Siren
Latest statistics and disclosures from Siren's latest quarterly 13F-HR filing:
- Top 5 stock holdings are SRRK, KYMR, ONC, EWTX, RVMD, and represent 32.91% of Siren's stock portfolio.
- Added to shares of these 10 stocks: OLMA (+$83M), SRRK (+$69M), ZYME (+$44M), DBVT (+$36M), ENGN (+$30M), RAPT (+$27M), MLYS (+$25M), RVMD (+$23M), FULC (+$22M), TNGX (+$20M).
- Started 26 new stock positions in MLYS, PVLA, ALMS, IVVD, IKT, BLLN, XFOR, FULC, DBVT, ZURA.
- Reduced shares in these 10 stocks: ARWR (-$78M), RNA (-$56M), RZLT (-$46M), SLNO (-$32M), DYN (-$24M), NAMS (-$22M), WVE (-$21M), QURE (-$16M), AVBP (-$13M), KYMR (-$11M).
- Sold out of its positions in AVBP, ALAB, RNA, BIOA, CCC, CHYM, CMG, CFLT, ELDN, HUBS.
- Siren was a net buyer of stock by $213M.
- Siren has $3.4B in assets under management (AUM), dropping by 31.14%.
- Central Index Key (CIK): 0002005245
Tip: Access up to 7 years of quarterly data
Positions held by Siren consolidated in one spreadsheet with up to 7 years of data
Download as csv
Download as Excel
Portfolio Holdings for Siren
Siren holds 113 positions in its portfolio as reported in the December 2025 quarterly 13F filing
| Company (Ticker) | Portfolio Weight | Valued At | Change in Shares | Share Count | Share Price | |
|---|---|---|---|---|---|---|
| Scholar Rock Hldg Corp (SRRK) | 14.2 | $477M | +17% | 11M | 44.05 |
|
| Kymera Therapeutics (KYMR) | 7.6 | $256M | -4% | 3.3M | 77.81 |
|
| BeOne Medicines Sponsored Ads (ONC) | 4.5 | $152M | 500k | 303.81 |
|
|
| Edgewise Therapeutics (EWTX) | 3.4 | $112M | +16% | 4.5M | 24.82 |
|
| Revolution Medicines (RVMD) | 3.2 | $106M | +27% | 1.3M | 79.65 |
|
| Centessa Pharmaceuticals Sponsored Ads (CNTA) | 3.0 | $101M | +24% | 4.0M | 25.01 |
|
| Arrowhead Pharmaceuticals (ARWR) | 3.0 | $100M | -43% | 1.5M | 66.39 |
|
| Bicara Therapeutics (BCAX) | 2.6 | $88M | 5.2M | 16.83 |
|
|
| Olema Pharmaceuticals (OLMA) | 2.5 | $83M | NEW | 3.3M | 25.00 |
|
| Disc Medicine (IRON) | 2.3 | $79M | +8% | 988k | 79.41 |
|
| Structure Therapeutics Sponsored Ads (GPCR) | 2.2 | $75M | +5% | 1.1M | 69.55 |
|
| Tango Therapeutics (TNGX) | 2.2 | $72M | +38% | 8.2M | 8.86 |
|
| Arcus Biosciences Incorporated (RCUS) | 2.1 | $72M | +3% | 3.0M | 23.83 |
|
| Stoke Therapeutics (STOK) | 2.1 | $71M | 2.2M | 31.74 |
|
|
