Siren
Latest statistics and disclosures from Siren's latest quarterly 13F-HR filing:
- Top 5 stock holdings are SRRK, KYMR, ONC, ARWR, BCAX, and represent 34.46% of Siren's stock portfolio.
- Added to shares of these 10 stocks: RZLT (+$46M), GPCR (+$29M), TNGX (+$21M), RAPP (+$20M), RELY (+$18M), RCUS (+$18M), QURE (+$16M), RAPT (+$15M), COGT (+$13M), EWTX (+$12M).
- Started 24 new stock positions in TENX, KDP, RAPT, CRWV, QURE, VTVT, AS, MNDY, PEPG, CHYM. ALAB, GPCR, IREN, CMG, PINS, CFLT, ESTC, GBIO, SPOT, IMAB, KVUE, RZLT, Niq Global Intelligence, FIG.
- Reduced shares in these 10 stocks: MRUS (-$45M), APGE (-$26M), MLTX (-$24M), AKRO (-$17M), TRVI (-$13M), IRON (-$12M), NAMS (-$12M), PCVX (-$9.6M), GOOGL (-$7.2M), VERA (-$5.8M).
- Sold out of its positions in AKRO, APGE, TEAM, DECK, Generation Bio, HOOK, IGMS, MLTX, PCG, PCRX. RDDT, RCKT, TRML, UNH, PCVX, VERA, VIGL, BIRK, MRUS.
- Siren was a net buyer of stock by $65M.
- Siren has $2.6B in assets under management (AUM), dropping by 32.28%.
- Central Index Key (CIK): 0002005245
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Portfolio Holdings for Siren
Siren holds 115 positions in its portfolio as reported in the September 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 13.5 | $345M | 9.3M | 37.24 |
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| Kymera Therapeutics (KYMR) | 7.6 | $194M | 3.4M | 56.60 |
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| BeOne Medicines Sponsored Ads (ONC) | 6.6 | $168M | -3% | 493k | 340.70 |
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| Arrowhead Pharmaceuticals (ARWR) | 3.6 | $92M | 2.7M | 34.49 |
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| Bicara Therapeutics (BCAX) | 3.2 | $82M | 5.2M | 15.79 |
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| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 3.1 | $78M | -6% | 3.2M | 24.25 |
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| Crinetics Pharmaceuticals In (CRNX) | 2.8 | $70M | 1.7M | 41.65 |
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| Edgewise Therapeutics (EWTX) | 2.5 | $63M | +23% | 3.9M | 16.22 |
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| Disc Medicine (IRON) | 2.4 | $60M | -16% | 913k | 66.08 |
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| Dyne Therapeutics (DYN) | 2.3 | $60M | -2% | 4.7M | 12.65 |
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| Apellis Pharmaceuticals (APLS) | 2.3 | $58M | 2.6M | 22.63 |
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| Avidity Biosciences Ord (RNA) | 2.2 | $56M | +15% | 1.3M | 43.57 |
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| Stoke Therapeutics (STOK) | 2.1 | $53M | 2.2M | 23.50 |
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| Lexicon Pharmaceuticals Com New (LXRX) | 2.1 | $53M | 39M | 1.35 |
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| Rhythm Pharmaceuticals (RYTM) | 2.0 | $51M | +22% | 500k | 100.99 |
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| Tango Therapeutics (TNGX) | 1.9 | $49M | +74% | 5.9M | 8.40 |
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| Revolution Medicines (RVMD) | 1.9 | $49M | +11% | 1.0M | 46.70 |
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| Ascendis Pharma A/S Sponsored Adr (ASND) | 1.8 | $47M | -4% | 236k | 198.81 |
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| Rezolute Com New (RZLT) | 1.8 | $46M | NEW | 4.9M | 9.40 |
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| Solid Biosciences Com New (SLDB) | 1.8 | $46M | 7.4M | 6.17 |
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| Septerna (SEPN) | 1.6 | $41M | 2.2M | 18.81 |
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| Arcus Biosciences Incorporated (RCUS) | 1.5 | $40M | +80% | 2.9M | 13.60 |
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| Taysha Gene Therapies Com Shs (TSHA) | 1.4 | $36M | 11M | 3.27 |
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| Taboola.com Ord Shs (TBLA) | 1.3 | $34M | 10M | 3.41 |
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| Xenon Pharmaceuticals (XENE) | 1.3 | $33M | 813k | 40.15 |
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| Soleno Therapeutics (SLNO) | 1.2 | $32M | 467k | 67.60 |
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| Rapport Therapeutics (RAPP) | 1.2 | $31M | +178% | 1.1M | 29.70 |
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| Structure Therapeutics Sponsored Ads (GPCR) | 1.1 | $29M | NEW | 1.0M | 28.00 |
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| WAVE Life Sciences SHS (WVE) | 1.1 | $27M | 3.7M | 7.32 |
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| Remitly Global (RELY) | 1.0 | $26M | +213% | 1.6M | 16.30 |
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| Cogent Biosciences (COGT) | 1.0 | $25M | +101% | 1.7M | 14.36 |
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| Trevi Therapeutics (TRVI) | 0.9 | $23M | -35% | 2.5M | 9.15 |
