3 $29M 250k 117.08
Kythera Biopharmaceuticals I 0.3 $29M 388k 75.31
Neurocrine Biosciences (NBIX) 0.2 $26M 542k 47.76
Idera Pharmaceuticals 0.2 $26M 7.0M 3.71
Bluebird Bio 0.2 $25M 151k 168.37
Derma Sciences 0.2 $25M 3.5M 7.16
Acorda Therapeutics 0.2 $25M 739k 33.33
Novavax 0.2 $22M 1.9M 11.14
Foamix Pharmaceuticals SHS 0.2 $21M 2.0M 10.25
Xencor (XNCR) 0.2 $19M 872k 21.97
Galapagos NV Sponsored Adr (GLPG) 0.2 $19M 369k 51.50
BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 Conv Bonds (Principal) 0.2 $19M 12M 1.55
Clovis Oncology 0.2 $18M 203k 87.88
Omeros Corporation (OMER) 0.2 $17M 965k 17.99
Zogenix 0.1 $17M 10M 1.68
Lion Biotechnologies 0.1 $17M 1.8M 9.17
ProQR Therapeutics SHS (PRQR) 0.1 $17M 988k 16.67
Repros Therapeutics 0.1 $14M 2.0M 7.15
Achillion Pharmaceuticals 0.1 $14M 1.5M 8.86
Ultragenyx Pharmaceutical (RARE) 0.1 $13M 124k 102.39
Threshold Pharmaceuticals 0.1 $12M 2.9M 4.04
Alcobra SHS 0.1 $12M 1.8M 6.54
Macrogenics (MGNX) 0.1 $12M 305k 37.97
Agios Pharmaceuticals (AGIO) 0.1 $11M 100k 111.14
La Jolla Pharmaceuticl Com Par 0.1 $10M 412k 24.51
Zafgen 0.1 $10M 288k 34.63
Osiris Therapeutics 0.1 $9.7M 499k 19.46
Sunesis Pharmaceuticals 0.1 $9.6M 3.2M 3.01
Ignyta 0.1 $8.6M 571k 15.09
Aquinox Pharmaceuticals 0.1 $8.3M 1.2M 6.94
Sage Therapeutics (SAGE) 0.1 $7.7M 105k 73.00
Ligand Pharmaceuticals In (LGND) 0.1 $7.4M 73k 100.90
Concert Pharmaceuticals I equity 0.1 $7.4M 496k 14.89
Arrowhead Research 0.1 $7.2M 1.0M 7.15
Karyopharm Therapeutics 0.1 $5.9M 217k 27.21
Epizyme 0.0 $5.6M 233k 24.00
Amarin Corporation Sponsored Adr 0.0 $5.4M 2.2M 2.46
Affimed Therapeutics B V 0.0 $5.4M 400k 13.47
Chimerix (CMRX) 0.0 $5.3M 115k 46.20
Aerie Pharmaceuticals 0.0 $5.3M 299k 17.65
Vanda Pharmaceuticals (VNDA) 0.0 $5.2M 410k 12.69
Seres Therapeutics 0.0 $5.2M 125k 41.50
Cytrx 0.0 $4.9M 1.3M 3.72
Assembly Biosciences 0.0 $4.8M 250k 19.26
Receptos 0.0 $4.5M 24k 190.04
Juno Therapeutics 0.0 $4.3M 80k 53.33
D Stemline Therapeutics 0.0 $3.9M 334k 11.77
NeuroDerm Ord Shs 0.0 $3.8M 250k 15.35
Array BioPharma Inc. Notes 3.0% 6/1/2020 Conv Bonds (Principal) 0.0 $3.8M 3.0M 1.26
Curis 0.0 $3.6M 1.1M 3.31
Enanta Pharmaceuticals (ENTA) 0.0 $3.4M 75k 44.99
Intra Cellular Therapies (ITCI) 0.0 $3.3M 104k 31.95
ISIS Pharmaceuticals 0.0 $3.3M 57k 57.54
Proteon Therapeutics 0.0 $3.2M 177k 17.86
Immune Design 0.0 $3.1M 149k 20.65
Bellerophon Therapeutics 0.0 $2.8M 350k 7.93
Vitae Pharmaceuticals 0.0 $2.7M 188k 14.40
Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 Conv Bonds (Principal) 0.0 $2.6M 3.4M 0.76
Discovery Laboratories 0.0 $2.4M 3.6M 0.68
Marinus Pharmaceuticals 0.0 $2.3M 200k 11.60
Mast Therapeutics 0.0 $2.3M 4.7M 0.49
ZIOPHARM Oncology 0.0 $2.3M 189k 12.00
Tekmira Pharmaceuticals Corporation 0.0 $2.1M 181k 11.86
Aurinia Pharmaceuticals (AUPH) 0.0 $2.1M 712k 2.99
Ironwood Pharmaceuticals (IRWD) 0.0 $2.0M 169k 12.06
Ophthotech 0.0 $1.9M 36k 52.06
Adaptimmune Therapeutics Sponsored Adr (ADAP) 0.0 $1.8M 100k 18.33
Palatin Technologies 0.0 $1.8M 2.1M 0.89
Cellectis Sponsored Adr (CLLS) 0.0 $1.8M 50k 36.08
Loxo Oncology 0.0 $1.8M 100k 18.03
Ritter Pharmaceuticals 0.0 $1.8M 400k 4.45
Ascendis Pharma A/S Sponsored Adr (ASND) 0.0 $1.8M 100k 17.68
Dermira 0.0 $1.8M 100k 17.55
Biota Pharmaceuticals 0.0 $1.7M 830k 2.07
BioDelivery Sciences International 0.0 $1.7M 210k 7.96
MediWound Ord Shs 0.0 $1.6M 225k 7.07
Alnylam Pharmaceuticals (ALNY) 0.0 $1.4M 11k 119.84
Tenax Therapeutics 0.0 $1.3M 355k 3.69
Aldeyra Therapeutics (ALDX) 0.0 $1.1M 142k 7.76
Ohr Pharmaceutical 0.0 $930k 370k 2.51
Acceleron Pharma 0.0 $910k 29k 31.64
UniQure B.V. SHS (QURE) 0.0 $810k 30k 27.00
Foundation Medicine 0.0 $707k 21k 33.84
Achaogen 0.0 $603k 100k 6.03
Five Prime Therapeutics 0.0 $478k 19k 24.84
Chemocentryx 0.0 $404k 49k 8.23
Aptose Biosciences 0.0 $170k 33k 5.09
Cyclacel Pharmaceuticals, Inc. Pfd. Conv. Ex 6% Pfd Conv Ex 6% 0.0 $85k 13k 6.41
BioTime, Inc. Rights Warrants 0.0 $23k 20k 1.15