| Crinetics Pharmaceuticals In (CRNX) | 2.1 | $70M | -10% | 1.5M | 46.55 |
|
| Dyne Therapeutics (DYN) | 2.0 | $69M | -25% | 3.5M | 19.56 |
|
| Apellis Pharmaceuticals (APLS) | 1.9 | $65M | 2.6M | 25.12 |
|
|
| Cogent Biosciences (COGT) | 1.7 | $58M | -5% | 1.6M | 35.52 |
|
| Septerna (SEPN) | 1.7 | $56M | -9% | 2.0M | 27.88 |
|
| Taysha Gene Therapies Com Shs (TSHA) | 1.7 | $56M | -8% | 10M | 5.50 |
|
| Rhythm Pharmaceuticals (RYTM) | 1.6 | $54M | 500k | 107.04 |
|
|
| Ascendis Pharma A/S Sponsored Adr (ASND) | 1.5 | $50M | 236k | 213.24 |
|
|
| RAPT Therapeutics Com New (RAPT) | 1.4 | $47M | +136% | 1.4M | 33.87 |
|
| Taboola.com Ord Shs (TBLA) | 1.4 | $46M | 10M | 4.61 |
|
|
| Lexicon Pharmaceuticals Com New (LXRX) | 1.3 | $45M | 39M | 1.15 |
|
|
| Zymeworks Del (ZYME) | 1.3 | $44M | NEW | 1.7M | 26.33 |
|
| Solid Biosciences Com New (SLDB) | 1.3 | $43M | +3% | 7.7M | 5.64 |
|
| WAVE Life Sciences SHS (WVE) | 1.2 | $42M | -33% | 2.5M | 17.00 |
|
| Xenon Pharmaceuticals (XENE) | 1.1 | $36M | 813k | 44.82 |
|
|
| Dbv Technologies SA Sponsored Ads (DBVT) | 1.1 | $36M | NEW | 1.9M | 19.17 |
|
| Erasca (ERAS) | 1.0 | $33M | 8.8M | 3.72 |
|
|
| Engene Holdings (ENGN) | 0.9 | $30M | NEW | 3.3M | 9.03 |
|
| Trevi Therapeutics (TRVI) | 0.9 | $29M | -9% | 2.3M | 12.52 |
|
| Spyre Therapeutics Com New (SYRE) | 0.8 | $27M | +122% | 819k | 32.76 |
|
| Mineralys Therapeutics (MLYS) | 0.8 | $25M | NEW | 700k | 36.29 |
|
| Denali Therapeutics (DNLI) | 0.7 | $23M | +69% | 1.4M | 16.51 |
|
| Remitly Global (RELY) | 0.7 | $22M | 1.6M | 13.80 |
|
|
| Fulcrum Therapeutics (FULC) | 0.7 | $22M | NEW | 2.0M | 11.31 |
|
| Rapport Therapeutics (RAPP) | 0.6 | $22M | -32% | 709k | 30.34 |
|
| Silence Therapeutics Ads (SLN) | 0.5 | $18M | 2.9M | 6.08 |
|
|
| IHS Holding Ord Shs (IHS) | 0.5 | $18M | 2.4M | 7.46 |
|
|
| Gossamer Bio (GOSS) | 0.5 | $16M | 5.2M | 3.10 |
|
|
| Upstream Bio (UPB) | 0.5 | $16M | -25% | 589k | 27.15 |
|
| Bicycle Therapeutics Sponsored Ads (BCYC) | 0.4 | $14M | 2.0M | 7.08 |
|
|
| Monopar Therapeutics Com New (MNPR) | 0.4 | $14M | NEW | 212k | 65.30 |
|
| Cullinan Oncology (CGEM) | 0.4 | $12M | 1.2M | 10.35 |
|
|
| Sionna Therapeutics (SION) | 0.4 | $12M | -7% | 300k | 41.14 |
|
| Inhibikase Therapeutics Com New (IKT) | 0.4 | $12M | NEW | 5.9M | 2.05 |
|
| NovaBridge Biosciences Sponsored Ads (NBP) | 0.4 | $12M | +157% | 3.0M | 3.98 |