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| NewAmsterdam Pharma Company NV Ordinary Shares (NAMS) | 0.9 | $22M | -35% | 766k | 28.44 |
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| Korro Bio (KRRO) | 0.8 | $20M | 419k | 47.89 |
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| Erasca (ERAS) | 0.7 | $19M | 8.8M | 2.18 |
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| IHS Holding Ord Shs (IHS) | 0.6 | $16M | 2.4M | 6.82 |
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| Uniqure NV SHS (QURE) | 0.6 | $16M | NEW | 275k | 58.37 |
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| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.6 | $16M | 2.0M | 7.74 |
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| Silence Therapeutics Ads (SLN) | 0.6 | $15M | 2.9M | 5.19 |
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| RAPT Therapeutics Com New (RAPT) | 0.6 | $15M | NEW | 581k | 25.79 |
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| Upstream Bio (UPB) | 0.6 | $15M | 789k | 18.81 |
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| Gossamer Bio (GOSS) | 0.5 | $14M | 5.2M | 2.63 |
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| Arrivent Biopharma (AVBP) | 0.5 | $13M | 700k | 18.45 |
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| Amazon (AMZN) | 0.5 | $13M | +3% | 59k | 219.57 |
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| Oric Pharmaceuticals (ORIC) | 0.5 | $12M | 1.0M | 12.00 |
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| Denali Therapeutics (DNLI) | 0.5 | $12M | 822k | 14.52 |
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| Ionq Inc Pipe (IONQ) | 0.4 | $11M | 170k | 61.50 |
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| Sionna Therapeutics (SION) | 0.4 | $9.6M | 325k | 29.41 |
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| CrowdStrike Holdings Cl A (CRWD) | 0.4 | $9.1M | 19k | 490.38 |
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| Microsoft Corporation (MSFT) | 0.3 | $8.9M | +6% | 17k | 517.95 |
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| Seer Com Cl A (SEER) | 0.3 | $8.7M | 4.0M | 2.17 |
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| Nebius Group NV Shs Class A (NBIS) | 0.3 | $8.2M | +42% | 73k | 112.27 |
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| Neumora Therapeutics (NMRA) | 0.3 | $7.9M | 4.4M | 1.82 |
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| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.3 | $7.9M | -7% | 28k | 279.29 |
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| salesforce (CRM) | 0.3 | $7.1M | +33% | 30k | 237.00 |
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| Cullinan Oncology (CGEM) | 0.3 | $7.1M | 1.2M | 5.93 |
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| NVIDIA Corporation (NVDA) | 0.3 | $7.0M | -25% | 38k | 186.57 |
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| Servicenow (NOW) | 0.3 | $6.6M | +39% | 7.1k | 920.28 |
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| Spyre Therapeutics Com New (SYRE) | 0.2 | $6.2M | 369k | 16.76 |
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| Cartesian Therapeutics Com New (RNAC) | 0.2 | $5.8M | 563k | 10.22 |
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| PDD Holdings Sponsored Ads (PDD) | 0.2 | $5.7M | -17% | 43k | 132.17 |
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| Eledon Pharmaceuticals (ELDN) | 0.2 | $5.4M | +200% | 2.1M | 2.59 |
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| Adobe Systems Incorporated (ADBE) | 0.2 | $5.3M | 15k | 352.75 |
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| Alphabet Cap Stk Cl A (GOOGL) | 0.2 | $5.2M | -58% | 21k | 243.10 |
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| Jfrog Ord Shs (FROG) | 0.2 | $5.1M | 107k | 47.33 |
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| Sagimet Biosciences Com Ser A (SGMT) | 0.2 | $5.0M | 725k | 6.86 |
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| Dynatrace Com New (DT) | 0.2 | $4.9M | +33% | 100k | 48.45 |
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| Datadog Cl A Com (DDOG) | 0.2 | $4.7M | -14% | 33k | 142.40 |
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| I-Mab Sponsored Ads (IMAB) | 0.2 | $4.4M | NEW | 1.2M | 3.78 |
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| Agenus Com New (AGEN) | 0.2 | $4.1M | 1.1M | 3.85 |
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| Lexeo Therapeutics (LXEO) | 0.2 | $4.0M | 603k | 6.64 |
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| Black Diamond Therapeutics (BDTX) | 0.2 | $4.0M | 1.0M | 3.79 |
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| Aadi Bioscience (WHWK) | 0.2 | $4.0M | 2.1M | 1.90 |
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| vTv Therapeutics Cl A New (VTVT) | 0.1 | $3.8M | NEW | 163k | 23.35 |
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| Instil Bio Com New (TIL) | 0.1 | $3.6M | 204k | 17.86 |
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| Foghorn Therapeutics (FHTX) | 0.1 | $3.5M | 721k | 4.89 |
