Perceptive Advisors
Latest statistics and disclosures from Perceptive Advisors's latest quarterly 13F-HR filing:
- Top 5 stock holdings are PRAX, CELC, RYTM, ASND, APGE, and represent 28.21% of Perceptive Advisors's stock portfolio.
- Added to shares of these 10 stocks: XBI (+$134M), PRAX (+$127M), EXAS (+$75M), APGE (+$74M), BSX (+$64M), SYRE (+$60M), BLTE (+$58M), DYN (+$58M), IVVD (+$54M), VRDN (+$49M).
- Started 39 new stock positions in XBI, IMMX, CDTX, MDLN, TECX, CVS, CPIX, MIRM, DHR, BCRX.
- Reduced shares in these 10 stocks: RYTM (-$45B), MRUS (-$127M), INSM (-$101M), ACLX (-$65M), VRNA (-$56M), AKRO (-$54M), PEN (-$34M), AQST (-$20M), MGTX (-$18M), NBIX (-$17M).
- Sold out of its positions in AKRO, APYX, HTFL, INSM, JANX, LYRA, PYXS, SCPH, SPRY, TEM. TRIB, VRNA, VKTX, MRUS, QURE.
- Perceptive Advisors was a net seller of stock by $-44B.
- Perceptive Advisors has $5.6B in assets under management (AUM), dropping by -87.67%.
- Central Index Key (CIK): 0001224962
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Portfolio Holdings for Perceptive Advisors
Perceptive Advisors holds 116 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Praxis Precision Medicines I Com New (PRAX) | 10.5 | $588M | +27% | 2.0M | 294.74 |
|
| Celcuity (CELC) | 5.6 | $315M | +6% | 3.2M | 99.74 |
|
| Rhythm Pharmaceuticals (RYTM) | 4.9 | $273M | -99% | 2.5M | 107.04 |
|
| Ascendis Pharma A/s Sponsored Adr (ASND) | 4.1 | $231M | 1.1M | 213.24 |
|
|
| Apogee Therapeutics (APGE) | 3.1 | $176M | +72% | 2.3M | 75.48 |
|
| Roivant Sciences SHS (ROIV) | 3.1 | $173M | +8% | 8.0M | 21.70 |
|
| Nuvalent Inc-a (NUVL) | 3.0 | $168M | +6% | 1.7M | 100.59 |
|
| Travere Therapeutics (TVTX) | 2.9 | $164M | +12% | 4.3M | 38.21 |
|
| Spdr Series Trust State Street Spd Put Option (XBI) | 2.4 | $134M | NEW | 1.1M | 121.93 |
|
| EXACT Sciences Corporation (EXAS) | 2.2 | $122M | +157% | 1.2M | 101.56 |
|
| Protagonist Therapeutics (PTGX) | 2.1 | $118M | +31% | 1.4M | 87.34 |
|
| Inhibrx Biosciences (INBX) | 2.0 | $115M | +9% | 1.5M | 79.00 |
|
| Edgewise Therapeutics (EWTX) | 2.0 | $111M | +17% | 4.5M | 24.82 |
|
| Immatics SHS (IMTX) | 1.9 | $109M | +10% | 10M | 10.50 |
|
| Spyre Therapeutics Com New (SYRE) | 1.8 | $101M | +149% | 3.1M | 32.76 |
|
| Amylyx Pharmaceuticals (AMLX) | 1.8 | $100M | -7% | 8.3M | 12.08 |
|
| Arcellx Common Stock (ACLX) | 1.7 | $96M | -40% | 1.5M | 65.20 |
|
| Miragen Therapeutics (VRDN) | 1.7 | $95M | +108% | 3.0M | 31.12 |
|
| Boston Scientific Corporation (BSX) | 1.7 | $93M | +215% | 979k | 95.35 |
|