|
| Amazon (AMZN) | 0.4 | $12M | -11% | 52k | 230.82 |
|
| Neumora Therapeutics (NMRA) | 0.3 | $11M | +44% | 6.3M | 1.79 |
|
| Mind Medicine Com New (MNMD) | 0.3 | $11M | NEW | 800k | 13.39 |
|
| Benitec Biopharma Com New (BNTC) | 0.3 | $10M | NEW | 775k | 13.47 |
|
| Adagio Therapeutics (IVVD) | 0.3 | $9.9M | NEW | 4.0M | 2.47 |
|
| Taiwan Semiconductor Manufacturing Sponsored Ads (TSM) | 0.3 | $8.4M | 28k | 303.89 |
|
|
| Oric Pharmaceuticals (ORIC) | 0.2 | $8.2M | 1.0M | 8.18 |
|
|
| Maplight Therapeutics (MPLT) | 0.2 | $7.9M | NEW | 450k | 17.57 |
|
| Palvella Therapeutics Inc Ne (PVLA) | 0.2 | $7.9M | NEW | 75k | 104.67 |
|
| CrowdStrike Holdings Cl A (CRWD) | 0.2 | $7.7M | -10% | 17k | 468.76 |
|
| Ionq Inc Pipe (IONQ) | 0.2 | $7.6M | 170k | 44.87 |
|
|
| Seer Com Cl A (SEER) | 0.2 | $7.3M | 4.0M | 1.83 |
|
|
| Microsoft Corporation (MSFT) | 0.2 | $7.3M | -12% | 15k | 483.62 |
|
| PDD Holdings Sponsored Ads (PDD) | 0.2 | $7.2M | +46% | 63k | 113.39 |
|
| Lexeo Therapeutics (LXEO) | 0.2 | $7.2M | +19% | 721k | 9.93 |
|
| NVIDIA Corporation (NVDA) | 0.2 | $7.0M | 38k | 186.50 |
|
|
| salesforce (CRM) | 0.2 | $6.9M | -13% | 26k | 264.91 |
|
| Compass Pathways Sponsored Ads (CMPS) | 0.2 | $6.9M | NEW | 1.0M | 6.90 |
|
| BillionToOne Cl A (BLLN) | 0.2 | $6.9M | NEW | 84k | 81.84 |
|
| Workiva Com Cl A (WK) | 0.2 | $6.8M | +163% | 79k | 86.25 |
|
| Zura Bio Class A Ord Shs (ZURA) | 0.2 | $6.8M | NEW | 1.3M | 5.24 |
|
| vTv Therapeutics Cl A New (VTVT) | 0.2 | $6.5M | 163k | 39.99 |
|
|
| Alphabet Cap Stk Cl A (GOOGL) | 0.2 | $6.5M | -2% | 21k | 313.00 |
|
| Nebius Group NV Shs Class A (NBIS) | 0.2 | $6.4M | +4% | 76k | 83.70 |
|
| Savara (SVRA) | 0.2 | $6.0M | NEW | 1.0M | 6.03 |
|
| X4 Pharmaceuticals Com New (XFOR) | 0.2 | $6.0M | NEW | 1.5M | 4.00 |
|
| Jfrog Ord Shs (FROG) | 0.2 | $5.8M | -12% | 94k | 62.46 |
|
| Servicenow (NOW) | 0.2 | $5.5M | +400% | 36k | 153.19 |
|
| Tenax Therapeutics Com New (TENX) | 0.2 | $5.2M | +21% | 427k | 12.19 |
|
| Aadi Bioscience (WHWK) | 0.2 | $5.0M | 2.1M | 2.42 |
|
|
| Dynatrace Com New (DT) | 0.1 | $5.0M | +14% | 115k | 43.34 |
|
| Datadog Cl A Com (DDOG) | 0.1 | $5.0M | +10% | 36k | 135.99 |
|
| Alumis (ALMS) | 0.1 | $4.9M | NEW | 500k | 9.76 |
|
| Meta Platforms Cl A (META) | 0.1 | $4.7M | NEW | 7.2k | 660.09 |
|
| Pepgen (PEPG) | 0.1 | $4.6M | 700k | 6.51 |