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| ProQR Therapeutics NV Shs Euro (PRQR) | 0.1 | $3.3M | 1.6M | 2.13 |
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| New Oriental Education & Technology Group Spon Adr (EDU) | 0.1 | $3.3M | -13% | 62k | 53.07 |
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| CoreWeave Com Cl A (CRWV) | 0.1 | $3.3M | NEW | 24k | 136.85 |
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| Pepgen (PEPG) | 0.1 | $3.2M | NEW | 700k | 4.62 |
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| GitLab Class A Com (GTLB) | 0.1 | $2.9M | +82% | 64k | 45.08 |
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| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $2.8M | +38% | 145k | 19.00 |
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| Palo Alto Networks (PANW) | 0.1 | $2.7M | +16% | 14k | 203.62 |
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| Tenax Therapeutics Com New (TENX) | 0.1 | $2.7M | NEW | 352k | 7.61 |
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| Workiva Com Cl A (WK) | 0.1 | $2.6M | +7% | 30k | 86.08 |
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| Qualcomm (QCOM) | 0.1 | $2.3M | 14k | 166.36 |
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| Bioage Labs (BIOA) | 0.1 | $2.2M | 382k | 5.88 |
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| Keurig Dr Pepper (KDP) | 0.1 | $2.0M | NEW | 77k | 25.51 |
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| Hubspot (HUBS) | 0.1 | $1.9M | +33% | 4.0k | 467.80 |
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| Chipotle Mexican Grill (CMG) | 0.1 | $1.9M | NEW | 48k | 39.19 |
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| Kalaris Therapeutics (KLRS) | 0.1 | $1.8M | +12% | 318k | 5.78 |
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| Generation Bio Com New (GBIO) | 0.1 | $1.8M | NEW | 297k | 6.12 |
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| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $1.7M | +50% | 90k | 18.53 |
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| Primo Brands Corp Class A Com Shs (PRMB) | 0.1 | $1.7M | +100% | 75k | 22.10 |
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| Spotify Technology SA SHS (SPOT) | 0.1 | $1.5M | NEW | 2.2k | 698.00 |
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| NIQ Global Intelligence Ordinary Shares | 0.1 | $1.5M | NEW | 95k | 15.70 |
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| monday.com SHS (MNDY) | 0.1 | $1.4M | NEW | 7.0k | 193.69 |
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| Sailpoint (SAIL) | 0.0 | $1.1M | 50k | 22.08 |
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| Elastic NV Ord Shs (ESTC) | 0.0 | $1.1M | NEW | 13k | 84.49 |
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| Iren Ordinary Shares (IREN) | 0.0 | $938k | NEW | 20k | 46.91 |
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| SEMrush Holdings Cl A Com (SEMR) | 0.0 | $885k | 125k | 7.08 |
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| Amer Sports Com Shs (AS) | 0.0 | $869k | NEW | 25k | 34.75 |
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| Pinterest Cl A (PINS) | 0.0 | $804k | NEW | 25k | 32.17 |
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| Figma Class A Com Stk (FIG) | 0.0 | $778k | NEW | 15k | 51.87 |
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| Confluent Class A Com (CFLT) | 0.0 | $743k | NEW | 38k | 19.80 |
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| Procore Technologies (PCOR) | 0.0 | $729k | 10k | 72.92 |
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| Astera Labs (ALAB) | 0.0 | $685k | NEW | 3.5k | 195.80 |
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| Tesla Motors (TSLA) | 0.0 | $667k | -62% | 1.5k | 444.72 |
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| Chime Financial Com Shs Cl A (CHYM) | 0.0 | $504k | NEW | 25k | 20.17 |
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| Ccc Intelligent Solutions Holdings (CCCS) | 0.0 | $456k | 50k | 9.11 |
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| Kenvue (KVUE) | 0.0 | $406k | NEW | 25k | 16.23 |
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| Vertiv Holdings Com Cl A (VRT) | 0.0 | $302k | 2.0k | 150.86 |
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| Cyclerion Therapeutics (CYCN) | 0.0 | $267k | 116k | 2.30 |
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| Caribou Biosciences (CRBU) | 0.0 | $246k | 105k | 2.33 |
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| Ironwood Pharmaceuticals Com Cl A (IRWD) | 0.0 | $145k | 111k | 1.31 |
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Past Filings by Siren
SEC 13F filings are viewable for Siren going back to 2024
- Siren 2025 Q3 filed Nov. 13, 2025
- Siren 2025 Q2 filed Aug. 13, 2025
- Siren 2025 Q1 restated filed May 23, 2025
- Siren 2025 Q1 filed May 14, 2025
- Siren 2024 Q4 filed Feb. 14, 2025
- Siren 2024 Q3 filed Nov. 13, 2024