| Amicus Therapeutics (FOLD) | 1.6 | $91M | 6.4M | 14.24 |
|
|
| Zymeworks Del (ZYME) | 1.5 | $86M | +56% | 3.3M | 26.33 |
|
| Astria Therapeutics | 1.5 | $85M | 6.5M | 13.09 |
|
|
| Meiragtx Holdings (MGTX) | 1.5 | $82M | -18% | 10M | 7.95 |
|
| CryoLife (AORT) | 1.4 | $79M | -14% | 1.7M | 45.61 |
|
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 1.3 | $73M | -5% | 2.9M | 25.01 |
|
| Dyne Therapeutics (DYN) | 1.2 | $68M | +543% | 3.5M | 19.56 |
|
| Nurix Therapeutics (NRIX) | 1.2 | $68M | +151% | 3.6M | 18.97 |
|
| Solid Biosciences Com New (SLDB) | 1.2 | $67M | 12M | 5.64 |
|
|
| Belite Bio Sponsored Ads (BLTE) | 1.2 | $66M | +732% | 414k | 159.96 |
|
| Abivax Sa Sponsored Ads (ABVX) | 1.1 | $62M | +17% | 458k | 134.85 |
|
| Adagio Therapeutics (IVVD) | 1.0 | $54M | NEW | 22M | 2.47 |
|
| Engene Holdings (ENGN) | 0.9 | $53M | +179% | 5.9M | 9.03 |
|
| Repligen Corporation (RGEN) | 0.9 | $52M | +16% | 316k | 163.86 |
|
| Immunovant (IMVT) | 0.9 | $51M | +25% | 2.0M | 25.42 |
|
| Intuitive Surgical Com New (ISRG) | 0.9 | $50M | +68% | 88k | 566.36 |
|
| Sionna Therapeutics (SION) | 0.9 | $49M | 1.2M | 41.14 |
|
|
| Neurocrine Biosciences (NBIX) | 0.8 | $47M | -26% | 331k | 141.83 |
|
| Danaher Corporation (DHR) | 0.8 | $46M | NEW | 200k | 228.92 |
|
| Oruka Therapeutics (ORKA) | 0.8 | $45M | +16% | 1.5M | 30.31 |
|
| Cytomx Therapeutics (CTMX) | 0.7 | $41M | 9.7M | 4.26 |
|
|
| Omada Health (OMDA) | 0.7 | $38M | 2.4M | 15.78 |
|
|
| Cidara Therapeutics Com New (CDTX) | 0.7 | $37M | NEW | 165k | 220.89 |
|
| Disc Medicine (IRON) | 0.6 | $36M | NEW | 451k | 79.41 |
|
| Bright Minds Biosciences Com New (DRUG) | 0.6 | $35M | 449k | 78.04 |
|
|
| Penumbra (PEN) | 0.6 | $34M | -49% | 111k | 310.91 |
|
| Alto Neuroscience Com Shs (ANRO) | 0.6 | $32M | +1048% | 1.8M | 17.80 |
|
| Caris Life Sciences (CAI) | 0.5 | $31M | +3% | 1.1M | 26.98 |
|
| Jazz Pharmaceuticals Shs Usd (JAZZ) | 0.5 | $29M | NEW | 170k | 170.00 |
|
| Palisade Bio (PALI) | 0.5 | $28M | NEW | 12M | 2.35 |
|
| Rapt Therapeutics Com New (RAPT) | 0.5 | $28M | +349% | 826k | 33.87 |
|
| Palvella Therapeutics Inc Ne (PVLA) | 0.5 | $28M | -32% | 266k | 104.67 |
|
| Axsome Therapeutics (AXSM) | 0.5 | $27M | 149k | 182.64 |
|
|
| Axogen (AXGN) | 0.5 | $26M | NEW | 784k | 32.73 |
|
| X4 Pharmaceuticals Com New (XFOR) | 0.5 | $25M | NEW | 6.3M | 4.00 |
|
| BioCryst Pharmaceuticals (BCRX) | 0.4 | $25M | NEW | 3.2M | 7.80 |
|
| Nautilus Biotechnology (NAUT) | 0.4 | $25M | 13M | 1.95 |
|
|
| Kodiak Sciences (KOD) | 0.4 | $24M | +33% | 849k | 27.96 |