|
|
| Sagimet Biosciences Com Ser A (SGMT) | 0.1 | $4.3M | 725k | 5.92 |
|
|
| Adobe Systems Incorporated (ADBE) | 0.1 | $4.2M | -19% | 12k | 349.99 |
|
| Foghorn Therapeutics (FHTX) | 0.1 | $3.9M | 721k | 5.40 |
|
|
| GitLab Class A Com (GTLB) | 0.1 | $3.7M | +54% | 99k | 37.53 |
|
| Kalaris Therapeutics (KLRS) | 0.1 | $3.7M | +36% | 436k | 8.44 |
|
| New Oriental Education & Technology Group Spon Adr (EDU) | 0.1 | $3.4M | 62k | 55.03 |
|
|
| Agenus Com New (AGEN) | 0.1 | $3.3M | 1.1M | 3.14 |
|
|
| Medline Com Cl A (MDLN) | 0.1 | $3.2M | NEW | 75k | 42.00 |
|
| Korro Bio (KRRO) | 0.1 | $2.8M | -16% | 348k | 8.01 |
|
| Cellebrite DI Ordinary Shares (CLBT) | 0.1 | $2.7M | +66% | 150k | 18.04 |
|
| Rani Therapeutics Holdings Com Cl A (RANI) | 0.1 | $2.7M | NEW | 2.0M | 1.35 |
|
| Zscaler Incorporated (ZS) | 0.1 | $2.7M | NEW | 12k | 224.92 |
|
| Black Diamond Therapeutics (BDTX) | 0.1 | $2.5M | 1.0M | 2.43 |
|
|
| monday.com SHS (MNDY) | 0.1 | $2.5M | +142% | 17k | 147.56 |
|
| Broadcom (AVGO) | 0.1 | $2.4M | NEW | 7.0k | 346.10 |
|
| Qualcomm (QCOM) | 0.1 | $2.4M | 14k | 171.05 |
|
|
| Arm Holdings Sponsored Ads (ARM) | 0.1 | $2.4M | NEW | 22k | 109.31 |
|
| Ke Holdings Sponsored Ads (BEKE) | 0.1 | $2.3M | 145k | 15.76 |
|
|
| Instil Bio Com New (TIL) | 0.1 | $2.2M | 204k | 11.00 |
|
|
| Palo Alto Networks (PANW) | 0.1 | $2.1M | -14% | 12k | 184.20 |
|
| CoreWeave Com Cl A (CRWV) | 0.1 | $2.0M | +14% | 28k | 71.61 |
|
| Iren Ordinary Shares (IREN) | 0.0 | $1.6M | +115% | 43k | 37.77 |
|
| Varonis Sys (VRNS) | 0.0 | $1.2M | NEW | 38k | 32.80 |
|
| Primo Brands Corp Class A Com Shs (PRMB) | 0.0 | $1.2M | 75k | 16.35 |
|
|
| Generation Bio Com New (GBIO) | 0.0 | $1.1M | -32% | 201k | 5.68 |
|
| Figma Class A Com Stk (FIG) | 0.0 | $934k | +66% | 25k | 37.37 |
|
| Tesla Motors (TSLA) | 0.0 | $675k | 1.5k | 449.72 |
|
|
| Caribou Biosciences (CRBU) | 0.0 | $168k | 105k | 1.59 |
|
|
| Cyclerion Therapeutics (CYCN) | 0.0 | $147k | 116k | 1.27 |
|
Past Filings by Siren
SEC 13F filings are viewable for Siren going back to 2024
- Siren 2025 Q4 filed Feb. 13, 2026
- Siren 2025 Q3 filed Nov. 13, 2025
- Siren 2025 Q2 filed Aug. 13, 2025
- Siren 2025 Q1 restated filed May 23, 2025
- Siren 2025 Q1 filed May 14, 2025
- Siren 2024 Q4 filed Feb. 14, 2025
- Siren 2024 Q3 filed Nov. 13, 2024