Baker Bros. Advisors

Baker Bros. Advisors as of Dec. 31, 2015

Portfolio Holdings for Baker Bros. Advisors

Baker Bros. Advisors holds 133 positions in its portfolio as reported in the December 2015 quarterly 13F filing

Company (Ticker) Portfolio Weight Valued At Change in Shares Share Count Share Price
Incyte Corporation (INCY) 17.5 $2.1B 20M 108.45
Seattle Genetics 13.9 $1.7B 37M 44.88
Alexion Pharmaceuticals 10.3 $1.2B 6.5M 190.75
Abbvie (ABBV) 7.0 $852M 14M 59.24
ACADIA Pharmaceuticals (ACAD) 6.0 $730M 21M 35.65
Incyte Corp Ltd conv 4.9 $596M 275M 2.17
Incyte Corp Incy Cvt 144a 0.37 convert 4.6 $557M 259M 2.15
Genomic Health 4.0 $481M 14M 35.20
Anacor Pharmaceuticals In 3.9 $474M 4.2M 112.97
BioMarin Pharmaceutical (BMRN) 3.6 $431M 4.1M 104.76
Dyax 2.6 $313M 8.3M 37.62
Dbv Technologies S A (DBVT) 1.6 $198M 5.5M 36.31
Acorda Therapeutics 1.3 $153M 3.6M 42.78
Anacor Pharmaceuticals Inc note 2.000%10/1 1.3 $153M 42M 3.63
BioCryst Pharmaceuticals (BCRX) 1.2 $147M 14M 10.32
Biomarin Pharmaceutical Inc note 1.875% 4/2 0.9 $115M 22M 5.15
Clovis Oncology Inc note 2.500% 9/1 0.9 $111M 129M 0.86
Bellicum Pharma 0.8 $99M 4.9M 20.27
Gilead Sciences conv 0.8 $93M 21M 4.46
Mirati Therapeutics (MRTX) 0.8 $93M 3.0M 31.60
Cerus Corporation (CERS) 0.7 $86M 14M 6.32
Aquinox Pharmaceuticals 0.7 $84M 6.7M 12.48
Heron Therapeutics (HRTX) 0.6 $78M 2.9M 26.70
ImmunoGen (IMGN) 0.5 $60M 4.5M 13.57
Acorda Therap note 1.75% 6/15 0.5 $59M 52M 1.15
Spark Therapeutics 0.5 $57M 1.3M 45.31
Invitae (NVTA) 0.5 $54M 6.6M 8.21
Neurocrine Biosciences (NBIX) 0.4 $48M 851k 56.57
Versartis 0.3 $40M 3.2M 12.39
Sangamo Biosciences (SGMO) 0.3 $37M 4.1M 9.13
Halozyme Therapeutics (HALO) 0.3 $34M 1.9M 17.33
Intra Cellular Therapies (ITCI) 0.3 $33M 609k 53.79
Medivation 0.3 $32M 660k 48.34
Progenics Pharmaceuticals 0.2 $27M 4.4M 6.13
Gilead Sciences (GILD) 0.2 $25M 250k 101.19
Tg Therapeutics (TGTX) 0.2 $24M 2.0M 11.93
Exelixis Inc cnv 0.2 $23M 20M 1.16
Galapagos Nv- (GLPG) 0.2 $23M 369k 62.88
Atyr Pharma Inc Common Stock Usd 0.001 0.2 $23M 2.3M 9.83
Idera Pharmaceuticals 0.2 $22M 7.0M 3.09
Achillion Pharmaceuticals 0.2 $22M 2.0M 10.79
Catalyst Pharmaceutical Partners (CPRX) 0.2 $20M 8.3M 2.45
XenoPort 0.2 $19M 3.5M 5.49
Alkermes (ALKS) 0.2 $20M 250k 79.38
Array BioPharma 0.1 $18M 4.3M 4.22
Novavax 0.1 $18M 2.2M 8.39
Insmed (INSM) 0.1 $18M 1.0M 18.15
Advanced Accelerat spon ads each rep 2 ord 0.1 $18M 568k 31.27
Derma Sciences 0.1 $17M 3.8M 4.57
Foamix Pharmaceuticals 0.1 $17M 2.0M 8.11
Aegerion Pharmaceuticals 2% Du cvbond 0.1 $18M 27M 0.66
Biomarin Pharmaceutical Inc note 0.750%10/1 0.1 $16M 12M 1.28
Alcobra 0.1 $15M 2.3M 6.28
Ultragenyx Pharmaceutical (RARE) 0.1 $14M 124k 112.18
Lion Biotechnologies 0.1 $14M 1.8M 7.72
Zogenix 0.1 $15M 1.0M 14.74
Dimension Therapeutics 0.1 $14M 1.2M 11.28
Xencor (XNCR) 0.1 $13M 872k 14.62
Global Blood Therapeutics In 0.1 $13M 400k 32.33
Macrogenics (MGNX) 0.1 $11M 364k 30.97
Bluebird Bio (BLUE) 0.1 $9.1M 141k 64.22
Concert Pharmaceuticals I equity 0.1 $9.4M 496k 18.97