|
| Biogen Idec (BIIB) | 0.4 | $22M | NEW | 124k | 175.99 |
|
| Aldeyra Therapeutics (ALDX) | 0.4 | $22M | -19% | 4.2M | 5.18 |
|
| Health Sciences Acq Corp 2 (OBIO) | 0.4 | $21M | -3% | 5.1M | 4.15 |
|
| Mirum Pharmaceuticals (MIRM) | 0.4 | $21M | NEW | 260k | 78.99 |
|
| Rapport Therapeutics (RAPP) | 0.4 | $20M | +66% | 674k | 30.34 |
|
| Grail (GRAL) | 0.4 | $20M | NEW | 237k | 85.59 |
|
| Irhythm Technologies (IRTC) | 0.3 | $19M | -12% | 108k | 177.44 |
|
| Beta Bionics (BBNX) | 0.3 | $18M | +116% | 603k | 30.47 |
|
| CVS Caremark Corporation (CVS) | 0.3 | $18M | NEW | 220k | 79.36 |
|
| Contineum Therapeutics Cl A (CTNM) | 0.3 | $17M | +104% | 1.5M | 11.43 |
|
| Guardant Health (GH) | 0.3 | $16M | NEW | 160k | 102.14 |
|
| Adma Biologics (ADMA) | 0.3 | $16M | -23% | 884k | 18.24 |
|
| Relay Therapeutics (RLAY) | 0.3 | $16M | NEW | 1.9M | 8.46 |
|
| Glaukos (GKOS) | 0.3 | $16M | NEW | 140k | 112.91 |
|
| Dex (DXCM) | 0.3 | $15M | NEW | 226k | 66.37 |
|
| Savara (SVRA) | 0.3 | $15M | NEW | 2.4M | 6.03 |
|
| Celcuity Note 2.750% 8/0 (Principal) | 0.3 | $14M | 6.5M | 2.17 |
|
|
| Athira Pharma | 0.3 | $14M | +244% | 1.9M | 7.57 |
|
| Septerna (SEPN) | 0.2 | $12M | -20% | 433k | 27.88 |
|
| Inhibikase Therapeutics Com New (IKT) | 0.2 | $11M | 5.4M | 2.05 |
|
|
| Adagio Med Hldgs (ADGM) | 0.2 | $10M | 9.9M | 1.04 |
|
|
| Oculis Holding Ordinary Shares (OCS) | 0.2 | $9.9M | NEW | 494k | 19.97 |
|
| Gossamer Bio (GOSS) | 0.2 | $9.7M | -17% | 3.1M | 3.10 |
|
| Maplight Therapeutics (MPLT) | 0.2 | $9.7M | NEW | 550k | 17.57 |
|
| Xenon Pharmaceuticals (XENE) | 0.2 | $9.0M | 201k | 44.82 |
|
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| Ocuphire Pharma (IRD) | 0.2 | $8.7M | 4.3M | 2.01 |
|
|
| Anteris Technologies Global (AVR) | 0.1 | $8.4M | 1.7M | 4.99 |
|
|
| Kestra Med Technologies SHS (KMTS) | 0.1 | $7.6M | NEW | 285k | 26.52 |
|
| Capricor Therapeutics Com New Call Option (CAPR) | 0.1 | $7.0M | NEW | 242k | 28.86 |
|
| Billiontoone Cl A (BLLN) | 0.1 | $6.0M | NEW | 73k | 81.84 |
|
| Biohaven Call Option (BHVN) | 0.1 | $5.6M | NEW | 500k | 11.29 |
|
| Kymera Therapeutics (KYMR) | 0.1 | $5.4M | -58% | 70k | 77.81 |
|
| Pepgen (PEPG) | 0.1 | $5.4M | 830k | 6.51 |
|
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| Crescent Biopharma (CBIO) | 0.1 | $5.4M | 454k | 11.86 |
|
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| Tenax Therapeutics Com New (TENX) | 0.1 | $5.4M | NEW | 439k | 12.19 |
|
| Corvus Pharmaceuticals (CRVS) | 0.1 | $5.3M | -51% | 692k | 7.70 |
|
| Tectonic Therapeutic Call Option (TECX) | 0.1 | $5.2M | NEW | 250k | 20.86 |
|
| Aquestive Therapeutics (AQST) | 0.1 | $4.8M | -80% | 747k | 6.46 |
|
| Tango Therapeutics (TNGX) | 0.1 | $4.5M | NEW | 513k | 8.86 |
|
| Krystal Biotech (KRYS) | 0.1 | $4.3M | -50% | 18k | 246.54 |
|
| Cogent Biosciences (COGT) | 0.1 | $4.3M | NEW | 121k | 35.52 |
|
| Olema Pharmaceuticals (OLMA) | 0.1 | $4.1M | NEW | 166k | 25.00 |
|
| Schrodinger (SDGR) | 0.1 | $3.6M | NEW | 202k | 17.88 |
|
| Outset Med Com New (OM) | 0.1 | $3.1M | 833k | 3.71 |
|
|
| Sab Biotherapeutics Com New (SABS) | 0.1 | $3.0M | NEW | 803k | 3.74 |
|
| Avalo Therapeutics Com New (AVTX) | 0.0 | $2.5M | 140k | 18.16 |
|
|
| Connect Biopharma Hldgs SHS (CNTB) | 0.0 | $2.2M | NEW | 793k | 2.82 |
|
| Immix Biopharma (IMMX) | 0.0 | $1.8M | NEW | 339k | 5.23 |
|
| Lexeo Therapeutics (LXEO) | 0.0 | $1.4M | 140k | 9.93 |
|
|
| Cumberland Pharmaceuticals (CPIX) | 0.0 | $1.4M | NEW | 341k | 3.98 |
|
| Medline Com Cl A (MDLN) | 0.0 | $1.2M | NEW | 28k | 42.00 |
|
| Palatin Technologies Com New (PTN) | 0.0 | $1.1M | NEW | 70k | 15.38 |
|
| Lenz Therapeutics (LENZ) | 0.0 | $800k | NEW | 50k | 16.00 |
|
| Biodesix (BDSX) | 0.0 | $739k | 109k | 6.80 |
|
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| Envveno Medical (NVNO) | 0.0 | $564k | 1.8M | 0.32 |
|
|
| Iovance Biotherapeutics (IOVA) | 0.0 | $417k | NEW | 153k | 2.73 |
|
| Revolution Medicines *w Exp 12/17/202 (RVMDW) | 0.0 | $235k | 250k | 0.94 |
|
|
| Ensysce Biosciences Com New (ENSC) | 0.0 | $80k | 87k | 0.92 |
|
|
| Surrozen *w Exp 08/01/203 (SRZNW) | 0.0 | $3.3k | 167k | 0.02 |
|
Past Filings by Perceptive Advisors
SEC 13F filings are viewable for Perceptive Advisors going back to 2010
- Perceptive Advisors 2025 Q4 filed Feb. 17, 2026
- Perceptive Advisors 2025 Q3 filed Nov. 14, 2025
- Perceptive Advisors 2025 Q2 filed Aug. 14, 2025
- Perceptive Advisors 2025 Q1 restated filed Aug. 6, 2025
- Perceptive Advisors 2025 Q1 filed May 15, 2025
- Perceptive Advisors 2024 Q4 filed Feb. 14, 2025
- Perceptive Advisors 2024 Q3 filed Nov. 14, 2024
- Perceptive Advisors 2024 Q2 restated filed Aug. 16, 2024
- Perceptive Advisors 2024 Q2 filed Aug. 14, 2024
- Perceptive Advisors 2024 Q1 restated filed Aug. 6, 2024
- Perceptive Advisors 2024 Q1 filed May 15, 2024
- Perceptive Advisors 2023 Q4 restated filed Feb. 26, 2024
- Perceptive Advisors 2023 Q4 filed Feb. 14, 2024
- Perceptive Advisors 2023 Q3 filed Nov. 14, 2023
- Perceptive Advisors 2023 Q2 restated filed Aug. 24, 2023
- Perceptive Advisors 2023 Q2 filed Aug. 14, 2023