Dermira 0.1 $9.5M 275k 34.61
Ascendis Pharma A S (ASND) 0.1 $9.3M 506k 18.32
Ligand Pharmaceuticals In (LGND) 0.1 $8.0M 73k 108.43
Proqr Thrapeutics N V shs euro (PRQR) 0.1 $8.6M 988k 8.68
Endocyte 0.1 $6.8M 1.7M 4.01
Aerie Pharmaceuticals 0.1 $7.3M 299k 24.35
Ignyta 0.1 $7.7M 571k 13.40
Curis 0.1 $5.8M 2.0M 2.91
Arrowhead Research 0.1 $6.2M 1.0M 6.15
Agios Pharmaceuticals (AGIO) 0.1 $6.5M 100k 64.92
Sage Therapeutics (SAGE) 0.1 $6.1M 105k 58.30
Akari Therapeutics 0.1 $5.7M 396k 14.50
Osiris Therapeutics 0.0 $5.2M 499k 10.38
Omeros Corporation (OMER) 0.0 $5.3M 336k 15.73
Medgenics 0.0 $4.6M 765k 6.02
Trevena 0.0 $4.7M 450k 10.50
Corsicanto Ltd conv bnd 0.0 $4.5M 5.0M 0.90
Neuroderm Ltd F 0.0 $5.2M 305k 17.05
Proteon Therapeutics 0.0 $4.6M 299k 15.51
Seres Therapeutics (MCRB) 0.0 $4.4M 125k 35.09
Aimmune Therapeutics 0.0 $4.6M 250k 18.45
Amarin Corporation (AMRN) 0.0 $4.2M 2.2M 1.89
Sunesis Pharmaceuticals 0.0 $4.0M 4.5M 0.90
Epizyme 0.0 $3.7M 233k 16.02
Vitae Pharmaceuticals 0.0 $3.4M 188k 18.10
Loxo Oncology 0.0 $3.9M 138k 28.45
Juno Therapeutics 0.0 $3.5M 80k 43.98
Nabriva Therapeutics 0.0 $3.4M 350k 9.62
Ionis Pharmaceuticals (IONS) 0.0 $3.5M 57k 61.94
Ironwood Pharmaceuticals (IRWD) 0.0 $2.0M 169k 11.59
Enanta Pharmaceuticals (ENTA) 0.0 $2.5M 75k 33.02
Mast Therapeutics 0.0 $2.0M 4.8M 0.42
D Stemline Therapeutics 0.0 $2.1M 334k 6.31
Array Biopharma Inc note 3.000% 6/0 0.0 $2.8M 3.0M 0.94
Ohr Pharmaceutical 0.0 $2.3M 370k 6.14
Ophthotech 0.0 $2.8M 36k 78.54
Karyopharm Therapeutics (KPTI) 0.0 $2.9M 217k 13.25
Flexion Therapeutics 0.0 $2.8M 147k 19.27
Mediwound Ltd cmn 0.0 $1.9M 225k 8.54
Immune Design 0.0 $3.0M 149k 20.08
Assembly Biosciences (ASMB) 0.0 $1.9M 250k 7.51
Affimed Therapeutics B V (AFMD) 0.0 $2.8M 400k 7.12
Dynavax Technologies (DVAX) 0.0 $1.8M 75k 24.16
Protalix Biotherapeutics Inc note 4.500% 9/1 0.0 $2.4M 3.4M 0.69
Trillium Therapeutics, Inc. Cmn 0.0 $2.7M 212k 12.61
Pronai Therapeutics 0.0 $3.0M 200k 15.04
Natera (NTRA) 0.0 $2.7M 250k 10.80
Alnylam Pharmaceuticals (ALNY) 0.0 $1.1M 11k 94.18
BioDelivery Sciences International 0.0 $1.0M 210k 4.79
Palatin Technologies 0.0 $1.4M 2.1M 0.66
Discovery Laboratories 0.0 $750k 3.6M 0.21
Cytrx 0.0 $1.7M 660k 2.65
Chimerix (CMRX) 0.0 $1.0M 115k 8.95
Acceleron Pharma 0.0 $1.4M 29k 48.77
Five Prime Therapeutics 0.0 $799k 19k 41.51
Aldeyra Therapeutics (ALDX) 0.0 $963k 142k 6.78
Aurinia Pharmaceuticals (AUPH) 0.0 $1.8M 712k 2.51
Marinus Pharmaceuticals 0.0 $1.5M 200k 7.64
Tenax Therapeutics 0.0 $1.4M 420k 3.28
Cellectis S A (CLLS) 0.0 $1.6M 50k 31.04
Adaptimmune Therapeutics (ADAP) 0.0 $1.2M 100k 12.06
Arbutus Biopharma (ABUS) 0.0 $804k 181k 4.45
Ritter Pharmaceuticals 0.0 $680k 400k 1.70
Cyclacel Pharmaceuticals Inc pfd conv ex 6% (CYCCP) 0.0 $52k 13k 3.92
Chemocentryx 0.0 $397k 49k 8.09
Foundation Medicine 0.0 $440k 21k 21.06
La Jolla Pharmaceuticl Com Par 0.0 $371k 14k 26.99
Achaogen 0.0 $574k 100k 5.74
Uniqure Nv (QURE) 0.0 $496k 30k 16.53
Biotime Inc wts oct 1 18 0.0 $24k 20k 1.19
Aptose Biosciences 0.0 $84k 33k 2.52